• 한국수의병리학회:학술대회논문집
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• 한국수의병리학회 2002년도 추계학술대회초록집
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• pp.146-146
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• 2002

Hepatic disease has been noted and reported for involvement various detrimental factors. Among many detrimental injury factors, alcohol has been noted for hepatitis, fatty liver, fibrosis, and hepatic cirrhosis. The purpose of this study is to develop animal model for hepatic fibrosis in pig with ethanol, and to search new anti-fibrogenic agent. Twelve male Landrace pigs were divided into 3 groups of 4 animals each. Group 1, 2 and 3 were fed with ceramic water only, ceramic water + liquid diet containing 20％ ethanol and normal tap water + containing 20％ ethanol for 12 weeks, respectively. At week 12, all pigs were immediately sacrificed for collection each tissue and blood. Serologically, serum ALT and AST levels were significantly reversed in group 2, comparing to group 3. They were normal range in pigs of group 1. Microscopically, macrovesicular lipid droplets and moderate necrosis were evident in the tap water + ethanol fed group 3. However, ceramic water intake group 1 showed normal. Moreover, in group 3, little fatty changes and mild necrosis were observed. Collagen fibers were detected in the spaces of surrounding periportal and interlobular areas in the group 3 of tap water + ethanol, but collagen synthesis and its thickness of fibrotic septa connecting portal tracts was markedly reduced in the group 2 of ceramic water + ethanol. In immunohistochemistry, myofibroblasts were detected in the ethanol and tap water treated group 3. No or a few myofibroblasts were observed in groups 1 and 2. CYP 2E1 was rarely detected in group 1 fed ceramic water. However, group 2 showed slightly activation of CYP 2E1 in the area of pericentral, while CYP 2E1 was significantly activated in group 3 fed tap and ethanol. Taken together above, alcohol fibrosis model in pig was established. Furthermore, ceramic water had an inhibitory and protecting ability for alcohol-induced hepatic damages.

• Archives of Pharmacal Research
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• 제29권5호
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• pp.418-423
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• 2006

Tabanus anticoagulant protein (TAP) was isolated from the whole body of the tabanus, Tabanus bivittatus, using three purification steps (ammonium sulfate fractionation, gel filtration on Bio-Gel P-60, and ion exchange chromatography on DEAE Sephadex gel). The purified TAP, with a molecular weight of 65 kDa, was assessed to be homogeneous by SDS-polyacrylamide gel electrophoresis, and an isoelectric point of 7.9 was determined by isoelectric focusing. The internal amino acid sequence of the purified protein was composed of Ser-Leu-Asn-Asn-Gln-Phe-Ala-Ser-Phe-lle-Asp-Lys-Val-Arg. The protein was activated by $Cu^{2+}\;and\;Zn^{2+}$, and the optimal conditions were found to be at pH $3\sim6\;and\;40\sim70^{\circ}C$. Standard coagulation screen assays were used to determine thrombin time and activated partial thromboplastin time. Chromogenic substrate assays were performed for thrombin and factor Xa activity. TAP considerably prolonged human plasma clotting time, especially activated partial thromboplastin time in a dose-dependent manner; it showed potent and specific antithrombin activity in the chromogenic substrate assay. Specific anti-factor Xa activity in TAP was not detected. Overall, this result suggested that TAP has significant anticoagulant activity on blood coagulation system.

• 한국동물위생학회지
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• 제26권4호
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• pp.345-359
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• 2003

A number of toxicants have been incriminated as a causing hepatic disease. Among many detrimental injury, alcohol has been noted for hepatitis, fatty liver, fibrosis, and hepatic cirrhosis. The purpose of this study was to develop animal model for hepatic fibrosis in pigs fed ethanol, and to search for a new anti-fibrogenic agent via this model. Twelve male Landrace pigs were divided into 3 groups of 4 animals each. Group 1, 2 and 3 were fed with active ceramic water only, ceramic water + liquid diet containing 15% ethanol and normal tap water + liquid diet containing 15% ethanol for 12 weeks, respectively. At week 12, all pigs were immediately sacrificed for collection each tissue and blood. Serologically, serum ALT and AST levels were significantly reversed in group 2, as compared to group 3. They were normal range in pigs of group 1. Microscopically, macrovesicular lipid droplets and moderate hepatocellular necrosis were evident in the tap water + ethanol fed group 3. However, the active ceramic water treated group 1 showed normal architecture. Moreover, in group 2, mild fatty changes and necrosis were observed in hepatocytes. Collagen fibers were increased in spaces surrounding periportal and interlobular connective tissues in the group 3 of tap water + ethanol, but collagen synthesis and its thickness of fibrotic septa connecting portal tracts were markedly reduced in the group 2 of ceramic water + ethanol. Myofibroblasts were detected mainly in the interlobular connective tissues of pig liver of group 3 treated ethanol and tap water. Few to no myofibroblasts were observed in groups 1 and 2. CYP2E1 was not or rarely detected in group 1 fed ceramic water. However, group 2 showed slightly activation of CYP2E1 in the area of pericentral vein, while CYP2E1 was significantly activated in group 3 fed tap water and ethanol. Based on the above data, we believe that we have developed a unique alcohol induced fibrosis model in pig, which will be useful in developing anti-fibrotic agents and drugs. Furthermore, the active ceramic water used in our study had an inhibitory and may be protective against ethanol induced hepatic toxicity and fibrosis.

