• Clinical and Experimental Pediatrics
• /
• v.63 no.9
• /
• pp.345-354
• /
• 2020

The widespread and contagious coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has become a burden in the global health domain. The subsequent discovery of the virus features and pathogenesis, and prompt and adequate management are still lacking and remain inconclusive. Children usually present milder symptoms than adults, and management focuses on providing symptomatic and respiratory supports. Several treatment modalities, including the utilization of mechanical ventilation (MV), antivirals, immune-modulating drugs, or other agents, may present promising results in reducing the symptoms of COVID-19, particularly in severe cases. Although no randomized clinical trials have been published to date, it is interesting to explore potential modalities for treating COVID-19 in children, based on review articles, case reports, and recent guidelines.

• Journal of Ginseng Research
• /
• v.46 no.6
• /
• pp.722-730
• /
• 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that causes coronavirus disease 2019 (COVID-19), with major symptoms including hyper-inflammation and cytokine storm, which consequently impairs the respiratory system and multiple organs, or even cause death. SARS-CoV-2 activates inflammasomes and inflammasome-mediated inflammatory signaling pathways, which are key determinants of hyperinflammation and cytokine storm in COVID-19 patients. Additionally, SARS-CoV-2 inhibits inflammasome activation to evade the host's antiviral immunity. Therefore, regulating inflammasome initiation has received increasing attention as a preventive measure in COVID-19 patients. Ginseng and its major active constituents, ginsenosides and saponins, improve the immune system and exert anti-inflammatory effects by targeting inflammasome stimulation. Therefore, this review discussed the potential preventive and therapeutic roles of ginseng in COVID-19 based on its regulatory role in inflammasome initiation and the host's antiviral immunity.

• Clinical and Experimental Vaccine Research
• /
• v.13 no.1
• /
• pp.63-67
• /
• 2024

This repeated cross-sectional study with two independent sample populations compared the antibody response to severe acute respiratory syndrome coronavirus 2 vaccines in Albania in July-August 2021 and 2022. In 2021, it found higher anti-spike-1 seropositivity and antibody levels in fully vaccinated individuals, especially with BNT162b2 and ChAdOx1 and to a lesser degree with CoronaVac. By 2022, all single-dose recipients showed high antibody responses, suggesting natural infection-enhanced immunity. The study indicates a significant evolution in the antibody response to different coronavirus disease 2019 vaccines and suggests that a single vaccine dose, coupled with natural infection, might suffice to maintain adequate immunity levels in an endemic scenario.

• Journal of Microbiology and Biotechnology
• /
• v.32 no.1
• /
• pp.1-5
• /
• 2022

Diagnostics, vaccines, and drugs are indispensable tools and control measures employed to overcome infectious diseases such as coronavirus disease 2019 (COVID-19). Diagnostic tools based on RT-PCR were developed early in the COVID-19 pandemic and were urgently required for quarantine (testing, tracing and isolation). Vaccines such as mRNA vaccines and virus-vectored vaccines were also successfully developed using new platform technologies within one year after identifying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent of COVID-19. Drug development has been conducted in various ways including drug repurposing, convalescent plasma therapy, and monoclonal antibody development. Among the above efforts, this review examines COVID-19 drug development along with the related and upcoming challenges.

• Journal of Yeungnam Medical Science
• /
• v.37 no.4
• /
• pp.286-295
• /
• 2020

Respiratory infections are very common and highly contagious. Respiratory infectious diseases affect not only the person infected but also the family members and the society. As medical sciences advance, several diseases have been conquered; however, the impact of novel infectious diseases on the society is enormous. As the clinical presentation of respiratory infections is similar regardless of the pathogen, the causative agent is not distinguishable by symptoms alone. Moreover, it is difficult to develop a cure because of the various viral mutations. Various respiratory infectious diseases ranging from influenza, which threaten the health of mankind globally, to the coronavirus disease 2019, which resulted in a pandemic, exist. Contrary to human expectations that development in health care and improvement in hygiene will conquer infectious diseases, humankind's health and social systems are threatened by novel infectious diseases. Owing to the development of transport and trading activity, the rate of spread of new infectious diseases is increasing. As respiratory infections can threaten the members of the global community at any time, investigations on preventing the transmission of these diseases as well as development of effective antivirals and vaccines are of utmost importance and require a worldwide effort.

