• Journal of Environmental Science International
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• v.23 no.4
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• pp.649-660
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• 2014

Spatial and temporal patterns of precipitation and temperature occur with regard to aspect and elevation of Mt. Halla in Jeju Island. Therefore, there is a need to predict regional drought associate with them to mitigate of impacts of drought. In this study, regional drought is predicted based on Palmer drought severity index (PDSI) and standardized precipitation index (SPI) using future (2015~2044) climate change scenario RCP (representative concentration pathways) 4.5 classified as 24 regions according to aspect and elevation. The results show that number and duration of drought will be decrease in Jeju Island. However, severity of severe drought will be increase in western and northern aspect with under 200 meters above mean sea level. These findings provide primary information for developing the proactive strategies to mitigate impacts of drought by future climate change in Jeju Island.

• Journal of the Korean Institute of Landscape Architecture
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• v.23 no.2
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• pp.157-166
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• 1995

To investigate walkability of ramps, walking patterns of 18 healthy adults,12 aged 20 to 26 and 6 aged 68 to 76,were studied at free,rhythm constrained walking up or down ramp using goniometer and footswitch Ramp inclinations were set 4,8,12,16,20 degrees. The results were as follows. 1)The step length of subjects were decreased significantly in12$^{\circ}C$′or 16′free downramp walking. With regard to step length, some subject groups walked abnormally in 16" or 20" ramp walking 2) The step width of subjects were increased significantly in 12" or 16" ramp walking. 3) The cadence duration of some subject groups were increased in 12" upramp walking. 4) The double stance duration and double stance ratio of some subject groups were increased significantly in 8",12", or 16"upramp walking. 5) The maximum knee flexion angle of stance phase were increased in 12" ramp walking. 6)Most temporal parameters and spatial parameters of gait were increased or decreassd greatly between 4" ramp and 8" ramp or between 8′ramp and 12′ramp. But statistics significancy were not recognized 7) The results suggest that ramp inclination less than 8′(14%) -12′(21%) is desirable for the normal gait the ramp inclination must not exceed 16" -20" in unavoidable circumstances.

• Journal of Climate Change Research
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• v.9 no.1
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• pp.31-45
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• 2018

This study implemented the prediction of drought properties (number of drought events, intensity, duration) using the user-oriented systematical procedures of downscaling climate change scenarios based the multiple global climate models (GCMs), AIMS (APCC Integrated Modeling Solution) program. The drought properties were defined and estimated with Effective Drought Index (EDI). The optimal 10 models among 29 GCMs were selected, by the estimation of the spatial and temporal reproducibility about the five climate change indices related with precipitation. In addition, Simple Quantile Mapping (SQM) as the downscaling technique is much better in describing the observed precipitation events than Spatial Disaggregation Quantile Delta Mapping (SDQDM). Even though the procedure was systematically applied, there are still limitations in describing the observed spatial precipitation properties well due to the offset of spatial variability in multi-model ensemble (MME) analysis. As a result, the farther into the future, the duration and the number of drought generation will be decreased, while the intensity of drought will be increased. Regionally, the drought at the central regions of the Korean Peninsula is expected to be mitigated, while that at the southern regions are expected to be severe.

• International Journal of Stem Cells
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• v.16 no.2
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• pp.156-167
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• 2023

Background and Objectives: Cellular reprogramming in regenerative medicine holds great promise for treating patients with neurological disorders. In this regard, small molecule-mediated cellular conversion has attracted special attention because of its ease of reproducibility, applicability, and fewer safety concerns. However, currently available protocols for the direct conversion of somatic cells to neurons are limited in clinical application due of their complex nature, lengthy process, and low conversion efficiency. Methods and Results: Here, we report a new protocol involving chemical-based direct conversion of human fibroblasts (HF) to matured neuron-like cells with a short duration and high conversion efficiency using temporal and strategic dual epigenetic regulation. In this protocol, epigenetic modulation by inhibition of histone deacetylase and bromodomain enabled to overcome "recalcitrant" nature of adult fibroblasts and shorten the duration of neuronal reprogramming. We further observed that an extended epigenetic regulation is necessary to maintain the induced neuronal program to generate a homogenous population of neuron-like cells. Conclusions: Therefore, our study provides a new protocol to produce neurons-like cells and highlights the need of proper epigenetic resetting to establish and maintain neuronal program in HF.

• Journal of the Korean Association of Geographic Information Studies
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• v.13 no.2
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• pp.41-53
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• 2010

Traffic safety assessment is often accomplished by analyzing the number of crashes occurring in some geographic space over certain specific time duration. In this paper, we introduce a procedure that can efficiently analyze spatial and temporal changes in traffic crashes before-and-after implementation of a certain traffic controlling measure. For the analysis, crash frequency data before-and-after closing a major highway around St. Louis in Missouri was collected through Transportation Management System(TMS) database that is maintained by Missouri Department of Transportation (MoDOT). In order to identify any spatial and temporal pattern in crashes, each crash is pinpointed on a map using the dynamic segmentation in GIS. Then, the identified pattern is statistically confirmed using an analysis of variance table. The advantage of this approach is to easily assess spatial and temporal trend of crashes that are not readily attainable otherwise. The results from this study can possibly be applied in enhancing the highway safety assessment procedure. This paper also makes several suggestions for future development of a comprehensive transportation data system in Korea which is similar to MoDOT's TMS database.

