• Bulletin of the Korean Chemical Society
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• 제33권9호
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• pp.2930-2936
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• 2012

A three-dimensional pharmacophore hypothesis was developed for atypical antipsychotics in order to map common structural features of highly active compounds by using HipHop in CATALYST program. The pharmacophore hypotheses were generated using 12 compounds as training set and validated using 11 compounds as test set. The most predictive hypothesis (Hypo1) comprises five features viz. two hydrophobic regions, two hydrogen bond acceptor lipid and one aromatic ring. In the absence of information like crystallized structure of 5-$HT_{2A}$ receptor and binding mode of antipsychotics with 5-$HT_{2A}$ receptor, this hypothesis will serve as a potentially valuable tool in the design of novel atypical antipsychotics acting primarily at 5-$HT_{2A}$ and $D_2$ receptors.

• 경영과학
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• 제19권2호
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• pp.75-89
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• 2002

According to the fast-paced environment of information technology and improving customer services, the design activities of logistics systems improve customer centric services and delivery performance implementing e-logistics system. The fundamental design issues that arise in the delivery system planning are optimizing the system with minimum cost and maximum throughput and service level. This study is concerned with the integrated model development of delivery system with customer responsive service level for DCM, Demand Chain Management. We used a two-step approach for this study. First, we formulated the supply. center facility planning using stochastic set-covering problem and assigned the customers to the supply center using clustering algorithm. Second, we developed vehicle delivery planning for a supply center based on GIS, GIS-VRP. Also we developed a GUI-type computer program for proposed method for supply center problem using GIS and Geo-DataBase of Busan area. The computational results showed that the proposed method was very effective on a set of test problems.

• 한국정밀공학회지
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• 제23권2호
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• pp.65-72
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• 2006

Downcoiler is one of the major facilities in hot strip mill operation. The key to good coiling is having good equipment, modem control systems, excellent maintenance and an understanding of coiling process. Therefore, this study aims to develop a program that is useful for calculating machine design parameters and simulating coiling process. In this study, the pinching and coiling mechanism of the downcoiler was thoroughly studied and some of operational factors and their effects on the coiling process were investigated. The software was developed to estimate engineering parameters for coiler component design and to determine optimal setting values for successful coiling operation. In order to check the accuracy and usefulness of the developed software, the simulation of the downcoiler in $\#2$ Hot Strip Mill in Pohang Works was performed. The simulation results suggested that the set-up value for unit tension could be lowered. Test coiling operation by using the lowered set-up value for unit tension resulted in much more successful coiling in the aspect of strip quality and power consumption.

• 초등상담연구
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• 제7권1호
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• pp.91-108
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• 2008

The goal of this study is to examine the sociality and school adjustment of elementary school lower-class students. The following research hypotheses were set up and addressed: Hypothesis 1: There would be significant differences in sociality of the elementary school lower-class students according to activity - making friends group counseling Program. Hypothesis 2: There would be significant differences in school adjustment of the elementary school lower-class students according to activity - making friends group counseling Program. The subjects for the study were 20 first grade students attending N elementary school in Daejeon area. The students were assigned to the two groups-experimental group(N=10) and controlled group(N=10). The experimental group received 10 sessions of the activity - making Friends group counseling program for 40 minutes by 2 times every week, and the controlled group didn't do anything. To verify the hypotheses, two tests(sociality and school adjustment tests) were administered for the pretest and post-test. Means and standard deviations obtained from these tests were analyzed with factorial covariance test using SPSSWIN(10.0). The results were as follows: Hypothesis 1 was confirmed. The scores of experimental group were significantly higher than those of controlled group in sociability, cooperation and independence, but not in observance. Hypothesis 2 was confirmed. The scores of experimental group were significantly higher than those of controlled group in teacher-student relationship, student-student relationship and classes, but not in the keeping rules. The conclusion of the result is that the program have a good effect on the elementary school lower-class students' sociality and school adjustment. Above all, along with long-term adaptability of the research, continuous studies are required.

• 생약학회지
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• 제41권4호
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• pp.303-307
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• 2010

To overcome the limit of morphological method for classification of herbal drug, a novel method to discriminate its origin using pyrolysis mass spectrometry-multivariate analysis was developed. This method was applied successfully to Scutellaria baicalensis Georgi, one of the most popular herbal drug in oriental countries. The ethylacetate soluble fractions were prepared by sonication from pulverized roots of S. baicalensis which were collected from various regions including Korea and China, and subjected to direct insertion probe (DIP) mass spectrometry to achieve mass spectra of pyrolizates of extracts. The probe temperature was elevated from $30^{\circ}C$ to $320^{\circ}C$ at increasing rate $64^{\circ}C/min$, and the average mass spectrum calculated from total ion chromatography (TIC) was obtained. The relative peak intensities versus m/z were subjected to SAS program, and the training set (9 from Korea origin and 22 from China origin) was clustered two groups as its origin. In the test set, 11 samples among total 13 test sample were successfully classified according to their origin by developed method with accuracy of 85%.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제16권5호
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• pp.571-575
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• 2010

클래스 수준 뮤테이션 분석(class-level mutation analysis)의 경우, 동등 뮤턴트(equivalent mutant)는 전체 뮤턴트들의 개수에서 많은 비중을 차지하기 때문에 동등 뮤턴트의 검출은 뮤테이션 수행 비용 절감에 매우 중요하다. 하지만 현재까지 클래스 수준 뮤테이션을 대상으로 동등 뮤턴트를 검출하는 연구는 미미한 실정이다. 본 논문에서는 클래스 수준 뮤테이션을 대상으로 의존성 그래프(dependency graph)를 이용하여 동등 뮤턴트를 검출하기 위한 기법을 제안한다. 제안한 기법은 인트라-클래스(intra-class) 수준에서 정적분석을 수행함으로써 인트라-메소드(intra-method) 수준의 분석 방법을 사용하는 기존의 연구들이 검출할 수 없었던 클래스 수준 동등 뮤턴트를 검출할 수 있었다.

