• 한국산학기술학회논문지
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• 제22권4호
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• pp.554-562
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• 2021

본 연구는 김치로부터 β-glucosidase 생산하는 Lactobacillus plantarum SM4를 분리하여 흰 민들레 발효를 수행하고 미백과 주름개선 효과를 가지는 생리활성 평가를 위해 총 폴리페놀 함량, 플라보노이드 함량, 항산화 활성, 타이로시네이즈 활성저해, 콜라게네이즈 활성저해, 자외선 차단율을 분석하였다. 흰 민들레 발효물의 총 폴리페놀 함량이 41.8±0.26 mg GAE/g DW로 열수추출물 21.4±0.67 mg GAE/g DW에 비해 2배 가량 증가하였으며 항산화 활성은 65.6±4.7%로 4배 증가하였다. 미백과 주름개선의 지표인 타이로시나아제 및 콜라게네이즈 활성저해에 있어 흰 민들레 발효물이 87.9±4.73%와 66.7±3.48%로 열수추출물에 비해 각각 2.4배와 1.5배 증가한 결과를 보였다. 흰 민들레 발효물과 열수추출물의 자외선 차단 효과를 비교하였을 때, UVA(320 nm) 차단율이 각각 64.7%와 15.2%로 측정되어 흰 민들레 발효물이 열수추출물에 비해 더 높은 효과를 나타내어 김치로부터 분리한 L. plantarum SM4가 생산하는 β-glucosidase를 발효를 통해 피부 미백, 주름 방지, 자외선 차단 효과가 증진됨을 확인하였다.

• Archives of Pharmacal Research
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• 제14권1호
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• pp.68-72
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• 1991

The polysaccharide fraction from Taraxii Herba showed potent immunopotentiating activities with antitumor activities. The fraction having small amount of protein inhibited the growth of solid tumor and increased peritoneal exudate cells and immunoorgan weights in normal mice, and also increased hypersensitivities in tumor bearing mice.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.318-319
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• 2010

• 한국자원식물학회지
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• 제25권6호
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• pp.731-738
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• 2012

Dandelion has been widely utilized for medicinal and edible purposes. This research was conducted to evaluate the effect of supplemental LED (light-emitting diode) light on germination, growth characteristics and anthocyanin content of dandelion (Taraxacum officinale) seedling using LED blue (460 nm), red (660 nm, R), blue + red (B:R=6:4) and fluorescent lamp light treatment. By LED illumination to T. officinale seed germination speed was delayed, and germination rate was the highest in the fluorescent light. The growth characteristics (plant height, number of leaves, root length and fresh weight) were greatly influenced by supplemental LED light compared with control treatment, and the growth promotion was the most effective in the red LED illumination. After 60 days of red and mixed LED light treatments, anthocyanin content of dandelion plants was significantly changed. The anthocyanin content was increased by 12~19 mg/100 g under the red LED and the mixed light conditions compared with the control and the blue LED. Results indicate that illumination with red and mix LEDs, compared with other light treatments, is beneficial for promotion of growth and anthocyanin content in dandelion.

• 동아시아식생활학회지
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• 제21권6호
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• pp.882-887
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• 2011

민들레 뿌리를 이용한 기능성 약주 개발의 기초 자료로 활용하고자 민들레 뿌리를 각각 0, 5, 10, 15%로 첨가하여 민들레 약주(기본적특성: pH 4.0~4.2, 산도4.6~4.8%, 알코올14.92~15.78%, 민들레 뿌리 5% 첨가한 약주를 가장 선호함)의 총 플라보노이드와 총 폴리페놀 함량 및 DPPH 라디칼 소거 활성을 이용한 항산화력을 측정하였으며, 활성 산소종 및 유리기에 전자를 공여하는 환원력을 조사하였다. 총 플라보노이드와 총 폴리페놀 함량은 민들레 뿌리 분말 첨가 비율이 증가할수록 높아졌다. 또한, DPPH 라디칼 소거 활성과 환원력에서도 민들레 뿌리 가루의 첨가비율이 높을수록 증가하였다. 이상의 결과로 보아 민들레 뿌리 가루를 첨가한 약주는 높은 생리활성물질과 항산화 활성을 가지고 있어 기능성 약주로서 개발이 가능하리라 판단된다.

• Asian-Australasian Journal of Animal Sciences
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• 제25권10호
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• pp.1439-1444
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• 2012

A total of 144 pigs ((Landrace${\times}$Yorkshire)${\times}$Duroc)] with an average initial BW of $8.45{\pm}0.57$ kg were used in a 5-wk growth trial. Pigs were randomly allocated to 4 treatments with 9 replications per pen in a randomized complex block design. Dietary treatments included: i) CON (basal diet), ii) ANT (CON+tylosin 1 g/kg), iii) H1 (CON+H. cordata 1 g/kg) and iv) T1 (CON+T. officinale 1 g/kg). In this study, pigs fed the ANT and T1 treatment had a higher (p<0.05) average daily gain (ADG) and gain:feed (G:F) ratio than those fed CON and H1 treatment. Dietary ANT and T1 treatment led to a higher energy digestibility than the CON group. No difference (p>0.05) was observed on the growth performance and apparent total tract digestibility with H1 supplementation compared with the CON treatment. The inclusion of ANT treatment led to a higher (p<0.05) lymphocyte concentration compared with the CON treatment. Dietary supplementation of herbs did not affect (p>0.05) the blood characteristics (white blood cell (WBC), red blood cell (RBC), IgG, lymphocyte). No difference was observed on (p<0.05) fecal microbial shedding (E. coli and lactobacillus) between ANT and CON groups. Treatments H1 and T1 reduced the fecal E. coli concentration compared with the CON treatment, whereas the fecal lactobacillus concentration was not affected by the herb supplementation (p>0.05). In conclusion, the inclusion of T. officinale (1 g/kg) increased growth performance, feed efficiency, energy digestibility similarly to the antibiotic treatment. Dietary supplementation of T. officinale and H. cordata (1 g/kg) reduced the fecal E. coli concentration in weaning pigs.