• Journal of Korea Water Resources Association
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• v.56 no.11
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• pp.785-799
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• 2023

In this study, we proposed a new concept termed the Secondary Peak Constant (SPC) and discerned the temporal characteristics of independent rainstorm events based on unit time and SPC about 24 observation stations in Seoul. Utilizing rainfall observations from 2000 to 2022, independent rainstorm events discreted from rainfall data per unit time. The temporal characteristics of these events were derived according to unit time, and temporal characteristics of the peak rainfall were identified through the SPC. Finally, the temporal characteristics of independent rainstorm events were examined distinctively when analyzed by unit time and SPC. Independent rainstorm events with smaller unit time showed significantly larger total rainfall, rainfall duration, and rainfall intensity. The temporal characteristics of the largest peak rainfall (1^st Peak) within independent rainstorm events followed a sequence of Q4>Q2>Q3>Q1. Additionally, the 2^nd Peak rainfall predominantly occurred the location where the 1^st Peak appeared. The proportion of independent rainstorm events with multiple peak rainfalls exceeded 50.0% when the SPC was 0.7 or lower. The average number of peak rainfalls within independent rainstorm events ranged from 1.5 to 3.4. This study identified the temporal characteristics of independent rainstorm events based on unit time. Then, the peak rainfall of temporal characteristics was quantified by SPC on this study. Hence, it is evident that the temporal characteristics of independent rainstorm events for specific area can be anlayzed and quantified based on unit time and SPC.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.5
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• pp.1871-1885
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• 2013

In this study, spatio-temporal distribution of future drought in South Korea was predicted by using the meteorological data generated from GCMs on which a variety of climate changing scenarios are applied. Drought phenomena was quantitatively analyzed using SPI(Standardized Precipitation Index). In addition, potential drought hazard maps for different drought duration and return period were made for the South Koreaby drought frequency analysis after deriving SDF(Severity-Duration-Frequency) curves using the 54 weather stations throughout the country. From the potential drought hazard maps, drought is expected to be severer in Nakdong River basin and Seomjin River basin under A2 scenario. It was also predicted that drought would be severe in the Han River basin by RCP8.5 scenario. In the future, potential drought hazard area would be expanded until the Eastern part of Nakdong River basin as compared with that of past under A2 scenario condition. Research results indicated that future drought would be extensively occurred all areas of South Korea not limiting in the southern part of country.

• Journal of Korea Water Resources Association
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• v.45 no.10
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• pp.1043-1050
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• 2012

In this study, drought Severity-affected Area-drought Duration (SAD) curves are analyzed in order to examine temporal and spatial behavior of drought. A copulas-based joint drought index which is studied recently is applied to express the severity of drought. JDIs across the country with 60 points are calculated monthly basis, and using EOF and Kriging techniques, locational JDIs are spatially extended into gridbased JDIs with spatial resolution of $10{\times}10$ km. JDIs by lattice is analyzed by drought duration and by affected area, and JDI-based SAD curves are created to represent Korean historical drought events. Though created curves, drought events that occurred in the past in our country can be spatially and temporally characterized. In addition, curves are expected to contribute to determine the exact situation on the current drought condition have an impact to some extent.

• Journal of Korea Water Resources Association
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• v.43 no.5
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• pp.483-493
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• 2010

In this study, for the purpose of analyzing variability and periodicity of Korean hydrologic weather parameters, 5 hydrologic weather parameters data such as annual precipitation, annual rainy days, annual average temperature, annual average relative humidity, annual duration of sunshine are collected from 63 domestic meteorological stations that has the hydrologic weather parameters records more than 30 years. And in this study the variability and periodicity using the statistical methods like Wald-Wolfowitz test, Mann-Whitney test, and Wavelet Transform about hydrologic weather parameters is analyzed. The results of statistical analysis of variability and periodicity can be summarized as follows: 1) Variability commonly appeared in annual average temperature and annual average relative humidity. 2) Annual precipitation, annual rainy days and annual duration of sunshine showed different results according to area. 3) Periodicity appeared in annual precipitation and annual rainy days but did not appeard in annual average temperature, annual average relative humidity and annual duration of sunshine.

• Physical Therapy Korea
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• v.28 no.1
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• pp.77-83
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• 2021

Background: Although symmetry of spatio-temporal parameter and center of pressure (COP) shift during walking is associated with knee adduction moment, research on clinical association with knee osteoarthritis (OA)-related knee pain and functional scores is lacking. Objects: The aims were 1) to compare symmetry of gait parameters and COP-shift in patients with unilateral knee OA and pain and matched controls, and 2) to investigate the relationship between symmetry of gait parameters and COP-shift, and clinical measures. Methods: Female subjects (n = 16) had with unilateral radiological knee OA and pain. Healthy controls (n = 15) were age-matched to OA group. Symmetry of foot rotation, step length, stance and swing phase, lateral symmetry of COP and anterior/posterior symmetry of COP during walking was assessed. To assess the clinical variables, pain intensity, pain duration and function using Knee Osteoarthritis Outcome Survey (KOOS) subscales were collected. We compared symmetry between groups using Mann-Whitney U-test or independent t-test. Relationships between clinical measures and symmetry index measured using Spearman's correlation test. Statistical significance was set at α = 0.05. Results: Knee OA group showed significantly greater values of only lateral symmetry of COP (p < 0.01) than healthy group. Values of lateral symmetry of COP had moderate or strong correlation significantly with the intensity of knee pain, pain duration, and scores of all KOOS subscales (p < 0.01). Conclusion: Patients with unilateral knee OA and pain showed more asymmetry of lateral COP-shift during walking compared with matched healthy controls. In addition, larger asymmetry of lateral COP-shift has the moderate or strong association with worse of knee pain, worse in KOOS scores and longer duration of knee pain. Asymmetry of lateral COP-shift during walking may be one of the characteristics of unilateral knee OA as the compensatory strategy response to unilateral OA of the knee.