• The Korean Journal of Food And Nutrition
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• v.26 no.3
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• pp.375-382
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• 2013

The present study is designed to explore an anti-tumor activity on crude extracts of Oplopanax elatus. Water extractions of Oplopanax elatus were performed at $100^{\circ}C$(OeE-100). OeE-100 doses up to $62.5{\mu}g/m{\ell}$ had no cytotoxicity on the tumor cell lines in vitro. In experimental lung metastasis of colon26-M3.1 carcinoma or B16-BL6 melanoma, the prophylactic intravenous ($4{\sim}100{\mu}g/mouse$) or oral (2 mg/mouse) administration of OeE-100 significantly inhibited tumor metastasis as compared with tumor controls. Peritoneal macrophages stimulated with OeE-100 produced various cytokines such as TNF-${\alpha}$, IL-6 and IL-12. In an analysis of NK-cell activities, i.v. administration of OeE-100 ($10{\sim}100{\mu}g/mouse$) significantly augmented the cytotoxicity to YAC-1 tumor cells. Vaccination of mice with boiling-treated tumor cells (BT-vaccine) in combination with OeE-100 ($100{\mu}g/mouse$) showed higher inhibitions in tumor metastasis when compared with the mice of BT-vaccine treatment. In addition, the splenocytes from OeE-100 admixed BT-vaccine immunized mice secreted a higher concentration of Th1 type cytokine such as IFN-${\gamma}$. These results suggested that the OeE-100 stimulated immune system and was a good candidate adjuvant of anti-tumor immune responses.

• The Korean Journal of Pain
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• v.34 no.4
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• pp.405-416
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• 2021

Background: This study investigated the effect of intrathecal Sec-O-glucosylhamaudol (SOG) on the p38/c-Jun N-terminal kinase (JNK) signaling pathways, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-related inflammatory responses, and autophagy in a spinal nerve ligation (SNL)-induced neuropathic pain model. Methods: The continuous administration of intrathecal SOG via an osmotic pump was performed on male Sprague-Dawley rats (n = 50) with SNL-induced neuropathic pain. Rats were randomized into four groups after the 7th day following SNL and treated for 2 weeks as follows (each n = 10): Group S, sham-operated; Group D, 70% dimethylsulfoxide; Group SOG96, SOG at 96 ㎍/day; and Group SOG192, SOG at 192 ㎍/day. The paw withdrawal threshold (PWT) test was performed to assess neuropathic pain. Western blotting of the spinal cord (L5) was performed to measure changes in the expression of signaling pathway components, cytokines, and autophagy. Additional studies with naloxone challenge (n = 10) and cells were carried out to evaluate the potential mechanisms underlying the effects of SOG. Results: Continuous intrathecal SOG administration increased the PWT with p38/JNK mitogen-activated protein kinase (MAPK) pathway and NF-κB signaling pathway inhibition, which induced a reduction in proinflammatory cytokines with the concomitant downregulation of autophagy. Conclusions: SOG alleviates mechanical allodynia, and its mechanism is thought to be related to the regulation of p38/JNK MAPK and NF-κB signaling pathways, associated with autophagy during neuroinflammatory processes after SNL.

• Earthquakes and Structures
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• v.16 no.3
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• pp.295-310
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• 2019

This study attempts to develop new simplified approximate formulas to predict the fundamental natural periods of vibration (T) for bearing wall systems engaged with special reinforced concrete shear walls (RCSW) under seismic loads. Commonly, seismic codes suggested empirical formulas established by regression analysis of measured T for buildings during earthquake motions. These formulas depend on structure type, building height, number, height and length of SW, and ratio of SW area to base area of structure. In this study, a parametric investigation is performed for T of 110 selected models of bearing RCSW systems with varying structural height, configuration of horizontal plans including building width, number and width of bays, presence of middle corridors and core SWs. For this purpose, a 3D non-linear response time history (TH) analysis is implemented using ETABS v16.2.1. New formulas to estimate T are anticipated and compared with those obtained from formulas of IBC 2012 and ASCE/SEI 7-10. Moreover, the study examines responses of an arbitrarily two selected test model of 60 m and 80 m in height with presence of SWs having middle corridors. It is observed that the performance of the tested buildings is different through arising of considerable errors when using codes' formulas for estimating T. Accordingly, using the present proposed formulas exhibits more reasonable and safer design compared to codes' formulas. The results showed that equitable enhancement is promising to improve T formulas approaching enhanced and accurate estimation of T with reliable analysis, design, and evaluation of bearing RCSW systems.

