• BMB Reports
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• v.55 no.7
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• pp.336-341
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• 2022

Narrowing of arteries supplying blood to the limbs provokes critical hindlimb ischemia (CLI). Although CLI results in irreversible sequelae, such as amputation, few therapeutic options induce the formation of new functional blood vessels. Based on the proangiogenic potentials of stem cells, in this study, it was examined whether a combination of dental pulp stem cells (DPSCs) and human umbilical vein endothelial cells (HUVECs) could result in enhanced therapeutic effects of stem cells for CLI compared with those of DPSCs or HUVECs alone. The DPSCs+ HUVECs combination therapy resulted in significantly higher blood flow and lower ischemia damage than DPSCs or HUVECs alone. The improved therapeutic effects in the DPSCs+ HUVECs group were accompanied by a significantly higher number of microvessels in the ischemic tissue than in the other groups. In vitro proliferation and tube formation assay showed that VEGF in the conditioned media of DPSCs induced proliferation and vessel-like tube formation of HUVECs. Altogether, our results demonstrated that the combination of DPSCs and HUVECs had significantly better therapeutic effects on CLI via VEGF-mediated crosstalk. This combinational strategy could be used to develop novel clinical protocols for CLI proangiogenic regenerative treatments.

• KIEAE Journal
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• v.16 no.3
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• pp.5-12
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• 2016

Purpose: In case of existing building, A lot of attempts are being made like changing thermal system or using high efficiency products to decrease energy load and increase energy efficiency. However, (1) Absence of systemed database of green-remodeling technology and products. (2) Absence of comparative analysis system and qualitative/quantitative evaluation method of energy performance and energy reduction cost. (3) Existing remodeling was very hard to access for non-experts. So, in this paper, the authors developed data base for green-remodeling(Impact Table A, Impact Table B) and optimum combination dedication tool for user convenience. Accordingly, purpose of this paper validate usefulness of Impact Table and optimum alternative dedication tool. Method: For validate the usefulness of Impact Table and optimum combination dedication tool, the authors selected five test model office buildings. Next, through research investigation, the authors diagnosed the present state of buildings. In base of diagnosis results, select technologies for remodeling by qualitative comparison (Impact Table A). Next, evaluate quantitative price and performance technologies that selected in Impact Table A (Impact Table B). Lastly, through final evaluation of Impact Taba A and Impact Table B, determine the direction of the green-remodeling. Result: Impact Table and optimum combination dedication tool can use relative indicator for green-remodeling, especially through ROI by detail field.

• Advances in concrete construction
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• v.7 no.2
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• pp.107-115
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• 2019

The possibility of using a combination of mineral admixtures as a replacement for cement may reduce the $CO_2$ emission which causes global warming and climatic changes on the environment. By using the combination of different byproducts from various industries, for replacing cement in concrete leads to saving in energy and natural resources. In this article, an attempt has been made to study the mechanical and water absorption properties of concrete incorporated with combination of Fly ash (FA), Alccofine (ALC) and Collodial Nano Silica (CNS) at 7, 28 and 56 days curing period. Cement has been partially replaced by combination of FA at 25%, ALC at 10% and CNS at 0.5%, 1%, 2% and 3% with water cement ratio of 0.43. The result indicates that the incorporation of combination of FA, ALC and CNS can be very effective in improvement of mechanical and water absorption properties of concrete. The Mix with a combination of 25% FA, 10% ALC and 1% CNS is most effective in improvement of mechanical and water absorption properties as compared with all other mixes.

• Journal of Advanced Navigation Technology
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• v.20 no.3
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• pp.203-209
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• 2016

Among the various fields in the communications, navigation, and surveillance/air traffic management (CNS/ATM) scheme, the surveillance field, which includes an automatic dependent surveillance - broadcast (ADS-B) system and a multilateration (MLAT) system, is implemented using satellite and digital communications technology. These systems provide better performance than radar, but still incur position error. To reduce the error, we propose an efficient information fusion method called the reweighted convex combination method for ADS-B and MLAT systems. The reweighted convex combination method improves aircraft tracking performance compared to the original convex combination method by readjusting the weights given to these systems. In this paper, we prove that the reweighted convex combination method always provides better performance than the original convex combination method. Performance from the fusion of ADS-B and MLAT improves an average of 51.51% when compared to the original data.

• Structural Engineering and Mechanics
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• v.75 no.1
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• pp.87-100
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• 2020

The present paper investigates the combination resonance behavior of imperfect spiral stiffened functionally graded (SSFG) cylindrical shells with internal and external functionally graded stiffeners under two-term large amplitude excitations. The structure is embedded within a generalized nonlinear viscoelastic foundation, which is composed of a two-parameter Winkler-Pasternak foundation augmented by a Kelvin-Voigt viscoelastic model with a nonlinear cubic stiffness, to account for the vibration hardening/softening phenomena and damping considerations. With regard to classical plate theory of shells, von-Kármán equation and Hook law, the relations of stress-strain are derived for shell and stiffeners. The spiral stiffeners of the cylindrical shell are modeled according to the smeared stiffener technique. According to the Galerkin method, the discretized motion equation is obtained. The combination resonance is obtained by using the multiple scales method. Finally, the influences of the stiffeners angles, foundation type, the nonlinear elastic foundation coefficients, material distribution, and excitation amplitude on the system resonances are investigated comprehensively.

