• Bulletin of the Korean Chemical Society
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• 제32권5호
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• pp.1511-1518
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• 2011

A series of 1,4-disubstituted octahydroquinoxaline-2,3-dione derivatives was prepared through two steps reaction. The latter involves the formation of N,N-disubstituted cyclohexane-1,2-diamine derivatives (la-j) through reductive alkylation of 1,2-cyclohexanediamine with different aldehydes in presence of sodium cyanoborohydride. Fusion of compounds (1a-j) with diethyl oxalate affording the target compounds (2a-j). Elucidation of structures of compounds (2a-j) was based upon different spectral data as well as the elemental methods of analyses. In addition, mass spectrometry and X-ray diffraction analyses were carried out. Moreover, the lipophilicity of the target compounds as expressed from the Clog P. Most of the test compounds (2a-j) showed weak to moderate antibacterial and antifungal activities against most of the used bacterial and fungal strains in comparison to chloramphenicol and clotrimazole as reference drugs respectively.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1994년도 Proceedings of the Korea Automatic Control Conference, 9th (KACC) ; Taejeon, Korea; 17-20 Oct. 1994
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• pp.440-445
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• 1994

An application of H$_{\infty}$ synthesis to contact control of a manipulator is suggested. Based on computed torque linearization of a manipulator, a target dynamics for contact motion control is defined and used as a reference model. The target dynamics relates position and force errors through free motion impedance and force error compensators. The H$_{\infty}$ control synthesis is adopted to find an optimum the compensator for position tied force control in various directions of the end-effector. The optimization is performed on the augmented criteria, which trades off the sensitivity function of the errors and the input load at the joints. A design example of the compensator is provided that meets the design specifications.s.

• 대한화학회지
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• 제55권2호
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• pp.243-250
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• 2011

Isoxazole계 화합물을 합성하고 항균활성연구를 수행하였다. 3-Di(alkylamino)acryloalkanones을 hydroxylamine hydrochloride 또는 hydroxylamine-O-sulphonic acid와 반응시켜서 target isoxazole계 화합물을 합성하였다.

• 한국음향학회지
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• 제20권3호
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• pp.15-23
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• 2001

본 논문에서는 임의의 사람이 발성한 음성을 마치 다른 사람이 발성한 것처럼 들리도록 하는 음성변환 기술에 대하여 설명하고, 화자간의 성도 특성과 여기신호 특성 파라미터 변환을 독립적으로 수행하기 위한 변환방법을 실험한다. 성도 특성 파라미터 변환은 입력되는 음성신호에서 LPC (Linear Predictive Cofficient)켑스트럼을 추출하여 선형다변회귀모델에 적용하여 수행하고, 여기신호 특성 파라미터 변환은 잔차신호를 추출하여 LP-PSOLA (Linear Predictive-Pitch Synchronous Overlap and Add) 합성방식을 이용한 화자간의 평균 피치주기 변환으로 수행된다. 실험결과는 선형다변회귀모델과 LP-PSOLA 합성방식을 이용하여 변환된 음성이 대상화자의 음성에 유사함을 보여준다

• Journal of Welding and Joining
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• 제32권5호
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• pp.72-79
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• 2014

Shaped charge(SC) ammunition is a weapon that penetrates directly the target by made jet from metal liner on impacting at a target. In SC, the liner occupies significantly important role causing an explosion and penetration of the target. The Al-Ni composite coating was deposited on copper liner in a solid state via kinetic spraying to improve the explosive force. The mechanical properties, reactivity and microstructure were investigated to confirm the possibility of kinetic sprayed Al/Ni composite coating as a reactive liner material. Reactive liner using Al/Ni composite exhibited much enhanced reactivity than pure copper liner due to Self-propagating High-temperature Synthesis (SHS) reaction with significantly improved adhesive bond strength. Especially, among the Al/Ni composite coatings, AN11 (the Al versus Ni atomic percent ratio is 1:1) showed the greatest reactivity due to its widest reaction area between deposited Al and Ni.

• 대한음성학회지:말소리
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• 제68권
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• pp.65-74
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• 2008

A statistical parametric speech synthesis system based on the hidden Markov models (HMMs) has grown in popularity over the last few years, because it needs less memory and low computation complexity and is suitable for the embedded system in comparison with a corpus-based unit concatenation text-to-speech (TTS) system. It also has the advantage that voice characteristics of the synthetic speech can be modified easily by transforming HMM parameters appropriately. In this paper, we present experimental results of voice characteristics conversion using the HMM-based Korean speech synthesis system. The results have shown that conversion of voice characteristics could be achieved using a few sentences uttered by a target speaker. Synthetic speech generated from adapted models with only ten sentences was very close to that from the speaker dependent models trained using 646 sentences.

• Biotechnology and Bioprocess Engineering:BBE
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• 제8권1호
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• pp.1-8
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• 2003

With current developments in enzyme-catalyzed reactions and techniques available for rational redesign of natural biocatalysts, the enzymatic biosynthesis can become one of the most valuable Synthetic methods. Enzymatic regioselective catalysis in organic media has played a key role in pursuing asymmetric synthesis for active chiral compounds. Here, we shortly do-scribe some historical issues of the rapidly growing area, enzymatic catalysis in synthetic organic chemistry and then review researches that have been carried out in the regioselective enzymatic catalysis for the past two decades. An application of this technology to the modification of some potential target drug co m pound will be adios presented.

• Archives of Pharmacal Research
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• 제19권3호
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• pp.240-242
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• 1996

We have reported the convenient biomimetic methodology for the synthesis of all kinds of substituent pattern benzo[c]phenanthridine alkaloids (Hanaoka et al., 1990; Hanaoka et al., 1991). Regioselective demethylation of C-8 position on oxyfagaridine (5), an intermediate for the synthesis of Fagaridine (4), would afford the precursor for the synthesis of Isofagaridine because the strong hydrogen bonding between amide and hydroxyl group of C-7 position probably resists to be reacted with week base and electrophiles. Thus, a selective alkylation of dihydroxy compound supposed to be possible and be lead to the target compound, Isofagaridine.

• Bulletin of the Korean Chemical Society
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• 제27권7호
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• pp.976-980
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• 2006

The synthesis of 4'-phenyl and 1'-methyl doubly branched carbocyclic nucleoside was accomplished from 2-hydroxy acetophenone. The 4'-phenyl group was installed via a [3,3]-sigmatropic rearrangement reaction, and the carbonyl addition of methylmagnesium bromide was used to introduce the 1'-methyl group. Cyclization of divinyl 9 was performed using $2^{nd}$ generation Grubbs catalyst. The coupling of cyclopentenol 12$\alpha$ with 6-chloropurine by Mitsunobu reaction and desilylation was used to synthesize the target nucleoside 15.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.341.3-342
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• 2002

The interest in polyhydroxyamines is based in their biological activity as enzyme inhibitors. and as starting materials in the synthesis of more complex compounds. Polyhydroxyamines is that amine group is continuing structurally with hydroxy groups and has become important target of the synthesis strategy because of the chirality control of amine group and each hydroxy groups. (omitted)