• Journal of Technologic Dentistry
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• v.41 no.3
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• pp.221-232
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• 2019

Purpose: This experiment aims to provide the fundamental resources in developing a programme intended to prevent students from dropping out of their academics by promoting students to develop an optimistic psychological state, through analysis of the factors that influence students' commitment to their major. Methods: A self-administered questionnaire was conducted from $19^{th}$ of November of the year 2018, till $1^{st}$ of December of the same year, with dental technology students located in W city as the subject. 261(93.2%) of the participants' responses were used for the final analysis. Results: A negative association between factors of commitment to major and factors of academic dropout decision were portrayed to be of statistical significance (p<.01), and factors of commitment to major that influence dropping out of their academics were shown to be that of 'autotelic experience' (p<.001) with a negative ( - ) relationship, and 'change in a sense of time' (p<.01) with a positive ( + ) relationship of statistical significance, while the explanatory power of the model was shown to be 33.6%. Conclusion: In order to prevent dental technology students from dropping out of their academics, following their entrance, To achieve this, the department must consider the implementation of, aside from subject matters of the major, other various extra-curricular programmes, and programmes in which the supervisor is consistently providing consultations that are tailored to each individual student.

• The Southeast Asian review
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• v.28 no.2
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• pp.119-145
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• 2018

Celebrating its $50^{th}$ anniversary in 2017, the leaders of ASEAN member sates have adopted a series of declarations and action plans for enhancing its institutional capability and functional cooperation. ASEAN's convening power is expected to underpin its centrality and resilience. Meanwhile, ASEAN's retreat from democracy has increasingly become a hindrance for its further development. This article reviews the process of ASEAN's community building and its external relations. First, it argues that there is increasing concerns over ASEAN's limited capability in dealing with regional issues mainly caused by the deprivation of human rights and the democracy in crisis. Second, this article considers the dynamics of ASEAN's external relations mainly focusing on its relations with China, the United States, and South Korea. The South China Sea issue and China's increasing economic influence in the region have contributed to the complexity of ASEAN-China relations. The ASEAN's responses to the shift in American foreign policy under the Trump administration posits the unity of ASEAN. The New Southern Policy initiated by South Korean President, Moon Jae-in appears to be a new focal point of Korea-ASEAN relations despite considerable challenges, which requires to maintain ASEAN centrality.

• Journal of the Korean Chemical Society
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• v.65 no.6
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• pp.455-467
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• 2021

The purpose of this study was to investigate the impact of negotiation-based peer and self-assessment activities on science-gifted students' modeling and students' perceptions of the impact of these assessment activities on modeling. For this purpose, 92 students in the 11th grade of a science high school, in a metropolitan city, were selected to conduct peer assessment, self-assessment, and science writing activities with four topics of Advanced Chemistry. The students' modeling was analyzed in terms of 'structuring scientific concepts', 'logic', 'multiple representations' and 'communication'. Based on the results, the mean scores of modeling increased for each element of evaluation according to the progress of assessment activities. Students' responses in the survey and interviews showed that students perceived the results of student assessment activities as valid, students also recognized the benefit of these assessment activities by referring to the assessment results before their next writing assignment.

