• Journal of Ginseng Research
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• 제44권2호
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• pp.238-246
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• 2020

Background: Dietary fat has been suggested to be the cause of various health issues. Obesity, hypertension, cardiovascular disease, diabetes, dyslipidemia, and kidney disease are known to be associated with a high-fat diet (HFD). Obesity and associated conditions, such as type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), are currently a worldwide health problem. Few prospective pharmaceutical therapies that directly target NAFLD are available at present. A Traditional Chinese Medicine, ginseng-plus-Bai-Hu-Tang (GBHT), is widely used by diabetic patients to control glucose level or thirst. However, whether it has therapeutic effects on fat-induced hepatic steatosis and metabolic syndrome remains unclear. Methods: This study was conducted to examine the therapeutic effect of GBHT on fat-induced obesity, hepatic steatosis, and insulin resistance in mice. Results: GBHT protected mice against HFD-induced body weight gain, hyperlipidemia, and hyperglycemia compared with mice that were not treated. GBHT inhibited the expansion of adipose tissue and adipocyte hypertrophy. No ectopic fat deposition was found in the livers of HFD mice treated with GBHT. In addition, glucose intolerance and insulin sensitivity in HFD mice was also improved by GBHT. Conclusion: GBHT prevents changes in lipid and carbohydrate metabolism in a HFD mouse model. Our findings provide evidence for the traditional use of GBHT as therapy for the management of metabolic syndrome.

• Archives of Pharmacal Research
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• 제24권3호
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• pp.207-210
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• 2001

A fully automated high performance liquid chromatography with column-switching was developed for the simultaneous determination of KR60436, a new reversible proton pump inhibitor, and its active metabolite O-Demethyl-KR60436 from rat plasma samples. Plasma sample (50$\mu$l) was directly introduced onto a Capcell Pak MF Ph-1 column ($10{\times}4$ mm I.D.) where primary separation was occurred to remove proteins and concentrate target Substances Using acetonitrile-Potassium Phosphate (PH 7, 0.1 M) (2 : 8, v/v). The drug molecules eluted from MF Ph-1 column were focused in an intermediate column ($10{\times}2$ I.D.) by the valve switching step. The substances enriched in intermediate column were eluted and separated on a Vydac 218MR53 column ($250{\times}3.2$ I.D.) using acetonitrilepotassium phosphate (pH 7, 0.02 M) (47:53, v/v) at a flow rate of 0.5 ml/min when the valve status was switched back to A position. The method showed excellent sensitivity (detection limit of 2 ng/ml) with small volume of samples ($50{\mu}$l), good precision and accuracy, and speed (total analysis time 24 min) without any loss in chromatographic efficiency. The response was linear ($r^2{\geq}0.797$) over the concentration range of 5-500 ng/ml.

• 한국철도학회논문집
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• 제19권2호
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• pp.187-194
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• 2016

철도교량의 신뢰도 기반 한계상태설계법 도입 시 목표신뢰도지수 산정을 위하여 기존 철도교량의 신뢰도지수 산정이 선행되어야 한다. 대표적인 복선 철도교량 중 하나인 6주형 PSC-I형 거더교량에 대해 신뢰도지수를 산정하였다. 최외측 거더의 휨모멘트에 대한 신뢰도 해석을 수행하였다. 휨저항강도 및 고정하중효과는 도로교 한계상태설계법 도입 시 적용된 선행연구자들의 평균과 변동계수를 활용하였고, 열차의 활하중 효과는 여객/화물 혼용선 중 중량화차 통행이 빈번한 중앙선에서 현장계측 데이터를 활용하였다. 한계상태방정식에 대하여 개선된 일계이차 모멘트법(AFOSM)으로 신뢰도 분석을 수행하였으며, 하중효과와 저항효과의 각 요소가 신뢰도지수에 미치는 민감도를 분석하여 중요도를 검토하였다.

