• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4005-4013
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• 2013

Background: Although breast cancer is a major public health worry among Asian women, adherence to screening for the disease remains an obstacle to its prevention. A variety of psycho-social and cultural factors predispose women to delay or avoidance of screening for breast cancer symptoms at the early stages when cure is most likely to be successful. Yet few interventions implemented to date to address this condition in this region have drawn on health behavior theory. Materials and Methods: This paper reviews the existing literature on several cognitive theories and models associated with breast cancer screening, with an emphasis on the work that has been done in relation to Asian women. To conduct this review, a number of electronic databases were searched with context-appropriate inclusion criteria. Results: Little empirical work was found that specifically addressed the applicability of health theories in promoting adherence to the current breast cancer prevention programs Among Asian women. However, a few studies were found that addressed individual cognitive factors that are likely to encourage women's motivation to protect themselves against breast cancer in this region of the world. The findings suggest that multi-level, socio-cultural interventions that focus on cognitive factors have much promise with this issue. Conclusions: Interventions are needed that effectively and efficiently target the personal motivation of at-risk Asian women to seek out and engage in breast cancer prevention. Concerning implications, personal motivation to seek out and engage in individual preventive actions for breast cancer prevention among Asian women is a timely, high priority target with practical implications for community development and health promotion. Further studies using qualitative, anthropologic approaches shaped for implementation in multi-ethnic Asian settings are needed to inform and guide these interventions.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.904-907
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• 2002

Optical disk drive device is improved in rotating speed for faster data reading. In the case of CD-ROM, rotating speed is over 10000 rpm in the practical use. As a result of high rotating speed, unexpected effects as like increasing disk fluctuation and acoustic noise are raised by the air friction on the rotating disk and the eccentricity of rotating parts. The overall acoustic noise of running CD-ROM could be classified into two different characterized noise. The first is the structural-borne noise which is generated from vibrating solid body. By the reason, the signal of structural borne noise has very similar to the signal of surface vibrating one. It has dense noise energy at specific frequency region. The other is the air-borne noise which is generated from turbulence or vortex caused by friction between disk and air. The signal of air-borne noise has no dominant peak point at acoustic pressure-frequency domain. The noise energy is widely distributed while comparatively high and large frequency region. The structural-borne noise could be reduced by reducing vibration of structure and in addition it's target reducing frequency is narrow. However the air-borne noise reduction is effectively needed of enclosing method for the noise source located near the disk surface because it is difficult to define target frequency point. In this study, the acoustic noise at driving CD-ROM is classified by the sides of it's character and tried to reduce the overall acoustic noise.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.185-185
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• 2011

ZnTe semiconductor is very attractive materials for optoelectronic devices in the visible green spectral region because of it has direct bandgap of 2.26 eV. The prototypes of ZnTe light emitting diodes (LEDs) have been reported [1], showing that their green emission peak closely matches the most sensitive region of the human eye. Another application to photovoltaics proved that ZnTe is useful for the production of high-efficiency multi-junction solar cells [2,3]. By using the pulse laser deposition system, ZnTe thin films were deposited on ZnO thin layer, which is grown on (0001) Al2O3substrates. To produce the plasma plume from an ablated ZnO and ZnTe target, a pulsed (10 Hz) YGA:Nd laser with energy density of 95 mJ/$cm^2$ and wavelength of 266 nm by a nonlinear fourth harmonic generator was used. The laser spot focused on the surface of the ZnO and ZnTe target by using an optical lens was approximately 1 mm2. The base pressure of the chamber was kept at a pressure around $10^{-6}$ Torr by using a turbo molecular pump. The oxygen gas flow was controlled around 3 sccm by using a mass flow controller system. During the ZnTe deposition, the substrate temperature was $400^{\circ}C$ and the ambient gas pressure was $10^{-2}$ Torr. The structural properties of the samples were analyzed by XRD measurement. The optical properties were investigated by using the photoluminescence spectra obtained with a 325 nm wavelength He-Cd laser. The film surface and carrier concentration were analyzed by an atomic force microscope and Hall measurement system.

