• Journal of Pharmaceutical Investigation
• /
• 제36권2호
• /
• pp.137-142
• /
• 2006

A bioequivalence of Daewoong $Alendronate^{TM}$ (Daewoong Pharmaceutical Co., Ltd., Korea) and $Fosamax^{TM}$ tablets (MSD Korea) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). A single 70 mg dose of sodium alendronate of each medicine was administered orally to 56 healthy male volunteers. This study was performed in a $2\;{\time}\;2$ crossover design. Concentrations of alendronate in the urine were monitored by a high-performance liquid chromatography (HPLC). $A_{et}$ (cumulative urinary excreted amount from time 0 to last sampling interval) was calculated by the accumulation of the urinary excreted alendronate. $U_{max}$ (maximum urinary excretion rate) and $T_{max}$ (time to reach $U_{max}$) were compiled from the urinary excretion rate - time data. Analysis of variance was performed using logarithmically transformed $A_{et}$ and $U_{max}$. No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the $A_{et}$ and $U_{max}$ for Daewoong $Alendronate^{TM}/Fosamax^{TM}$ were 0.89-1.12 and 0.82-1.02, respectively. This study demonstrated the bioequivalence of Daewoong $Alendronate^{TM}$ and $Fosamax^{TM}$ with respect to the rate and extent of absorption.

• 유통과학연구
• /
• 제12권11호
• /
• pp.85-100
• /
• 2014

Purpose - Recently, the prevalence of high-speed mobile communication technology (4G) and mobile devices (smart phones, tablet PC, etc.) is leading innovative changes across all fields in society as well as business environments. Furthermore, a diversified mobile application service has spread rapidly through mobile devices such as smart phones and tablet PCs. Accordingly, the traditional E-government services paradigm has rapidly changed into mobile intelligence. To identify the influencing factors on the using intention of G4C smart app services, based on previous studies, the variables that influence using G4C smart app services are defined; these are user cognitive factors (perceived usefulness, perceived easiness), user characteristics factors (user innovativeness, self-efficiency, social influence), service quality factors (convenience, interactivity, accessibility), and system quality factors (instant connectivity, safety). Research design, data, and methodology - This is designed not only to collect data with a questionnaire survey (9/22/13~10/23/13) but also to test hypotheses with SEM by SPSS 21.0 and AMOS 21.0 in both Korea and China. All items are used with Likert 5 scales. A total of 643 questionnaires (Korea 318, China 325) are used. Results - The perceived usefulness and perceived easiness in user cognitive factors have positive influence on using intention. The user innovativeness, self-efficiency, and social factors in user characteristics factors have positive influences on using intention. The convenience, interactivity, and accessibility in service quality factors have positive influences on both reliability and using intention. Safety in system quality has positive influence on both reliability and using intention. Reliability has positive influence on using intention. The control variables (Korea and China) affect its control hypothesis. Strategies and implications are suggested to assist the public using the intention of smartphone's e-government services based on the results of the empirical analysis. The mobile application service can be considered a new emergence of the paradigm just like the government's on-line portal websites appeared in the past. Under this prevailing situation of mobile smart devices, to promote the success of e-government mobile APP services, accurate analysis and understanding of users should precede anything, to provide services to grasp and satisfy users' desire properly. Conclusions - This study proposes implications to help E-governmental officers and companies make strategies. First, this is expected to give some information on the understanding and knowledge regarding the process of G4C smart APP service based on the empirical study. Second, this helps to make future policies and ways about E-government G4C smart APP service. Third, it is proved that super speed mobile communication technology and devices including phones will be crucial to change the structure of E-government services in 2-3 years. Fourth, it is necessary to increase the trust and using intention of users. Fifth, considering what type of environment users are placed in, to present proper public information matching their inclination, is important. Finally, various ways of experiencing service to explore potential users and ceaseless public relations are required.

• Journal of Pharmaceutical Investigation
• /
• 제34권4호
• /
• pp.319-325
• /
• 2004

A bioequivalence of $Etodol^{TM}$ tablets (Yuhan corporation) and $Kuhnillodine^{TM}$ tablets (Kuhnil Pharm. Co., Ltd.) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Single 200 mg dose of etodolac of each medicine was administered orally to 24 healthy male volunteers. This study was performed in a $2{\times}2$ crossover design. Concentrations of etodolac in human plasma were monitored by a high-performance liquid chromatography. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Etodol^{TM}/Kuhnillodine^{TM}$ were 1.01-1.10 and 0.87-1.06, respectively. This study demonstrated a bioequivalence of $Etodol^{TM}$ and $Kuhnillodine^{TM}$ with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
• /
• 제34권6호
• /
• pp.505-511
• /
• 2004