• The Korean Journal of Pain
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• 제27권2호
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• pp.178-185
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• 2014

Epidural adhesions cause pain by interfering with the free movement of the spinal nerves and increasing neural sensitivity as a consequence of neural compression. To remove adhesions and deliver injected drugs to target sites, percutaneous epidural adhesiolysis (PEA) is performed in patients who are unresponsive to conservative treatments. We describe four patients who were treated with a newly developed inflatable balloon catheter for more effective PEA and relief of stenosis. In the present patients, treatments with repetitive epidural steroid injection and/or PEA with the Racz catheter or the NaviCath did not yield long-lasting effects or functional improvements. However, PEA and decompression with the inflatable balloon catheter led to maintenance of pain relief for more than seven months and improvements in the functional status with increases in the walking distance. The present case series suggests that the inflatable balloon catheter may be an effective alternative to performing PEA when conventional methods fail to remove adhesions or sufficiently relieve stenosis.

• 분석과학
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• 제13권1호
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• pp.72-80
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• 2000

헤드스페이스/가스크로마토그래프/질량분석계(HS/GC/MS)을 이용하여 환경 시료 중 폐기물 시료인 슬러지 중의 휘발성 유기화합물을 분석하였다. 본 연구에서는 헤드스페이스를 이용한 휘발성 물질의 분석에서 염(salt)의 첨가 유무, 평형온도 및 평형시간 등이 미치는 영향을 파악하기 위해서 수행되었다. NaCl을 첨가한 경우와 첨가하시 않은 경우 이들 분석물질의 회수율 변화는 NaCl을 넣었을 때 1,2-dibromo-3-chloropropane이 2.61배로 가장 큰 회수율의 변화를 보였으며, trlchlorofluoromethane이 1.07배로 가장 적은 변화를 나타내었다. 또한, 평형온도는 $80^{\circ}C$에서 $90^{\circ}C$(30분)로 증가됨에 따라 피이크의 면적이 크게 증가한 것으로 나타났으며, 평형도달 시간은 30분($85^{\circ}C$)이 최적 조건으로 조사되었다. 또한, 55종의 분석대상물질의 재현성도 매우 높게 나타나, 이 방법을 이용한 폐기물 시료중의 휘발성 유기화합물의 분석이 가능하리라 판단되어진다.

• 패션비즈니스
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• 제13권4호
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• pp.178-190
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• 2009

The purpose of this study is to make reference for geometric fashion by investigating geometric patterns by linear types and to propose high value added print and fashion design by designing and producing geometric prints and apparel with them focusing on digital textile printing. As a method of the study, visual and textural data were investigated for theory of geometric pattern and fashion design samples were illustrated. The geometric pattern could be defined as abstract pattern which was crossed with straight line or curve. We could group it into three classes such as straight linear, curved, and mixed type. Images varied with linear types. The image of straight linear type was sharp and modern, that of curved one was soft and feminine and that of mixed one was gorgeous and artistic. And then, 3 geometric prints and 3 one-pieces were designed. The concept of design was simple optimism which was based on sixties. Target was young optimistic women group from the mid teens to the mid twenties who continued to seek after their unique individuality keeping their modern lifestyle. Geometric patterns with straight linear, curved, and mixed type were designed and dresses which went well with them were designed and produced. According to the result of this study, images of geometric fashion can be represented diversely by varying linear type, digital textile printing is good method for high value added geometric fashion because of its high quality and degree of sensitivity, and geometric pattern is a good source for contemporary fashion.

• 수산해양기술연구
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• 제46권2호
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• pp.173-183
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• 2010

In a split beam echo sounder, the transducer design needs to have minimal side lobes because the angular position and level of the side lobes establishes the usable signal level and phase angle limits for determining target strength. In order to suppress effectively the generation of unwanted side lobes in the directivity pattern of split beam transducer, the spacing and size of the transducer elements need to be controlled less than half of a wavelength. With this purpose, a 50 kHz tonpilz type transducer with a half-wavelength diameter in relation to the development of a split beam transducer was designed using the equivalent circuit model, and the underwater performance characteristics were measured and analyzed. From the in-air and in-water impedance responses, the measured value of the electro-acoustic conversion efficiency for the designed transducer was 51.6%. A maximum transmitting voltage response (TVR) value of 172.25dB re $1{\mu}Pa/V$ at 1m was achieved at 52.92kHz with a specially designed matching network and the quality factor was 10.3 with the transmitting bandwidth of 5.14kHz. A maximum receiving sensitivity (SRT) of -183.57dB re $1V/{\mu}Pa$ was measured at 51.45kHz and the receiving bandwidth at -3dB was 1.71kHz. These results suggest that the designed tonpilz type transducer can be effectively used in the development of a split beam transducer for a 50kHz fish sizing echo sounder.

