• Journal of Korean Biological Nursing Science
• /
• 제4권2호
• /
• pp.69-77
• /
• 2002

The purpose of this study was to identify the relationship of symptom distress and natural killer cell cytotoxicity in breast cancer patients who had been radiation therapy and/or chemotherapy after surgery. Symptom distress measured by modified Lee's(1994) physical symptom questionnaire. For measuring the natural killer cell cytotoxic activity. 8ml to 10ml blood was collected from the subjects. Mononuclear cell was isolated by centrifuge of the blood and cultured by putting $Cr^{51}$, and reacted with target cell, K562 cell. Amount of $Cr^{51}$ was measured, and %lysis was calculated. The results were as follows. 1) Symptom distress score was 42.18, which is moderate symptom distress. 2) Natural killer cell cytotoxic activities were 42.18%lysis(effector : target cell ratio=100 : 1) and 28.05%lysis(effector : target cell ratio=50 : 1). 3) Correlation coefficients of symptom distress and natural killer cell cytotoxic activity were $-.134{\sim}-.461$. Though significant correlation was not found between total score of symptom distress and natural killer cell cytotoxic activity, 3('pain' 'feel hot on radiation site' and 'difficulty in breathing') of 19 symptom distress items and natural killer cell cytotoxic activity showed significant negative correlation(p<.05). These findings suggest that 1) breast cancer patients who had been radiation therapy and/or chemotherapy after surgery have moderate symptom distress and decreased natural killer cell cytotoxic activity. 2) The symptom distress was not related to natural killer cell cytotoxic activity.

• 동의생리병리학회지
• /
• 제19권2호
• /
• pp.544-548
• /
• 2005

I studied on the influence of BUDDEUMI(moxa and cupping a boil) in the live blood condition and the favorable turn up a subjective symptom of chronic irritable bowel syndrome patient. The results are as follows : After the perform of BUDDEUMI, in the Erythrocyte Aggregation, the efficiency is 87%(3persons decrease and 10 persons destroy/15 persons). In the Rouleau, the efficiency is 78%(2persons decrease and 5 persons destroy/9 persons). In the Target Cells, the efficiency is 90%(3persons decrease and 6 persons destroy/10 persons). In the Ovalocytes, the efficiency is 88%(3persons decrease and 4 persons destroy/8 persons). In the Poikilocytes, the efficiency is 76%(1persons decrease and 2 persons destroy/4 persons). After the perform of BUDDEUMI, in the Cholesterol Crystals, the efficiency is 82%(3persons decrease and 6 persons destroy/11 persons). In the Atherosclerotic Plaque, the efficiency is 80%(2persons decrease and 2 persons destroy/5 persons). In the Chylous, the efficiency is 86%(3persons decrease and 9 persons destroy/14 persons). On the favorable turn up a subjective symptom, the efficiency of symptom of appetite and digestion is 91%(5persons turn up exceedingly favorable, 9 persons turn up favorable, 7 persons turn up good, 2 persons turn up invalid / 23persons). In the efficiency of symptom of fatigue and feeble is 85%(3persons turn up exceedingly favorable, 6 persons turn up favorable, 8 persons turn up good, 3 persons turn up invalid / 20persons). And the efficiency of symptom of abdominal swelling and displeasure is 88%(2persons turn up exceedingly favorable, 10 persons turn up favorable, 8 persons turn up good, 3 persons turn up invalid / 24persons). In the efficiency of symptom of abdominal pain is 88%(4persons turn up exceedingly favorable, 10 persons turn up favorable, 8 persons turn up good, 3 persons turn up invalid / 25persons). The efficiency of symptom of constipation and diarrhoea is 90%(5persons turn up exceedingly favorable, 9 persons turn up favorable, 6 persons turn up good, 2 persons turn up invalid / 22persons).

• 대한인간공학회지
• /
• 제27권3호
• /
• pp.81-92
• /
• 2008

Musculoskeletal disorder (MSD) problems have been increasingly reported in hospital sector but the problems were not addressed with respect to holistic aspects of the target population in Korea. Often, it is required to understand how MSD symptoms are associated with factors such as personal, work environmental and psychosocial stressors. To examine features of association between sets of MSD symptoms and the factors, a questionnaire survey was conducted in a university hospital. A 140-item questionnaire was developed and used for collecting information including factors (e.g., job/occupation, task/activity, job stress) and MSD symptoms. A total of 1,091 workers (male 23.7% and female 76.3%) were finally determined for data analyses. Prevalence rate for the whole body was 72% and, among body parts, the highest was 48.7% for the shoulder, followed by 34.6%(the low back), 32.7%(the leg/foot), 27.9%(the neck), 26.7%(the wrist) and 12%(the elbow). The symptoms were significantly different by job/occupational variable in each of all body parts except the neck. The symptoms were very significantly different by task/activity variables in each of all body parts while those symptoms were significantly different by psychosocial variables, depending on body part and gender. In the logistic regression analyses performed for MSD symptoms by body part and each of 3 factors, odds ratio values varied, ranging from 0.7 to 3.3. The controls for reducing the symptoms were discussed on the basis of the findings. The results show that the MSD symptoms can remarkably vary by the factors and, in particular, can be highly differential for the task/activity factor. This study suggests that MSD symptom features be examined by using various factors and then a higher differential factor be primarily utilized for controling MSD symptoms in general industry including hospital settings.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제18권2호
• /
• pp.109-116
• /
• 2007

The objective of this review is to establish practice parameters for pharmacological treatment of children and adolescents with pervasive developmental disorders. We performed a detailed review of the literature, including a wide range of controlled clinical trials, open trials, case reports, and side-effect profiles of related drugs. Few medications have a treatment indication for pervasive developmental disorders, and few studies with well-controlled methodology are available for evaluating treatment results. Pharmacological treatments focus on associated target symptoms because symptom reduction may improve educational and social ability and enhance quality of life. Well-controlled trials have been conducted for some SSRI(selective serotonin reuptake inhibitor) antidepressants, risperidone, and methylphenidate, and showed reduction of some target symptoms. Since the medications are not specific to autism and do not treat core symptoms of the disorder, their potential side effects should be carefully considered. Family education is necessary to give proper information on target symptoms, limitation of drug treatments, and risks.

