• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5469-5475
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• 2012

Background and Objectives: Acute lymphoblastic leukemia (ALL) is a complex genetic disease involving many fusion oncogenes (FO) having prognostic significance. The frequency of various FO can vary in different ethnic groups, with important implications for prognosis, drug selection and treatment outcome. Method: We studied fusion oncogenes in 101 pediatric ALL patients using interphase FISH and RT-PCR, and their associations with clinical features and treatment outcome. Results: Five most common fusion genes i.e. BCR-ABL t (22; 9), TCF3-PBX1 (t 1; 19), ETV6-RUNX1 (t 12; 21), MLL-AF4 (t 4; 11) and SIL-TAL1 (del 1p32) were found in 89/101 (88.1%) patients. Frequency of BCR-ABL was 44.5% (45/101). BCR-ABL positive patients had a significantly lower survival ($43.7{\pm}4.24$ weeks) and higher white cell count as compared to others, except patients with MLL-AF4. The highest relapse-free survival was documented with ETV6-RUNX1 (14.2 months) followed closely by those cases in which no gene was detected (13.100). RFS with BCR-ABL, MLL-AF4, TCF3-PBX1 and SIL-TAL1 was less than 10 months (8.0, 3.6, 5.5 and 8.1 months, respectively). Conclusions: This is the first study from Pakistan correlating molecular markers with disease biology and treatment outcome in pediatric ALL. It revealed the highest reported frequency of BCR-ABL FO in pediatric ALL, associated with poor overall survival. Our data indicate an immediate need for incorporation of tyrosine kinase inhibitors in the treatment of BCR-ABL+ pediatric ALL in this population and the development of facilities for stem cell transplantation.

• The Journal of the Petrological Society of Korea
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• v.11 no.3_4
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• pp.234-249
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• 2002

The Miwon-Boeun area in the central and northern part of Okcheon metamorphic zone, Korea, is composed of Okcheon Supergroup and Mesozoic Cheongju and Boeun granitoids which intruded it. The Okcheon Supergroup consists mainly of quartzite (Midongsan Formation), meta-calcareous rocks (Daehyangsan Formation, Hwajeonri Formation), meta-psammitic rocks (Unkyori Formation), meta-politic rocks (Munjuri Formation), meta-conglomeratic rocks (Hwanggangni Formation) in the study area, showing a zonal distribution of NE trend. Its' general trend is locally changed into NS to EW trend in and around high-angle fault of NS or NW trend. This study focused on deformation history of the Okcheon Supergroup, suggesting that the geological structure was formed at least by four phases of deformation. (1) The first phase of deformation occurred under ductile shear deformation of top-to-the southeast movement, forming sheath fold or A-type fold, asymmetric isoclinal fold, NW-SE trending stretching lineation. (2) The second phase of deformation took place under compression of NW-SE direction, forming subhorizontal, tight upright fold of M trend in the earlier phase, and formed semi-brittle thrust fault (Guryongsan Thrust Fault) of top-to-the southeast movement and associated snake-head fold in the later phase. (3) The third phase of deformation formed subhorizontal, open recumbent fold through gravitational or extensional collapses which might be generated from crustal thickening and gravitational instability. (4) The fourth phase of deformation formed moderately plunging, steeply inclined kink fold related to high-angle faulting, being closely connected with the local change of NE-trending regional foliation into NS to EW direction of strike in the vicinity of the high-angle fault.

• Journal of Food Hygiene and Safety
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• v.20 no.1
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• pp.64-68
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• 2005

An analytical method of nine synthetic foods colors in Korea, Japan, Joint FAO/WHO Expert Committee of Food Additives (JECFA), and USA were compared. Contents of water insoluble matter in synthetic food colors tested were not different by general test methods of various organs. Contents of chloride and sulfate salts in Food Green No.3, Food Red No.3, Food Blue No.2, and Food Yellow No.4 slightly differed in various methods, and but up to the standard, and general test methods of JECFA and USA needed far more time. For the measurement of arsenic contents in food colors, colorimetric method in Korea and Japan, and silver diethyldithiocarbamate colorimetric method in USA and JECFA were used, but the standards of them were different. Content of heavy metals was up to the standard, but the methods were used colorimetric method in Korea, atomic absorption method in Japan, and both methods in JECFA and USA.

• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.1
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• pp.75-80
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• 2005

This study was carried out to measure the amount of daily intake on three synthetic food red colors (Amaranth: R2, Erythrosine: R3, Allura Red: R40) in foods by Korean. Analysis of three synthetic food red colors was conducted by HPLC with the foods including bread, confection, candy, alcoholic beverage, soft drink, ice cream, chocolate, and chewing gum. Recovery rates from the known concentrations of three standard food red colors which were spiked into foods were ranged from 85.1 to 100.4 (%) for each foods. Total Estimated Daily Intake (∑EDI) was from 0 to 1.632 mg/kg bw/day for each food item and from 0.512 to 7.281 mg/person/day for ages (1∼over 65 years old). The data of average food intake for each food item per person per day were obtained from the report of Korean National Nutrition Survey conducted by the Korea Ministry of Health and Welfare in 2001. Total EDI of each red colors per person per day were showed as follows; 0.742 mg/kg bw/day for R2, 0.391 mg/kg bw/day for R3 and 2.018 mg/kg bw/day for R40 as total amount respectively, and the ranges of these values were 0.5∼7.1% of FAO/WHO's Acceptable Daily Intake (ADI) values. Therefore, the amount of daily intake of three synthetic food red colors in Korea was regarded as safe.

• Economic and Environmental Geology
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• v.48 no.3
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• pp.261-271
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• 2015

Toxicity results of metals, nanoparticles (NPs), and soils contaminated with metals were introduced on this review. Following methods were used: seed germination, bioluminescence, enzyme activity, and mutation. In general, different sensitivities were observed, depending on types of bioassays and pollutants. Among tested seeds, sensitivities of Lactucus and Raphanus were greater than others. Of single metal exposure, effect by As(III) was greater than others, and high revertant mutation ratio (5.1) was observed at 1 mg/L arsenite, indicating high mutagenicity. No general pattern was observed on the effect of metal mixture, but synergistic effect was observed with seeds. In case of soils, no correlation was observed between total metal contents and toxicity. Toxicity of NPs was observed as follows: CuO > ZnO > NiO > $TiO_2$, $Fe_2O_3$, $Co_3O_4$. Especially, no considerable effects were observed by $TiO_2$, $Fe_2O_3$, and $Co_3O_4$ under tested concentration (max. 1,000 mg/L). The evaluation results of interactive toxic effects using various bioassays may comprise a useful tool for the bioassessment of various environmental pollutants.

• Korean Journal of Psychosomatic Medicine
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• v.3 no.1
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• pp.39-48
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• 1995

This study was designed to investigate the role of weight control in the formation of underlying pathology in eating disorder or eating related problems. The subjects were 304 college athletes(Male : 187. Female: 121) and they were divided into two groups according to need for weight control(Weght control group: 110, Weght non control group: 194). The authors used self report questionnaire which was composed of epidemiologic data, food habit scale, eating attitude test, scale for locus of control for weight, scale for food preference and eating behavior. And we also used Eysenck Personality Questionnaire of Korean standardized edition for assessment of personality characteristics, Beck depression inventory, and the scale of hypochondriasis. The results were as follows: 1) Body mass index and the amount of cigarrette smoking and alcohol drinking showed significant differences by sex but not by need for weight control. 2) Eating habit of female athletes was the worst in all athletes. The score of eating attitude test of female athletes was higher than that of male athletes but there was no significant difference by need for weight control. Food preference and eating related behavior was also different by sex. 3) There were no significant differences in all subscales of Eysenck Personality Questionnaire, Beck depression inventory, and the scale of hypochondriasis between two groups which were divided by need for weight control. Neuroticism score was higher in female atheletes and psychoticism score was the highest in weight control male atheletes. 4) There was no significant difference in number of population with abnormal EAT score(to-tal score$\geq$26) between two groups which were divided by need for weight control. 5) The score of eating attitude test had positive correlation with the score of psychoticism and the tendency of depression in weight control male athletes but not in non-weight control male athletes. In non-weight control male athletes, the score of eating attitude test had positive correlation with the score of lie scale. so its correlation is different from those of weight control male athletes. But in female athletes, the score of eating attitude test had significant positive correlation with the score of psychoticism in both groups. In conclusion, these results suggest that the differences of eating traits in athletes are depend upon the sex difference, not upon the need for weight control. and that the role of weight control in eating disorder or abnormal eating attitude differs according to sex.

