• Korean Journal of Audiology
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• v.25 no.3
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• pp.124-130
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• 2021

Background and Objectives: The study investigated vowel context effects on the perception of stop consonants in Malayalam. It also probed into the role of vowel context effects in determining the frequency of occurrence of various consonant-vowel (CV) syllables in Malayalam. Subjects and Methods: The study used a cross-sectional pre-experimental post-test only research design on 30 individuals with normal hearing, who were native speakers of Malayalam. The stimuli included three stop consonants, each spoken in three different vowel contexts. The resultant nine syllables were presented in original form and five gating conditions. The consonant recognition in different vowel contexts of the participants was assessed. The frequency of occurrence of the nine target syllables in the spoken corpus of Malayalam was also systematically derived. Results: The consonant recognition score was better in the /u/ vowel context compared with /i/ and /a/ contexts. The frequency of occurrence of the target syllables derived from the spoken corpus of Malayalam showed that the three stop consonants occurred more frequently with the vowel /a/ compared with /u/ and /i/. Conclusions: The findings show a definite vowel context effect on the perception of the Malayalam stop consonants. This context effect observed is different from that in other languages. Stop consonants are perceived better in the context of /u/ compared with the /a/ and /i/ contexts. Furthermore, the vowel context effects do not appear to determine the frequency of occurrence of different CV syllables in Malayalam.

• Journal of Convergence for Information Technology
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• v.10 no.3
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• pp.16-21
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• 2020

This paper describes the jamming characteristics of a stand-off jammer jamming the LPI radar. The LPI radar reduces the side lobes of the receiving antenna to reduce the effect of jamming. It is easy a radar to predict the effect of jamming on a self-protection jammer where the jammer is in the same position as the target. However, for stand-off jammer jamming at different locations from the target, the prediction of jamming effect is complex. In this paper, the jamming effect of LPI radar is analyzed using signal to jamming ratio and burn-through range. Also, when the antenna's side lobe decreases below -30 dB, the stand-off jamming effect in the side lobe direction is weak. So we proposed a new jamming method for the main lobe and analyzed the jamming effect. This study is expected to be useful for the design and operation of aircraft jammers.

• Journal of Radiation Industry
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• v.9 no.4
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• pp.193-198
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• 2015

Most of targeted therapies block the action of certain enzymes, proteins, or other molecules involved in the growth and spread of cancer cells to produce its cytotoxic effect. Either small molecule drugs or monoclonal antibodies are mostly used in targeted therapies. Unfortunately, targeted therapy has a certain degree of unwanted side effect like other cytotoxicity inducing chemotherapies. To overcome and to reduce unwanted side effects during a cancer therapy, recently radiopeptide therapies has got the worlds' attraction for the tumor targeting modalities due to its beneficial effect on less side effect compared to cytotoxic chemotherapies. Among radiopeptide therapies, $^{177}Lu$-DOTATATE is a major modality as an effective one invented so far in treating neuroendocrine tumor (NET) and it has been in clinical trials at least one decade. Although it does have rather effective therapeutic effect on NET, it has less effective in rather large solid tumor. There are many ways to improve or increase therapeutic effect of radiopeptide are a finding the potent small molecules to target the tumor site selectively, or a labeling with radioisotope of emitting high energy, or an improving its biological half-life by introducing different moieties to increase lipophilicity. Present study was focus to increase a biological half-life of radio somatostatin which will target the somatostatin receptor by altering the bifunctional chelator (BFCA) by introducing lipophilic moiety to the somatostatin, which would make the labeled peptide stay longer in the tumor site and thus it can intensify the therapeutic effect on tumor cell itself and around tissues.

