• Journal of Ginseng Research
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• v.46 no.6
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• pp.750-758
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• 2022

Background: Mild cognitive impairment (MCI) is a transitional condition between normality and dementia. Ginseng is known to have effects on attenuating cognitive deficits in neurogenerative diseases. Ginsenosides are the main bioactive component of ginseng, and their protein targets have not been fully understood. Furthermore, no thorough analysis is reported in ginsenoside-related protein targets in MCI. Methods: The candidate protein targets of ginsenosides in brain tissues were identified by drug affinity responsive target stability (DARTS) coupled with label-free liquid chromatography-mass spectrometry (LC-MS) analysis. Network pharmacology approach was used to collect the therapeutic targets for MCI. Based on the above-mentioned overlapping targets, we built up a proteineprotein interaction (PPI) network in STRING database and conducted gene ontology (GO) enrichment analysis. Finally, we assessed the effects of ginseng total saponins (GTS) and different ginsenosides on mitochondrial function by measuring the activity of the mitochondrial respiratory chain complex and performing molecular docking. Results: We screened 2526 MCI-related protein targets by databases and 349 ginsenoside-related protein targets by DARTS. On the basis of these 81 overlapping genes, enrichment analysis showed the mitochondria played an important role in GTS-mediated MCI pharmacological process. Mitochondrial function analysis showed GTS, protopanaxatriol (PPT), and Rd increased the activities of complex I in a dose-dependent manner. Molecular docking also predicted the docking pockets between PPT or Rd and mitochondrial respiratory chain complex I. Conclusion: This study indicated that ginsenosides might alleviate MCI by targeting respiratory chain complex I and regulating mitochondrial function, supporting ginseng's therapeutic application in cognitive deficits.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.10
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• pp.5006-5022
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• 2017

Effect and robust detection of targets in infrared images has crucial meaning for many applications, such as infrared guidance, early warning, and video surveillance. However, it is not an easy task due to the special characteristics of the infrared images, in which the background clutters are severe and the targets are weak. The recent literature demonstrates that sparse representation can help handle the detection problem, however, the detection performance should be improved. To this end, in this text, a hybrid method based on local sparse representation and contrast is proposed, which can effectively and robustly detect the infrared targets. First, a residual image is calculated based on local sparse representation for the original image, in which the target can be effectively highlighted. Then, a local contrast based method is adopted to compute the target prediction image, in which the background clutters can be highly suppressed. Subsequently, the residual image and the target prediction image are combined together adaptively so as to accurately and robustly locate the targets. Based on a set of comprehensive experiments, our algorithm has demonstrated better performance than other existing alternatives.

• Phonetics and Speech Sciences
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• v.5 no.1
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• pp.123-130
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• 2013

Previous researches on Korean intonation have been mainly focused on $F_0$ target frequencies, $F_0$ slope, and the duration of intonation patterns. This study investigated Korean intonation patterns, both boundary and phrasal tones, in relation to the $F_0$ percentage change between pitch targets. We measured the percentage change between the pitch targets of both boundary and phrasal tones. Additionally, the $F_0$ change between the preceding pitch target and the first pitch target of the boundary tone and the $F_0$ targets of the sequence of two LH phrasal tones ('LH + LH') were also measured. Two phrasal tones, LHLH and HLH, were compared with 'LH + LH' and the 'HLH' in the LHLH pattern respectively. We found that the percentage change between pitch targets in the phrasal tone is fixed to some extent. This helped explain why the slope of the phrasal tone is closely related to the number of syllables and the duration of the phrasal tone as discussed in previous studies. Since we analyzed the intonation patterns with the utterances from a large speech corpus, the results of this paper are expected to be used in building a larger annotated corpus of Korean.

• KDI Journal of Economic Policy
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• v.35 no.3
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• pp.91-124
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• 2013

This paper analyzes a situation where multiple targets are exposed to a potential terrorist attack. The probability of an attack is determined endogenously in a game where a terrorist chooses the target while the targets independently determine the level of deterrence. As each target tries to divert an attack to others, the symmetric equilibrium becomes suboptimal and exhibits dispersion in the level of deterrence. The analysis shows that the first best deterrence level may be achieved when the targets can write a binding risk-sharing contract. Such a contract has limited applicability however as it suffers from a potential verification problem.

