• Journal of Society of Preventive Korean Medicine
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• v.4 no.2
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• pp.25-56
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• 2000

Trace element are involved in enzymatic activities, immunological reactions. physiological mechanisms. Deficiency in some trace elements, such as iron and iodine. is still an important health problem, The role of trace elements deficiency is suspected in various clinical situations and is now confirmed by well designed supplementation studies. However, the importance of trace elements as chinese herbal constituents is not sufficiently appreciated by the oriental medical profession, although in recent years a significant increase of new finding on their essential character in chinese herbal medicine occurred. It is well known that herbal medicine contains a variety of trace elements which would show therapeutic effects with active components in herbal medicine . In china, recent work showed some positive correlation between trace element and traditional chinese medicine (TCM) in terms of therapeutic effects even if their role in therapeutic effects is still obscure. In korea, not much attention has been on the therapeutic importance of trace element contained in herbal medicine Here, the therapeutic effects of trace element in TCM were reviewed and summarized. 1. Iron, copper, zinc and manganese are mainly contained in TCM. In addtion, chromium, magnesium, molybdenum, nickel, alminium, cobalt, arsenic and selenium has been studied for their therapeutic effects 2. Zinc, is decreased in patients who have deficiency of kindney(腎虛) and chronic disease. Fe is decreased in patients who have deficiency of blood(血虛). However copper is increased in patients who have chronic disease and hepatic disease.3 Iron concentration is high in herbs used for tonifying and nourishing yin or blood(補陰補血藥) Zinc concentration is high also in herb used for tonifying kidiney and vital essence(補腎補精藥). In addition. copper concentration Is high in herb used for replenishing qi(補氣藥) 4 In herbal drugs, the therapeutic substances in TCM are not only organic but also inorganic. It seems that trace elements would be one of components in herb for its therapeutic effects. This indicates that therapeutic effects of TCM should be extended not only to herb itself, bur also to trace elements contained in herb.

• Journal of The Korea Institute of Healthcare Architecture
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• v.16 no.1
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• pp.25-33
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• 2010

This study is to realize the importance of the therapeutic environment of nursing facilities for elderly people; to comparatively analyze the therapeutic environment elements of the facilities in Gwangju, Jeonnam area, Seoul, and Japan by classifying the therapeutic environment elements according to two aspects on the basis of preceding studies; and to find out the differences among the three regional groupsnaFirst, all therapeutic elements were put together on the basis of two preceding studies based on the two aspects. Second, an expert group was organized primarily with architects and care-givers to find out the therapeutic environment elements of nursing facilities for elderly people with dementia, and to draw up an evaluation standard. Third, the regional differences were analyzed, by comparing the distribution of therapeutic elements of the facilities in Gwangju-Jeonnam area, Seoul, and Japan, through the found therapeutic environment elements. Consequently, eighteen therapeutic environment elements were found out of total 32 elements, and the elements were classified into nine factors based on the meaning of each element. The therapeutic environment elements were showed highest in Japan, and lowest in Gwangju-Chonnam area according to the comparative case analysis based on the nine factors. Especially, there were great regional differences in terms of awareness, safety, orientation, privacy, and freedom of choice.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.35 no.9
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• pp.65-75
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• 2019

This study aims at analyzing the therapeutic design characteristics implemented in the indoor atriums of the outpatient areas in four children's hospitals in London and San Francisco. A mixed-method approach was used to examine the spatial configurations and design elements in the atriums, while a literature review was conducted to understand the therapeutic design characteristics relevant to atrium spaces and children's healthcare facilities. The spatial design and the pattern of use of the atrium in each hospital were studied during field visits and interviews with the hospital management staff. Based on the literature review and the observations from the field study, a Visibility Graphic Analysis was chosen to examine the visibility, accessibility, and intelligibility of the spatial configurations in the atriums of each hospital. In addition, the openness, restfulness, and vibrant ambience of the design elements in the atriums of each hospital were investigated by surveying fifty-two design professionals on the quality of the design elements in the atriums. A spatial configuration analysis, confirmed that all the atrium spaces had high visibility, accessibility, and intelligibility due to their high connectivity, integration, intelligibility, and because the atriums were laid out in the open lobby space, along the major circulation axis, or in the circulation intersection. In the survey of the design element evaluation, all atriums proved to be appropriate in terms of openness, while the adequacy of restfulness and vibrant ambience differed depending on the hospitals. Notably, location and orientation, access, natural light, outdoor view, and play facilities were found significant environmental design elements determining the successful implementation of the therapeutic design in the atriums. The observations from the aforementioned are further discussed to enhance the therapeutic design quality of atrium spaces in children's hospitals.

• Proceedings of the Microbiological Society of Korea Conference
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• 2002.10a
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• pp.109-115
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• 2002

Gene therapy is to treat and cure diseases by an introduction of therapeutic genes in defective cells or tissues of human body. Gene delivery system, gene expression system, and therapeutic gene are three core elements for gene therapy. The efficient delivery of therapeutic genes and appropriate gene expression are the crucial issues for therapeutic outcome of gene delivery. Because it can be used in common for the treatment and cure of various diseases, gene delivery system is the most important core element for a successful gene therapy. Viruses are naturally evolved to transfer their genomes into host cells efficiently. This ability has made vectorologists exploit viruses as attractive vehicles for the delivery of therapeutic genes. Viral vectors based on adenovirus (Ad) and adeno-associated virus (AAV) have been often used for gene delivery in laboratory. Ad and AAV vectors derived from human DNA viruses differ greatly in their life cycle, expression level and duration of transgenes, immunogenicity, and vector preparation. Both vectors can be used as effective tools for gene therapy and more recently in functional genomics. Here, the characteristics of Ad and AAV vectors are discussed.

• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.497-509
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• 2022

Lines are the oldest visual elements in human history and are closely related to human life and drawings and symbols drawn with lines on cave paintings and rocks have existed as alternative images for human survival. In arts the line reveals the core of the object within a short period of time and in art therapy it becomes a medium that can diagnose the client's psychological state and intervene therapeutically. However although line drawing has therapeutic importance in the process as well as diagnosis studies on its effectiveness and therapeutic characteristic have not been actively conducted. Therefore in this study the characteristics related to line art in art therapy are first derived through 'Triangular Verification of Theory', 'Qualitative Content Analysis', and 'Finding Common Parts' in domestic and foreign literature. As a result I will examine the Movement which is a key therapeutic element of line drawing in connection with the brain structure. Through this I will examine the therapeutic mechanisms that affect the body, brain and mind of the movement of line drawing and examine and suggest how it can be used in art therapy.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2002.09a
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• pp.211-213
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• 2002

The purpose of this work is acquiring some parameters of therapeutic heavy ion beams after penetrating a thick target. The experiments were performed using a pencil-like $\^$12/C beam of about 3 mm in diameter from NIRS-HIMAC, and the data were taken at several points of the target thickness for $\^$12/C beam of 290 MeV/u and 400 MeV/u. By the simultaneous measurements using some detectors, the atomic number of each fragment particle was identified, and the beam profile, the dose distribution and the LET spectrum for each element were derived.

• Korean Institute of Interior Design Journal
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• v.24 no.3
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• pp.205-212
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• 2015

This study starts at the at-risk children(the students in the margins)' needs for the inclusive education environment who increased lately. It is studied in the limited scope, which is about spacially 'playground' and 'Sensory integrative therapy' in terms of the special education therapy. The 6 environmental setting principles are suggested, which is redefined in terms of suitable for applying to the environment design based on the training way and arbitration principle of J. Ayres' Sensory integrative therapy. And then various environment design methods are drawn from above-mentioned 6 principles, they are categorized in 4 elements for environmental setting - sensory element, behavior element, mental element and design expression element. This trial brings daily practice of therapeutic stimulate to sensory integration dysfunction children, and sensory experiential diversity promoting development to general children. Expecially it has some advantage that at-risk children(the students in the margins) feel a sense of belonging as a member of society.

• The Journal of Korean Physical Therapy
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• v.12 no.3
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• pp.369-377
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• 2000

Hot spring water is petrifaction water and mixed with animals and plants disintegrated water in the underground. The ingredient are complicated and abundant. The contained element is used to facilitate the function of human body. activate the human structure movement. discharge waste material due to increase circulation and metabolism, also it can remain the homeostasis. We can not find research for spa therapy in our country. We use to drink and bath in the hot spring water bue don't have rehabilitation facilities

• BMB Reports
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• v.37 no.2
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• pp.139-143
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• 2004

The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P)H: quinone oxidoreductase 1, glutathione S-transferases, and glutamate-cysteine ligase. Interestingly, it has been reported that Nrf2 (NF-E2-related factor 2) regulates a wide array of ARE-driven genes in various cell types. Nrf2 is a basic leucine zipper transcription factor, which was originally identified as a binding protein of locus control region of ss-globin gene. The DNA binding sequence of Nrf2 and ARE sequence are very similar, and many studies demonstrated that Nrf2 binds to the ARE sites leading to up-regulation of downstream genes. The function of Nrf2 and its downstream target genes suggests that the Nrf2-ARE pathway is important in the cellular antioxidant defense system. In support of this, many studies showed a critical role of Nrf2 in cellular protection and anti-carcinogenicity, implying that the Nrf2-ARE pathway may serve as a therapeutic target for neurodegenerative diseases and cancers, in which oxidative stress is closely implicated.

• The Korea Journal of Herbology
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• v.28 no.4
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• pp.49-55
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• 2013

Objectives : Mori Folium was popularly used as one of the traditional medicinal herbs. Although M. Folium has been cultivated for rearing silkworm historically, it's use has been expanded as natural therapeutic agent for the treatment of filariasis, diabetes and dropsy in East Asia. However, little has been known about the effect of M. Folium on liver fibrosis. Therefore, we would like to explore an anti-fibrogenic potential of M. Folium extract (MFE) using immortalized human hepatic stellate cell line, LX-2 cells. Methods : We examined the effects of MFE on the transforming growth factor ${\beta}1$ ($TGF{\beta}1$)-induced liver fibrosis in LX-2 cells. Cell viability, Smad binding element-driven luciferase activity, phosphorylations level of Smad 2/3, and expression level of $TGF{\beta}1$-dependent target genes were monitored in the MFE-treated LX-2 cells. Results : Up to 30 ${\mu}g/ml$ MFE treatment did not show any possible toxic effect in LX-2 cells. MFE inhibited $TGF{\beta}1$-inducible Smad binding element-driven luciferase activity and decreased the $TGF{\beta}1$-inducible phosphorylations of Smad 2 and Smad 3 in hepatic stellate cell in a dose dependent manner. Furthermore, increases of plasminogen activator inhibitor type 1, $TGF{\beta}1$ and matrix metalloproteinases 2 genes by $TGF{\beta}1$ were also attenuated by MFE treatment. Conclusions : These findings suggested that MFE would be used as a potential therapeutic agent for the treatment liver fibrosis, which might be mediated by the inhibition of $TGF{\beta}1$-inducible Smad 2/3 transactivation and target genes expression.