• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2002년도 춘계학술대회 및 총회
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• pp.17-24
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• 2002

Recurrence of colorectal cancer after apparently curative resection remains common, with reported relapse rates of up to 40%. Because complete resection of solitary metastases or local recurrence may improve long-term survival, surgical management of such cases has become increasingly aggressive but has led to only modest survival benefit. The limitations of current approaches based on structural imaging are well documented, with over half of the patients who are thought suitable for curative surgery being found to have unresectable disease at operation. Therefore, better preoperative assessment is crucial. The increasing use of FDG-PET as an oncologic staging investigation has significantly improved the assessment of patients with suspected colorectal cancer recurrence. Several studios show that substantial and largely appropriate changes in patient management occur, often soaring patients the significant morbidity and mortality associated with aggressive but futile therapies while also saving scarce community resources. Nevertheless, the clinical relevance of these findings has still been questioned. The utility of PET in routine clinical practice will likely depend on its ability to provide incremental information compared with CT in selected patients rather than to serve as a replacement for CT. In conclusion, in patients with suspected recurrent or metastatic colorectal carcinoma, FDG-PET should be performed (1) when there is rising carcinoembryonic antigen levels in the absence of a known source, (2) to increase the specificity of structural imaging when there is an equivocal lesion, and (3) as a screening method for the entire body in the preoperative staging before curative resection of recurrent disease.

• 대한한방소아과학회지
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• 제15권1호
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• pp.203-216
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• 2001

Objective : The purpose of this study is to investigite the more effective oriental medical treatment in pediatric diseases and its clinical applicability and chief complaints at oriental pediatrics in an area of busan and kyeungnam. Method : 884 new patients of theirs ages between 0 term 20 years who were treated at the pediatrics in Dong-Eui Oriental Medicine Busan Hospital from 1. 2000 to 29. Feb. 2001 Result : 1. The number of male cases was 514 (58%) and female cases 370 (42%) an so male cases 1.38 more than female. In age distribution, 0-1year: 242 patients(27.4%), 2-6years: 455 patients(51.4%), 7-20years: 187 patients(21.2%). 2. The Chief Complaint according to systemical division was Resparatory diseases (37.4%) for common cold, chronic cought, take a easy cold etc and the Digestive diseases(23.6%) for anorexia, diarrhea, abdominal pain etc and Nervous also Mental(11.8%) diseases for sezure, tic, etc and Allergic diseases(6.2%) for atopic dermititis, allergic rhinitis, etc and Physique diseases(5.4%) for short stature, leg pain, etc and Genaral symptoms(4.5%) for sweat profusely, headache, etc and Urinary diseases(3.3%) for bed wetting, frequently voiding, etc Discussion : 1. The Chief Complaint cannot be found a regional specificity 2. The oriental medicine treatment was still congnated as a way to improve the weakness by patients, also was widely noised about preventive medicine. In particular, Respiratory and Disestive diseases are dependent on the oriental medicine. 3. The new diseases and the new treatment method should be investigated as field of oriental medical treatment.

• 한국경제지리학회지
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• 제12권4호
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• pp.454-476
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• 2009

본 연구는 부산시 물류창고업의 신뢰형성 수준과 연계의 공간적 특성 간의 관계를 밝히고자 하였으며, 그 결과는 다음과 같다. 첫째, 신뢰형성 요인 중 '장기적 반복적 상호작용', '정보공유와 호혜성', '상호의존과 자산전용성'은 신뢰형성이 높은 수준인 미시적 신뢰, '근접성'과'불확실성'은 중간 수준인 중시적 신뢰, 그리고 '기업의 문화 및 규범과 공식적 제도'는 낮은 수준인 거시적 신뢰에 상대적으로 많은 영향을 미친다. 둘째, 거시적 신뢰, 중시적 신뢰, 미시적 신뢰 모두 공간적 근접성이 매우 큰 국지적 범위에서 대부분 형성되고, 신뢰형성 수준이 높을수록 연계의 공간적 범위는 국가적 범위, 국제적 범위로 확대된다. 셋째, 이러한 현상은 구매연계보다 판매연계에서, 제공하는 서비스 영역이 클수록, 수직적 연계보다 수평적 연계에서, 기업 간 관계가 발전할수록, 아웃소싱보다 공급사슬관리로 업무가 진행될 때 더욱 뚜렷하게 나타난다.