• Journal of the Korea Institute of Military Science and Technology
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• v.7 no.4 s.19
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• pp.5-12
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• 2004

The tracking algorithm based on the interacting multiple model(IMM) requires a considerable number of sub-models for the various maneuvering targets in order to have a good performance. But it is not feasible to use the nm algorithm in the real system because of the computational burden. Therefore, we need an algorithm which requires less computing resources while maintaining a good performance. In this paper, we propose a fuzzy interacting multiple model algorithm(FIMMA) for the tracking of maneuvering targets, which uses a minimal number of sub-models by considering the maneuvering properties and adjusts the mode transition probabilities by using the mode probability as a fuzzy input. In order to verify the performance of FIMMA, the developed algorithm is applied to the tracking of i borne targets. Simulation results show that the FIMMA is very effective in the tracking of maneuvering targets.

• Journal of Satellite, Information and Communications
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• v.12 no.1
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• pp.34-37
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• 2017

This letter presents the signal processing of a CW radar (Continuous Wave or Doppler radar) sensor which enables the radar to detect the multiple targets' approaching and retreating using both I and Q channels. The proposed algorithm utilizes the phase change of the Quadrature signal, which occurs when targets move back and forth from the radar. The verification is carried out with the board containing a commercially available MMIC chip and an MCU by analyzing the received data from MMIC. Also the proposed algorithm is downloaded to MCU and the approaching and retreating movement is confirmed. The CW frequency is 24.125 GHz and the transmitter output power used is 7.2 dBm. Detectable distance is about 12 m.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.2444-2447
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• 2005

The purpose of this study was to analyze the gait motion of the aged with a lower limbs orthosis. The gait motion was analyzed with and without lower limbs orthosis using APAS 3D Motion Analysis System. The pattern of lower limbs motion was tracked based on four targets attached to the body of the subject. The targets were positioned at hip, knee, ankle, and foot. The parameters measured were the displacement, the velocity, and the acceleration of the four targets. The improvement in the measured values on the displacement and the velocity of the four targets were small with the orthosis due to inconvenience of wearing it, but the increase in the acceleration was large due to the elastic force of the rubber actuator. Especially, the increase of the acceleration of foot with lower limbs orthosis seems to help the gait motion of the elderly.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.764-769
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• 2003

The paper introduces a development result for displacement measurement system of multiple moving objects based on image processing technique. The image processing method adopts inertia moment theory for obtaining the centroid of the targets and basic processing algorithms of gray, binary, closing, labeling and etc. To get precise displacement measurement in spite of multiple moving targets, a CCD camera with zoom is used and the position of camera is changed by a pan/tilt system. The fiducial marks on the fixed positions are used as the sensing points for the image processing to recognize the position errors in directions of X -Y coordinates. The precise alignment device is pan /tilt of X - Y type and the pan/tilt is controlled by DC servomotors which are driven by 80c196kc microprocessor based controller. The centers of the fiducial marks are obtained by a inertia moment method. By applying the developed precise position control system for multiple targets, the displacement of multiple moving targets are detected automatically and are stored in the database system in a real time. By using database system and internet, displacement data can be confirmed at a great distance and analyzed. The developed system shows the effectiveness such that it realizes the precision about 0.12mm in the position control of X -Y coordinates.

• The Journal of the Acoustical Society of Korea
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• v.15 no.5
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• pp.118-124
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• 1996

Signal frequency lines generated from the acoustic targets are of particular importance for target detection and classification in passive sonar systems. The underwater noise consists of a mixture of ambient noise and radiated noise of targets. Detction of exact signal frequency lines depends on signal detection threshold and variation of ambient noise. In this paper, a detection method of signal frequency lines for acoustic targets using autoassociative memory (ASM) neural network, which is not sensitive to variation of signal detection threshold and ambient noise, is proposed. It is confirmed by simulation and application of real acoustic targets that the proposed method shows good performance for detection of signal frequency lines.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.11
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• pp.1044-1052
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• 2010

In this paper, a new realtime algorithm called the RTPBTD-HPDAF (Recursive Temporal Profile Base Target Detection with Highest Probability Data Association Filter) is presented for tracking fast moving small targets with IIR (Imaging Infrared) sensor systems. Spatial filter algorithms are mainly used for target in IIR sensor system detection and tracking however they often generate high density clutter due to various shapes of cloud. The TPBTD (Temporal Profile Base Target Detection) algorithm based on the analysis of temporal behavior of individual pixels is known to have good performance for detection and tracking of fast moving target with suppressing clutter. However it is not suitable to detect stationary and abruptly maneuvering targets. Moreover its computational load may not be negligible. The PTPBTD-HPDAF algorithm proposed in this paper for real-time target detection and tracking is shown to be computationally cheap while it has benefit of tracking targets with abrupt maneuvers. The performance of the proposed RTPBTD-HPDAF algorithm is tested and compared with the spatial filter with HPDAF algorithm for run-time and track initiation at real IIR video.