A bioequivalence study of $Bestidine^{TM}$ tablets (Choong Wae Pharma. Corp., Korea) to Dong-A $Gaster^{TM}$ (Dong-A Pharmaceutical Co., Ltd., Korea) tablets was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the famotidine dose of 40 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of famotidine were monitored by a high-performance liquid chromatography for over a period of 12 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the Cmax ratio for $Bestidine^{TM}/Gaster^{TM}$ were log 0.90-log 1.06 and log 0.98-log 1.20, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstrated the bioequivalence of $Bestidine^{TM}$ and $Gaster^{TM}$ with respect to the rate and extent of absorption.

• Journal of electromagnetic engineering and science
• /
• 제17권3호
• /
• pp.126-132
• /
• 2017

In this study, we designed, measured, and analyzed a rearranged L-shape magnetic resonance coupling wireless power transfer (MR-WPT) system for practical applications with laptops. The typical four resonator MR-WPT (Tx part: source loop and Tx coil; Rx part: Rx coil and load loop) is difficult to apply to small-sized stationary and mobile applications, such as laptop computers, tablet-PCs, and smartphones, owing to the large volume of the Rx part and the spatial restrictions of the Tx and Rx coils. Therefore, an L-shape structure, which is the orthogonal arrangement of the Tx and Rx parts, is proposed for indoor environment applications, such as at an L-shaped wall or desk. The relatively large Tx part and Rx coil can be installed in the wall and the desk, respectively, while the load loop is embedded in the small stationary or mobile devices. The transfer efficiency (TE) of the proposed system was measured according to the transfer distance (TD) and the misaligned locations of the load loop. In addition, we measured the TE in the active/non-active state and monitor-open/closed state of the laptop computer. The overall highest TE of the L-shape MR-WPT was 61.43% at 45 cm TD, and the TE decreased to 27.9% in the active and monitor-open state of the laptop computer. The conductive ground plane has a much higher impact on the performance when compared to the impact of the active/non-active states. We verified the characteristics and practical benefits of the proposed L-shape MR-WPT compared to the typical MR-WPT for applications to L-shaped corners.

• 한국실내디자인학회논문집
• /
• 제25권5호
• /
• pp.111-120
• /
• 2016

Unlike the past, brick-and-mortar is no longer on the priority list for the shopping activity. Instead, it is replaced by various non-store shopping alternatives, such as Internet, TV, catalog, mobile, etc. As consumers engage digitally, they made fewer trips to stores. Especially, as mobile shopping made the price comparison possible while shopping in the store, new shopping trend of 'showrooming' came to the fore as the serious issue. In order to cope with the this crisis, many brick-and-mortar retailers utilize omni-channel strategy for their countermeasure. This research paper is to suggest the omni-channel strategy that is applicable for the brick-and-mortar retailers. The results are as follows. First, in order to set up the connected-channel shopping environment, consumers have to be exposed to the environment that can deliver the continuous brand experience under the same price policy, brand and store management, etc, as integrating the various purchasing channels into one. Especially, in-store environment needs to change for the place where consumer experience is stressed for the most as using virtual reality devices with augmented reality technology. Also, the online digital kiosk, and tablet that consumer can order the products through the online channel while shopping in-store Second, the barrier-free in-store environment should be offered in order to increase the consumer convenience. This change will allow consumer communicate with the store environment more effectively. Lastly, brick-and-mortar should extend the physical territory as utilizing the offline's advantage and disadvantage through setting up the digital interactive wall or pop-up store for increasing the opportunity of customer interaction with the store. Moreover, visiting service for the elderly, housewife with the baby, or disabled person will be one of the effective substitute.

• 한국정보통신학회:학술대회논문집
• /
• 한국정보통신학회 2018년도 춘계학술대회
• /
• pp.445-448
• /
• 2018

본 논문에서는 효율적인 통신을 위한 GPS/WiFi용 마이크로스트립 안테나를 설계하였다. 제안된 안테나의 기판은 FR-4(er=4.3)이고 크기는 $40mm{\times}50mm$이며 GPS 주파수대역인 1.6GHz와 WiFi 주파수의 대역인 5GHz의 대역에서 사용할 수 있는 특성을 갖도록 설계하였다 시뮬레이션은 CST Microwave Studio 2014을 사용하였으며 시뮬레이션 결과 이득은 1.6GHz일 때 1.909dB, 5GHz일 때 4.607dB이다. S-Parameter 또한 원하는 주파수 대역에서 -10dB(WSWR2:1) 이하의 결과를 볼 수 있었고, 적은 변수와 가격이 저렴하고 소형화된 안테나를 설계하였다. 최근 스마트폰, 태블릿 PC 등에서도 많이 사용되는 GPS를 WiFi와 결합 및 적용하여 쉽고 편리하게 스마트폰을 활용한 GPS 시스템을 사용가능할 것으로 전망한다.

