• Journal of Korean Society of Industrial and Systems Engineering
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• v.42 no.4
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• pp.1-7
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• 2019

The customer of massage chair is expanding day by day from middle age to all ages. In 2018, the market size was 700 billion KRW, an increase of 30 times over 10 years. However, most related SMEs suffer from excessive competition by the market monopoly of some major companies. In this situation, in order for a related company to survive, it is necessary to steadily research and develop new products. Founded in 2009, company L produces massage chairs for health and relaxation of customers. L's products use a sound wave vibration module that is favorable for human body, unlike other products that use vibration motor type. However, frequent breakdowns of massage chair due to the vulnerability of plate (leaf) springs, which play an important role in sound wave vibration modules, made sap its competitiveness. In this paper, we propose a method to design desirable plate spring structure by sequentially experimenting with five different plate springs. The results of this study are expected to contribute to improve the quality of plate spring and the reliability of sound wave vibration module. In the future, it is necessary to find a way to use it in the development of foot massage or scalp management device as well as continuous research to find optimal plate spring structure through various analysis.

• Korean Journal of Materials Research
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• v.17 no.6
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• pp.318-322
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• 2007

Porous ${\beta}-tricalcium$ phosphate $({\beta}-TCP)$ bioceramic was fabricated by pressureless sintering using commercial HAp and different volume percentages of PMMA powders (30-60 vol.%). The range of spherical pore size was about $200-250\;{\mu}m$ in diameter. By increasing the PMMA content, the number of pores and their morphology were dramatically changed as well as decreased the material properties. In case of using 60 vol.% PMMA content, network-type pores were found, due to the necking of the PMMA powders. The values of relative density, elastic modulus, bending strength and hardness of the 60 vol.% PMMA content sample, sintered at $1500^{\circ}C$, were about 46%, 22.2 GPa, 5MPa and 182 Hv respectively. Human osteoblast-like MG-63 cells and osteoclast-like Raw 264.7 cells were well grown and fully covered all of the porous ${\beta}-TCP$ bodies sintered at $1500^{\circ}C$.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2335-2340
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• 2014

Paclitaxel is hydrophobic in nature and is recognized as a highly toxic anticancer drug, showing adverse effects in normal body sites. In this study, we developed a polymeric nano drug carrier for safe delivery of the paclitaxel to the cancer that releases the drug in a sustained manner and reduces side effects. N-isopropylacrylamide/vinyl pyrrolidone (NIPAAm/VP) nanoparticles were synthesized by radical polymerization. Physicochemical characterization of the polymeric nanoparticles was conducted using dynamic light scattering, transmission electron microscopy, scanning electron microscopy and nuclear magnetic resonance, which confirmedpolymerization of formulated nanoparticles. Drug release was assessed using a spectrophotometer and cell viability assays were carried out on the MCF-7 breast cancer and B16F0 skin cancer cell lines. NIPAAm/VP nanoparticles demonstrated a size distribution in the 65-108 nm range and surface charge measured -15.4 mV. SEM showed the nanoparticles to be spherical in shape with a slow drug release of ~70% in PBS at $38^{\circ}C$ over 96 h. Drug loaded nanoparticles were associated with increased viability of MCF-7 and B16F0 cells in comparison to free paclitaxel. Nano loaded paclitaxel shows high therapeutic efficiency by sustained release action for the longer period of time, i increasing its efficacy and biocompatibility for human cancer therapy. Therefore, paclitaxel loaded (NIPAAm/VP) nanoparticles may provide opportunities to expand delivery of the drug for clinical selection.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.2
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• pp.666-671
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• 2016

This paper introduces a device providing close local lighting to the affected part, where the operation-purpose astral lamp alone cannot shed light directly, in an operation room of hospitals or clinics, which helps clinical doctors perform safe treatment of the affected part deep inside a human body. This medical assisting lighting is a device necessary to prevent fatal operation failures, which can occur with minute operation processes, such as tumor removal or angiorrhaphy. The components, such as the light source and power supply were designed to be low power consuming and small in size, have a narrow angle lens was used to increase the light spreading effect and focused illumination. The end-caps of the light transmission device using an optical cable and the lighting device were designed in the waterproof type to enable disinfection of these devices after use for the next patients. According to the measurement of the light source properties made after development of the retractor lighting device, the illumination intensity was 490 lux, the brightness was $11,550cd/m^2$, general color rendering index was 78, color temperature was 11,000K, and the intensity distribution was even, which were confirmed to be adequate for medical assisting local lighting.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.1
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• pp.135-143
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• 2004

The Human body is subject to two patterns of senescence, both of which are represented in the eye and vision. This article discusses the anatomical and physiological changes in anterior and posterior segments which occur with age. The areas covered include the globe, lids, tears, conjunctiva, cornea, sclera, anterior chamber angle, iris, lens, choroid, vitreous and retina. A sample of 219 individuals between the ages of 50 and 79 years was tested with case history, slit lamp examination, palpebral fissure, horizontal visible iris diameter(HVID) and pupil size. The palpebral fissure decreases with age while HVID remains constant in all age classes. This study suggests that an understanding of anatomical and physiological changes which occur with age is helpful to all eye clinicians because the aging process affects all of the ocular tissues.

