• Journal of Internet Computing and Services
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• 제11권1호
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• pp.143-151
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• 2010

According to increasing requirements in embedded systems. embedded software has been more complicated then before. a optimum software is difficult in embedded system. software developer make a difficult optimum software. this paper suggests a software profiling tool with which a software developer can easily profiling the embedded system software in cross-development environments. the suggested tool is designed based on host/target architecture. this tool insert program source for make profiling log to target program. a target program executed in target system. a target system communicate profiling log to host system. this tool in host system analyze profiling log data. and make a XML of profiling log and a profiling report. a profiling report is graphic viewer based GUI. a target system in this tool needs a few computing power. and XSLT can conversion of profile log XML to other format data. and suggested tool based on eclipse plug-in, therefore developer can use operates in eclipse.

• Ocean Systems Engineering
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• 제1권3호
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• pp.195-205
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• 2011

A method for calibrating a laser profiling system for seafloor micro-topography measurements is described. The system consists of a digital camera and an arrangement of six red lasers that are mounted as a unit on a remotely operated vehicle (ROV). The lasers project as parallel planes onto the seafloor, creating profiles of the local topography that are interpreted from the digital camera image. The goal of the calibration was to determine the plane equations for the six lasers relative to the camera. This was accomplished in two stages. First, distortions in the digital image were corrected using an interpolation method based on a virtual pinhole camera model. Then, the laser planes were determined according to their intersections with a calibration target. The position and orientation of the target were obtained by a registration process. The selection of the target shape and size was found to be critical to a successful calibration at sea, due to the limitations in the manoeuvrability of the ROV.

• Journal of the Korea Institute of Information Security & Cryptology
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• 제27권1호
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• pp.15-23
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• 2017

Template attack is a powerful side-channel analysis technique which can be performed by an attacker who has a test device that is identical to target device. Template attack is consisted of building template in profiling phase and matching the target device using template that were calculated in profiling phase. One methods to improve the success rate of template attack is to better estimate template which is consisted sample mean and sample covariance matrix of gaussian distribution in template profiling. However restriction of power trace in profiling phase led to poor template estimation. In this paper, we propose new method to select noisy power trace in profiling phase. By eliminating noisy power trace in profiling phase, we can construct more advanced mean and covariance matrix which relates to better performance in template attack. We proved that the proposed method is valid through experiments.

• 대한약리학회:학술대회논문집
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• 대한약리학회 2006년도 58th Annual Meeting of The Korean Society of Pharmacology
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• pp.44-44
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• 2006

• Genomics & Informatics
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• 제12권2호
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• pp.50-57
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• 2014

We present a new next-generation sequencing-based method to identify somatic mutations of lung cancer. It is a comprehensive mutation profiling protocol to detect somatic mutations in 30 genes found frequently in lung adenocarcinoma. The total length of the target regions is 107 kb, and a capture assay was designed to cover 99% of it. This method exhibited about 97% mean coverage at $30{\times}$ sequencing depth and 42% average specificity when sequencing of more than 3.25 Gb was carried out for the normal sample. We discovered 513 variations from targeted exome sequencing of lung cancer cells, which is 3.9-fold higher than in the normal sample. The variations in cancer cells included previously reported somatic mutations in the COSMIC database, such as variations in TP53, KRAS, and STK11 of sample H-23 and in EGFR of sample H-1650, especially with more than $1,000{\times}$ coverage. Among the somatic mutations, up to 91% of single nucleotide polymorphisms from the two cancer samples were validated by DNA microarray-based genotyping. Our results demonstrated the feasibility of high-throughput mutation profiling with lung adenocarcinoma samples, and the profiling method can be used as a robust and effective protocol for somatic variant screening.

• Mass Spectrometry Letters
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• 제11권2호
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• pp.25-29
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• 2020

Pseudopodia are dynamic actin cytoskeleton-based membrane protrusions of cells that enable directional cell migration. Pseudopodia of cancer cells play key roles in cancer metastasis. Recent studies using pseudopodial subcellular fractionation methodologies combined with mass spectrometry-based proteomic profiling have provided insight into the pseudopodiome that control the protrusions of invasive metastatic cancer cells. This review highlights how to characterize the protein composition of pseudopodia and develop strategies to identify biomarkers or drug candidates that target reduction or prevention of metastatic cancer.

• Journal of the Korean Magnetic Resonance Society
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• 제17권1호
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• pp.1-10
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• 2013

Metabolomics is the study which detects the changes of metabolites level. Metabolomics is a terminal view of the biological system. The end products of the metabolism, metabolites, reflect the responses to external environment. Therefore metabolomics gives the additional information about understanding the metabolic pathways. These metabolites can be used as biomarkers that indicate the disease or external stresses such as exposure to toxicant. Many kinds of biological samples are used in metabolomics, for example, cell, tissue, and bio fluids. NMR spectroscopy is one of the tools of metabolomics. NMR data are analyzed by multivariate statistical analysis and target profiling technique. Recently, NMR-based metabolomics is a growing field in various studies such as disease diagnosis, forensic science, and toxicity assessment.

• BMB Reports
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• 제43권11호
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• pp.711-719
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• 2010

Kinomics is an emerging and promising approach for deciphering kinomes. Chemical kinomics is a discipline of chemical genomics that is also referred to as "chemogenomics", which is derived from chemistry and biology. Chemical kinomics has become a powerful approach to decipher complicated phosphorylation-based cellular signaling networks with the aid of small molecules that modulate kinase functions. Moreover, chemical kinomics has played a pivotal role in the field of kinase drug discovery as it enables identification of new molecular targets of small molecule kinase modulators and/or exploitation of novel functions of known kinases and has also provided novel chemical entities as hit/lead compounds. In this short review, contemporary chemical kinomics technologies such as activity-based protein profiling, T7 kinasetagged phages, kinobeads, three-hybrid systems, fluorescenttagged kinase binding assays, and chemical genomic profiling are discussed along with a novel allosteric Bcr-Abl kinase inhibitor (GNF-2/GNF-5) as a successful application of chemical kinomics approaches.

• Journal of the Institute of Electronics Engineers of Korea SD
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• 제41권10호
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• pp.85-94
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• 2004

In this paper, a register allocation techlique that translates memory accesses to register accesses Is presented to enhance embedded software performance. In the proposed method, a source code is profiled to generate a memory trace. From the profiling results, target functions with high dynamic call counts are selected, and the proposed register allocation technique is applied only to the target functions to save the compilation time. The memory trace of the target functions is searched for the memory accesses that result in cycle count reduction when replaced by register accesses, and they are translated to register accesses by modifying the intermediate code and allocating Promotion registers. The experiments where the performance is measured in terms of the cycle count on MediaBench and DSPstone benchmark programs show that the proposed method increases the performance by 14% and 18% on the average for ARM and MCORE, respectively.

• The KIPS Transactions:PartA
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• 제11A권5호
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• pp.373-382
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• 2004

In this paper, a register promotion technique that translates memory accesses to register accesses is presented to enhance embedded software performance. In the proposed method, a source code is profiled to generate a memory trace. From the profiling results, target functions with high dynamic call counts are selected, and the proposed register promotion technique is applied only to the target functions to save the compilation time. The memory trace of the target functions is searched for the memory accesses that result in cycle count reduction when replaced by register accesses, and they are translated to register accesses by modifying the intermediate code and allocating promotion registers. The experiments on MediaBench and DSPstone benchmark programs show that the proposed method increases the performance by 14% and 18% on the average for ARM and MCORE, respectively.