• Title/Summary/Keyword: TetraAs

Search Result 339, Processing Time 0.019 seconds

Anti-proliferative Effect of Tetra-arsenic Oxide (TetraAs®) in Human Gastric Cancer Cells in Vitro

  • Chung, Won-Heui;Koo, Hye-Jin;Kuh, Hyo-Jeong
    • Journal of Pharmaceutical Investigation
    • /
    • v.37 no.5
    • /
    • pp.305-309
    • /
    • 2007
  • Arsenic compounds have been used to treat various diseases including cancer in oriental medicine. Arsenic trioxide ($As_2O_3,\;Trisenox^{(R)}$) has been used for the treatment of leukemia and its anti-solid tumor activity has also been reported recently. Tetra-arsenic oxide ($As_4O_6,\;TetraAs^{(R)}$) is a newly developed arsenic compound which has shown an anticancer activity in some human cancer cell lines. The purpose of this study was to evaluate the anti-gastric cancer potential of TetraAs and to search for an agent with synergistic interaction with TetraAs against human gastric cancers. We analysed anti-proliferative effect of TetraAs when given alone and in combination with other chemotherapeutic agents such as 5-FU, paclitaxel, and cisplatin in SNU-216, a human gastric cancer cell line. The $IC_{50}$ of these 4 anti-cancer drugs ranged from 5.8 nM to $7.5\;{\mu}M$ with a potency rank of order paclitaxel>TetraAs>cisplatin>5-FU. TetraAs showed 10-fold greater potency than 5-FU and cisplatin at the same effect level of $IC_{50}$. TetraAs+5-FU and TetraAs+paclitaxel showed synergistic and additive interaction, respectively. On the other hand, TetraAs with cisplatin group appeared to be strongly antagonistic. Apoptotic population was measured and compared between single and combination treatment. The apoptotic cells for the combination of TetraAs+5-FU showed significant increase compared to single TetraAs treatment. On the contrary, TetraAs+cisplatin showed less apoptotic cells compared to TetraAs or cisplatin alone treatment. Overall, our results indicate that TetraAs can be effectively combined with 5-FU or paclitaxel, but not with cisplatin for synergistic anti-cancer effect, which warrants further evaluation using in vivo models.

Gateway Platform for Connecting D-TRS in Electric Power IT (전력 IT용 D-TRS 접속을 위한 게이트웨이 플랫폼)

  • Song, Byung-Kwen;Jeong, Tae-Eui
    • Journal of the Korean Society for Railway
    • /
    • v.12 no.1
    • /
    • pp.45-54
    • /
    • 2009
  • TETRA(Terrestrial Trunked Radio) is the standard of D-TRS(Digital Trunked Radio System) developed by the ETSI(European Telecommunications Standards Institute). Currently, TETRA has been selected as Electric Power IT Wireless Backbone Network. Traditional distribution automation system has used the wireless network of Mobile Service Provider using CDMA(Code-Division Multiple Access) and WCDMA(Wideband CDMA) modem. Therefore, the development of gateway platform is indispensable according to the change to TETRA network. In this paper, we propose an embedded Linux-based Gateway platform for transmitting Industrial Electric Power IT protocol using TETRA network.

Packet Data Performance Measurement in D-TRS Wireless Network Environment (D-TRS 무선망 환경에서의 패킷 데이터 성능 측정)

  • Song, Byung-Kwen;Jin, Myung-Suk
    • Journal of the Korean Society for Railway
    • /
    • v.12 no.6
    • /
    • pp.902-908
    • /
    • 2009
  • TETRA is the standard of Digital Trunked Radio System developed by the ETSI (European Telecommunications Standards Institute). It is currently adopted as Electric Power IT Wireless Backbone Network in Korea, and a national enterprise is going on for versatile utilization of TETRA. To use TETRA wireless network, TETRA modem is very necessary such that performance measurements are very crucial for each TETRA modem by various manufacturers. In this paper, PED (Protocol Evaluation Data) is suggested for PD performance measurement in D-TRS wireless network environment. The performance measurements for different data lengths and transmission intervals are done using TG (Traffic Generator) on Test Bed. The data size is increased by 10 bytes from 10-byte to 400-byte, and it is measured 1,000 times for each transmission interval of 0.5, 1.0, and 1.5 seconds. Based on the transmission time measured, average transmission speed and MER (Message Error Rate) are derived for TETRA Modem performance measurement. Two TMR880i's of EADS are used for TETRA modem, and SwMI (Switching and Management Infrastructure) of EADS is used for switching system in this paper.