• 대한한의학회지
• /
• 제31권6호
• /
• pp.16-20
• /
• 2010

Objective: This study aimed to produce a description of features of chronic fatigue patients visiting an Oriental Hospital. Methods: 121 patients (75 male and 46 female) who visited a fatigue-care center were enrolled in this study, and the main complaints besides fatigue feeling, symptom differentiation, and health-related factors were analyzed. Results: On a visual analogue scale (VAS), average severity of fatigue was 7.0 (male 6.77 and female 7.4; 0 indicates no fatigue vs. 10 indicates intolerable fatigue), and the main complaints included headache (male and female) and dyspepsia (female). Patients generally slept about 7 hrs and caught a cold 2.4 times per year (same in both male and female). 54.6 % of patients used functional supplements, and red ginseng, vitamin and herbal medicine were chosen in that order. Conclusions: Chronic fatigue is a main target of traditional Korean medicine (TKM). This study can be helpful to design TKM-based treatment for chronic fatigue-related symptoms.

• Journal of information and communication convergence engineering
• /
• 제8권3호
• /
• pp.339-342
• /
• 2010

An iris image pattern positioning with preserved edge detector, ring zone and clock zone, frequency distribution and overlay matching is presented in this paper. Edge detector is required to be powerful and detail. That is proposed by overlaying Canny with LOG (CLOG). The two reference patterns are made from allocating each gray level on the clock zone and ring zone respectively. The normalized target image is overlaid with the clock zone reference pattern and the ring zone pattern to extract overlapped number, and make a matched frequency distribution to look through a symptom and position of human organ and tissue. The iterating experiments result in the ring and clock zone positioning evaluation.

• Journal of Chest Surgery
• /
• 제33권7호
• /
• pp.597-600
• /
• 2000

폐실질에 발생하는 자궁내막증은 월경시마다 반복되는 특징적인 증상을 갖는 드문 질환이다. 저자는 유산 및 출산 경험이 없는 3개월의 월경성 각혈의 증상을 가진 19세의 여자 환자를 흉부 전산화 단층촬영으로 확진 하였으며 우측 병변은 흉강경을 이용한 쐐기 절제술, 연이어 좌측 병변은 개흉술을 통한 상분엽절제술을 시행하였다. 수술 전에 시행하였던 투시경(fluoroscopy) 도음하의 hooking이 일측폐 마취에서의 병변의 확인에 도움을 주었다.

• Biomolecules & Therapeutics
• /
• 제21권3호
• /
• pp.181-189
• /
• 2013

Motilitone$^{(R)}$ (DA-9701) is a new herbal drug that was launched for the treatment of functional dyspepsia in December 2011 in Korea. The heterogeneous symptom pattern and multiple causes of functional dyspepsia have resulted in multiple drug target strategies for its treatment. DA-9701, a compound consisting of a combination of Corydalis Tuber and Pharbitidis Semen, has being developed for treatment of functional dyspepsia. It has multiple mechanisms of action such as fundus relaxation, visceral analgesia, and prokinetic effects. Furthermore, it was found to significantly enhance meal-induced gastric accommodation and increase gastric compliance in dogs. DA-9701 also showed an analgesic effect in rats with colorectal distension induced visceral hypersensitivity and an antinociceptive effect in beagle dogs with gastric distension-induced nociception. The pharmacological effects of DA-9701 also include conventional effects, such as enhanced gastric emptying and gastrointestinal transit. The safety profile of DA-9701 is also preferable to that of other treatments.

• 대한불안의학회지
• /
• 제18권1호
• /
• pp.1-9
• /
• 2022

Mindfulness has been widely researched in mental, physical health, and healthy populations. The effectiveness of mindfulness-based interventions have also been demonstrated in research studies. This report reviews the research on mindfulness based interventions currently employed for the treatment of posttraumatic stress disorder (PTSD). Mindfulness-based theories postulate that symptoms of PTSD are developed and maintained by experiential avoidance and non-mindful behaviors. Recent emerging work indicates that mindfulness based interventions, such as mindfulness-based stress reduction and mindfulness-based cognitive therapy, may improve the symptoms of PTSD. Further advances are needed to gain a better understanding of the ability of mindfulness based interventions to target specific symptom dimensions of PTSD and the psychological/neurobiological mechanisms of actions underlying these interventions.

• 한국축산식품학회지
• /
• 제42권6호
• /
• pp.981-995
• /
• 2022

Cognitive dysfunction is a common symptom of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and is known to be caused by the structural and functional loss of neurons. Many natural agents that can improve cognitive function have been developed and assessed for efficacy using various cognitive deficit animal models. As the gut environment is known to be closely connected to brain function, probiotics are attracting attention as an effective treatment target that can prevent and mitigate cognitive deficits as a result of neurodegenerative diseases. Thus, the objective of this review is to provide useful information about the types and characteristics of cognitive deficit animal models, which can be used to evaluate the anti-cognitive effects of probiotics. In addition, this work reviewed recent studies describing the effects and treatment conditions of probiotics on cognitive deficit animal models. Collectively, this review shows the potential of probiotics as edible natural agents that can mitigate cognitive impairment. It also provides useful information for the design of probiotic treatments for cognitive deficit patients in future clinical studies.