• 대한안전경영과학회지
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• 제11권3호
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• pp.217-226
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• 2009

The combustion reaction of polyvinylchloride(PVC) was investigated using a thermogravimetric technique under an air atmosphere condition at several heating rates from 10 to $50^{\circ}C$/min. To obtain information on the kinetic parameters, the dynamic thermogravimetric analysis curve and its derivative were analyzed by a variety of analytical methods such as Kissinger, Friedman, Chatterjee-Conrad, Ozawa and Coats-Redfern methods. The combustion reaction of PVC proceeded in two steps; the first step was caused by the dehydrochlorination process in PVC, and the second step by the combustion of polyene. The comparative works for the kinetic results obtained from various methods should be performed to determine the kinetic parameters, because there are tremendous differences in the calculated kinetic parameters depending upon the mathematical method taken in the analysis.

• Archives of Pharmacal Research
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• 제28권2호
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• pp.220-226
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• 2005

Temperature and medium composition were changed with the aim of increasing growth and erythropoietin (EPO) production in EPO-producing Chinese hamster ovary (CHO) cells. We used the CHO cell line, IBE, and its derivative, CO5, which over-expresses the first two enzymes of the urea cycle, carbamoyl phosphate synthetase I (CPS I) and ornithine transcar-bamoylase (OTC). When supplements were added to the medium at $33\;^{\circ}C$, the growth of IBE and CO5 cells increased by $27\%\;and;26\%$, respectively and the maximum yield of EPO was increased by $40\%$ in both cell lines. The absolute EPO concentration in the CO5 cells was always $55{\sim}60\%$ higher than in the IBE cells. In addition, when the two cell lines were continuously cultured with supplements at $33\;^{\circ}C$ until their growth rates approached those at $37\;^{\circ}C$, the growth rates of both IBE and CO5 cells increased by $54\%$ and their maximum EPO levels increased by up to $73\%\;and\;56\%$, respectively. Therefore, the growth and EPO expression levels of CO5 cells increased 2.2-fold and 2.6-fold, respectively, compared to those of the IBE cells. These results indicate that adaptation to lower temperature as well as medium supplementation could be important for improving cell growth and EPO production.

• Structural Engineering and Mechanics
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• 제88권5호
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• pp.439-449
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• 2023

Non-linear vibration characteristics of functionally graded CNT-reinforced composite (FG-CNTRC) cylindrical shell panel on elastic foundation have not been sufficiently examined. In this situation, this study aims at the profound numerical investigation of the non-linear vibration response of FG-CNTRC cylindrical panels on Winkler-Pasternak foundation by introducing an accurate and effective 2-D meshfree-based non-linear numerical method. The large-amplitude free vibration problem is formulated according to the first-order shear deformation theory (FSDT) with the von Karman non-linearity, and it is approximated by Laplace interpolation functions in 2-D natural element method (NEM) and a non-linear partial derivative operator H_NL. The complex and painstaking numerical derivation on the curved surface and the crucial shear locking are overcome by adopting the geometry transformation and the MITC3+ shell elements. The derived nonlinear modal equations are iteratively solved by introducing a three-step iterative solving technique which is combined with Lanczos transformation and Jacobi iteration. The developed non-linear numerical method is estimated through the benchmark test, and the effects of foundation stiffness, CNT volume fraction and functionally graded pattern, panel dimensions and boundary condition on the non-linear vibration of FG-CNTRC cylindrical panels on elastic foundation are parametrically investigated.

• Journal of Microbiology and Biotechnology
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• 제27권4호
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• pp.725-730
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• 2017

A heteronemertean, Yininemertes pratensis, was collected in Han River Estuary, South Korea. This estuarine nemertean has been known by the local fishermen for harmful effects to the glass eels, juveniles of Japanese eel Anguilla japonica, migrating to fresh water. The present study confirmed the neurotoxic effects of this heteronemertean ribbon worm at the cellular level. Derivative types of neurotoxic tetrodotoxin (TTX), 5,11-dideoxy TTX (m/z 288) and 11-norTTX-6(S)-01 (m/z 305.97), were identified through HPLC and MALDI-TOF MS. However, significant neurotoxicity was confirmed in the fraction containing an undefined molecule corresponding to the 291.1 (m/z) peak, when tested in rat primary astrocytes and dorsal ganglion cells. This study is the first to report neurotoxins of the estuarine nemertean, fairly abundant in the Han River estuary, and suggests the long-term monitoring of population dynamics and surveillance of the toxicity in this river estuary.

• 한국자동차공학회논문집
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• 제23권5호
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• pp.478-485
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• 2015

Availability of the climbing angle information is crucial for the intelligent vehicle system. However, the climbing angle information can't be measured with the sensor mounted on the vehicle. In this paper, climbing angle estimation system is proposed. First, longitudinal acceleration obtained from gyro-sensor is compared with the actual longitudinal acceleration of the vehicle. If the vehicle is in yawing motion, actual longitudinal acceleration can't be approximated from time derivative of wheel speed, because lateral velocity and yaw rate affect actual longitudinal acceleration. Wheel speed and yaw rate can be obtained from the sensors mounted on the vehicle, but lateral velocity can't be measured from the sensor. Therefore, lateral velocity is estimated using unknown input observer with nonlinear tire model. Simulation results show that the compensated results using lateral velocity and yaw rate show better performance than uncompensated results.