• 한국산업융합학회 논문집
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• 제13권1호
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• pp.15-22
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• 2010

This paper was originated to set up a test equipment and to obtain the proper installation condition of the plastic damper for the hydraulic clutch control system. Performance tests with different specifications have been applied to the damper to investigate the workability and the vibration characteristics of each case, and the result was utilized into the system simulation for the optimal condition for the damper. The procedure has been developed to set up a damper test system to analyze the dynamic properties and the operation of the system, and further to setup a simulation program for the realistic situations. The result can also be applied to the dampers and the clutch systems to be developed in the future for the property tests and the optimization of the installation conditions.

• Elastomers and Composites
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• 제37권2호
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• pp.107-114
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• 2002

청정실(Clean room)에 사용되는 환기팬용 모터의 방진고무부품의 수명을 예측하기 위해서 가속 열 노화 시험을 수행하였다. 방진고무부품은 EPDM으로 만들었다. 노화 수명을 판단하기 위한 한계점을 20%의 압축 영구 줄음률로 하여 절대 온도의 역수 값으로 아레니우스 선도를 유도하였다. 아레니우스 관계식으로부터 방진고무부품의 다양한 온도에서의 수명과 활성화에너지를 구하였다. 그리고 수명을 판단하는데 있어 상당한 시간을 대체할 수 있는 가속 시험법을 설계하였다. 또한 방진고무부품에 첨가되는 노화 방지제가 수명에 미치는 영향을 알아보았다.

• 한국운동역학회지
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• 제26권4호
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• pp.397-405
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• 2016

Objective: Pilates is a low/mid-intensity exercise that can be easily performed by elderly individuals as it is an individual body-oriented exercise. It is also a cardio workout that can be performed anywhere to develop strength and flexibility. Therefore, we investigated the effects of 8 week Pilates program on the balancing ability of elderly individuals. Method: The research participants were selected from elderly residents in B city. Ten individuals voluntarily signed an agreement to undergo free measurements as well as to participate in the workout program. (Height: $157.1{\pm}11.9cm$, Weight: $61.7{\pm}8.0kg$). The Pilates exercise was performed 60 minutes a day, three times a week for a total of eight weeks. The measurement variables used to test balance were the vestibular test, 5 m habitual and maximum walk test and 3 m tandem walk test. A series of paired t-test were conducted using IBM SPSS Statistics 23.0 to analyze all the research data collected in order to determine the balance ability of the participants before and after the Pilates program. Additionally, the statistically significant level for all analysis was set to ${\alpha}=.05$. Results: In the vestibular test, some meaningful changes were observed in the length envelope area (ENV) while standing on one foot, but there were no significant differences in the ENV, rectangle(REC), root mean square, and total length. Results also revealed that statistically significant differences existed in the 5 m habitual and maximum walk test, as well as the 3 m tandem walk test. Conclusion: To summarize the findings, the 8 week Pilates program employed in this study significantly improved the dynamic balance of the elderly participants. Thus, elderly individuals that frequent perform Pilates are expected to enjoy positive benefits such as increased balance and fewer falling accidents.

• Steel and Composite Structures
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• 제35권6호
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• pp.789-798
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• 2020

The effect of Chitosan (CS), Carbon Nanotube (CNT) and hybrid (CS-CNT) fillers on the natural frequency of drilled composite plate is investigated by experimentally in this study. The numerical validation is also made with a program based on Finite Element Method (SolidWorks). Nine types filled and one neat composite plates are used in the study. The fillers ratios are 1% CS, 2% CS, 3% CS, 0.1% CNT, 0.2% CNT, 0.3% CNT, 1% CS+0.3% CNT, 2% CS+0.3% CNT, 3% CS+0.3% CNT. The specimens cut to certain sizes by water jet from the plates 400 mm × 400 mm in dimensions. Some of them are drilled in certain dimensions with drill. The natural frequency of each specimen is measured by the vibration test set up to determine the vibration characteristic. The vibration test set up includes an accelerometer, a current source power unit, a data acquisition card and a computer. A code is written in Matlab^® program for the signal processing. The study are investigated and discussed in four main points to understand the effect of the fillers on the natural frequency of the composite plate. These are the effect of fillers contents and amounts, orientation angles of fibers, holes numbers and holes sizes. As results, the natural frequency of the plate with 1% CS and 0.1% CNT hybrid filler is lower than those of the plates with other fillers ratios for 45° orientation angle. Besides, in the composite plate with 0° orientation angle, the natural frequency increases with increasing the filler ratio. Moreover, the natural frequency increases until a certain hole number and then it decreases. Furthermore, the natural frequency is not affected until a certain hole diameter but then it decreases.