• Composites Research
• /
• 제30권1호
• /
• pp.65-70
• /
• 2017

일방향 탄소섬유 복합재료는 복잡한 성형 공정과 낮은 드레이핑능을 보여 비교적 단순한 형태의 구조물 제작에 제한적으로 사용되어 왔으나, 최근 이를 해결하고자 성형성과 생산효율이 우수한 장섬유 복합재료(Long Fiber Prepreg Sheet; LFPS)가 제안되었다. 본 연구에서는 단순한 성형 공정과 높은 성형 정밀도를 갖는 LFPS를 활용하여 전자 기기용 커버 플레이트 설계를 수행하였다. 설계에 앞서 리브 구조가 적용되는 대상 구조물을 8-inch 태블릿 PC 제품의 뒷 커버로 선정하였다. 해당 구조물에 평판에 적용되는 대표적인 하중 조건을 선정하여 유한요소해석에 적용하였고, 이를 활용하여 리브 구조물의 패턴과 리브 형상 변화에 따른 구조물의 구조 강성을 확인하였다. 해석 결과 제한된 부피 내에서 최적의 리브 패턴과 형상을 확보하였으며, 리브 폭이 균일하지 않은 경우가 균일한 경우에 비해 6~10% 처짐량이 감소함을 확인하였다.

• 디지털융복합연구
• /
• 제9권2호
• /
• pp.131-140
• /
• 2011

최근 무선 통신 기술과 반도체 설계 및 공정 기술의 비약적인 발전으로 기존 데스크톱 컴퓨팅 환경은 급속히 테블렛 PC와 스마트 폰 기반의 모바일 환경으로 이동하고 있다. 특히 스마트 폰의 확산은 증강현실 기술을 이용한 사용자 인터페이스의 위치기반 서비스 응용분야를 확대시키고 있다. 이에 본 논문에서는 안드로이드 기반의 OpenAPI를 이용한 증강현실 시스템을 구현하였으며, 동시에 다양한 실시간 사용자의 정보를 이용 가능하도록 위치기반 소셜네트워크 서비스도 OpenAPI를 이용하여 통합 구현하였다. 구현에 이용된 다양한 OpenAPI들은 개발자가 포털 사이트의 방대한 정보에 쉽게 접근하여 어플리케이션을 개발하도록 지원한다. 제안 시스템은 프로토타입으로 구현되어 스카이사의 시리우스 안드로이드 폰에 동작시킴으로 모바일 기기에서도 증강현실을 이용한 위치기반서비스의 가능성을 보여주었다. 또한 사용자의 실시간 사진, 동영상, 메시지 데이터들의 공유가 가능하도록 소셜네트워크 서비스도 효율적으로 연동시켰다.

• 방송공학회논문지
• /
• 제23권2호
• /
• pp.253-260
• /
• 2018

1인 미디어 방송 서비스는 기존의 방송 서비스와 다르게 고가의 장비 없이 제작자의 영상과 음성을 획득하는 디바이스와 전송 플랫폼만 있으면 제작자가 원하는 독창적 주제로 자신만의 방송을 제작할 수 있다. 본 논문에서는 이러한 개인 방송 서비스 프레임워크를 세미나 또는 학회와 같은 컨퍼런스에 적용함으로써 새로운 중계방송 시스템을 개발 및 구현하였다. 각 컨퍼런스 행사장마다 영상과 음성 획득 장치를 설치하고, 스트리밍 서버를 통해 이들을 통합하여 중계방송 함으로써 개인의 모바일 디바이스 또는 노트북, 태블릿 PC와 같은 멀티 해상도 스크린을 통해 시청이 가능하도록 하였다. 사용자는 원하는 스크린을 통해 실시간 스트리밍 및 VOD 서비스뿐만 아니라 컨퍼런스 관련 추가적인 정보를 제공받을 수 있다는 장점이 있다. 즉, 컨퍼런스 참석자들에게 개인 모바일 디바이스를 통해 정보를 얻을 수 있도록 함으로써 편의성을 제공하고 컨퍼런스 참여도 향상의 효과와 향후 연구를 위한 기반 기술이 될 것으로 기대한다.