• Asian Pacific Journal of Cancer Prevention
• /
• 제13권11호
• /
• pp.5605-5611
• /
• 2012

Background: In the last two decades, pioneering research on anti-tumour activity of saffron has shed light on the role of crocetin, picrocrocin and safranal, as broad spectrum anti-neoplastic agents. However, the exact mechanisms have yet to be elucidated. Identification and characterization of the targets of bioactive constituents will play an imperative role in demystifying the complex anti-neoplastic machinery. Methods: In the quest of potential target identification, a dual virtual screening approach utilizing two inverse screening systems, one predicated on idTarget and the other on PharmMapper was here employed. A set of target proteins associated with multiple forms of cancer and ranked by Fit Score and Binding energy were obtained from the two independent inverse screening platforms. The validity of the results was checked by meticulously analyzing the post-docking binding pose of the picrocrocin with Hsp90 alpha in AutoDock. Results: The docking pose reveals that electrostatic and hydrogen bonds play the key role in inter-molecular interactions in ligand binding. Picrocrocin binds to the Hsp90 alpha with a definite orientation appropriate for nucleophilic attacks by several electrical residues inside the Hsp90-alpha ATPase catalytic site. Conclusion: This study reveals functional information about the anti-tumor mechanism of saffron bioactive constituents. Also, a tractable set of anti-neoplastic targets for saffron has been generated in this study which can be further authenticated by in vivo and in vitro experiments.

• 한국전자파학회논문지
• /
• 제30권2호
• /
• pp.152-159
• /
• 2019

도플러 레이다는 단일 주파수의 정현파를 이용하므로 움직이는 이동체의 속도만을 측정할 수 있다고 알려져 있다. 일반적으로 이동체의 거리를 측정하기 위해서는 FMCW 레이다나 펄스 레이다를 이용하여야 하는데, 이 경우 하드웨어 구성 및 신호처리가 복잡할 뿐만 아니라, 주파수 대역폭을 넓게 사용하기 때문에 24 GHz나 77 GHz 대역의 밀리미터파를 사용할 수밖에 없어 가격이 비싸다. 따라서 가격이 저렴한 도플러 레이다에서 다중 톤 주파수를 이용하여 이동체의 속도 외에 거리까지 센싱하는 연구가 시작되고 있다. 이에 본 연구에서는 2.4 GHz 도플러 레이다에 내장된 PLL만을 이용한 주파수 조정만으로도 이동체의 거리 센싱이 가능함을 보인다. 특히, 기존에 제안된 DC 기반의 거리 계산에서 필요한 DC 정보를 제거하고, 교류결합된 AC 정보만을 이용하여 거리를 센싱할 수 있음을 보인다. 제안된 기술은 2.4 GHz 대역의 이동체 식별용 특정소출력 무선기기 기술기준을 만족하므로 45 dBm EIRP 출력을 이용하여 이동체 거리 센싱이 필요한 다양한 응용이 가능하다.

• 한국정보통신학회:학술대회논문집
• /
• 한국해양정보통신학회 2005년도 춘계종합학술대회
• /
• pp.565-568
• /
• 2005

RFID 시스템은 사물에 초소형 칩을 부착하여 사물의 정보를 무선 주파수로 전송하는 비접촉식 식별 기술이다. 최근 많은 기업들은 상품에 관한 정보를 자동으로 수집하기 위하여 이와 같은 RFID시스템을 생산 공정 등에 이용하고 있다. 여러 개의 태그들 중 하나와 통신하기 위하여 목표로 하는 태그는 먼저 식별되어야 한다. 이를 위하여 리더는 인식범위 내에 있는 모든 태그들의 식별 코드를 인식하여야 한다. 본 논문에서는 리더의 이전 질의에 대한 이력을 기억할 필요 없이 현재의 질의만을 이용하여 태그가 응답하는 무기억 특성을 갖는 태그 식별 프로토콜인 QT와 QT-sl 프로토콜의 성능을 분석한다.

• International Journal of Advanced Culture Technology
• /
• 제9권3호
• /
• pp.352-359
• /
• 2021

The purpose of this study is to design and build fake news discrimination systems and methods using fact-checking guidelines. In other words, the main content of this study is the system for identifying fake news using Artificial Intelligence -based Fact-checking guidelines. Specifically planned guidelines are needed to determine fake news that is prevalent these days, and the purpose of these guidelines is fact-checking. Identifying fake news immediately after seeing a huge amount of news is inefficient in handling and ineffective in handling. For this reason, we would like to design a fake news identification system using the fact-checking guidelines to create guidelines based on pattern analysis against fake news and real news data. The model will monitor the fact-checking guideline model modeled to determine the Fact-checking target within the news article and news articles shared on social networking service sites. Through this, the model is reflected in the fact-checking guideline model by analyzing news monitoring devices that select suspicious news articles based on their user responses. The core of this research model is a fake news identification device that determines the authenticity of this suspected news article. So, we propose news article identification methods with fact-checking guideline on Artificial Intelligence & Bigdata. This study will help news subscribers determine news that is unclear in its authenticity.