• 한국응용과학기술학회지
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• 제14권1호
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• pp.27-32
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• 1997

Furfurylidene acetophenone derivatives were synthesis, it was measured that nucleophilic addition made use of UV at a wide pH 1.0${\sim}$13.0 range in 30% dioxane-$H_2O$ solution, 25$^{\circ}C$. On the basis of general base catalysis, substitutent effect, confirmation of nucleophilic addition products, it was measured the reaction rate of furfurylidene acetophenone derivatives for the pH change. It may be concluded that a part was unrelated to pH and another part was in proportion to concentration of hydroxide ion: Above pH 10.0. sulfide anion adds to the double bond (Michael type addition), a part having no concern with pH, addition reaction to double bond is initiated by addition of neutral thiourea molecule. From the result of measurement the reaction rate, nucleophilic addition of furfurylidene acetophenone derivatives confirmed to the irreversible first order. Through measurement the substituent effect. It found that reaction rate was accelerated by electron attracting group. On the basis of these findings, nucleophilic addition of thiourea for the furfurylidene acetophenone derivative was proposed a fitting mechanisms.

• International Journal of Aeronautical and Space Sciences
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• 제9권2호
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• pp.48-57
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• 2008

The noise is one of the serious problems concerning helicopters operations. The issue of helicopter external noise generated mainly from a helicopter rotor has always affected the use of rotorcrafts, especially in the urban environment. The noise sources depend on the flight configurations. In particular, a noise generated by the interaction between blades and tip vortices mainly occurs during descent flight. This noise is called blade-vortex interaction (BVI) noise, and this BVI noise is particularly penalizing for helicopters. In this paper, a numerical study to capture the BVI noise is carried out. The numerical study is performed in two phases. In the first phase, a 2D simulation based on parallel BYI event of Kitapliglu et al experiment is performed. In the second phase, 3D simulation based on HART Ⅱ experiment is performed. Several experimental data such as thrust, torque, blade sectional load, its derivative and vortex location are compared with calculation results and the comparison showed reasonably good agreement.

• 대한수학회지
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• 제58권3호
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• pp.553-569
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• 2021

In this paper, we present and analyze a fully discrete numerical method for solving the time-fractional diffusion wave equation: ∂^β_tu - div(a∇u) = f, 1 < β < 2. We first construct a difference formula to approximate ∂^β_tu by using an interpolation of derivative type. The truncation error of this formula is of O(△t^2+δ-β)-order if function u(t) ∈ C^2,δ[0, T] where 0 ≤ δ ≤ 1 is the Hölder continuity index. This error order can come up to O(△t^3-β) if u(t) ∈ C³ [0, T]. Then, in combinination with the linear finite volume discretization on spatial domain, we give a fully discrete scheme for the fractional wave equation. We prove that the fully discrete scheme is unconditionally stable and the discrete solution admits the optimal error estimates in the H¹-norm and L₂-norm, respectively. Numerical examples are provided to verify the effectiveness of the proposed numerical method.

• Macromolecular Research
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• 제13권6호
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• pp.467-476
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• 2005

The main objective of this study was to develop and characterize pH-sensitive biodegradable polymeric materials. For pH-sensitivity, we employed three kinds of moieties: 2-amino-3-(lH-imidazol-4-yl)-propionic acid (H), N-[4-( 4,6-dimethyl-pyrimidin-2ylsulfamoyl)-phenyl]succinamic acid (SM), and 2- {3-[ 4-( 4,6-dimethyl-pyrim­idin- 2-ylsulfamoyl)-phenylcarbamoyl]-propionylamino} -3-(3 H - imidazol-4-yl)-propionic acid (SH). The pH -sensitive diblock copolymers were synthesized by ring opening polymerization and coupling reaction from poly(ethylene glycol) (MPEG), $\varepsilon$-caprolactone (CL), D,L-lactide (LA) and pH-sensitive moieties. The pH-sensitive SH molecule was synthesized in a two-step reaction. The first step involved the synthesis of SHM, a methyl ester derivative of SH, by coupling reaction of SM and L-histidine methyl ester dihydrochloride, whereas the second step involved the hydrolysis of the same. The synthesized SM, SHM and SH molecules were characterized by FTIR, $^{1}H$-NMR and $^{13}C$-NMR spectroscopy, whereas diblock copolymers and pH-sensitive diblock copolymer were characterized by $^{1}H$-NMR and GPC analysis. The critical micelle concentrations were determined at various pH conditions by fluorescence technique using pyrene as a probe. The micellization and demicellization studies of pH-sensitive diblock copolymers were also done at different pH conditions. The pH-sensitivity was further established by acid-based titration and DLS analysis.

• 한국해안해양공학회지
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• 제15권2호
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• pp.108-115
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• 2003

천수방정식에 기초한 ADCIRC 유한요소모형을 이용하여 지진해일 전파를 수치모의할 때 분산효과를 고려하기 위한 두 가지 일차원 분산보정기법을 개발하였다. 첫 번째 방법은 음해법으로, 각 시간단계의 공간미분항에 부여되는 가중치를 조정함으로써 분산보정을 수행한다. 두 번째는 양해법으로, 유한요소의 크기를 조정하여 분산을 고려한다. 새로운 기법을 이용하여 계산한 수치해와 파의 분산효과를 고려한 해석해의 비교를 통해 본 연구에서 제안한 분산보정기법의 타당성을 확인하였다.