• 한국산업보건학회지
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• 제27권1호
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• pp.1-12
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• 2017

Objectives: The major objectives of this study are to review the requirements for the advancement of occupational safety and health administrative organization and to propose measures to establish an Occupational Safety and Health Executive. Methods: The problems of occupational safety and health administrative organization in korea were examined empirically and cases of occupational safety and health administrative organizations in developed countries were investigated (United Kingdom, United States, Germany, and Japan). A plan for establishing an Occupational Safety and Health Executive was proposed over the short and medium term. Results: An occupational safety and health administration is characterized by a professional and technical nature, and even more so in modern society. Therefore the greatest value required by an occupational safety and health administrative organization is expertise. In addition, administrative values it requires include efficiency, specificity, independence, and activity. The Korean occupational safety and health administrative organization has a number of problems in terms of these values. The most appropriate way to realize these values is to establish an Occupational Safety and Health Executive. It is desirable to establish such an Occupational Safety and Health Executive in a phased manner taking into consideration its relationship with Korea Occupational Safety and Health Agency(KOSHA), including KOSHA's functional adjustment Conclusions: In order to solve the deep-seated problems in occupational safety and health administrative organization and to advance occupational safety and health administration in Korea, it is necessary to establish an Occupational Safety and Health Executive as a foundation for achieving an advanced industrial safety and health administration.

• Molecules and Cells
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• 제44권10호
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• pp.710-722
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• 2021

Hypoxia, or low oxygen tension, is a hallmark of the tumor microenvironment. The hypoxia-inducible factor-1α (HIF-1α) subunit plays a critical role in the adaptive cellular response of hypoxic tumor cells to low oxygen tension by activating gene-expression programs that control cancer cell metabolism, angiogenesis, and therapy resistance. Phosphorylation is involved in the stabilization and regulation of HIF-1α transcriptional activity. HIF-1α is activated by several factors, including the mitogen-activated protein kinase (MAPK) superfamily. MAPK phosphatase 3 (MKP-3) is a cytoplasmic dual-specificity phosphatase specific for extracellular signal-regulated kinase 1/2 (Erk1/2). Recent evidence indicates that hypoxia increases the endogenous levels of both MKP-3 mRNA and protein. However, its role in the response of cells to hypoxia is poorly understood. Herein, we demonstrated that small-interfering RNA (siRNA)-mediated knockdown of MKP-3 enhanced HIF-1α (not HIF-2α) levels. Conversely, MKP-3 overexpression suppressed HIF-1α (not HIF-2α) levels, as well as the expression levels of hypoxia-responsive genes (LDHA, CA9, GLUT-1, and VEGF), in hypoxic colon cancer cells. These findings indicated that MKP-3, induced by HIF-1α in hypoxia, negatively regulates HIF-1α protein levels and hypoxia-responsive genes. However, we also found that long-term hypoxia (>12 h) induced proteasomal degradation of MKP-3 in a lactic acid-dependent manner. Taken together, MKP-3 expression is modulated by the hypoxic conditions prevailing in colon cancer, and plays a role in cellular adaptation to tumor hypoxia and tumor progression. Thus, MKP-3 may serve as a potential therapeutic target for colon cancer treatment.

• 의정연구
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• 제24권1호
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• pp.31-66
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• 2018

본 연구는 한국의 대북정책 결정과정에서 대통령의 영향력이 제한적으로 나타나게 되는 제도적 요인과 정치적 환경을 분석하는 것을 목적으로 한다. 대통령은 국가수반으로서 대북정책에 대한 최고 결정권을 보유하고 있다. 하지만 대북정책에서 대통령의 영향력이 언제나 절대적인 것은 아니다. 권력분립과 민주주의의 제도화에 의한 관료정치, 분점정부 여부나 대통령의 남은 임기 등 정책을 추진하는 시점의 정치적 환경, 정책의 특수성 등 여러 요인들이 대북정책에 대한 대통령의 영향력을 제한하는 요인으로 작동할 수 있다. 본 연구는 2007년 남북한 정상의 합의로 계획되었던 '서해평화협력특별지대' 조성에 관한 정책결정 과정의 동학을 분석하여, 그 과정에서 대통령의 영향력이 제도적 환경과 정치적 여건에 의해 제한적으로 나타나고 있음을 살펴보았다.

