• Asian-Australasian Journal of Animal Sciences
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• 제26권6호
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• pp.772-779
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• 2013

Linkage disequilibrium (LD) plays an important role in genomic selection and mapping quantitative trait loci (QTL). In this study, the pattern of LD and effective population size ($N_e$) were investigated in Chinese beef Simmental cattle. A total of 640 bulls were genotyped with IlluminaBovinSNP50BeadChip and IlluminaBovinHDBeadChip. We estimated LD for each autosomal chromosome at the distance between two random SNPs of <0 to 25 kb, 25 to 50 kb, 50 to 100 kb, 100 to 500 kb, 0.5 to 1 Mb, 1 to 5 Mb and 5 to 10 Mb. The mean values of $r^2$ were 0.30, 0.16 and 0.08, when the separation between SNPs ranged from 0 to 25 kb to 50 to 100 kb and then to 0.5 to 1 Mb, respectively. The LD estimates decreased as the distance increased in SNP pairs, and increased with the increase of minor allelic frequency (MAF) and with the decrease of sample sizes. Estimates of effective population size for Chinese beef Simmental cattle decreased in the past generations and $N_e$ was 73 at five generations ago.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6305-6309
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• 2013

Background: TIAM2, a Rac guanine nucleotide exchange factor, is closely associated with cell adherence and migration. Here, we aimed to investigate the role of TIAM2 in non-small cell lung cancer (NSCLC) cells. Materials and Methods: A small interference RNA (siRNA) was introduced to silence the expression of TIAM2. Invasion and motility assays were then performed to assess the invasion and motility potential of NSCLC cells. GST-pull down assays were used to detect activation of Rac1. Results: TIAM2 was highly expressed in NSCLC cells. Knockdown of TIAM2 inhibited the invasion and motility, and suppressed activation of Rac1. Further experiments demonstrated that knockdown of TIAM2 could up-regulate the expression of E-cadherin, and down-regulate the expression of MMP-3, Twist and Snail. Conclusions: Our data suggest that TIAM2 can promote invasion and motility of NSCLC cells. Activation of Rac1 and regulation of some EMT/invasion-related genes may be involved in the underlying processes.

• 건축역사연구
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• 제26권3호
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• pp.19-30
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• 2017

This paper studies the style emergence of Liujin Dougong in the ancient Chinese architecture. Dougong is the bracket set of the ancient Chinese wood structural architecture, and Liujin Dougong is one of the late styles of Chinese Dougong. It emerged in the period of the Ming Dynasty and has been installed in imperial palaces and imperial temples till the late period of the Qing Dynasty. Through the long term field survey and documental investigation, this research found out the some prototypes of Liujin Dougong among the earlier Xia-ang style Dougongs in the Song and Yuan Dynasty architectures. The symptom of style change appeared in the bracket composition. In the beginning, because Shuatou, the horizontal member just on Xia-ang was needed to be fixed to the inner main structure system, it was changed to the diagonal member and replaced Xia-ang. It brought continuous changes, the other horizontal members of Dougong also began to change to the diagonal form. And in accordance with these compositional changes of Dougong members, the decoration of inner parts also began to change. This paper analyzed every step of the compositional and decorative changes from Xia-ang Dougong style to Liujin Dougong style. In the addition, it also proposed the typical model of Qing style Liujin Dougong of which tail end is not placed on the beam and is just placed under the purlin, based on the its own research and analysis.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
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• pp.30-33
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• 2001

The number of hidden neurons of the feed-forward neural networks is generally decided on the basis of experience. The method usually results in the lack or redundancy of hidden neurons, and causes the shortage of capacity for storing information of learning overmuch. This research proposes a new method for optimizing the number of hidden neurons bases on information entropy, Firstly, an initial neural network with enough hidden neurons should be trained by a set of training samples. Second, the activation values of hidden neurons should be calculated by inputting the training samples that can be identified correctly by the trained neural network. Third, all kinds of partitions should be tried and its information gain should be calculated, and then a decision-tree correctly dividing the whole sample space can be constructed. Finally, the important and related hidden neurons that are included in the tree can be found by searching the whole tree, and other redundant hidden neurons can be deleted. Thus, the number of hidden neurons can be decided. In the case of building a neural network with the best number of hidden units for tea quality evaluation, the proposed method is applied. And the result shows that the method is effective

• 천문학논총
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• 제39권2호
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• pp.53-67
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• 2024

Islamic Jamal al-Din zij and Chinese Shoushi-li(授時曆) are astronomical hand books compiled by Jamal al-Din(札馬魯丁) and Guo Shujing(郭守敬) of the Islamic and Chinese Astronomical Bureau in Yuan(元) China, respectively. Jamal al-Din zij is an Islamic zij based on the Almagest of Ptolemaios, while Shoushii-li is a calendrical treatise by the traditional Chinese calendar system. In case of the parallax correction method, however, both of them have a common origin from Indian astronomy in 6-7 Century. This paper examines and discusses the parallax theory and its origin adopted in Jamal al-Din zij and Shoushi-li as following: 1) Definitions of the parallax theory and parallax correction methods. 2) Similarities and origins of the parallax correction methods adopted in the Jamal al-Din zij and Shoushi-li. 3) Comparison of the parallax correction tables included in the Sanjufini zij of Tibet, the Huihui-lifa(回回曆法) of Ming(明) China and the Chiljeongsan-Oepyeon(七政算外篇) of Joseon(朝鮮) Korea. 4) Routes of the parallax theory transmitted from ancient Greece and India to Joseon via Islam world and China, respectively. 5) Astronomical exchanges and mutual influence between the East and the West.