• Journal of the Korea Society of Computer and Information
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• v.13 no.6
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• pp.77-86
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• 2008

The Web information sources can be regarded as the largest distributed database to the users. By virtually integrating the distributed information sources and regarding them as a single huge database, we can query the database to extract information. This capability is important to develop Web application programs. We have to infer a database schema from browsing-oriented Web documents in order to integrate databases. This paper presents a heuristic algorithm to infer the XML Schema fully automatically from semi-structured Web documents. The algorithm first extracts candidate pattern regions based on predefined structure-making tags, and determines a target pattern region using a few heuristic factors, and then derives XML Schema extraction rules from the target pattern region. The schema extraction rule is represented in XQuery, which makes development of various application systems possible using open standard XML tools. We also present the experimental results for several public web sources to show the effectiveness of the algorithm.

• Molecules and Cells
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• v.41 no.9
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• pp.842-852
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• 2018

Notch signaling is an evolutionarily conserved pathway and involves in the regulation of various cellular and developmental processes. Ligand binding releases the intracellular domain of Notch receptor (NICD), which interacts with DNA-bound CSL [CBF1/Su(H)/Lag-1] to activate transcription of target genes. In the absence of NICD binding, CSL down-regulates target gene expression through the recruitment of various corepressor proteins including SMRT/NCoR (silencing mediator of retinoid and thyroid receptors/nuclear receptor corepressor), SHARP (SMRT/HDAC1-associated repressor protein), and KyoT2. Structural and functional studies revealed the molecular basis of these interactions, in which NICD coactivator and corepressor proteins competitively bind to ${\beta}-trefoil$ domain (BTD) of CSL using a conserved ${\varphi}W{\varphi}P$ motif (${\varphi}$ denotes any hydrophobic residues). To date, there are conflicting ideas regarding the molecular mechanism of SMRT-mediated repression of CSL as to whether CSL-SMRT interaction is direct or indirect (via the bridge factor SHARP). To solve this issue, we mapped the CSL-binding region of SMRT and employed a 'one- plus two-hybrid system' to obtain CSL interaction-defective mutants for this region. We identified the CSL-interaction module of SMRT (CIMS; amino acid 1816-1846) as the molecular determinant of its direct interaction with CSL. Notably, CIMS contains a canonical ${\varphi}W{\varphi}P$ sequence (APIWRP, amino acids 1832-1837) and directly interacts with CSL-BTD in a mode similar to other BTD-binding corepressors. Finally, we showed that CSL-interaction motif, rather than SHARP-interaction motif, of SMRT is involved in transcriptional repression of NICD in a cell-based assay. These results strongly suggest that SMRT participates in CSL-mediated repression via direct binding to CSL.

• Journal of the Korean Solar Energy Society
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• v.22 no.3
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• pp.31-37
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• 2002

This experimental study represents the results of an analysis on the characteristics of flux density distributions in the focal region of solar concentrator. The characteristics of flux density distributions are investigated to optimally design and position a cavity receiver. This deemed very useful to find and correct various errors associated with a dish concentrator. We estimated the flux density distribution on the target placed along with focal lengths from the dish vertex to experimentally determine the focal length. It is observed that the actual focal point exists when the focal length is 2.17 m. We also evaluated the position of flux centroid, and it was found that there were errors within 2 cm from the target center. The total integrated power of 2467 W was measured under focal flux distributions, which corresponds to the intercept rate of 85.8%. As a result of the percent power within radius, approximately 90% of the incident radiation is intercepted by about 0.06 m radius.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.20 no.1
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• pp.1-11
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• 2002

This study set up a purpose in the efficient utilization of security target objects. This purpose is the following: Firstly, this study analyzed problem about deleted areas for security described on aerial photography image. Secondly, this study made clustering and labeling to recognize censored areas of image. Finally, this study tried to maximize various utilizability of digital image data through postprocessing algorithm. Based on these courses, the results of this study appeared that brightness value of image increased depending on topography and quantities of topographic features. It was estimated that these was able to utilized by useful estimative data in judging information of topography and topographic features included in the total image. Besides, in the image recognition and postprocessing, the better result value was not elicited than in a mountainous region. Because it was included that a lots of topography and topographic features was similarly recognized with the process for deletion of the existing security target objects in urban and suburb region. This result appeared that the topography and quantities of topographic features absolutely affected the recognition and processing of image.