• 동의생리병리학회지
• /
• 제34권6호
• /
• pp.362-371
• /
• 2020

In order to find out the relationship between the Eight Principle Pattern Identification of Yin-Yang, Exterior-Interior and the Sasang constitution, we analyzed the clinical data from 500 women with menstrual pain and women without menstrual pain. In the previous study, the subject's information of Typology Complexion Pulse and Symptom was collected, and Eight Principle Pattern Identification was executed based on this. Later, The relationship between the Sasang constitution and the Eight Principle Pattern Identification was statistically analyzed. The obvious difference between the experimental group and the control group in the patterns of Yin-Yang and Exterior-Interior is that patients who complain of menstrual pain do not maintain harmony with the yin-yang ratio, it can be said that the patterns of Yin-Yang and Exterior-Interior can be a identification standard that significantly obscures the condition of the disease. There was a significant difference between the Sasang constitution and the Eight Principle Pattern Identification of Yin-Yang. There was no significant difference between the Sasang constitution and the Eight Principle Pattern Identification of Exterior-Interior. It is assumed that the relationship between the Eight Principle Pattern Identification and the Sasang constitution has changed depending on the difference a view of emotional Qi and pathogenic Qi.

• 안보군사학연구
• /
• 통권1호
• /
• pp.191-229
• /
• 2003

Multi-sensor data fusion techniques combine evidences from multiple sensors in order to get more accurate and efficient meaningful information through several process levels that may not be possible from a single sensor alone. One of the most important parts in the data fusion system is the identification fusion, and it can be categorized into physical models, parametric classification and cognitive-based models, and parametric classification technique is usually used in multi-sensor data fusion system by its characteristic. In this paper, we propose a novel heuristic identification fusion method in which we adopt desirable properties from not only parametric classification technique but also cognitive-based models in order to meet the realtime processing requirements.

• 비파괴검사학회지
• /
• 제30권6호
• /
• pp.527-538
• /
• 2010

This paper presents a nondestructive evaluation approach for system identification (SID) of real railway bridges using field vibration test results. First, a multi-phase SID scheme designed on the basis of eigenvalue sensitivity concept is presented. Next, the proposed multi-phase approach is evaluated from field vibration tests on a real railway bridge (Wondongcheon bridge) located in Yangsan, Korea. On the steel girder bridge, a few natural frequencies and mode shapes are experimentally measured under the ambient vibration condition. The corresponding modal parameters are numerically calculated from a three-dimensional finite element (FE) model established for the target bridge. Eigenvalue sensitivities are analyzed for potential model-updating parameters of the FE model. Then, structural subsystems are identified phase-by-phase using the proposed model-updating procedure. Based on model-updating results, a baseline model and a nondestructive evaluation of test bridge are identified.

• 한국미생물·생명공학회지
• /
• 제28권2호
• /
• pp.124-127
• /
• 2000

Beneficial bacteria, which have been used for medical purpose and for medicines for treating intestinal disorders, include strains of Bifidobacterium sp., Lactobacillus sp., Enterococcus sp., Clostridium butyricum, Lactobacillus sporogenes, Bacillus subtilis, Bacillus polyfermenticus and the like. Bacillus polyfermenticuss SCD with is commonly called as Bispan strain has been appropriately used for the treatment of long-term intestinal disorders, since the live strains in the form of active endospores can successfully reach the target intestine. In this study, the identification and characterization of Bispan strain was done using SEM observation, API 50CHB kits, isoprenoid quinone analysis, and fatty acid analysis. These results suggest that Bispan strain is very similar to Bacillus subtilis.

• 한국미생물·생명공학회지
• /
• 제23권2호
• /
• pp.123-130
• /
• 1995

DNA topoisomerase I have been shown to be important therapeutic target in cancer chemotherapy. Chemotaxonomy and numerical identification were carried out for an isolate strain No.7489 producing an antibiotic that inhibits DNA topoisomerase I activity. The genus of strain No.7489 was determined as Streptomyces sp. from culture, morphological and chemotaxonomic data. Thirty-nine taxonomic unit characters were tested and the data were analyzed numerically using the TAXON program. The isolate was best matched to Streptomyces melanosporofaciens in the major cluster 32 of Streptomyces. Therefore, it was concluded that the isolate was identified to be a member of Streptomyces melanosporofaciens.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2001년도 춘계학술대회논문집
• /
• pp.786-792
• /
• 2001

In this paper, the identification of connections for a vibration system has been presented using FRF-based substructural sensitivity analysis. The substructural design sensitivity formula is derived and plugged into a commercial optimization program, MATLAB, to identify connection stiffness of an air-conditioner system of passenger car. The air-conditioner system, composed of a compressor and a bracket is analyzed by using FRF-based substructural(FBS) method. To obtain the FRFs, FE model is built for the bracket, and the impact hammer test is performed for the compressor. Obtained FRFs are combined to calculate the reaction force at the connection point and the system response. Connection element properties are determined by minimizing the difference between a target FRF and calculated one. It is shown that the proposed identification method is effective even for a real problem.