• 대한방사선기술학회지:방사선기술과학
• /
• 제44권3호
• /
• pp.211-218
• /
• 2021

The purpose of this study was to investigate the effect of sex and menopausal age on the thickness and density of squamous portion of the temporal bone as the membranous bone. Patients who visited a general hospital in Chungnam and had a computed tomography (CT) examination of the head. A retrospective study was conducted with 120 subjects (30 men under 55 years old, 30 men over 56 years old, 30 women under 55 years old, and 30 women over 56 years old). Axial images of the squamous portion in the temporal bone were obtained from CT of the head. For this image, a slice sensitive profile (SSP) was acquired with an image analysis program and these were evaluated. The thickness was measured by using a digital ruler to measure the full width at half maximum (FWHM) of the SSP, and the density was measured in hounsfield unit (HU). These by gender were measured to be about 0.5 mm thinner in the temporal bone in men than in women, and there was a significant difference. The density was measured to be about 200 HU higher in women than in men of it, and there was a significant difference. As a result, it in women was thicker and had a lower density. The thickness of it in men and women over 56 years of age was 0.8 mm or more thicker in women and less than 400 HU in density. As a result, the women group over the age of 56 showed a distinct increase in thickness and decrease in density, different from other target groups. It is expected that the results of this study could be used as basic data for a new bone density measurement site study.

• 한국축산식품학회지
• /
• 제41권2호
• /
• pp.312-323
• /
• 2021

The purpose of this study was to use 1H nuclear magnetic resonance (1H NMR) to quantify taste-active and bioactive compounds in chicken breasts and thighs from Korean native chicken (KNC) [newly developed KNCs (KNC-A, -C, and -D) and commercial KNC-H] and white-semi broiler (WSB) used in Samgye. Further, each breed was differentiated using multivariate analyses, including a machine learning algorithm designed to use metabolic information from each type of chicken obtained using 1H-13C heteronuclear single quantum coherence (2D NMR). Breast meat from KNC-D chickens were superior to those of conventional KNC-H and WSB chickens in terms of both taste-active and bioactive compounds. In the multivariate analysis, meat portions (breast and thigh) and chicken breeds (KNCs and WSB) could be clearly distinguished based on the outcomes of the principal component analysis and partial least square-discriminant analysis (R2=0.945; Q2=0.901). Based on this, we determined the receiver operating characteristic (ROC) curve for each of these components. AUC analysis identified 10 features which could be consistently applied to distinguish between all KNCs and WSB chickens in both breast (0.988) and thigh (1.000) meat without error. Here, both 1H NMR and 2D NMR could successfully quantify various target metabolites which could be used to distinguish between different chicken breeds based on their metabolic profile.

• 한국지진공학회논문집
• /
• 제25권5호
• /
• pp.223-232
• /
• 2021

The spatial variation characteristics of seismic motions at the nuclear power plant's site and structures were analyzed using earthquake records obtained at the Fukushima nuclear power plant during the Great East Japan Earthquake. The ground responses amplified as they approached the soil surface from the lower rock surface, and the amplification occurred intensively at about 50 m near the ground. Due to the soil layer's nonlinear characteristics caused by the strong seismic motion, the ground's natural frequency derived from the response spectrum ratio appeared to be smaller than that calculated from the shear wave velocity profile. The spatial variation of the peak ground acceleration at the ground surface of the power plant site showed a significant difference of about 0.6 g at the maximum. As a result of comparing the response spectrums at the basement of the structure with the design response spectrum, there was a large variability by each power plant unit. The difference was more significant in the Fukushima Daiichi site record, which showed larger peak ground acceleration at the surface. The earthquake motions input to the basement of the structure amplified according to the structure's height. The natural frequency obtained from the recorded results was lower than that indicated in the previous research. Also, the floor response spectrum change according to the location at the same height was investigated. The vertical response on the foundation surface showed a significant difference in spectral acceleration depending on the location. The amplified response in the structure showed a different variability depending on the type of structure and the target frequency.

• Journal of Veterinary Science
• /
• 제21권5호
• /
• pp.60.1-60.11
• /
• 2020

Background: Tumor-associated neoangiogenesis is a crucial target for antitumor therapies. Thalidomide (TAL) is a promising anti-neoangiogenetic drug that has recently been used in the treatment of several malignancies in dogs. Objectives: The aim of the study was to assess the pharmacokinetics of TAL after single oral administration in dogs. Additionally, the influence of feeding on the pharmacokinetic profile of TAL in dogs has been preliminarily investigated. Methods: Six healthy adult female Labradors were enrolled according to a randomized single-dose, 2-treatment, 2-phase, paired 2 × 2 cross-over study design. The dogs were administered a single 400 mg capsule of TAL in fasted and fed conditions. Blood was collected from 15 min to 48 h after dosing, and TAL quantified in plasma by a validated high-performance liquid chromatography method. The pharmacokinetics of TAL were analyzed using a non-compartmental approach. Results: TAL concentration was quantifiable up to 10 h and 24 h after fasted and fed conditions, respectively. C_max (fasted, 1.34 ± 0.12 ㎍/mL; fed, 2.47 ± 0.19 ㎍/mL) and T_max (fasted, 3 h; fed, 10 h) differed substantially between the 2 groups. AUC and t_1/2λz were significantly higher in fed (42.46 ± 6.64 mg × h/L; 17.14 ± 4.68 h) compared to fasted (12.38 ± 1.13 mg × h/L; 6.55 ± 1.25 h) dogs. The relative oral bioavailability of TAL for the fasted group was low (36.92% ± 3.28%). Conclusions: Feeding affects the pharmacokinetics of oral TAL in dogs, showing a delayed, but higher absorption with different rate of elimination. These findings are of importance in clinical veterinary settings, and represent a starting point for further related studies.