• 한국통신학회논문지
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• 제37권6A호
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• pp.464-472
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• 2012

본 논문에서는 연속된 프레임을 갖는 영상의 프레임간 움직임 추정 기법을 응용하여 고해상도 영상을 생성하는 초해상도 기법을 제안한다. 단일 영상을 이용한 초해상도 기법의 경우 영상에서의 고주파 대역을 찾기 위해 확률 및 이산 웨이블릿 변환(discrete wavelet transform: DWT) 기반 등 다양한 방법이 제시되었으나, 연산에 사용할 수 있는 정보가 제한적이라는 문제가 존재한다. 이러한 문제를 해결하기 위해 연속된 프레임을 이용한 초해상도 기법이 다양하게 제안되었다. 연속 프레임 기반 초해상도 기법의 핵심인 입력 저해상도 영상 간 정합(registration)의 정확도는 초해상도 기법의 결과에 큰 영향을 갖는다. 본 논문에서는 영상 간 정합의 정확도를 높이기 위하여 6-tap FIR(finite impulse response) 필터를 부화소(sub-pixel) 단위의 정합에 사용한다. 실험을 통하여 제안하는 기법의 결과영상이 기존의 최단입점(nearest neighborhood), 이중선형(bi-linear), 고등차수(bi-cubic) 보간법 보다는 우수하고 DWT 기반의 초해상도 기법과는 비슷한 성능을 가진다는 것을 확인할 수 있었다.

• 한국환경교육학회지:환경교육
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• 제17권2호
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• pp.60-78
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• 2004

A survey performed on property of water usage, a recognition and stand on water, and awareness of practice related to water saving among primary and secondary teachers in Daegu metropolitan city leads to the following result. First, regarding the actual condition of water usage, boiled tap water was most preferred, followed by purified tap water, mineral water, and water from a mineral spring respectively. Second, the result of a survey regarding a recognition and stand on water presents that the quality of purified water and mineral water is generally trusted, not including tap water. A majority of teachers barely had any ideas on the process of tap water supplies and sewage disposal system. Third, another survey was performed to determine whether there's a gender difference on a general recognition of and stand on water usage, actual practice of water saving and love for water. As a result, 7 out of 25 questions showed the difference of significance by p<.05. As for tap water service and sewage disposal system, there were differences on 5 out of 6 questions, indicating that male teachers are more knowledgable than their female counterparts. Fourth, the result of the research about the recognition and attitudes about water and water saving of the teachers who were categorized by the age group showed that 14 questions of the 25 questions had differences in p<.05 level. Teachers in their twenties and thirties had less interest than those in their forties and fifties.

• 한국지하수토양환경학회지:지하수토양환경
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• 제16권1호
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• pp.12-18
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• 2011

To investigate the natural reduction characteristics of radon with a short half-life (3.82 day) in drinking Qgroundwater, we analyzed the changes of radon concentrations of groundwater, waters in storage tanks, and tap waters from the small-scale groundwater-supply systems (N = 301) by LSC (Liquid Scintillation Counter). We also analyzed the concentrations of uranium (half-life 4.5 billion years) in the waters by ICP/MS to compare with natural reduction of radon concentration. The radon concentrations of 68 groundwater-supply systems occupying 22.6% of the total samples exceeded the US EPA's Alternative Maximum Contaminant Level (AMCL : 4,000 pCi/L), with the average radon concentration of 7,316 pCi/L (groundwaters), 3,833 pCi/L (tank waters) and 3,407 pCi/L (tap waters). Compared to the radon levels of pumped groundwaters, those of tank and tap waters naturally reduced significantly down to about 50%. Especially, in case of 29 groundwater-supply systems with the groundwater radon concentrations of 4,000~6,000 pCi/L, average radon concentrations of the tank and tap waters naturally decreased down to the AMCL. Therefore this study implies that radon concentrations of drinking groundwater can be effectively reduced by sufficient storage and residence in tanks.