• Journal of radiological science and technology
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• v.37 no.3
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• pp.203-209
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• 2014

Usefulness and clinical availability for surgery efficiency were evaluated by conducting pre-operative planning with a model manufactured by desktop 3D printer by using clavicle CT image. The patient-customized clavicle fracture model was manufactured by desktop 3D printer of FDM wire laminated processing method by converting the CT image into STL file in Open Source DICOM Viewer Osirix. Also, the model of the original shape before damaged was restored and manufactured by Mirror technique based on STL file of not fractured clavicle of the other side by using the symmetry feature of the human body. For the model, the position and size, degree of the fracture was equally printed out. Using the clavicle model directly manufactured with low cost and less time in Department of Radiology is considered to be useful because it can reduce secondary damage during surgery and increase surgery efficiency with Minimal invasive percutaneous plate osteosynthesis(MIPO).

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.23 no.2
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• pp.244-250
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• 2012

The compact dipole antenna elements and array structure is proposed. The array structure is designed for applicator in regional hyperthermia treatment to enhance the uniformity of the heat distribution which makes the treatment effective and prevents overheating. The compact dipole is designed with branched dipole and matching network to have small size and symmetric shape. The temperature simulation with specific absorption rate(SAR) and bio-heat equation is performed to have heat distribution. The applicator is designed, fabricated, and measured with multi-channel thermometer in 30 and 60 minutes. The simulation and measurement results showed agreement and the simulation in body circumstance has proper temperature result for hyperthermia therapy.

• Applied Chemistry for Engineering
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• v.34 no.2
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• pp.121-125
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• 2023

Casein is a milk protein and one of the most important nutrients in milk. The composition is over 80% in cow's milk and about 20~45% in human's milk. Casein is highly biocompatible and biodegradable, so it has been studied for various biomedical materials applications as well as drug delivery systems. It is widely known that casein can be prepared as nanoparticles in the presence of the Ca²⁺ metal ion. Because casein is amphiphilic, hydrophobic drugs could be loaded inside to form a protein-based drug delivery system. In this study, we studied the optimum conditions for casein nanoparticle formation using natural metal ions present in the body, such as calcium, magnesium, zinc, and iron. It was confirmed that nanoparticles have a uniform size of around 150 nm and negative zeta potential values. In addition, it was demonstrated that casein nanoparticles have a cell viability of more than 80% and efficient intracellular uptake properties using confocal microscopy. From the results, it was also shown that the casein nanoparticles prepared using various metal ions have the potential to be biocompatible drug delivery carriers.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.308-311
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• 2015

Because worldwide interest in the health is increased, the real-time health monitoring system has been demanded to be more convenient non-contact and precise medical devices than conventional. Therefore we developed the blood pressure monitoring system using UWB(Ultra Wide Band) radio wave which contact to the human body through the radar and continuously collect a movement signal of the blood vessel. Then the collected data including pulse rate, systolic blood pressure, diastolic blood pressure is processed in real time. The system monitors and controls through a program-based embedded LCD(Liquid Crystal Display) using Qt GUI(Graphic User Interface) to be displayed in real time. We implement the system as a embedded system because of reducing the size of the limited resources. Existing PC GUI design mode is used relatively large memory, therefore it requires more CPU(Central Processing Unit) capacity and processing time.

• Applied Chemistry for Engineering
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• v.25 no.5
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• pp.548-551
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• 2014

In order to reduce toxicity on the human body, four new cleaning agents (1-4) containing ester and ether functionalities have been invented. The synthesized cleaning agents's physical properties, biodegradabilities, and $LD_{50}$ values, which were conducted by Korea Testing Certification Institute by using standard method, showed excellent values. A specimen for cleaning ability was prepared by cutting in $60{\times}40mm$ size of stainless steel plate. The surface of the above specimens was treated with four different kinds of contaminants, such as cutting oil, anti-rust oil, drawing oil, and lubricating oil. Contaminated specimens were then immersed in compounds (1-4) for 1 to 5 minutes to dissolve oil in the cleaning agent. The data indicate that all compounds (1-4) exhibit good cleaning ability toward four contaminant oils. It is also confirmed that these compounds can be applicable to various industrial cleaning fields as nontoxic and biodegradable cleaning agents because of their excellent biodegradabilities and $LD_{50}$ values.