• Journal of Navigation and Port Research
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• v.26 no.2
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• pp.221-226
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• 2002

To provide reliable data for drift prediction models, field experiments were carried out in the coastal region off Busan port. Four different size of vessels(10, 30, 50, 90G/T ton) were deployed for the experiment. Among them G/T 50ton class vessel was equipped with instruments measuring the currents, winds, headings and trajectory data. In the rest of vessels only the position data were recorded for the purpose of target divergence study. The trajectories of each vessel were measured by DGPS(Differential Global Positioning System) and collected by APRS(Automatic Position Reporting System). The experiment was done in wind of 2~10m/s and current of 0.5~1.5m/s. The leeway was derived by subtracting surface current velocity from target drifting velocity. The leeway rate of G/T 50ton vessel was found to be about 3.6% and the computed leeway speed equation was $U_L$=0.042 W - 0.034. The processed leeway angle data were deflected by $-30^{\circ}$~$40^{\circ}$ from the direction of ship drift.

• BMB Reports
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• v.54 no.7
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• pp.386-391
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• 2021

Owing to rapid advancements in NGS (next generation sequencing), genomic alteration is now considered an essential predictive biomarkers that impact the treatment decision in many cases of cancer. Among the various predictive biomarkers, tumor mutation burden (TMB) was identified by NGS and was considered to be useful in predicting a clinical response in cancer cases treated by immunotherapy. In this study, we directly compared the lab-developed-test (LDT) results by target sequencing panel, K-MASTER panel v3.0 and whole-exome sequencing (WES) to evaluate the concordance of TMB. As an initial step, the reference materials (n = 3) with known TMB status were used as an exploratory test. To validate and evaluate TMB, we used one hundred samples that were acquired from surgically resected tissues of non-small cell lung cancer (NSCLC) patients. The TMB of each sample was tested by using both LDT and WES methods, which extracted the DNA from samples at the same time. In addition, we evaluated the impact of capture region, which might lead to different values of TMB; the evaluation of capture region was based on the size of NGS and target sequencing panels. In this pilot study, TMB was evaluated by LDT and WES by using duplicated reference samples; the results of TMB showed high concordance rate (R² = 0.887). This was also reflected in clinical samples (n = 100), which showed R² of 0.71. The difference between the coding sequence ratio (3.49%) and the ratio of mutations (4.8%) indicated that the LDT panel identified a relatively higher number of mutations. It was feasible to calculate TMB with LDT panel, which can be useful in clinical practice. Furthermore, a customized approach must be developed for calculating TMB, which differs according to cancer types and specific clinical settings.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.33-33
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• 2022

Rice (Oryza sativa L.) is a widely studied domesticated model plant. Seed awning is an unfavorable trait during rice harvesting and processing. Hence, awn was one of the target characters selected during domestication. However, the genetic mechanisms underlying awn development in rice are not well understood. In this study, we analyzed the genes for awn development using a mapping population derived from a cross between the Korean indica cultivar 'Milyang23' and NIL4/9 (derived from a cross between 'Hwaseong' and O. minuta). Two quantitative trait loci (QTLs), qAwn4 and qAwn9 were mapped on chromosome 4 and 9, respectively, increased awn length in an additive manner. Through comparative sequencing analyses parental lines, LABA1 was determined as the causal gene underlying qAwn4. qAwn9 was mapped to a 199-kb physical region between markers RM24663 and RM24679. Within this interval, 27 annotated genes were identified, and five genes, including a basic leucine zipper transcription factor 76 (OsbZIP76), were considered candidate genes for qAwn9 based on their functional annotations and sequence variations. Haplotype analysis using the candidate genes revealed tropical japonica specific sequence variants in the qAwn9 region, which partly explains the non-detection of qAwn9 in previous studies that used progenies from interspecific crosses. This provides further evidence that OsbZIP76 is possibly a causal gene for qAwn9. The O. minuta qAwn9 allele was identified as a major QTL associated with awn development in rice, providing an important molecular target for basic genetic research and domestication studies. Our results lay the foundation for further cloning of the awn gene underlying qAwn9.