• 한국물환경학회지
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• 제20권3호
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• pp.281-289
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• 2004

Optimal analytical conditions have been established for mixing and reaction coil length, concentrations of ECR, CTAB, and acetate, reaction temperature and pH in the determination of aluminum by using flow injection analysis(FIA). Detection limit and repeatability for this system were $3{\mu}g/L$ and better than 1% of relative standard deviation, respectively. The interference from iron(III) was suppressed up to 6mg/L of iron(III) by $0.1{\mu}M$ ascorbic acid, and the interference from fluoride could be tolerated in absorption of Al/ECR/CTAB derivative by 10mM boric acid at pH 3.5 adjusted with nitric acid. This FIA system was applied to the determination of aluminum leached from cooking utensils by distilled and tap water containing fluoride ranged from 0.5 to 2mg/L by measurement of absorbance for Al/ECR/CTAB at 585nm. The leached aluminum content was increased with increasing concentration of fluoride. The aluminum contents leached from aluminum utensils by tap water were about 9 fold higher than those leached by distilled water, whereas aluminum contents leached by distilled water containing fluoride were about 2 fold higher compared to those leached by distilled water. That represented that other dissolved substances as well as fluoride in tap water contributed to liberation of aluminum from aluminum utensils. A comparison between FIA data and ICP-AES data by correlation and paired t test showed that the FIA system could be accepted as a good alternative method for the determination of aluminum in tap water.

• 한국전자파학회논문지
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• 제30권6호
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• pp.445-451
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• 2019

본 논문은 고출력 RF load 중 간단한 구조를 갖는 UHF 대역의 수냉식 RF load를 설계하였다. RF 정합에 영향을 주는 물성을 얻기 위한 수식을 정립 후, load에 채어줄 수돗물의 유전율과 $tan{\delta}$(Loss tangent)을 측정하였다. 또한, 높은 출력의 전자파가 인가될 경우, 수돗물의 온도가 올라가기 때문에 온도의 변화에 따른 유전율과 $tan{\delta}$의 변화도 측정하였다. Water-load의 길이를 줄이기 위해 molybdate를 수돗물과 혼합시켜 주어 농도에 따른 물성 변화도 측정하였다. 측정 결과, 일반 냉각수에 비해서 혼합물의 경우 $tan{\delta}$ 값이 약 26배 증가함을 확인하였다. 이를 바탕으로 수냉식 RF load를 제작하였고, 주파수 460 MHz에서 반사계수 -19 dB, 대역폭 15 %의 우수한 결과를 얻었다.

• Restorative Dentistry and Endodontics
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• 제46권4호
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• pp.52.1-52.11
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• 2021

Objectives: This study evaluated the effects of low and moderate concentrations of triple antibiotic paste (TAP) and double antibiotic paste (DAP) loaded into a hydrogel system on crown discoloration and explored whether application of an adhesive bonding agent prevented crown discoloration. Materials and Methods: Intact human molars (n = 160) were horizontally sectioned 1 mm apical to the cementoenamel junction. The crowns were randomized into 8 experimental groups (calcium hydroxide, Ca[OH]₂; 1, 10, and 1,000 mg/mL TAP and DAP; and no medicament. The pulp chambers in half of the samples were coated with an adhesive bonding agent before receiving the intracanal medicament. Color changes (ΔE) were detected by spectrophotometry after 1 day, 1 week, and 4 weeks, and after 5,000 thermal cycles, with ΔE = 3.7 as a perceptible threshold. The 1-sample t-test was used to determine the significance of color changes relative to 3.7. Analysis of variance was used to evaluate the effects of treatment, adhesive, and time on color change, and the level of significance was p < 0.05. Results: Ca(OH)₂ and 1 and 10 mg/mL DAP did not cause clinically perceivable tooth discoloration. Adhesive agent use significantly decreased tooth discoloration in the 1,000 mg/mL TAP group up to 4 weeks. However, adhesive use did not significantly improve coronal discoloration after thermocycling when 1,000 mg/mL TAP was used. Conclusions: Ca(OH)₂ and 1 and 10 mg/mL DAP showed no clinical discoloration. Using an adhesive significantly improved coronal discoloration up to 4 weeks with 1,000 mg/mL TAP.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 하계학술대회 논문집 B
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• pp.909-911
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• 2002

Rises of current level at power applications, such as transformer, motor, power cable need for using stacked HTS tapes. In this paper, we measured rises of temperature and tap voltage in 4-stacked HTS tapes under over-current condition. We measured 4-stacked HTS tapes properties under over-current condition with a little temperature rise as well as a large temperature rise. Rises of temperature and tap voltage are measured by using E-type thermocouples and voltage taps, respectively. According to the results of measurement, rises of tap voltage under over-current condition with a large temperature rises depends on rises of temperature.