The Development of Gateway System for Power Automation based on TETRA (TETRA 기반 전력자동화 게이트웨이 시스템 개발)

  • Song, Byung-Kwen;Kim, Geon-Ung
    • Journal of IKEEE
    • /
    • v.14 no.2
    • /
    • pp.41-50
    • /
    • 2010
  • TETRA is the standard of Digital Trunked Radio System suggested by the ETSI(European Telecommunications Standards Institut ). It is adopted as Electric Power IT Wireless Backbone Network in Korea. Police station and Fire Station are using TETRA network. Currently, Power Automation Protocols are DNP3.0 in Distribution Automation System, DLMS in Auto Metering Infrastructure, IEC61850 in Substation Automation. These protocols are transmissions using CDMA or WCDMA modem. If Power Automation protocol uses TETRA networks, it can be interoperable with the systems in police or fire stations. And it has outstanding ability to handle problems in a disaster situation. So, This paper propose a gateway system of Power Automation which can transmit the power automation protocol using TETRA.

Counter-diffusion of Aromatic Compounds in Catalyst Supports (촉매담체내에서 방향족 화합물의 역확산)

  • Chung, Kyeong-Hwan;Seo, Gon
    • Applied Chemistry for Engineering
    • /
    • v.10 no.4
    • /
    • pp.608-614
    • /
    • 1999
  • The counter-diffusion of aromatic compounds such as coronene and tetra-phenylporphine by injection of acetone or tetra-phenylporphine solution was studied on aluminas and silica-alumina used widely as catalysts support. The counter-diffusivity was determined from simulation results by using the counter-diffusion model employing ideal adsorbed solution theory. The counter-diffusivities of aromatic compounds in the catalyst supports were ranged in ${\sim}10^{-15}m^2/sec$ in the desorption process by the injection of excess acetone. In the counter-diffusion process with tetra-phenylporphine solution which have similar concentration with adsorption solution, the counter-diffusivities of coronene were also ${\sim}10^{-15}m^2/sec$, and that of tetra-phenylporphine into pores were determined as ${\sim}10^{-11}m^2/sec$. The counter-diffusivities of coronene desobed from the adsorbent were significantly redyced in comparison with the effective diffusivities when there is counter-diffusion flux. The values mainly depended on the existence of counter-diffusion flux, but not concerned with the species and amount of desorbates.

  • PDF

DLMS SCADA System based on TETRA (TETRA 기반 DLMS 원방감시 시스템)

  • Song, Byung-Kwen;Lee, Suk-Hee
    • Journal of IKEEE
    • /
    • v.13 no.3
    • /
    • pp.95-102
    • /
    • 2009
  • TETRA(TErrestrial Trunked RAdio) is wireless communication system generally adopted to public network and backbone network, as the technology of Trunked Radio System specified by ETSI(European Telecommunications Standards Institute) and currently adopted to the Electric Power IT Backbone Network in Korea. DLMS(Device Language Message Specification) is used in order to meter an electric measuring instrument value. In this paper, DLMS Server and Client simulator are used based on Window operating system. The multi-functional gateway, which transforms the communications based on RS-232C between DLMS Server Simulator and Client Simulator to the one based on TETRA PEI(Peripheral Equipment Interface), is developed such that DLMS SCADA(Supervisory Control And Data Acquisition) system is constructed based on TETRA.