• 한국콘텐츠학회논문지
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• 제9권6호
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• pp.126-133
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• 2009

본 연구는 제품에 있어서 감성제품의 성공사례를 중심으로 소비자들이 생각하는 감성디자인 제품에 대해 어떠한 요소가 창의적 사고와 관련성이 있는지 조사하였다. 실험에 사용된 디자인 창의성 속성은 2007년 김은주(Kim Eun-Ju)의 디자인 창의성 평가도구 개발에서 밝힌 형태, 기능, 크기가 다양한 MP3를 대상으로 실험하였다. 실험결과, MP3는 차별성, 호감성, 유모성, 편리성과 관련이 있는 것으로 나타났다. 따라서 감성제품에 대한 디자인 창의성 항목의 공통적 특성을 파악하였다. 위의 2가지 실험 내용을 종합해보면 감성디자인은 디자인 창의성 평가 항목 중 독창성의 흥미성 항목과 실용성의 기능성 항목과 관련이 높은 것을 밝혔다. 따라서 향후에는 MP3 이외에 다른 제품의 디자인 창의성 항목간의 공통적 특성을 조사할 필요가 있다.

• 미술이론과 현장
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• 제8호
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• pp.145-162
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• 2009

Space is a phenomenon which is formed in the connection between environment and human beings and public space is built by a complex phenomenon of space. Each and every individual is connected to an environment and these individuals are connected to one another. A public commemorative space means souvenir and memorial which is designed for special purpose of remembrance of a specific area. One of the purposes of public commemorative space is memorial and that is the reason of doing public relation and educating citizens over the transom. However, the meaning and value of commemorative subject cannot be delivered or stuffed one-sidely. The target who receives messages from public commemorative space has reinterpreted the messages of his own with his personal experience, knowledge and sensitivity. It results in an unexpected phenomenon of public commemorative space. Therefore, public commemorative space should be considered in a mutual communication structure rather than a purpose of memorial itself. Korean public commemorative space is focused on public relation and education for memorial. In other words, Korean public commemorative space is neglected its important possibility of the productive chapter of mutual communication. The mutual communication structure of public commemorative space which is based on variety and haecceity is ripped up by the message over the transom. It destroys the self-control and creativity of public commemorative space, and derives a negative result. By studying the function and meaning of public commemorative space, we should make the best use of it.

• 대한금속재료학회지
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• 제56권11호
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• pp.813-821
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• 2018

The basic oxygen furnace (BOF) steelmaking process in the steel industry is highly complicated, and subject to variations in raw material composition. During the BOF steelmaking process, it is essential to maintain the carbon content and the endpoint temperature at their set points in the liquid steel. This paper presents intelligent models used to estimate the endpoint temperature in the basic oxygen furnace (BOF) steelmaking process. An artificial neural network (ANN) model and a least-squares support vector machine (LSSVM) model are proposed and their estimation performance compared. The classical partial least-squares (PLS) method was also compared with the others. Results of the estimations using the ANN, LSSVM and PLS models were compared with the operation data, and the root-mean square error (RMSE) for each model was calculated to evaluate estimation performance. The RMSE of the LSSVM model 15.91, which turned out to be the best estimation. RMSE values for the ANN and PLS models were 17.24 and 21.31, respectively, indicating their relative estimation performance. The essential input parameters used in the models can be selected by sensitivity analysis. The RMSE for each model was calculated again after a sequential input selection process was used to remove insignificant input parameters. The RMSE of the LSSVM was then 13.21, which is better than the previous RMSE with all 16 parameters. The results show that LSSVM model using 13 input parameters can be utilized to calculate the required values for oxygen volume and coolant needed to optimally adjust the steel target temperature.