• Title/Summary/Keyword: Test Validation

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T1 Map-Based Radiomics for Prediction of Left Ventricular Reverse Remodeling in Patients With Nonischemic Dilated Cardiomyopathy

  • Suyon Chang;Kyunghwa Han;Yonghan Kwon;Lina Kim;Seunghyun Hwang;Hwiyoung Kim;Byoung Wook Choi
    • Korean Journal of Radiology
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    • v.24 no.5
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    • pp.395-405
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    • 2023
  • Objective: This study aimed to develop and validate models using radiomics features on a native T1 map from cardiac magnetic resonance (CMR) to predict left ventricular reverse remodeling (LVRR) in patients with nonischemic dilated cardiomyopathy (NIDCM). Materials and Methods: Data from 274 patients with NIDCM who underwent CMR imaging with T1 mapping at Severance Hospital between April 2012 and December 2018 were retrospectively reviewed. Radiomic features were extracted from the native T1 maps. LVRR was determined using echocardiography performed ≥ 180 days after the CMR. The radiomics score was generated using the least absolute shrinkage and selection operator logistic regression models. Clinical, clinical + late gadolinium enhancement (LGE), clinical + radiomics, and clinical + LGE + radiomics models were built using a logistic regression method to predict LVRR. For internal validation of the result, bootstrap validation with 1000 resampling iterations was performed, and the optimism-corrected area under the receiver operating characteristic curve (AUC) with 95% confidence interval (CI) was computed. Model performance was compared using AUC with the DeLong test and bootstrap. Results: Among 274 patients, 123 (44.9%) were classified as LVRR-positive and 151 (55.1%) as LVRR-negative. The optimism-corrected AUC of the radiomics model in internal validation with bootstrapping was 0.753 (95% CI, 0.698-0.813). The clinical + radiomics model revealed a higher optimism-corrected AUC than that of the clinical + LGE model (0.794 vs. 0.716; difference, 0.078 [99% CI, 0.003-0.151]). The clinical + LGE + radiomics model significantly improved the prediction of LVRR compared with the clinical + LGE model (optimism-corrected AUC of 0.811 vs. 0.716; difference, 0.095 [99% CI, 0.022-0.139]). Conclusion: The radiomic characteristics extracted from a non-enhanced T1 map may improve the prediction of LVRR and offer added value over traditional LGE in patients with NIDCM. Additional external validation research is required.

Study on Flight Test Safety Management Operations and Processes (국내 비행종합시험을 위한 비행시험 및 안전관리 운영·절차에 관한 연구)

  • Mok, Jihyun;Lee, Kyelim;Ko, Sangho
    • Journal of Aerospace System Engineering
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    • v.11 no.3
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    • pp.31-38
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    • 2017
  • As demand for best practices relative to flight test safety management operations and processes in the aviation industry grows, standards for such aspects of the industry in Korea should be examined. Therefore, in this paper, we conducted flight test operation processes and safety management program development studies based on documents related to flight tests of the Korean civil aviation KC-100, the military aircraft T-50, the FAA (Federal Aviation Administration), and CAAC (Civil Aviation Administration of China) for performance validation, test evaluation and safety certification for aircraft under development and remodeling. In addition, we introduced and analyzed best practices of the FTSC (Flight Test Safety Committee) applicable to aircraft flight test processes.

Validation of sequence test method of Pb-free solder joint for automotive electronics (자동차 전장품용 무연솔더 접합부의 시리즈 시험 유효성)

  • Kim, A Young;Oh, Chul Min;Hong, Won Sik
    • Journal of Welding and Joining
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    • v.33 no.3
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    • pp.25-31
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    • 2015
  • Due to environmental regulations (RoHS, WEEE and ELV) of the European Union, electronics and automotive electronics have to eliminate toxic substance from electronic devices and system. Specifically, reliability issue of lead-free solder joint have an increasing demand for the car electronics caused by ELV banning. The authors prepared engine control unit and cabin electronics soldered with Sn-3.0Ag-0.5Cu (SAC305). To compare with the degradation characteristics of solder joint strength, thermal cycling test (TC), power-thermal cycling test (PTC) and series tests were conducted. Series tests were conducted for TC and PTC combined stress test using the same sample in sequence and continuously. TC test was performed at $-40{\sim}125^{\circ}C$ and soak time 10 min for 1000 cycles. PTC test was applied by pulse power and full function conditions during 100 cycles. Combined stress test was tested in accordance with automotive company standard. Solder joint degradation was observed by optical microscopy and environment scanning electron microscopy (ESEM). In addition, to compare with deterioration of bond strength of quad flat package (QFP) and chip components, we have measured lead pull and shear strength. Based on the series test results, consequently, we have validated of series test method for lifetime and reliability of Pb-free solder joint in automotive electronics.