  • PDF

Building IEC 61850 SCADA system based on TETRA (TETRA 기반 IEC 61850 SCADA 시스템 구축)

  • Song, Byung-Kwen;Jeong, Tae-Ui
    • Journal of IKEEE
    • /
    • v.13 no.3
    • /
    • pp.87-94
    • /
    • 2009
  • TETRA(TErrestrial Trunked RAdio) is the wireless communication system generally adopted to public network and backbone network, as the technology of Trunked Radio System specified by ETSI(European Telecommunications Standards Institute) and currently adopted to the Electric Power IT Backbone Network in Korea. IEC 61850 is the protocol proposed for SAS(Substation Automation System) of SCADA(Supervisory Control And Data Acquisition) system. In this paper, IEC 61850 Server and Client simulator are used based on Linux operating system. The multi-functional gateway, which transforms the communication based on TCP/IP between IEC 61850 Server Simulator and Client Simulator to the one based on TETRA Packet Data Service, is developed such that IEC 61850 SCADA system is constructed based on TETRA.

  • PDF

SD(Short Data) Performance Measurement in D-TRS Wireless Network Environment (D-TRS 무선망환경에서의 SD(Short Data) 성능측정)

  • Song, Byung-Kwen;Kim, Geon-Ung
    • Journal of IKEEE
    • /
    • v.13 no.3
    • /
    • pp.80-86
    • /
    • 2009
  • TETRA is the standard of Digital Trunked Radio System developed by the ETSI(European Telecommunications Standards Institute). It is adopted as Electric Power IT Wireless Backbone Network in Korea. To use TETRA wireless network, TETRA modem is very necessary. In this paper, the performance measurements of modem and its results are analyzed according to traffics in TETRA network. In this paper, SDS type-4 transmission method is used in the transmission standards suggested by PEI(Peripheral Equipment Interface) of ETSI. Performance measurements are done by varying the data size and transmission interval. The data size is increased by 10 bytes from 10-byte to 140-byte, and it is measured 1,000 times for each transmission interval of 0.5, 1.0, and 1.5 seconds. MU-1000MD of Unimo is used for TETRA modem, and SwMI(Switching and Management Infrastructure) of Teltronic is used for switching system in this paper.

  • PDF

Radio Coverage Prediction of DMO Terminal in TETRA TRS (TETRA TRS에서 DMO 단말기의 전파도달범위 예측)

  • Lee, Soon-Hwa;Kim, Chang-Bock
    • The Journal of the Institute of Internet, Broadcasting and Communication
    • /
    • v.14 no.3
    • /
    • pp.51-56
    • /
    • 2014
  • TETRA(TErrestrial Trunked RAdio) provide specialized disaster radio communication services as a standard European for digital TRS(Trunked Radio System). Especially, DMO(Direct Mode Operation) feature is used effectively in the radio shadow areas which base station does not propagate radio signal because it can communicate directly with terminal to terminal without base station's relay function. However, to effectively used DMO feature, radio coverage prediction information should be provided to users. Therefore in this paper, we were calculated link budget of TETRA DMO terminals which were distributing and operating in the country and then predicted reaching distance about radio propagation to be applied with path loss model.

Spectrum Requirement Estimation for Korean Wireless Communication Network of Public Protection and Disaster Relief Based on ITU-R M.2033 in TETRA-TRS (TETRA-TRS의 ITU-R M.2033 기반 국내 재난안전 무선통신망 주파수 소요량 산출)

  • Lee, Soon-Hwa;Kim, Chang-Bock
    • The Journal of Korean Institute of Communications and Information Sciences
    • /
    • v.37A no.10
    • /
    • pp.858-864
    • /
    • 2012
  • In South Korea, to effective and systematic response to disasters, the government will build wireless communication network for PPDR(Public Protection and Disaster Relief) on a national level by 2015. To do it, as MOPAS(Ministry of Public Administration and Security) requested the new frequency assignment for PPDR, KCC(Korea Communications Commission) has been examined new frequency allocations about TETRA and WiBro technologies. In this paper, we were defined the technical parameters, were estimated the spectrum of TETRA-TRS requirements for Korean wireless communication of PPDR based on M.2033 methodology recommended by ITU-R.