• 대한방사성의약품학회지
• /
• 제7권2호
• /
• pp.79-84
• /
• 2021

Radiopharmaceuticals are important for tumor diagnosis and therapy. To deliver a radiotracer at the desired target excluding non-targeted tissues is difficult The development of a targeted tracer that has a good clearance profile while maintaining high biostability and biocompatibility is key to optimizing its biodistribution and transport across biological barriers. Improving the hydrophilicity of radiotracers by PEGylation can reduce serum binding, allowing the tracer to circulate without retention and reducing its affinity for non-targeted tissues. In this study, we synthesized a new benzamido tracer (SnBz-PEG₃₆) with the introduction of a low molecular weight polyethylene glycol unit (PEG₃₆, ~2,100 Da). The tumor targeting efficiency and biodistribution of [¹³¹I]-Bz-PEG₃₆ or radiotracer-loaded liposomes were evaluated after their administration to normal mice or mouse tumor models including CT26 (xenograft) and 4T1 (xenograft and orthotopic). Most of the radiotracer was cleared out rapidly (1-24 h post-administration) through the kidney and there was little tumor uptake.

• 복식문화연구
• /
• 제30권6호
• /
• pp.828-841
• /
• 2022

This study aims to develop a fitted torso pattern suitable for males in their forties and fifties who are obese-a group that accounts for more than fifty percent of men in this age group-using a 3D virtual fitting program. Size Korea's 2022 data for obese males in their forties and fifties is utilized for this study. In terms of the research method, a 3D program (CLO 3D) is used to implement the target group's various body types and to apply fitted torsos that enable verification and evaluation of the pattern's fit and ease. The characteristics of fitted torso patterns for obese bodies are as follows: the front centerline is a profile line; shoulder darts are added by reflecting waist-abdominal protrusion in the front panel; and shoulder, arm, waist, and center-back darts are constructed for the back panel. For obese bodies, the minimum circumference ease amounts should be approximately 6-7cm for the chest, 6cm for the waist, and 6-7cm for the hips. Based on an evaluation of the virtual fit of the developed fitted torso pattern, the data shows that a pattern (foundation) such as this is well suited for obese body types with an average of 4.67/5 points for reverse triangular obesity, an average of 6.67/7 points for log obesity, and an average of 6.69 points for the ease amount.

• 한국음향학회지
• /
• 제25권4호
• /
• pp.184-190
• /
• 2006

최근에 Lee 등은 1차원 수평배열 센서만을 사용하여 다중경로를 통해 들어오는 신호로부터 표적의 3차원 위치를 추정하였다. 그러나 이 기법에서 음속은 수심에 상관없이 일정하다고 가정하였기 때문에 음속이 수심에 따라 다양하게 변화하는 실제 해양환경에서는 그 추정 성능이 현저하게 저하된다. 따라서 본 논문에서는 비균일 음속 환경에 적합한 근거리 표적의 3차원 위치추정 기법을 제안한다. 제안한 기법에서는 선형의 음속구조를 가지는 근거리 다중경로 환경에서 음파전달 모델을 기반으로 한 위치추정함수를 구성하였으며 이로부터 표적의 방위각, 거리 및 깊이를 3차원 탐색을 통하여 추정하였다. 선형 음속구조 및 실제 환경과 유사한 비선형 음속구조를 적용하여 제안한 기법의 성능을 기존의 기법과 비교, 분석하였으며 기존의 기법에 비해 거리 추정 오차는 최대 100m, 깊이 추정 오차는 50m정도 감소됨을 확인하였다.

• 한국포장학회지
• /
• 제29권3호
• /
• pp.223-228
• /
• 2023

Sustainable energy supplies without the recharging and replacement of the charge storage device have become increasingly important. Among various energy harvesters, the triboelectric nanogenerator (TENG) has attracted considerable attention due to its high instantaneous output power, broad selection of available materials, eco-friendly and inexpensive fabrication process, and various working modes customized for target applications. In this study, the amount of voltage and current generated was measured by applying the PSD profile random vibration test of the electronic vibration tester and ISTA 3A according to the time of Anodized Aluminum Oxide (AAO) pore widening of the manufactured TENG device Teflon and AAO. The discharge and charging tests of the integrated module during the random simulated transport environment and the recognition distance of RFID were measured while agricultural products (onion) were loaded into the returnable folding plastic box. As a result, it was found that AAO alumina etching processing time to maximize TENG performance was optimal at 31 min in terms of voltage and current generation, and the integrated module applied with the TENG module showed a charging effect even during the continuous use of RFID, so the voltage was kept constant without discharge. In addition, the RFID recognition distance of the integrated module was measured as a maximum of 1.4 m. Therefore, it was found that the surface condition of AAO, a TENG element, has a great influence on the power generation of the integrated module, and due to the characteristics of TENG, the power generation increases as the surface dries, so it is judged that the power generation can be increased if the surface drying treatment (ozone treatment, etc.) of AAO is applied in the future.

