• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.26 no.3
• /
• pp.113-119
• /
• 2014

We carried out flow and structural response analysis of a box-type artificial reef (AR), which is made of concrete and structural steel. From the flow analysis, the wake region and drag coefficient were evaluated and accordingly, the structural analysis was performed to evaluate the stress and deformation of the target reef by considering the pressure field obtained from the flow analysis. The concept of wake volume was presented to quantitatively estimate the wake region and its variation according to flow direction and velocity. From the results, it is shown that the flow responses are only sensitive to the flow direction; the structural responses are sensitive to both of the flow velocity and direction although the magnitudes are negligible; and the wake volume became 3.52 times the AR volume with an optimum installation condition ($30^{\circ}$, flow direction) of the target unit.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.19 no.3
• /
• pp.659-666
• /
• 2015

In this paper, we propose a novel reconstruction method of spatially filtered 3D images in integral imaging based on parallel lens array. The parallel lens array is composed of two lens arrays, which are positioned side by side through longitudinal direction. Conventional spatial filtering method by using convolution property between periodic functions has drawback that is the limitation of the position of target object. this caused the result that the target object should be located on the low depth resolution region. The available spatial filtering region of the spatial filtering method is depending on the focal length and the number of elemental lens in the integral imaging pickup system. In this regard, we propose the parallel lens array system to enhance the available spatial filtering region and depth resolution. The experiment result indicate that the proposed method outperforms the conventional method.

• Genomics & Informatics
• /
• v.12 no.4
• /
• pp.268-275
• /
• 2014

The harshness of legionellosis differs from mild Pontiac fever to potentially fatal Legionnaire's disease. The increasing development of drug resistance against legionellosis has led to explore new novel drug targets. It has been found that phosphoglucosamine mutase, phosphomannomutase, and phosphoglyceromutase enzymes can be used as the most probable therapeutic drug targets through extensive data mining. Phosphoglucosamine mutase is involved in amino sugar and nucleotide sugar metabolism. The purpose of this study was to predict the potential target of that specific drug. For this, the 3D structure of phosphoglucosamine mutase of Legionella pneumophila (strain Paris) was determined by means of homology modeling through Phyre2 and refined by ModRefiner. Then, the designed model was evaluated with a structure validation program, for instance, PROCHECK, ERRAT, Verify3D, and QMEAN, for further structural analysis. Secondary structural features were determined through self-optimized prediction method with alignment (SOPMA) and interacting networks by STRING. Consequently, we performed molecular docking studies. The analytical result of PROCHECK showed that 95.0% of the residues are in the most favored region, 4.50% are in the additional allowed region and 0.50% are in the generously allowed region of the Ramachandran plot. Verify3D graph value indicates a score of 0.71 and 89.791, 1.11 for ERRAT and QMEAN respectively. Arg419, Thr414, Ser412, and Thr9 were found to dock the substrate for the most favorable binding of S-mercaptocysteine. However, these findings from this current study will pave the way for further extensive investigation of this enzyme in wet lab experiments and in that way assist drug design against legionellosis.

• Journal of Integrative Natural Science
• /
• v.10 no.2
• /
• pp.95-104
• /
• 2017

Proviral Integration site of Moloney (Pim) murine Leukemia virus kinases is a serine/threonine specific protein kinase. It is largely involved in cell survival and proliferation. Pim-1 phosphorylates multiple cellular substrates to inhibit apoptosis and promote cell cycle progression. Over expression of Pim-1 kinase is observed in a range of malignancies and various solid cancers. High level of Pim-1 expression is seen in myeloma, acute myeloid leukemia, prostate cancer and liver carcinomas. Hence, Pim-1 is considered as an interesting cancer target. In the present study, we have performed region-focused CoMFA study on a series of imidazopyridazine derivatives as Pim-1 kinase inhibitors. A statistically acceptable region-focused CoMFA model ($q^2=0.571$; ONC=3; $r^2=0.909$) was developed. The model was then validated using Bootsrapping and progressive sampling. The contour map highlighted the regions favorable to increase the activity. Bulky substitutions in $R^2$ position of the phenyl ring could increase the activity. Similarly, small negative substitution in the $R^1$ position of the Pyridine ring could increase the activity considerably. Our results will be useful to design novel Pim-1 kinase inhibitors of this series.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.45 no.6
• /
• pp.517-522
• /
• 2017

Launch Acceptability Region(LAR) is a region for an aircraft which carries air-to-ground guided bombs to enter such that it can successfully hit the target. LAR should consider the release condition of an aircraft, impact condition for targets, and environmental condition of atmosphere. In this paper, LAR algorithm was developed using the database of many simulations which were varied by inputs, such as the release, impact, and environmental conditions. The algorithm was tested through the direct simulation results, and found that it was suitable to apply as LAR for air-to-ground guided bomb.