• Journal of Chest Surgery
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• v.29 no.8
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• pp.861-866
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• 1996

Surgical angioplasty of isolated stenosis of the left main coronary artery(LMCA) restores a more physiologic flow to the myocardium, allows percutdneous transluminal coronary angioplasty (PTCA) of distal coronary stenoses at a later stage, and is a less time consuming and convenient procedure than the conventional coronary artery bypass grafting(CABG) . Between Jul. 1994 and Dec. 1995, 7 surgical angioplasty had been performed. LMCA stenoses involved ostium in 2 patients, middle third in 3, and dis- tal third in 2. In 2 patients, the origin of left anterior descending coronary artery was involved in conjunction with LMCA. T e additional coronary artery stenoses were found in 2 cases. One patient was emergently operated after coronary angiography following his cardiac arrest. LMCA was approached anteriorly in all patients. The pulmonary artery was transected in 3 patients for a better exposure. The onlay patch consisted or autologous or bovine pericardium. There was no postoperative myocardial infarction or mortality. Left ventricular functions were well preserved in all patients. Postoperative coronary angiography revealed widely patent LMCA in 5 cases, and mild narrowing of distal anastomotic sites in 2 cases. Provided that well defined indications are followed correctly, surgical angioplasty can be a safe alternative to conventional CABG.

• Journal of Food Hygiene and Safety
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• v.19 no.4
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• pp.171-175
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• 2004

An analytical method of nine synthetic food colors in Korea, Japan, Joint FAO/WHO Expert Committee of Food Additives (JECFA), and USA were compared. Contents of water insoluble matter in synthetic food colors tested were not different by general test methods of various organs. Contents of chloride and sulfate salts in Food Green No.3, Food Red No.3, Food Blue No.2, and Food Yellow No.4 slightly differed in various methods, and but up to the standard, and general test methods of JECFA and USA needed far more time. For the measurement of arsenic contents in food colors, colorimetric method in Korea and Japan, and silver diethyldithiocarbamate colorimetric method in USA and JECFA were used, but the standards of them were different. Content of heavy metals was up to the standard, but the methods were used colorimetric method in Korea, atomic absorption method in Japan, and both methods in JECFA and USA.

• Journal of Food Hygiene and Safety
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• v.20 no.2
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• pp.73-76
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• 2005

Center for Food Standard Evaluation, Korea Food and Drug AdministrationThis study was performed to compare analytical methods of nine synthetic food colors and six food color lakes in Korea, Japan, Joint FAO/WHO Expert Committee of Food Additives (JECFA), and USA. The experimental protocol of this study consists of three parts: titration method with titanium chloride, gravimetric and spectrophotometric method. To measure the total contents of food colors, Korea and Japan used titration method with titanium chloride, USA used the average value of titration method with titanium chloride equipped with Kipp generator and spectrophotometric method. Also, JECFA used titration method with titanium chloride equipped with KiPP generator. However, All the low organizations used gravimetric method to measure the total content of coloring matter on Food Red No.3. Although all organizations use various methods for analysis of coloring matters, total contents of coloring matter on food colors tested fell into the standard showing $85.08-96.40\%$ in synthetic food colors and $10.00-36.86\%$ in food color lakes.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.14 no.2
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• pp.69-78
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• 1978

It is well known that the aluminizing steel is excellent in corrosion resistance and heat resistance. Therefore it has been used as boiler parts, heat exchanger parts and guide rails which are used under comparatively simple conditions. Recently, it has been noticed that aluminizing steel has high resistance to various atmosphere, high temperature oxidation and seawater resistance. So its usage has been extended widely to the production of parts such as intake and exhaust valve of internal combustion engine, turbine blade and pipelines On ships which required such properties. It is considered that aluminium coated steel is excellent in wear resistance because of high hardness on main ingredient FezAIs of Fe-AI alloy layer existed in diffusion coating layer. And it will beused as a new material taking wear resitance with seawater resistance in marine field. However it is difficult to findout any report concering the wear behaviors or properties of alum in izing steel. In this study the experiment was carried out under the condition of rolling-sliding contact using an Amsler-type wear testing machine at 0.80, 0.91, 1. 10, 1. 25% of slip ratio and 55.43, 78.38, 110.85 kg/mm^2 of Hertz's contact stress in run-in period for the purpose of service-ability test of aluminizing steel as a wear resisting material and obtaining the available design data. The followings are the obtained results from the experimen tal study; 1) The 2nd diffusion material has most excellent wear resistance. This material has brought out about 18% decrease of wear weight in a lower friction load level and 40~G decrease in a higher level comparing to the raw material. 2) Satisfactory effect of wear resistivity cannot be much expected in 2nd diffusion specimens. This is considered due to the formation of fine void in the alloy layer near the boundary to the aluminium layer. 3) Fracture on friction surface of aluminizing steel by the rolling-sliding contact is spalling, and spalling crack occurres initially beneath the specimen surface near the boundary in diffusion coating layer.