• Culinary science and hospitality research
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• v.22 no.4
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• pp.37-50
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• 2016

This study aims to examine the effect that the degree of knowledge about country-of-origin labeling on country-of-origin labeling work performance, which is a culinary staff task. This study is also intended to analyze differences in knowledge depending on hours of origin labeling education, and the moderating effect of education hours in the relationship between knowledge and performance. This study targeted culinary staff members working in ten five-star hotels in Seoul. A total of 205 self-administered questionnaires were distributed from November 14th to 27th, 2014, and 240 questionnaires(98.4%) were used for analysis after the exclusion of 4 with unreliable responses. Based on the data collected, frequency analysis, reliability test, exploratory factor analysis, simple regression analysis, t-test and moderating regression analysis were conducted using SPSS 18.0 program. The study findings are as follows. Culinary staff knowledge of origin labeling had a significantly positive effect on job performance and the degree of knowledge was higher in the group that attended one to two-hour periods of education. This suggests a differences in knowledge depending on the hours of education, which then had a moderating effect on the relationship between knowledge and performance. In conclusion, in order to improve knowledge of country-of-origin labeling and the level of performance, there is a need to increase education hours and enable culinary staff memebers to learn more knowledge and apply it to actual tasks. Based on these results, the limitation of the study and the direction of future research were also discussed.

• Culinary science and hospitality research
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• v.22 no.2
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• pp.234-251
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• 2016

The purpose of this study is to verify the effects of service quality and usage review of smartphone Maiib application(apps) on satisfaction, and reuse intention, convenience sampling method was employed and survey was conducted during the 15th of September, 2015 to the 30th on October as perceived by smartphone Maiib app users. Total of 312 responses were collected, and 295 usable data were used for statistical analysis excluding missing data. Descriptive analysis, factor analysis, and SEM were used to verify the hypothesis. The results from this study are as follows: first, reliability, empathy, usefulness of service quality significantly impact on Majib app satisfaction except informativeness and mobility; second, review assentation of the usage review characteristics significantly impact on Majib app satisfaction but review usefulness of the usage review characteristics significantly did not influence on Majib app satisfaction; third, smartphone Majib app satisfaction critically influences on reuse intention. Based on these results, current study can contribute to verify useful information is very important antecedent to construct the effective marketing strategy by smartphone app.

• Journal of the Korean Chemical Society
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• v.60 no.1
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• pp.48-58
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• 2016

This study was to investigate the types of middle school students’ conceptual change on electrolyte and ion. Data were collected by pre- and post- exams of 9th grade students’ conceptions of electrolyte and ion, and by semi-structured interviews with nine students served as case representatives who participated in the study. All interviews were transcribed, analyzed and classified by conceptual change according to the responses of the students. The results are as follows: First, students’ ion conceptual change was classified into four types; simple conception to sophisticated conception, incomplete conception to scientific conception, misconception to confused conception, and misconception to misconception. Most students had difficulty in understanding of the concepts of ion in pre- and post-class, and they failed to distinguish between atom and subatomic particles precisely. Second, students’ conceptual change of electrolyte was also classified into the following four types; partially scientific conception to sophisticated conception, misconception to partial misconception, incomplete conception to incomplete conception and misconception to misconception. The study found that students had difficulty distinguishing the difference between electrolytes and nonelectrolytes. Third, students also had difficulty understanding the concepts on particles because they learned the ‘electrolyte and ion’ unit so quickly in the second semester of 9th grade in order to fill in the academic reports for applying high schools. Furthermore, some suggestions were made based on the results for understanding scientific concepts on particles.

• Journal of the korean academy of Pediatric Dentistry
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• v.37 no.4
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• pp.395-402
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• 2010

The purpose of this study was to analyse the stability and validity of the related factors to the caries incidence according to the duration. The subjects were 249 elementary school students. Among them, the number of male students was 137 (55.0%). In the first year, all subjects gave the responses of the questionnaire composed of demographic variables and oral heath behaviors. They also received oral examination and tests of Dentocult SM and Dentocult LB. In the 2nd-4th year, they received second oral examination for the assessment of caries incidence on permanent teeth. The relation of oral health-related factors with caries incidence was analyzed by chi square method and adjusted Relative Risk (RR). In the caries incidence rate for 1 year, those who had 2 or higher score of dentocult LB was 2.3 times higher than those who had 1 or lower. The caries incidence rate for 2 years was highly associated with caries on deciduous molars and dentocult LB. The caries on deciduous molars showed strong association with the caries incidence for 3 years. It was suggested that the association between the caries incidence and the related factors was different according to the duration. Therefore, dentists could need to consider the visiting period in the education of the risk factors of dental caries.