• Journal of Contemporary Eastern Asia
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• 제22권2호
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• pp.18-38
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• 2023

This paper examines the Chinese government's response to four epidemic crises, including COVID-19, and analyzes the similarities and differences in these responses. It argues that while the Chinese government learned from previous epidemics and improved its handling of subsequent outbreaks, a significant variation occurred during the COVID-19 pandemic, which had a detrimental impact globally. Existing scholarly research on China's epidemic responses has often been limited in scope, focusing on individual crises and neglecting the central-local government relationship in crisis decision-making. By adopting a comprehensive approach, this paper delves into the nuanced dynamics of China's responses to these epidemics. It highlights the variations in responses, attributing them to the Chinese government's fear of undermined legitimacy and its consideration of its international image. The government's recognition of the importance of public perception and trust, both domestically and globally, has shaped its crisis management strategies. Through a detailed analysis of these factors, this paper contributes to a deeper understanding of the variations observed in China's epidemic responses. It emphasizes the significance of the central-local government relationship and the government's international image in determining its actions during epidemics. Recognizing these factors can provide policymakers and researchers with insights to shape future epidemic response strategies and foster effective global health governance.

• 접착 및 계면
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• 제7권4호
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• pp.39-44
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• 2006

A new kind of silicone-epoxy composite is reported in this research. The silicone-epoxy resin was synthesized by the hydrosilylation of tetramethycyclotetrasiloxane and 4-vinyl-1-cyclohexene 1,2-epoxy with a high reaction yield. It was found that the obtained silicone-epoxy resin shows a high reactive activity to the aluminum complex-silanol catalyst. The resin could be cured under the catalysis of $(Al(acac)_3/Ph_2Si(OH)_2$ at a concentration below 0.1 wt% to give a hard cured resin showing excellent optical clarity, UV resistance and thermal stability. It was also found that the Si-H groups facilitated the curing reaction and the silicone-epoxy resin bearing Si-H group could be cured effectively even if $Ph_2Si(OH)_2h$ was absent. Moreover, the UV resistance and thermal stability were improved significantly by the introduction of Si-H groups. This is possibly due to the reductive property of Si-H groups which can annihilate radical and peroxide effectively. This kind of silicone-containing epoxy composite might have very promising applications as optical resin, optical adhesive and encapsulation materials for electronic devices.

• Molecules and Cells
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• 제41권3호
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• pp.198-206
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• 2018

Aortic dissection (AD) is a catastrophic disease with high mortality and morbidity, characterized with fragmentation of elastin and loss of smooth muscle cells. Although AD has been largely attributable to polymorphisms defect in the elastin-coding gene, tropoelastin (TE), other undermined factors also appear to play roles in AD onset. Here, we investigated the effects of post-transcriptional control of TE by microRNAs (miRNAs) on elastin levels in aortic smooth muscle cells (ASMC). We found that miR-144-3p is a miRNA that targets TE mRNA in both human and mouse. Bioinformatics analyses and dual luciferase reporter assay showed that miR-144-3p inhibited protein translation of TE, through binding to the 3'-UTR of the TE mRNA. Interestingly, higher miR-144-3p levels and lower TE were detected in the ASMC obtained from AD patients, compared to those from non-AD controls. In a mouse model for human AD, infusion of adeno-associated viruses (serotype 6) carrying antisense for miR-144-3p (asmiR-144-3p) under CAG promoter significantly reduced the incidence and severity of AD, seemingly through enhancement of TE levels in ASMC. Thus, our data suggest an essential role of miR-144-3p on the pathogenesis of AD.

• Asian-Australasian Journal of Animal Sciences
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• 제19권9호
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• pp.1240-1244
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• 2006

The complete coding region sequence of the SRY gene in Chinese swamp buffalo was determined by PCR product sequencing. Comparison of swamp and river buffalo SRY gene sequences revealed a single nucleotide polymorphism (SNP, C/G) at the 202 bp site of the coding region. Further, a total of 124 male domestic buffaloes were genotyped at this SNP site using the PCR-SSCP method, and it was found that all Chinese indigenous swamp buffaloes had a guanine (G) at this site, while introduced river buffaloes and crossbred buffaloes showed a cytosine (C). Our findings suggested that this Y-linked SNP displayed type-specific alleles differentiating swamp and river buffaloes, and could be used as an effective marker to detect crossbreeding of swamp buffaloes with introduced river buffaloes in native buffalo populations, and thereby assess genetic diversity status and make proper conservation decisions for indigenous swamp buffaloes. In addition, this SNP can be potentially applied in the study of Asian water buffalo phylogeny from a male perspective.

• Asian-Australasian Journal of Animal Sciences
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• 제22권11호
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• pp.1477-1486
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• 2009

Female germ cell meiotic divisions are typically asymmetric, giving rise to two daughter cells with different sizes. Spindle movements including spindle migration from the oocyte center to the cortex and spindle rotation from parallel to perpendicular (typically in the mouse) at the cortex are crucial for these asymmetric divisions and therefore are crucial for gamete production. Different regulatory mechanisms for spindle movements have been determined in different species and a wide variety of different molecular components and processes that are involved in spindle movements have also been identified in different species. Here, we review the current state of knowledge as well as our understanding of mechanisms for spindle movements in different systems with focus on three main aspects: microtubules (MT), microfilaments (MF) and molecules associated with cytoskeletal organization as well as molecules that are not directly related to the cytoskeleton. How they might interact or function independently during female meiotic divisions in different species is discussed in detail.