Fast Consolidation Test Using Seepage Forces : Method and Validation (침투압을 이용한 급속압밀시험 : 방법 및 검증)

  • Lee, Kang-Il;Kim, Tae-Hyung;Znidarcic, Dobroslav
    • Journal of the Korean Geotechnical Society
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    • v.25 no.4
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    • pp.31-38
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    • 2009
  • A continuous, fast, and convenient experimental method, replacing recent tests such as standard oedometer or self weight consolidation test, is needed for the determination of the consolidation behavior of unformed soft soils. This study introduced the seepage induced fast consolidation test using the flow pump technique. It can obtain the consolidation characteristics of unformed soft soils conveniently and fast. The seepage induced consolidation test apparatus consists of a modified triaxial cell, differential pressure transducer, flow pump, and displacement transducer. The test continuously proceeds with starting seepage forces induced consolidation, loading consolidation, and permeability test on the same sample. In addition, this test result was compared with the standard oedometer test result to make this method valid. From this study it was found that this method is a convenient and time saving effective method for obtaining data required for calculation of consolidation settlement of unformed soft soils.

A Comprehensive Review on Regression Test Case Prioritization Techniques for Web Services

  • Hasnain, Muhammad;Ghani, Imran;Pasha, Muhammad Fermi;Lim, Chern Hong;Jeong, Seung Ryul
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.14 no.5
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    • pp.1861-1885
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    • 2020
  • Test Case Prioritization (TCP) involves the rearrangement of test cases on a prioritized basis for various services. This research work focuses on TCP in web services, as it has been a growing challenge for researchers. Web services continuously evolve and hence require reforming and re-execution of test cases to ensure the accurate working of web services. This study aims to investigate gaps, issues, and existing solutions related to test case prioritization. This study examines research publications within popular selected databases. We perform a meticulous screening of research publications and selected 65 papers through which to answer the proposed research questions. The results show that criteria-based test case prioritization techniques are reported mainly in 41 primary studies. Test case prioritization models, frameworks, and related algorithms are also reported in primary studies. In addition, there are eight issues related to TCP techniques. Among these eight issues, optimization and high effectiveness are most discussed within primary studies. This systematic review has identified that a significant proportion of primary studies are not involved in the use of statistical methods in measuring or comparing the effectiveness of TCP techniques. However, a large number of primary studies use 'Average Percentage of Faults Detected' (APFD) or extended APFD metrics to compute the performance of techniques for web services.

SEPARATE AND INTEGRAL EFFECT TESTS FOR VALIDATION OF COOLING AND OPERATIONAL PERFORMANCE OF THE APR+ PASSIVE AUXILIARY FEEDWATER SYSTEM

  • Kang, Kyoung-Ho;Kim, Seok;Bae, Byoung-Uhn;Cho, Yun-Je;Park, Yu-Sun;Yun, Byoung-Jo
    • Nuclear Engineering and Technology
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    • v.44 no.6
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    • pp.597-610
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    • 2012
  • The passive auxiliary feedwater system (PAFS) is one of the advanced safety features adopted in the APR+, which is intended to completely replace the conventional active auxiliary feedwater system. With an aim of validating the cooling and operational performance of PAFS, an experimental program is in progress at KAERI, which is composed of two kinds of tests; the separate effect test and the integral effect test. The separate effect test, PASCAL ($\underline{P}$AF$\underline{S}$ $\underline{C}$ondensing Heat Removal $\underline{A}$ssessment $\underline{L}$oop), is being performed to experimentally investigate the condensation heat transfer and natural convection phenomena in PAFS. A single, nearly-horizontal U-tube, whose dimensions are the same as the prototypic U-tube of the APR+ PAFS, is simulated in the PASCAL test. The PASCAL experimental result showed that the present design of PAFS satisfied the heat removal requirement for cooling down the reactor core during the anticipated accident transients. The integral effect test is in progress to confirm the operational performance of PAFS, coupled with the reactor coolant systems using the ATLAS facility. As the first integral effect test, an FLB (feedwater line break) accident was simulated for the APR+. From the integral effect test result, it could be concluded that the APR+ has the capability of coping with the hypothetical FLB accident by adopting PAFS and proper set-points of its operation.

Uncertainty Analysis for Seakeeping Model Tests (정현파 중 운동모형시험에 대한 불확실성 해석)

  • Deuk-Joon Yum;Ho-Young Lee;Choung-Mook Lee
    • Journal of the Society of Naval Architects of Korea
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    • v.30 no.3
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    • pp.75-89
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    • 1993
  • The present paper describes an application of UA(Uncertainty Analysis) to seakeeping model test, basically according to the Performance Test Code of ASME(American Society of Mechanical Engineers), in which all the possible error sources involved in the preparation of test, calibration of instruments, data acquisition and analysis are quantified, and summed up with error propagation coefficients to the final uncertainties. The differences between the static test such as resistance and propulsion test and the dynamic test like seakeeping test are clearly identified during all the procedures of UA and asymmetric bias errors are considered. The DRE(data reduction equation) subject to present UA are the heave and pitch response amplitude operator and nondimensionalized absolute frequency. The usefulness of UA in seakeeping test were confirmed not only for quantifying errors and improving measurement accuracy but also for the validation of various seakeeping analysis tools.