• Asia Marketing Journal
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• v.14 no.4
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• pp.57-75
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• 2013

It is a well-established theory that emotion is influential in cognitive processing. Extensive prior research on emotion has shown that emotional factors, such as affect, mood, and feeling, play as information indicating whether he or she has enough knowledge. Most of their findings focused on the effect of emotional valence (i.g., one's subjective positivity or negativity related with the emotion). Recently, several studies on emotion suggest that there is another dimension of emotion, which affects the type of cognitive processing. The studies argue that emotional certainty facilitates heuristic processing, whereas emotional uncertainty promotes systematic processing. Based on the findings, current study examines the effect of certainty on attitudes and recall. Specifically, the authors investigate the effect of certainty on how much effort individuals use to process advertising information and how certainty affects attitude formation toward the advertised product. The authors also focus on recall to clarify the working mechanism of certainty on attitudes, because recall performance reflects the depth of information processing. Based on previous findings, the authors hypothesize that uncertainty (vs. certainty) leads to more favorable attitudes as well as better recall, and conduct an experiment using a fictitious advertisement with 218 participants. The results confirm the predicted effects of certainty only on attitudes not recall. A possible explanation of this discrepancy between attitudes and recall lies in the measurement method, unaided recall. To rule out this possibility, the authors perform an additional analysis with the participants who recall any correct information of the target advertisement. The results show certainty has a negative effect on both attitudes and recall. A bootstrapping test reveals that recall mediates the effect of certainty on attitudes. This result confirms that certainty decreases elaboration, which in turn leads to less favorable attitudes relative to uncertainty. Additionally, our data shows the association among certainty, recall, and attitudes by showing the indirect effect of certainty on attitudes via recall. This research encourages practitioners in the field to emphasize that they should focus on target audiences' emotional certainty before they provide the persuasive message, by showing that uncertainty promotes effortful processing, which in turn leads to better memory and more favorable attitudes.

• Cartoon and Animation Studies
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• s.31
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• pp.153-176
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• 2013

In the early 20th century, the some of futurist painter was attempted to represents the 'fast-paced' and 'dynamism' on a two-dimensional picture. The expression of fast-paced and dynamic for look like move image in the painting have evolved as a variety of visual symbol. Visual symbols that represent these movements were settled as the line of the most movement expression in the comic. The of Toriyama Akira gained worldwide popularity is emphasized speed and dynamism as the action genre in cartoon, is nice a data to research the line of the movement expression of cartoon. There is three terms as the action line, The speed line, the effect line on the movement expression in The glossary of in the dictionary of , but it not easy to Separate them by means similar. This study is willing to says the semantically problem of previous lines on the movement expression and to present a new alternative in order to study the line on the movement expression of . This study Separate the line on movement expression from symbolic the perspective and try to newly define by using, was classified lines of four kinds by add the afterimage line on existing the speed line, the motion line, the effect line. First, the speed line was defined as 'The line expressing the movement expression of a moving target as the concept of speed'. It on the way of expression was subdivided the direct as speed line when it alter the shape of the target and the indirect speed line when it alter the background of the target. Second, the motion line was defined as 'The line simplified the moving form or the moving path of moving target'. Third, the effect line was defined as 'the line emphasizing the movement expression of a moving target by Sensory expression or emotional expression. Fourth, the afterimage lines was defined as 'The line expressing slowly moving or swaying the movement expression of target to the afterimage effect. The terminology presented in this study will be able to help the understanding of the line on the movement expression .

• Korean Journal of Applied Biomechanics
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• v.17 no.2
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• pp.227-237
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• 2007

The purpose of this study was to examine the effect of precision that kinematics had when short approach shots were taken. In this study, the subjects chosen were 5 skilled and 5 unskilled subjects, who were allowed to shoot 10 rounds of shots at target distances of 1m, 2m, 4m, and 8m. Three dimensional analysis was used as methods to obtain kinematics of each shots. In order to verify the statistical significance of the kinematic factors followed by the results of different skills and target distances, we used the two-way repeated ANOVA. The study was experimented within the level of p<.05. The results obtained were as follows: 1) the difference of shots of the forward and backward variations were larger than those of the left and right variations, the unskilled subjects' shot distances greatly got larger than that of the skilled subjects as the distance of the target increased, 2) not being affected by the target distance variations, the skilled subjects' rate of down-swing was shorter than the back-swing on short approach shots, 3) the skilled subjects' center of body weight tended to move more naturally towards the target when doing the down-swing to finish than that of the unskilled subjects on short approach shots, 4) the skilled subjects' right hand angle of cocking were narrower and tended to be kept much more consistent than that of the unskilled subjects on short approach shots, 5) the unskilled subjects when doing their back-swings, their right hips swayed towards the back, their trunk-flexion angles were shown to be lower than that of the skilled subjects on short approach shots, 6) the skilled subjects`body weight tended to move more naturally towards the left foot when doing the down-swing to finish than that of the unskilled subjects on short approach shots.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.1
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• pp.47-58
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• 2011

