• 대한한방내과학회지
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• 제43권6호
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• pp.1122-1133
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• 2022

Objectives: The aim of this study was to retrospectively evaluate the efficacy and safety of Ongyeong-tang (OGT) in the treatment of insomnia in patients afflicted with neurological diseases, according to the medical records of one medical institution. OGT is a herbal prescription that originates from the "Synopsis of Prescriptions of the Golden Chamber" and has been used for menopausal symptoms, uterine diseases, skin diseases, insomnia, and other neuropsychiatric symptoms. Methods: Medical records of patients who visited Kyung Hee University Korean Medicine Hospital from January 1, 2021 to June 30, 2022, received outpatient or inpatient treatment, and met the inclusion criteria were used in this study. Results: Twenty-four patients satisfied the inclusion criteria and were included. The Pittsburgh Sleep Quality Index-Korean version (PSQI-K) score was used to evaluate the outcomes before and after treatment. After an average of 14.42±9.2 days of OGT extract intake, 20 patients (83.3%) experienced improvement. The remaining four (16.7%) had no change in their symptoms, but none demonstrated worsening of symptoms. The total PSQI-K score showed a statistically significant decrease from 13.08±4.54 to 10.42±4.58 (p<0.001). Sleep quality, sleep duration, sleep disturbance, use of sleeping medications, and daytime dysfunction also showed statistically significant improvements. Conclusions: Administration of OGT extract may be a relatively safe and effective therapeutic option for insomnia in patients with neurological diseases.

• 생약학회지
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• 제53권1호
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• pp.29-41
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• 2022

This study was conducted to verify the availability of immature persimmon ethanol extract (IPEE) as a natural and functional ingredient in protecting inflammation and allergy of skin based on the mechanism. The major content analysis, antioxidant activities, anti-allergic activity, anti-inflammatory effect, and safety related to irritation of IPEE were evaluated. The gallic acid content per 10 mg/mL of IPEE was 0.522% (5.22 mg/g). The total polyphenol and flavonoid contents were 428.3 mg/g and 31.1 mg/g, respectively. In ABTS+ activity, DPPH ability and SOD-like activity, it showed a concentration-dependent increase, which indicated IPEE has excellent antioxidant activities. As for the anti-allergy test in RBL-2H3 cells, the IPEE showed a decrease in β-hexosaminidase secretion as the concentration increases, and IPEE tended to decrease IL-4 secretion in all RBL-2H3 cells compared to the IgE + HSA group. IPEE showed good anti-inflammatory effect in RAW 264.7 cells by decrease of NO production and inflammation cytokines (TNF-α and IL-6). Also IPEE showed non-irritant in BCOP assay. By the results of this study, the IPEE containing high tannins, had good antioxidant, anti-allergic, and anti-inflammatory effects, which indicated that the immature persimmon is considered to be a useful for the development of related functional ingredients.

• Archives of Plastic Surgery
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• 제40권6호
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• pp.666-675
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• 2013

Background Stem cells are a unique cell population characterized by self-renewal and cellular differentiation capabilities. These characteristics, among other traits, make them an attractive option for regenerative treatments of tissues defects and for aesthetic procedures in plastic surgery. As research regarding the isolation, culture and behavior of stem cells has progressed, stem cells, particularly adult stem cells, have shown promising results in both translational and clinical applications. Methods The purpose of this review is to evaluate the applications of stem cells in the plastic surgery literature, with particular focus on the advances and limitations of current stem cell therapies. Different key areas amenable to stem cell therapy are addressed in the literature review; these include regeneration of soft tissue, bone, cartilage, and peripheral nerves, as well as wound healing and skin aging. Results The reviewed studies demonstrate promising results, with favorable outcomes and minimal complications in the cited cases. In particular, adipose tissue derived stem cell (ADSC) transplants appear to provide effective treatment options for bony and soft tissue defects, and non-healing wounds. ADSCs have also been shown to be useful in aesthetic surgery. Conclusions Further studies involving both the basic and clinical science aspects of stem cell therapies are warranted. In particular, the mechanism of action of stem cells, their interactions with the surrounding microenvironment and their long-term fate require further elucidation. Larger randomized trials are also necessary to demonstrate the continued safety of transplanted stem cells as well as the efficacy of cellular therapies in comparison to the current standards of care.

