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http://dx.doi.org/10.5478/MSL.2020.11.2.25

Mass Spectrometry-Based Proteomic Profiling of Pseudopodia of Metastatic Cancer Cells  

Choi, Sunkyu (Proteomics Core, Weill Cornell Medicine-Qatar, Qatar Foundation - Education City)
Publication Information
Mass Spectrometry Letters / v.11, no.2, 2020 , pp. 25-29 More about this Journal
Abstract
Pseudopodia are dynamic actin cytoskeleton-based membrane protrusions of cells that enable directional cell migration. Pseudopodia of cancer cells play key roles in cancer metastasis. Recent studies using pseudopodial subcellular fractionation methodologies combined with mass spectrometry-based proteomic profiling have provided insight into the pseudopodiome that control the protrusions of invasive metastatic cancer cells. This review highlights how to characterize the protein composition of pseudopodia and develop strategies to identify biomarkers or drug candidates that target reduction or prevention of metastatic cancer.
Keywords
Pseudopodia; Cancer metastasis; Proteomics; Mass spectrometry;
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