• Journal of the Korea Fashion and Costume Design Association
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• v.12 no.1
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• pp.103-116
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• 2010

In view of our contemporary fashion, it is found that crossover between clothing and other items leads to creation of a new design and crossover of various cultural codes, ultimately creating a multicultural clothing design or any external outline of emerging costume designs by attempting mutual combination with other fields. Starting from a viewpoint that mutual combination style has significant effects on our contemporary fashion designs, this study intends to characterize external aspects of fashion design that changes through mutual combination style. This study focused upon analyzing costumes released by contemporary fashion designers after 2000, and addressed a variety of mutual combination styles. It gives various examples on mutual combination in fashion, seeking first to look into typical examples of mutual combination styling between fashion and art, between fashion and space and between fashion and technology. Based on those examples, this study classified crossover styles into 6 major categories such as attachment, suspension, modification, fusion, association and embedment. As a result, this study comes to a conclusion that external changes by mutual combination are characterized largely by overlap, simultaneity and deconstruction.

• Journal of Pharmacopuncture
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• v.26 no.4
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• pp.298-306
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• 2023

Objectives: Cucumis sativus L. (C. sativus) is vegetable commonly used for managing blood pressure and often consumed in combination with standard antihypertensive therapy, despite lack of scientific evidence supporting their use. Combination of herbs and standard medication could have positive or negative effects. Therefore, this study aimed to evaluate the antihypertensive activity of C. sativus and the combined effect with losartan in the hypertensive rat model induced by angiotensin II. Angiotensin II is a component of the renin-angiotensin-aldosterone system that, upon binding to its receptor, constricts blood vessels leading to elevation of blood pressure. Methods: In an antihypertensive study, rats received C. sativus orally at doses of 9, 18, 27, and 36 mg/kg (full dose); while in a combination study, animals received losartan 2.25 mg/kg combined by either with C. sativus 9 or 18 mg/kg. The standards group received losartan 2.25 mg/kg or 4.5 mg/kg (full dose). Results: Blood pressure was measured using the tail-cuff method. C. sativus significantly attenuated angiotensin II-induced hypertension as observed in groups receiving C. sativus at 9, 18, 27, and 36 mg/kg at 30 minutes after induction showed the average change (Δ) of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with respect to time zero were 28.8/18.3, 24.8/15.8, 22.8/15.5, and 11.5/9.0 mmHg, respectively. Whereas the average change (Δ) of SBP and DBP in the rats receiving the combination of half doses of C. sativus and losartan were 8.8/9.0 mmHg, respectively. These diminished effects were better than a full dose of C. sativus and comparable with a full dose of losartan (6.5/7.8 mmHg). Conclusion: The present findings indicate that C. sativus dose-dependently blocks blood pressure elevation induced by angiotensin II. The combination of half dose of C. sativus and losartan has an additive effect in lowering blood pressure.

• Nuclear Engineering and Technology
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• v.54 no.4
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• pp.1526-1533
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• 2022

Small modular reactors have garnered considerable attention in the recent years. Plate fuel elements exhibit a good application prospect in small modular pressurized water reactors for marine applications. Further, improved economic benefits can be achieved by extending the core lifetime of small modular reactors. However, it is necessary to realize a large initial residual reactivity for achieving a relatively long burnup depth finally. Thus, the selection of a suitable burnable poison (BP) is a crucial factor that should be considered in the design of small modular reactors. In this study, some candidate BPs are selected to realize the effective control of reactivity. The results show that ²³¹Pa₂O₃, ²⁴⁰Pu₂O₃, ¹⁶⁷Er₂O₃, PACS-J, and PACS-L are ideal candidates of BP, and since the characteristics of BP can increase the final burnup depth of assembly, the economic benefits are gained. Additionally, an optimal combination scheme of BPs is established. Specifically, it is proved that through a reasonable combination of BPs, a low reactivity fluctuation during the lifetime can be achieved, leading to a large final burnup depth.

• Journal of the Korean Wood Science and Technology
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• v.49 no.4
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• pp.328-335
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• 2021

Considerable differences exist in the characteristics of size reduction and classification because of biomass species. Miscanthus sacchariflorus (M. sacchariflorus) Goedae-Uksae 1 is not used efficiently because of the imperfections of the processing technology for this biomass. Therefore, for the best use of specific biomass, improvement in the feedstock preparation of the biomass for processing, such as pellet manufacturing, is necessary. In this study, a laboratory-scale cone grinder and air classifier were designed and combined to investigate the performance of the combination system for M. sacchariflorus. The average equivalent spherical diameter of particles showed a close relationship with air velocity for air classification. The air velocity range to classify proper particles for pelletization was determined to be 6.0-6.8 m/s. The mass ratios of the collected particles to feed mass for four lengths of chopped M. sacchariflorus were 45.1%:46.1%, 39.1%:46.6%, and 44.1%:52.8% at the first, second, and third steps in simulating the multistep combination system, respectively.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.2
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• pp.522-539
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• 2021

In order to solve the problems of the existing audio fingerprint method when extracting audio fingerprints from long speech segments, such as too large fingerprint dimension, poor robustness, and low retrieval accuracy and efficiency, a robust audio fingerprint retrieval method based on feature dimension reduction and feature combination is proposed. Firstly, the Mel-frequency cepstral coefficient (MFCC) and linear prediction cepstrum coefficient (LPCC) of the original speech are extracted respectively, and the MFCC feature matrix and LPCC feature matrix are combined. Secondly, the feature dimension reduction method based on information entropy is used for column dimension reduction, and the feature matrix after dimension reduction is used for row dimension reduction based on energy feature dimension reduction method. Finally, the audio fingerprint is constructed by using the feature combination matrix after dimension reduction. When speech's user retrieval, the normalized Hamming distance algorithm is used for matching retrieval. Experiment results show that the proposed method has smaller audio fingerprint dimension and better robustness for long speech segments, and has higher retrieval efficiency while maintaining a higher recall rate and precision rate.