• 자원환경지질
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• 제55권2호
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• pp.127-135
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• 2022

Excessive presence of As level in groundwater is a major health problem worldwide. In the Red River Delta in Vietnam, several million residents possess a high risk of chronic As poisoning. The As releases into groundwater caused by natural process through microbially-driven reductive dissolution of Fe (III) oxides. It has been extracted by Red River residents using private tube wells for drinking and daily purposes because of their unawareness of the contamination. This long-term consumption of As-contaminated groundwater could lead to various health problems. Therefore, a predictive model would be useful to expose contamination risks of the wells in the Red River Delta Vietnam area. This study used four machine learning algorithms to predict the As probability of study sites in Red River Delta, Vietnam. The GBM was the best performing model with the accuracy, precision, sensitivity, and specificity of 98.7%, 100%, 95.2%, and 100%, respectively. In addition, it resulted the highest AUC of 92% and 96% for the PRC and ROC curves, with Eh and Fe as the most important variables. The partial dependence plot of As concentration on the model parameters showed that the probability of high level of As is related to the low number of wells' depth, Eh, and SO₄, along with high PO₄^3- and NH₄⁺. This condition triggers the reductive dissolution of iron phases, thus releasing As into groundwater.

• 시스템엔지니어링학술지
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• 제18권2호
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• pp.108-116
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• 2022

Accurately predicting wartime resources requirements and preparing war supplies in peacetime is an important task that can determine the outcome of the war by guaranteeing the duration of the operation. The wartime warship damage rate is a measure of estimating the battle damage of our warships in the process of performing battles to achieve the war goal. In the previously studied wartime warship damage rate estimation method, when damage occurs, long-term repair is required due to the complexity and specificity of the ship structure. Only the case of a complete defeat at the level of sinking was defined as a damage, and even if it was impossible to perform a maritime operation mission, it was not estimated as a damage if the level of sinking was not reached. Therefore, in order to improve the reliability of the wartime warship damage rate, the equipment damage assessment level can be estimated based on the warhead weight of the threat weapon system, the vulnerability rate of the warship's equipment, and the warship's hull. In the future, it is expected that the estimation methodology proposed in this study will be used as a simulation logic when developing a model for analyzing the wartime resources requirements for the warship's equipment and hull.

• 산업융합연구
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• 제20권11호
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• pp.197-203
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• 2022

본 연구의 목적은 역사적인 특성을 가지고 있는 제천 최고(古)의 시장이자 최대의 시장인 제천중앙시장의 공간적인 장소성과 문화적인 특수성을 고려한 S.I.(Space Identity)를 구축하는데 있다. 이를 위해 문화관광형시장의 흐름을 파악하고 제천중앙시장의 현황을 조사 분석한 후 공간별 스토리텔링에 입각한 방향성을 제시한다. 공간디자인의 컨셉은 공존으로 공간, 시간, 사람, 문화로 나누어 상인과 상품, 상가는 하나의 공간에서 시간성을 공유하고 공존함을 세부내용으로 하였다. 따라서 각 층별 시설물은 각 층별로 게이트, 안내판, 조명, 휴게공간, 디자인 벤치시설, 안내센터, 영업 준수선, 바닥사인물, 게이트 바닥사인으로 구성하였다. 이를 통해 제천중앙시장 상가의 새로운 수요창출 및 매출이 증대되는 경제적인 효과를 예측할 수 있도록 단계별 추진전략을 구축하여 중장기 발전전략을 수립해야 할 것이다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권5호
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• pp.1396-1412
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• 2023

Conversation modeling is an important and challenging task in the field of natural language processing because it is a key component promoting the development of automated humanmachine conversation. Most recent research concerning conversation modeling focuses only on the current utterance (considered as the current question) to generate a response, and thus fails to capture the conversation's logic from its beginning. Some studies concatenate the current question with previous conversation sentences and use it as input for response generation. Another approach is to use an encoder to store all previous utterances. Each time a new question is encountered, the encoder is updated and used to generate the response. Our approach in this paper differs from previous studies in that we explicitly separate the encoding of the question from the encoding of its context. This results in different encoding models for the question and the context, capturing the specificity of each. In this way, we have access to the entire context when generating the response. To this end, we propose a deep neural network-based model, called the Context Model, to encode previous utterances' information and combine it with the current question. This approach satisfies the need for context information while keeping the different roles of the current question and its context separate while generating a response. We investigate two approaches for representing the context: Long short-term memory and Convolutional neural network. Experiments show that our Context Model outperforms a baseline model on both ConvAI2 Dataset and a collected dataset of conversational English.