MTI filter is used to separate target signal from clutter in many radar signal processing. By suppressing clutter before CFAR detection, the detection performance can be improved. As a radar system designed, a design engineer generally takes averaged SNR and CNR into account and does not include the effect of MTI filter's frequency response. In practice, when the signals including clutter are pass through the filter, SNR is widely varying according to target velocity and CNR is also varying according to clutter center frequency and spectrum spreading. In this paper, we have derived the relationship between the MTI filter's frequency response and a target's velocity and a clutter's spectrum characteristics. With the variation of SNR and CNR at the filter output, the detection performance of CFAR has been analyzed by the simulation and has made certain of their influences on the performance.

• Radiation Oncology Journal
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• v.38 no.1
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• pp.18-25
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• 2020

Purpose: This study was aim to evaluate the patterns of failure according to radiotherapy (RT) target volume for cervical lymph nodes in metastases of unknown primary origin in head and neck region (HNMUO). Materials and Methods: Sixty-two patients with HNMUO between 1998 and 2016 were retrospectively reviewed. We analyzed the clinical outcomes and primary site failure depending on the radiation target volume. The target volume was classified according to whether the potential head and neck mucosal sites were included and whether the neck node was treated involved side only or bilaterally. Results: Potential mucosal site RT (mucosal RT) was done to 23 patients and 39 patients did not receive mucosal RT. Mucosal RT showed no significant effect on overall survival (OS) and locoregional recurrence (LRR). The location of primary site failure encountered during follow-up period was found to be unpredictable and 75% of patients with recurrence received successful salvage therapies. No significant differences in OS and LRR were found between patients treated to unilateral (n = 35) and bilateral neck irradiation (n = 21). Treatment of both necks resulted in significantly higher mucositis. Conclusions: We found no advantages in OS and LRR of patients with HNMUO when mucosal sites and bilateral neck node were included in the radiation target volume.

• The Journal of the Acoustical Society of Korea
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• v.37 no.6
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• pp.412-421
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• 2018

The Line array sonar consisting of several hydrophones increases array gain and improves the performance for detecting the direction of the target compared to single hydrophone. However, line array sonar produces the bearing error that makes it difficult to determine the bearing of incoming source signal due to the relation between bearing angle of target and vertical angle of multipath signals. Vertical angles of multipath are varied with the geometry of receiver and target and various underwater environments, therefore it is necessary to consider the bearing error to estimate accurately the bearing of the target. In this study, acoustic modelling was performed to understand the effect of multipath signals on the target signal. The errors of bearing angle estimated from the bottom bounced signals are calculated with several environment. In addition, the expected bearing line, as a function of source-receiver range, compensated for the bearing error is predicted from the estimated bearing angle.

• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.48-54
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• 2022

GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism. GPR43 couples with Gα_i/o and Gα_q/11 heterotrimeric proteins and is capable of decreasing cyclic AMP and inducing Ca²⁺ flux. The GPR43 receptor has additionally been shown to bind β-arrestin 2 and inhibit inflammatory pathways, such as NF-κB. However, GPR43 shares the same ligands as GPR41, including acetate, propionate, and butyrate, and determination of its precise functions in association with endogenous ligands, such as SCFAs alone, therefore remains a considerable challenge. In this study, we generated novel synthetic agonists that display allosteric modulatory effects on GPR43 and downregulate NF-κB activity. In particular, the potency of compound 187 was significantly superior to that of pre-existing compounds in vitro. However, in the colitis model in vivo, compound 110 induced more potent attenuation of inflammation. These novel allosteric agonists of GPR43 clearly display anti-inflammatory potential, supporting their clinical utility as therapeutic drugs.