• Journal of the Korean Society for Precision Engineering
• /
• v.32 no.5
• /
• pp.471-481
• /
• 2015

This paper presents the robot vision control schemes using Extended Kalman Filter (EKF) method for the slender bar placement in the appearance of obstacles during robot movement. The vision system model used for this study involves the six camera parameters($C_1{\sim}C_6$). In order to develop the robot vision control scheme, first, the six parameters are estimated. Then, based on the estimated parameters, the robot's joint angles are estimated for the slender bar placement. Especially, robot trajectory caused by obstacles is divided into three obstacle regions, which are beginning region, middle region and near target region. Finally, the effects of number of obstacles using the proposed robot's vision control schemes are investigated in each obstacle region by performing experiments of the slender bar placement.

• The Transactions of the Korea Information Processing Society
• /
• v.3 no.2
• /
• pp.348-358
• /
• 1996

If a method of character region extraction will have general purposes, it could not but make use of common features which all target images have. This paper suggests these common features should be considered as the coalitions for the region to be extracted within a framework of the cost minimization. The method suggested above could be effective by minimizing a cost function estmating the extent that character regions satify quantitatively the features, through Simulated Annealing Method. This method has an uniqueness in that it defines the cost function. Experimental result verify the usefulness of this cost minimization approach to characer region extraction.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.52 no.1
• /
• pp.74-80
• /
• 2019

Nonylphenol is an endocrine-disrupting chemical that is the degradation product of the nonionic surfactants nonylphenol ethoxylates. To understand the contamination and behavioral characteristics of nonylphenol, we measured the nonylphenol concentrations in surface water in the lower reaches of the Suyeong River, Korea. The results were used to estimate the material balance. The target area was divided into three regions to estimate the material balance of nonylphenol. In region 1, in flux of the dissolved nonylphenol was 282.3 g/day and the nonylphenol influx in particulate suspended solids was 1,582.8 g/day. The dissolved nonylphenol outflow discharged toward region 2 was 192.5 g/day, while the adsorption to particulate suspended solids was 89.8 g/day. Within the particulate suspended solids, the outflow to region 2 was 1,250.0 g/day, while the estimated amount settling in the sediments was 422.7 g/day. The adsorption of dissolved nonylphenol to the particulate suspended solids in regions 1 and 2 was 31.8% and 54.9%, respectively. In region 3, the desorption rate was 8.8%.

• Progress in Medical Physics
• /
• v.7 no.2
• /
• pp.19-28
• /
• 1996

It is important that the precise decision of the region and the accurate delivery of radiation dose required for treatment in the stereotactic radiosurgery. In this research, radiosurgery was carried with Leksell streotactic frame(LSF) which is especially developed water phantom to verify in experiment. Leksell Gamma Knife and LSF are used in radiosurgery is the spherical water phantom has the thickness of 2 mm, the radius of 160mm. The film for target localization and ionchamber for dose delivery was used in measurement instruments We compare the coordinate of target which is initialized by biplannar film with simple X-ray to the coordinate of film measured directly. The calculated dose by computer simulation and the measured dose by ionization chamber are compared. In this research, the target localization has the range ${\pm}$0.3mm for the acceptable error range and the absolute dose is :${\pm}$0.3mm for the acceptable error range. This research shows that the values measured by using the especially manufactured phantom are included the acceptable error range. Thus, this water phantom will be used continuously in the periodic quality assurance of Gamma Knife Unit and Leksell Stereotactic Frame.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.11
• /
• pp.6315-6319
• /
• 2013

To study the differentiated expression of the proto-oncogene Pokemon in nasopharyngeal carcinoma (NPC) cell lines and tissues, mRNA and protein expression levels of CNE1, CNE2, CNE3 and C666-1 were detected separately by reverse transcription polymerase chain reaction (RT-PCR), real-time PCR and Western-blotting. The immortalized nasopharyngeal epithelial cell line NP69 was used as a control. The Pokemon protein expression level in biopsy specimens from chronic rhinitis patients and undifferentiated non keratinizing NPC patients was determined by Western-blotting and arranged from high to low: C666-1>CNE1>CNE2> CNE3>NP69. The Pokemon mRNA expression level was also arranged from high to low: CNE1>CNE2>NP69>C666-1>CNE3. Pokemon expression of NP69 and C666-1 obviously varied from mRNA to protein. The Pokemon protein level of NPC biopsy specimens was obviously higher than in chronic rhinitis. The data suggest that high Pokemon protein expression is closely associated with undifferentiated non-keratinizing NPC and may provide useful information for NPC molecular target therapy.