• 한방안이비인후피부과학회지
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• 제30권1호
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• pp.10-16
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• 2017

Objectives : Atopic Dermatitis is a recurrent, chronic, allergic eczema with severe itching sensation. This study designed to research Sihocheonggan-tang & Sihocheonggan-san to find out treatability for atopic dermatitis. Methods : We got 14 search results with searching word '시호청간탕', '시호청간산' in 'OASIS', 'NDSL', 'RISS'. We classified these studies according to the type of study, diseases, treatment methods and treatment outcomes. Results : In the analysis of the diseases, Sihocheonggan-tang & Sihocheonggan-san was given for Eczema nummulare, Ermatitis seborrheica, Erythema multiforme, Eczema and Atopic dermatitis. In the analysis of the treatment methodes, the dosage form of Sihocheonggan-tang & Sihocheonggan-san was herbal medication, pill, granules and herbal medication & pill. In the analysis of the treatment outcomes, the symptoms of all patients were improved. In the experimental researches, it was proved that Sihocheonggan-tang & Sihocheonggan-san has effects that affect anti-inflammatory, skin protection and recovery of keratinocyte. Conclusions : For this study, we can consider Sihocheonggan-tang & Sihocheonggan-san is effective for atopic deramatitis. So, it is necessary to carry out clinical trial for Sihocheonggan-tang & Sihocheonggan-san in atopic dermatitis to evaluate safety and efficacy.

• 한국환경보건학회지
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• 제45권2호
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• pp.154-163
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• 2019

Objectives: The hazardous heavy metal contents of cosmetics were investigated and the resulting values were compared by type of cosmetics: skin care preparations (SCP), hair preparations (HP), makeup preparations (MP), and eye makeup preparations (EMP). Methods: The hazardous heavy metal contents (Pb, As, Cd, Sb, Ni and Hg) were analyzed for 358 cosmetics products (187 SCP, 82 HP, 56 MP, and 33 EMP). Hg was measured by the amalgamation method, and other hazardous heavy metals were measured by inductively coupled plasma optical emission spectrometer (ICP-OES) after decomposition using the microwave method. Results: The mean contents of Pb, As, Cd, Sb, Ni, and Hg in cosmetics were 0.424, 0.068, 0.024, 0.398, $0.567{\mu}/g$, and Not Detected, respectively. All of the hazardous heavy metals were detected in most products, but below the recommended maximums of the Ministry of Food and Drug Safety. The level of Cd was the lowest at 14.8%, and Sb was the highest at 41.2%. Pb, Sb and Ni showed the highest mean value and detection rate in EMP. As, Cd, and Hg showed the highest in SCP, HP, and MP, respectively. Conclusion: Hazardous heavy metals were detected in most products. In particular, Pb, Sb, and Ni were broadly detected in EMP, meaning more stringent quality control is required.

• 패션비즈니스
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• 제4권3호
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• pp.141-155
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• 2000

The purpose of this study is to offer basic data to adolescents' cosmetic culture by investigating and analysing the choices made by female students who have been becoming principle consumers of cosmetics these days. Firstly, social and cultural backgrounds and concepts of N generation, and then characteristics and influencing powers of female students were reviewed. And this study also included questionnaire surveys of 500 female students in middle and high schools located in Seoul. Data were processed using a SPSS$^+$ program and analyzed by using frequency, percentage and the $X^2$-test. The major findings run as follows: Female students have the effects of spreading their words quickly and abilities of making a decision what to buy. And they accept consuming behaviors itself as a part of cultural lives. Therefore, industries have acknowledged them as new principal consumers with a powerful influence in the market. They also play an important role in active consumer as emotional generation who has distinct personalities and prefer fashion trends, changes and innovations. They show conformities with their peer groups and they also want to identify themselves with characters or stars. The cosmetic behaviors of female students relating to demographic characteristics showed a significant relation to grades, majors, school groups and places of residence. Female students have a lot of interest and knowledge about cosmetics. And they use various cosmetic products. This study demonstrated the age for using make-up for the first time has been becoming younger more and more. Recently, female adolescents tend to use face powder, lip gloss, mascara and eye shadow. It is assumed that cosmetic purchases of female students can be considered as an impulsive aspects. However, before purchases, the proportion of students having any particular cosmetic brand in mind previously has been increasing. They take into consideration skin safety, the quality of product and color, when purchasing cosmetic products.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.498-498
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• 2013

Atmospheric Pressure Plasmas have pioneered a new field of plasma for biomedical application bridging plasma physics and biology. Biological and medical applications of plasmas have attracted considerable attention due to promising applications in medicine such as electro-surgery, dentistry, skin care and sterilization of heat-sensitive medical instruments [1]. Traditional approaches using electronic devices have limits in heating, high voltage shock, and high current shock for patients. It is a great demand for plasma medical industrial acceptance that the plasma generation device should be compact, inexpensive, and safe for patients. Microwave-excited micro-plasma has the highest feasibility compared with other types of plasma sources since it has the advantages of low power, low voltage, safety from high-voltage shock, electromagnetic compatibility, and long lifetime due to the low energy of striking ions [2]. Recent experiment [2] shows three-log reduction within 180-s treatment of S. mutans with a low-power palm-size microwave power module for biomedical application. Experiments using microwave plasma are discussed. This low-power palm-size microwave power module board includes a power amplifier (PA) chip, a phase locked loop (PLL) chip, and an impedance matching network. As it has been a success, more compact-size module is needed for the portability of microwave devices and for the various medical applications of microwave plasma source. For the plasma generator, a 1.35-GHz coaxial transmission line resonator (CTLR) [3] is used. The way of reducing the size and enhancing the performances of the module is examined.

