• The Journal of Internal Korean Medicine
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• v.27 no.2
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• pp.356-370
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• 2006

Objectives: The aim of this experimental study is to investigate effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tangon the anti-cathartic action of mice and guinea pigs to develop effective herbal medicine and prescription to cure diarrhea early and to prevent side effect of chronic diarrhea. Methods: To compare effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tangon the anti-cathartic action of mice and guinea pigs, we evaluated the actions on isolated gastrointestinal smooth muscles. on the transportability of small and large intestines, onthe neostigmine-induced transportability of small intestine and on diarrhea induced by castor oil, pilocarpine, barium chloride. Results: (1) Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang showed the strong alleviation on the contraction of mice's isolated gastrointestinal smooth muscles induced by acetylcholine chloride and barium chloride. while Terminaliae Fructus, strong, Bojanggunbi-tang, intermediate and Dolichoris Semenshowed the minor alleviation on the contraction of guinea pigs' isolated gastrointestinal smooth muscles induced by acetylcholine chloride and histamine. All effects depended on the density in each medicine. (2) The tranbportability of small intestine was contrained in the groups controlled by 600 mg/kg of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang, and 200 mg/kg of D olichoris Semen and Terminaliae Fructus. However, the enhancement of neostigmine-induced transportability of small intestine was constrained only in the groups controlled by 600 mg/kg of Dolichoris Semen, Terminaliae Fructus and Boianggunbi-tang. (3) The transportability of large intestine was constrained by Dolichoris Semen and Bojanggunbi-tang. They showed substantial results. which depended on the amount of each medicine. (4) Terminaliae Fructus showed substantial anti-cathartic effects on diarrhea induced by caster oil in both groups controlled by 200 and 600 mg/kg of it. However, Bojanggunbi-tangshowed the effects only in the group controlled by 600 mg/kg. in diarrhea induced by pilocarpine, the groups controlled by 600 mg/kg or Terminaliae Fructus and 200 and 600 mg/kg of Boianggnbi-tangshowed substantial results. In diarrhea induced by barium chloride. the groups controlled by 200 and 600 mg/kg of Terminaliae Fructus and 600 mg/kg of Boianggunbi-tangshowed substantial results in anti-cathartic effects. Conclusions: These results show that Terminaliae Fructus is more effective on the contraction of mice and guinea pigs' isolated gastrointestinal smooth muscles, Dolichoris Semen is more effective on the transportability of small intestine, Dolichoris Semen and Bojanggunbi-tang are more effective on the transportability of large intestine. Terminaliae Fructus and Bojanggunbi-tang show substantial results in anti-cathartic actions.

• Korean Journal of Medicinal Crop Science
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• v.8 no.2
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• pp.109-116
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• 2000

This study was carried out to screen herbs among herbal plants showing antimicrobial activity against some food spoilage and pathogenic microorganisms. One hundred fifteen kinds of herbal plants were extracted by 70% ethanol, and then they have been screened for antimicroorganisms. Six herbal plants such as Salviae radix, Dryopteris rhizoma, Terminaliae fructus, Araliae radix, Psoraleae fructus and Schisandrae fructus showed strong antimicrobial activities against Bacillus subtilis. Antimicrobial activities were showed in Anemarrhena radix and Dryopteris rhizoma on Candida albicans, and in Anemarrhenae radix, Dryopteris rhizoma and Polygalae radix on Schizosaccharomyces sp. It was revealed that eight herbal plants such as Dryopteris rhizoma, Salviae radix, Sappan ligunum, Sinomeniae radix, Schisandrae fructus, Rhui fructus, Sophorae radix and Inulae radix also showed antimicrobial activities on Streptococcus mutans. In addition, Anemarrhena radix, Curcuma tuber, Inulae radix, Polygonum radix, Sanguisorbae radix, Scutellariae radix and Terminaliae fructus and showed antimicrobial activities on Trichophyton mentagrophytes. Four kinds of herbal plants such as Dropteris rhizoma, Salviae radix, Terminaliae fructus and Scutellariae radix which showed broad antimicrobial spectrums were mixed by 1 : 1 ratio with the other herbal paints showing relatively strong microbial activities such as Terminaliae fructus, Sinomeniae radix and Scutellariae radix etc. The extracts of mixed herbal paints showed higher antimicrobial activities than those of single herbal plant.

• Archives of Pharmacal Research
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• v.23 no.3
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• pp.261-266
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• 2000

The inhibitory activity of several crude drugs on $\alpha$-glucosidases, which are the key enzymes for carbohydrate digestion and the prevention of diabetic complications, was investigated. Several crude drugs including Terminaliae Fructus, Mori Cortex Radicis, Caesalpiniae Lignum and Cyrophora esculenta potently inhibited maltase and sucrase isolated from rat intestine, while Arecae Semen and Corni Fructus remarkably inhibited $\alpha$-amylase. Caesalpiniae Lignum and Gyrophora esculenta exhibited significant reductions of blood glucose elevation in mice loaded with maltose and sucrose.

• Journal of Ginseng Research
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• v.23 no.2 s.54
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• pp.67-73
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• 1999

This study carried out to scanning and select the antimicrobial pharmaceuticals which were suppress the rottening of fresh ginseng. We are isolated 20 kinds of microorganisms from rotten ginseng. In these of the microorganisms, five bacteria, fresh ginseng root-rottening, are identified to Pseudomonas putida, Pseudomonas putida biotype A, Bacillus spp, Enterobacter cloacae, and Klebsiella pneumoniae. Particularly. Bacillus spp was rapidly rotted the ginseng root, compared with the others. The antimicrobial activity were tested with 19 kinds of water extracts, and 34 kinds of essential oils. The water extract of Terminaliae Fructus, and Schiandra chinensis are strongly inhibited the growth of bacteria causing the ginseng root-rottening. And 5 kind of essential oils are inhibited bacteria. It was regarded that the water extract of Terminaliae Fructus has weekly water insoluble and polar antimicrobial components.

• Journal of Food Hygiene and Safety
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• v.15 no.1
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• pp.36-40
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• 2000

This study was carried out to know the active faction of Dryopteris rhizoma on antimicrobial activity against some food spoilage microorganisms. Also, antimicrobial activities were investigated for the aqueous and ethanolic extracts of four herbs such as Teminaliae fructus, Eugeniae flos, Salviae miltior-rhizae radix and Dryopteris rhizoma. Antimicrobial activities of three herbs except for Terminaliae fructus showed higher activities in 75% ethanolic extracts than in aqueous extract. Ethanolic extract of Dryopteris rhizoma showed the highest antimicrobial activity among extracts of four herbs. Antimicrobial activity intensities of solvent fractions of Dryopteris rhizoma extracted by 75% ethanol were order to CHC1$_3$fraction>EtOAc fraction >BuOH fraction>$H_2O$ fraction. The CHC1$_3$, EtOAc and BuOH fractions also inhibited growth of food spoilage microorganisms as the concentration increased, respectively. In case of EtOAc fraction, 1000 ppm of fraction almost inhibited completely the growth of microorganisms tested.