• 대한본초학회지
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• 제25권4호
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• pp.77-84
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• 2010

Objectives : Taraxaci Herba et Radix (THR) is widely used as a food and medicinal herb in Korea. It has been used for treatment of virus inflammatory disease, liver diseases and gastritis. So far, anti-inflammatory effects and constituents of various species in THR has not been studied for comparison. The aim of this study is to compare the anti-inflammatory effects of the aerial part and root from various THR. Also, we have compared the contents of its known constituents with each. Methods : In this study, we estimated anti-inflammatory effect and compared their constituent by HPLC. For the determination of anti-inflammatory effects, we investigated NO and $PGE_2$ production by ELISA. The expressions of iNOS was determined by western blotting in LPS-induced RAW 264.7 macrophage cells. And, standard compounds which are methyl gallate, gallic acid, syringic acid and esculetin of THR were analyzed by HPLC using a $C_{18}$ column. Results : Methanol extracts of THR decreased NO and $PGE_2$ production. The expressions of iNOS protein were also decreased in methanol extracts of THR. As a result, HPLC analysis showed that they showed similar patterns. Methyl gallate and esculetin showed the highest content. Methyl gallate was included over 10% content in each aerial part and root of THR. Conclusions : These results indicate that most of THR distributed in Korea might represent therapeutic agent for treatment of inflammatory diseases.

• Preventive Nutrition and Food Science
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• 제13권4호
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• pp.269-275
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• 2008

Dandelion (Taraxacum officinale) has been widely used as an anti-inflammatory agent in oriental medicine. In the current study, we investigated the protective effect, and the possible mechanism, of dandelion extracts against ethanol-induced acute hepatotoxicity in C57BL/6 mice. Dandelion water and ethanol extract was administered at 2 g/kg body weight (BW) once daily for 7 consecutive days, whereas control and ethanol groups received water by gavage. Ethanol (50% ethanol; 6 g/kg BW) was administered 12 hr before sacrificing the mice in order to generate liver injury. Significantly increased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities as well as liver triglyceride (TG) and cholesterol levels were attenuated by dandelion supplementation. In addition, dandelion extracts not only enhanced alcohol dehydrogenase (ADH) and anti-oxidative enzyme activities, but reduced lipid peroxidation. Cytochrome P450 2E1 (CYP 2E1), one of the critical enzymes xenobiotic metabolism, expression was lower with ethanol treatment but restored by dandelion supplementation. These results were confirmed by improved histopathological changes in fatty liver and hepatic lesions induced by ethanol. In conclusion, dandelion could protect liver against ethanol administration by attenuating of oxidative stress and inflammatory responses.

• 한국콘텐츠학회논문지
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• 제13권1호
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• pp.287-293
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• 2013

민들레는 한방에서 산화방지, 위장 점막 보호 및 담즙 등에 탁월한 효과가 있다고 알려져 있다. 민들레 잎과 뿌리에서 추출한 물질을 SD Rat에 투여한 후 10Gy 방사선 조사 후에 생존율, 혈액변화, 소장조직변화 및 간 조직 변화를 관찰하였다. 관찰결과 민들레 추출물을 투여한 실험군에서 생존율이 4배 이상 높았으며 백혈구, 혈소판 등의 혈액변화에서도 뚜렷한 차이가 보였다. 또한 소장 조직 관찰결과 소장점막세포 소멸 억제 및 소장 점막근판 조직의 염증과 공포가 감소되었다. 따라서 민들레 추출물이 방사선 조사에 따른 혈액구성세포와 소장 조직 손상에 대한 방사선 방호효과를 확인하였다.

• 한방안이비인후피부과학회지
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• 제6권1호
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• pp.15-29
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• 1993

Yenhwagamchotang has been widely used in treatment of inflammatory disease which is based on Oriental Medical literatures. These studies were attempted experimental effects of Yenhwagamchotang(sample A), Yenhwagamchotang plus Forsythia koreana NAKAI.(sample B), and Yenhwa-gamchotang plus Taraxacum mongolicum HAND- MAZZ(sample C),on the Anti-allergic reaction, the antipyretic action,the anti-inflammatory and the analgesic action,in rats. THe results of the studies were as follow: 1. Vascular permeability responses to intradermal serotonin in rats were showed significant effect at all sample groups. 2. The homologous passive cutaneous anaphylaxis in rats provoked by the IgE-like antibody aganist egg white albumin showed the decreasing effect. 3. The delayed type hypersensitivity responses to picryl chloride in mice were showed significant effect at all sample groups. 4. The delayed type hypersensitivity response to sheep red blood cell in mice were showed significant effect at all sample groups. 5. In anti-pyretic effect by yeast method were showed significant effect at all sample groups. 6. The anti-inflammatory effect by carrageenin method were showed significant effect at all sample groups. 7. The analgesic action by acetic acid method in mice were showed significant effect at all sample groups. According to the above result, Yenhwagamchotang(sample A), Yenhwagamchotang plus Forsythia koreana NAKAI(sample B), AND yenhwagamchotang plus Taraxacum mongolicum HNAN- MAZZ.(sample C ) were concluded to have the anti-allergic reaction, the antipyretic action, the anti-inflammatory, the analgesic action.