• 지능정보연구
• /
• 제21권4호
• /
• pp.1-16
• /
• 2015

교통사고의 원인을 규명하고 미래의 사고를 방지하기 위한 노력의 일환으로 데이터 마이닝 기법을 이용한 교통 데이터 분석의 연구가 이루어지고 있다. 하지만 기존의 교통 데이터를 이용한 마이닝 연구들은 학습된 결과를 사람이 이해하기 어려워 분석에 많은 노력이 필요하다는 문제가 있었다. 본 논문에서는 많은 속성들로 표현된 교통사고 데이터로부터 유용한 패턴을 발견하기 위해 규칙 학습 기반의 데이터 마이닝 기법인 연관규칙 학습기법과 서브그룹 발견기법을 적용하였다. 연관규칙 학습기법은 비지도 학습 기법의 하나로 데이터 내에서 동시에 많이 등장하는 아이템(item)들을 찾아 규칙의 형태로 가공해 주며, 서브그룹 발견기법은 사용자가 지정한 대상 속성이 결론부에 나타나는 규칙을 학습하는 지도학습 기반 기법으로 일반성과 흥미도가 높은 규칙을 학습한다. 규칙 학습 시 사용자의 의도를 반영하기 위해서는 하나 이상의 관심 속성들을 조합한 합성 속성을 만들어 규칙을 학습할 수 있다. 규칙이 도출되고 나면 후처리 과정을 통해 중복된 규칙을 제거하고 유사한 규칙을 일반화하여 규칙들을 더 단순하고 이해하기 쉬운 형태로 가공한다. 교통사고 데이터를 대상으로 두 기법을 적용한 결과 대상 속성을 지정하지 않고 연관규칙 학습기법을 적용하는 경우 사용자가 쉽게 알기 어려운 속성 사이의 숨겨진 관계를 발견할 수 있었으며, 대상 속성을 지정하여 연관규칙 학습기법과 서브그룹 발견기법을 적용하는 경우 파라미터 조정에 많은 노력을 기울여야 하는 연관규칙 학습기법에 비해 서브그룹 발견기법이 흥미로운 규칙들을 더 쉽게 찾을 수 있음을 확인하였다.

• 전자공학회논문지
• /
• 제50권8호
• /
• pp.253-263
• /
• 2013

광학측정기법 중 주파수 스캐닝 간섭계는 기존 3차원 측정기법과 비교하여 광학 하드웨어 구조가 측정과정동안 고정되어 있어, 대물렌즈나 대상물체의 수직 스캐닝 없이 단지 광원의 주파수만 특정한 주파수 밴드내에서 스캐닝 하여 대상물체에 주사되므로, 우수한 광학 측정 성능을 보인다. 광원의 주파수를 변경하여 간섭계를 통해 간섭 영상을 획득한 후, 밝기 영상 데이터를 주파수 영역 데이터로 변환하고, 고속 푸리에 변환을 통한 주파수 분석을 이용하여 대상 물체의 높이 정보를 계측한다. 하지만, 대상물체의 광학적 특성에 기인한 광학노이즈와 주파수 스캐닝동안 획득되는 영상의 수에 따라 증가하는 영상처리시간은 여전히 주파수 스캐닝 간섭계의 문제이다. 이를 위해, 1) 편광기반 주파수 스캐닝 간섭계가 광학 노이즈에 대한 강인성을 확보하기 위해 제안되어진다. 시스템은 주파수 변조 레이저, 참조 거울 앞단의 ${\lambda}/4$ 판, 대상 물체 앞단의 ${\lambda}/4$ 판, 편광 광분배기, 이미지 센서 앞단의 편광기, 광섬유 광원 앞단의 편광기, 편광 광분배기와 광원의 편광기 사이에 위치하는 ${\lambda}/2$ 판으로 구성된다. 제안된 시스템을 이용하여, 편광을 기반으로한 간섭이미지의 대조대비를 조절할 수 있다. 2) 신호처리 고속화 방법이 간섭계 시스템을 위해 제안되며, 이는 그래픽 처리 유닛(GPU)과 같은 병렬처리 하드웨어와 계산 통합 기기 구조(CUDA)와 같은 프로그래밍 언어로 구현된다. 제안된 방법을 통해 신호처리 시간은 실시간 처리가 가능한 작업시간을 얻을 수 있었다. 최종적으로 다양한 실험을 통해 제안된 시스템을 정확도와 신호처리 시간의 관점으로 평가하였고, 실험결과를 통해 제안한 시스템이 광학측정기법의 실적용을 위해 효율적임을 보였다.