Browse > Article
http://dx.doi.org/10.5392/JKCA.2013.13.01.287

Radioprotective Effects of Dandelion(Taraxacum officinale)  

Choi, Jun-Hyeok (인제대학교 방사선방재센터)
Ji, Tae-Jeong (가야대학교 방사선학과)
Min, Byung-In (인제대학교 원자력응용공학부)
Publication Information
The Journal of the Korea Contents Association / v.13, no.1, 2013 , pp. 287-293 More about this Journal
Abstract
Dandelion(Taraxacum officinale), an oriental herbal medicine, has been shown to favorably affect choleretic, antioxidative and protection of gastric mucosa. The protective effects of common dandelion leaf and root extract were investigated by irradiation in Sprague-Dawley rats. Male SD rats, 6weeks, were orally injected with dandelion extract(100mg/kg) for 10days. Immediately after final injection, rats were whole body irradiated with 10Gy used irradiation facility(Elekta Linac, Sweden). At 24h-15days after irradiation, complete blood counted test and apoptosis in jejunal crypt cell. Stimulated recovery by the extract was observed in platelet but was not showed in the erythrocyte and leucocyte. The jejunal crypt cells were protected significantly(p<0.05) and the radiation-induced apoptosis was reduced(p<0.05). The survival rate were carried for 15days, the survival ratio was 15% and 85% for the control and experimental group. Observations intestinal inhibition of cell death, intestinal mucosa and tissue decreased systemic inflammation and vacuole. Base on these data, we propose that dandelion may be a useful radioprotector, especially since it is a relatively nontoxic natural product.
Keywords
Dandelion; Platelet; Jejunal Crypt; Apotosis; Radioprotector;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 J. Hall and S. Angele. "Radiation, DNA damage and cancer," Mol Med Today, Vol.5, No.4, pp.157-164, 1999.   DOI   ScienceOn
2 C. Stewart and H. Bushong, Radiologic science for technologist. Mosby Pub, 1984.
3 S. Y. Cho, J. Y. Park, and E. M. Park, "Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocininduced diabetic rats by supplementation of dandelion water extract," Clin Chim Acta, Vol.317, pp.109-117, 2002.   DOI   ScienceOn
4 H. Y. Kil, W. S. Oh, and K. H. Hong, "Effect of fentanyl on the TNF-$\alpha$ and IL-$1\beta$ level during global ischemia/reperfusion in rats," J of Korean Anesthesiology, Vol.38, pp.546-558, 2000   DOI
5 홍석화. 한국의 토종 101가지, 웅진출판사, 1990.
6 K. S. Yang, and C. M. Jeon, "Effect of Taraxacum coreanum nakai on low density lipoprotein oxidation," J of Korea Pharmacogn Vol.27, pp.267-273, 1996.   과학기술학회마을
7 J. Y. Park, C. M. Park, and J. J. Kim, "Hepatoprotective Activity of Dandelion (Taraxacum officinale) Water Extract against D-Galactosamine-induced Hepatitis in Rats," J of Korea Soc Food Sci Nutr, Vol.37, No.2, pp.177-183, 2008.   과학기술학회마을   DOI   ScienceOn
8 A. W. Christine, G. Fiona, and G. Jenny, "Flavonoids, cinnamic acid and coumarins from different tissues and medical preparations of Taraxacum officinale," Phytochemistry, Vol.42, pp.121-126, 1996.   DOI   ScienceOn
9 R. Hans-Willi, and H. Jai-tung, "Taraxaoside, A type of acylated γ-butyrolactone glycoside from Taraxacum officinale," Phytochemistry, Vol.24, pp.1557-1562, 1985.   DOI   ScienceOn
10 황완균, 오인세, 이무택, "좀민들레의 약효 성분(I) 좀민들레 지상부의 Phenol 성분", 생약학회지, 제25권, 제3호, pp.209-213, 1994.   과학기술학회마을
11 임광식, 최영호, 이상록, "Ixaria속 식물의 약화학적 연구", 부산대학교약학연구지, 제28권, 제1호, pp.1-6, 1991.
12 B. Sredni, M. Albeck, and G. Kazimirsky, "The immunomodulator AS101 administered orally as a chemoprotective and radioprotective agent," J of International Immunopharmacol, Vol.4, No.4, pp.613-619, 1992.
13 R. Neta, "Role of cytokines in radioprotection," Pharmacol Ther. Vol.39, pp.261-267, 1991.
14 김성호, 안미라, 나승렬, "방사선 조사 마우스에서 소장움세포 apoptosis 발생에 미치는 생약의 효과", 방사선방어학회지, 제26권, 제1호, pp.27-33, 2001
15 지태정, 이상훈, "프로폴리스 복강 주사 후 소장 흡수상피조직의 방사선 손상기전과 방어효과", 한국컨텐츠학회논문지, 제10권, 제7호, pp.297-304, 2010.