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The Development of Performance Test Equipment For Evaluating Endothermic Performance of Fuel Supply and Cooling System in High-Speed Vehicles (고속비행체 연료 공급 및 냉각 계통의 흡열성능 평가를 위한 성능시험 장치 개발)

  • Kim, Minsang;Choi, Won;Jun, Pilsun;Park, Jeongbae
    • Journal of Aerospace System Engineering
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    • v.13 no.4
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    • pp.43-49
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    • 2019
  • In this study, a test equipment which enables to feed endothermic fuel which is heated in the inside and outside environment of a high-speed vehicle and evaluate the heat exchangers' performance was designed and manufactured. For smooth operation of the test equipment, a test procedure that supplied endothermic fuel at high temperatures was established. The catalyst performance test was conducted based on the supply condition of the endothermic fuel and the amount of heat absorbed was analyzed. The validation of the test equipment was proved by comparing the results of catalytic reaction with the previous studies under similar reaction condition. This test equipment can be utilized in the endothermic reaction tests of catalyzed endothermic fuel under various conditions.

VALIDATION AND UTILIZATION OF THE SKINTEXTM SYSTEM

  • Gordon, V.C.;Realica, B.;Tolstrup, K.;Puls, B.
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.17 no.1
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    • pp.64-80
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    • 1991
  • The SKINTEX Method is based on a two-compartment physico-chemical model which includes a Biomembrane Barrier in compartment one and an organized macromolecular matrix in compartment two. Test samples absorb onto or permeate through the keratin/collagen Biomembrane Barrier and then can interact with the organized macromolecular matrix. Changes in the integrity of the barrier release a dye indicator: Changes in the matrix can alter its transparency. The sum of these two responses is read spectrophotometrically at 470nm. An early investigation of 950 chemicals and formulations in the SKINTEX System produced results which were 89% concordance to in vivo Draize dermal irritation results obtained with 24-hour occluded application of test samples with-out abrasion and standard scoring. Alkaline materials were analyzed in a specialized SKINTEX AMA Protocol. In this early study, the model did not distinguish nonirritant test materials and formulation with PDII(Primary Dermal Irritation Index)in the range from 0 to 1.2, A High Sensitivity Assay Protocol(HSA)was developed to amplify the changes in both compartments of this model and provide more accurate calibration of these changes. A study of 60 low irritation test samples including cosmetics, household products, chemicals and petro-chemicals distinguished nonirritants with PDII $\leq$ 0.7 for 26 of 30 nonirritants. A second protocol was developed to evaluate the SKINTEX model predictability with respect to human irritation. The Human Response Assay (HRA )has been optimized based on differences in penetration and irritation responses in humans and rabbits. An additional 32 test materials with different mechanisms and degrees of dermal toxicity were evaluated by the HRA. These in vitro results were 86% concordant to human patch test results. In order to further evaluate this model, a Standard Chemical Labelling (SCL) Protocol was developed to optimize this system to predict Draize dermal irritation results after a 4-hour application of the test material. In a study of 52 chemicals including acids, bases, solvents, salts, surfactants and preservatives, the SCL results demonstrated 85% concordance to Draize results for a 4-hour application of test samples on non-abraded rabbit skin. The SKINTEX System, including three specialized protocols, provided results which demonstrated good correlation to the endpoint of dermal irritation in man and rabbits at different application times.

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Evaluation of Classification and Accuracy in Chest X-ray Images using Deep Learning with Convolution Neural Network (컨볼루션 뉴럴 네트워크 기반의 딥러닝을 이용한 흉부 X-ray 영상의 분류 및 정확도 평가)

  • Song, Ho-Jun;Lee, Eun-Byeol;Jo, Heung-Joon;Park, Se-Young;Kim, So-Young;Kim, Hyeon-Jeong;Hong, Joo-Wan
    • Journal of the Korean Society of Radiology
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    • v.14 no.1
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    • pp.39-44
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    • 2020
  • The purpose of this study was learning about chest X-ray image classification and accuracy research through Deep Learning using big data technology with Convolution Neural Network. Normal 1,583 and Pneumonia 4,289 were used in chest X-ray images. The data were classified as train (88.8%), validation (0.2%) and test (11%). Constructed as Convolution Layer, Max pooling layer size 2×2, Flatten layer, and Image Data Generator. The number of filters, filter size, drop out, epoch, batch size, and loss function values were set when the Convolution layer were 3 and 4 respectively. The test data verification results showed that the predicted accuracy was 94.67% when the number of filters was 64-128-128-128, filter size 3×3, drop out 0.25, epoch 5, batch size 15, and loss function RMSprop was 4. In this study, the classification of chest X-ray Normal and Pneumonia was predictable with high accuracy, and it is believed to be of great help not only to chest X-ray images but also to other medical images.