• Biomedical Science Letters
• /
• v.26 no.3
• /
• pp.127-135
• /
• 2020

Coronavirus is generally known to cause minor respiratory diseases in animals and humans. However, some coronavirus genus is reported to cause animal-to-human interspecies infection. Since the end of 2019, a new type of coronavirus (COVID-19) infection is spreading rapidly throughout the world, leading to the declaration of the pandemic by the World Health Organization (WHO). Despite various clinical studies to counter COVID-19 infection, the total confirmed cases and death rates are still accumulating. To break down this new threat, we should pay attention to newly revealed information based on scientific facts. In this review, we introduced the clinical characteristics, diagnostic methods, and treatment of patients infected with COVID-19. Moreover, we highlighted the correlation between COVID-19 severity and patients with underlying diseases. Potential risks associated with COVID-19 can be differed depending on the condition of patients and can cause pulmonary complications. Therefore, lung capacity exams are expected to help predict the progression of the disease along with previously established detection methods such as molecular diagnostics and immunoassay. Although physiological research hasn't yet been emphasized to evaluate COVID-19 infection, this review is expected to be valuable to give new inspiration to deal with COVID-19 which might strike again in the future.

• Journal of Microbiology and Biotechnology
• /
• v.30 no.8
• /
• pp.1109-1115
• /
• 2020

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally, and the WHO has declared this outbreak a pandemic. Vaccines are an effective way to prevent the rapid spread of COVID-19. Furthermore, the immune response against SARS-CoV-2 infection needs to be understood for the development of an efficient and safe vaccine. Here, we review the current understanding of vaccine targets and the status of vaccine development for COVID-19. We also describe host immune responses to highly pathogenic human coronaviruses in terms of innate and adaptive immunities.

• IMMUNE NETWORK
• /
• v.21 no.2
• /
• pp.16.1-16.8
• /
• 2021

Patients with severe coronavirus disease 2019 (COVID-19) demonstrate dysregulated immune responses including exacerbated neutrophil functions. Massive neutrophil infiltrations accompanying neutrophil extracellular trap (NET) formations are also observed in patients with severe COVID-19. However, the mechanism underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced NET formation has not yet been elucidated. Here we show that 2 viral proteins encoded by SARS-CoV-2, the nucleocapsid protein and the whole spike protein, induce NET formation from neutrophils. NET formation was ROSindependent and was completely inhibited by the spleen tyrosine kinase inhibition. The inhibition of p38 MAPK, protein kinase C, and JNK signaling pathways also inhibited viral protein-induced NET formation. Our findings demonstrate one method by which SARSCoV-2 evades innate immunity and provide a potential target for therapeutics to treat patients with severe COVID-19.

• International Journal of Computer Science & Network Security
• /
• v.22 no.10
• /
• pp.352-358
• /
• 2022

In this paper, we study the relationship between infection rates of covid 19 and the precautionary measures and strict protocols taken by Saudi Arabia to combat the spread of the coronavirus disease and minimize the number of infected people. Based on the infection rates and the timetable of precautionary measures, the best framework of precautionary measures was identified by applying the traveling salesman problem (TSP) that relies on ant colony optimization (ACO) algorithms. The proposed algorithm was applied to daily infected cases data in Saudi Arabia during three periods of precautionary measures: partial curfew, whole curfew, and gatherings penalties. The results showed the partial curfew and the whole curfew for some cities have the minimum total cases over other precautionary measures. The gatherings penalties had no real effect in reducing infected cases as the other two precautionary measures. Therefore, in future similar circumstances, we recommend first applying the partial curfew and the whole curfew for some cities, and not considering the gatherings penalties as an effective precautionary measure. We also recommend re-study the application of the grouping penalty, to identify the reasons behind the lack of its effectiveness in reducing the number of infected cases.

• Korean Journal of Organic Agriculture
• /
• v.28 no.2
• /
• pp.171-188
• /
• 2020

The Coronavirus disease (COVID-19), first identified in China in December 2019, has widely spread worldwide and is an ongoing pandemic. It is expected that the ripple effect of COVID-19 on the global economy including the agricultural sector will increase substantially if not properly controlled shortly. This study examines the potential impact of COVID-19 on the Korean beef cattle sector and farm labor demand for Korean beef cattle using a dynamic partial equilibrium model. The agricultural production value and farm labor demand for Korean beef cattle in the scenario assuming pessimistic GDP growth rate (-1.2% in 2020) with no direct supply shocks fell by up to 4.00% and 0.67%, respectively, compared to the baseline which represents the future without COVID-19 outbreak. On the other hand, the agricultural production value and farm labor demand for Korean beef cattle in the scenario assuming both pessimistic GDP growth rate and supply shocks (-12.7% beef imports and + 2.4% feed cost in 2020) increased by up to 12.08% and 1.99%, respectively, compared to the baseline.