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http://dx.doi.org/10.5012/jkcs.2011.55.2.243

Synthesis and Antibacterial Activity of Novel 5-(heteroaryl)isoxazole Derivatives  

RamaRao, R. Janaki (Natco Research Centre, Natco Pharma Ltd.)
Rao, A.K.S. Bhujanga (Natco Research Centre, Natco Pharma Ltd.)
Sreenivas, N. (Natco Research Centre, Natco Pharma Ltd.)
Kumar, B. Suneel (Natco Research Centre, Natco Pharma Ltd.)
Murthy, Y. L. N. (Department of Organic Chemistry, Andhra University)
Publication Information
Journal of the Korean Chemical Society / v.55, no.2, 2011 , pp. 243-250 More about this Journal
Abstract
The synthesis, characterization and antibacterial activity of novel isoxazole derivatives were reported. 3-Di (alkylamino)acryloalkanones were prepared and used as synthons to get the target isoxazole derivatives via reaction with hydroxylamine hydrochloride or hydroxylamine-O-sulphonic acid.
Keywords
Isoxazole derivatives; 3-di(alkylamino)acryloalkanones; Hydroxylamine hydrochloride; Hydroxylamine-O-sulphonic acid; Antibacterial activity;
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