• 패션비즈니스
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• 제4권4호
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• pp.107-121
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• 2000

The purpose of this study is to offer basic data to adolescents' cosmetic culture by investigating and analysing the choices made by female students who have been becoming principle consumers of cosmetics these days. Firstly, social and cultural backgrounds and concepts of N generation, and then characteristics and influencing powers of female students were reviewed. And this study also included questionnaire surveys of 500 female students in middle and high schools located in Seoul. Data were processed using a SPSS$^+$ program and analyzed by using frequency, percentage and the $X^2$-test. The major findings run as follows: Female students have the effects of spreading their words quickly and abilities of making a decision what to buy. And they accept consuming behaviors itself as a part of cultural lives. Therefore, industries have acknowledged them as new principal consumers with a powerful influence in the market. They also play an important role in active consumer as emotional generation who has distinct personalities and prefer fashion trends, changes and innovations. They show conformities with their peer groups and they also want to identify themselves with characters or stars. The cosmetic behaviors of female students relating to demographic characteristics showed a significant relation to grades, majors, school groups and places of residence. Female students have a lot of interest and knowledge about cosmetics. And they use various cosmetic products. This study demonstrated the age for using make-up for the first time has been becoming younger more and more. Recently, female adolescents tend to use face powder, lip gloss, mascara and eye shadow. It is assumed that cosmetic purchases of female students can be considered as an impulsive aspects. However, before purchases, the proportion of students having any particular cosmetic brand in mind previously has been increasing. They take into consideration skin safety, the quality of product and color, when purchasing cosmetic products.

• 대한화장품학회지
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• 제18권1호
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• pp.1-41
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• 1992

A new and unique class of nonionic surfactants was synthesized by reacting biological a-tocopherol with ethylene oxide for functional cosmetics. The structures were confirmed by Hl-UMR, FT-lR, TLC and elemental analysis. POV and conjugated diene value study for EPO showed POE(n)TE had antioxidative effect similar to tocopheryl acetate Protective effect on cell membrane in photohemolysis of POE(5)TE, POE(10)TE and POE(18)TE were slightly lower than tocopherol but higher than nonoxynol-12, and POE(10)TE had UV absorption power comparable with tocopherol and homosalate. Biological activity of the hydrophobic group of the new surfactants make them unique and different from those of conventional nonionic surfactants Systematic safety evaluations of POE(n)TEs on the skin and eye proved that they are as safe as tocopherol. The results of physicochemical study showed POE(10)TE had the lowest CMC value, POE(18)TE had the maximum surface tension reduction and the highest foam volume and POE(n)TEs had various HLB values by the degree of ethoxylation. The test resul Is of technological and practical applications of these surfactants for cosmetics showed some POE(n)TEs were superior to conventional surfactants. POE(5)TE in W/O emulsions, POE(10)TE and POE(12)TE in O/W emulsions, POE(12)TE in dispersions, POE(18)TE in solubilizations and POE(50)TE in gelations were shown to be excellent which was considered due to the structural characteristic and formation of liquid crystals of POE(n)TEs. By the development and applications of these excel lent multi-functional surfactants, innovative functional cosmetics were successfully formulated.

• 간호행정학회지
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• 제8권3호
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• pp.361-372
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• 2002

Purpose : The purpose of study was to identify to analysis of core nursing interventions performed by Operating Room nurses. Method : The subjects of the study were arbitrarily selected nurses(n=104) working in Operating Room. The period for data collection was 15 days from July, 15, 2002 to July, 30. 2002. The instrument for study was 486 Nursing Interventions Classification developed by McClosky & Bulechek(2000) and was translated into Korean. In 486 nursing interventions, 57 nursing interventions were selected by more than half of 47 professional nurses group of Operating Room. 57 nursing interventions were used as a secondary questionnaire. In the secondary questionnaire, labels and definitions of all 57 interventions were listed. The collected data were self reported by Operating Room nurses. The data were analysed with SPSS program. Result : In 57 nursing interventions, the 'Behavior' domain was the most frequently used. Core interventions of Operating Room were performed several times a day by more than 50% of Operating Room nurses. Core interventions of Operating Room were 16 Core interventions, 7 classes, 5 domains. In the core interventions, the 'Physiological:Complex' domain was the most frequently used. Core interventions of Operating Room were Surgical Preperation, Infection Control:Intraoperative, Surgical Precautions, Fall Prevention, Documentation, Surgical Assistance, Environmental Management:Safety, Skin Surveillance, Physical Restraint, Pressure Ulcer Prevention, Environmental Management:Comfort, Infection Protection, Presence, Emotional Support, Specimen Management, Shift Report. Conclusion : Core interventions of Operating Room have implications for nursing care practice, nursing education, nursing research, and nursing information system in Operating Room.