• Proceedings of the KIEE Conference
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• 2005.07b
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• pp.1537-1539
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• 2005

This paper proposes 210[kVA] rated SIV(Static Inverter) system for the TTX(Tilting Train eXpress). The SIV provides power of a fluorescent light in the car, Air-conditioner, and other equipments. To control output voltage it is used voltage control loop for constant voltage control and simultaneously used current control loop for instantaneous control at load changing. The performance of SIV system will be verified by simulation and experimental results.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.23 no.3
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• pp.263-265
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• 1990

• Proceedings of the KSR Conference
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• 2006.05b
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• pp.188-193
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• 2006

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1518-1524
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• 2008

Ponciri Fructus (PF), the immature fruit of Poncirus trifoliata, has been used for treatment of constipation in Korean traditional medicine. It has been reported that PF has a prokinetic effect on gastrointestinal tract, but little is known about the effect on colonic contraction. The aim of this study was to investigate the effect of PF on spontaneous contractions of proximal and distal colon in rats. The aqueous extract of PF was centrifuged and filtered and its supernatant was used for in vitro motility study. The removed colon from rats was divided into proximal and distal segments. Each segment was mounted in a 10 ml organ bath and measured the change of the spontaneous contraction with increasing dose (1, 5, 10, 50, 100, 500, $1000{\mu}g/ml$) of PF extract administration. Also the effect of PF on the spontaneous contraction was measured under treatment of atropine, acetylcholine (Ach), and tetrodotoxin (TTX). PF increased the spontaneous phasic contraction of distal colon dose dependently, but there was no change in proximal colon. The contractile response induced by PF in distal colon was lower than that of Ach and was partially blocked by atropine ($10^{-6}M$). TTX increased the spontaneous contraction and it was reinforced with Ach addition. But the extract of PF had no or little contractile effect of TTX in colon. PF increased spontaneous contractions selectively in distal colon. The prokinetic effect of PF may be due to enhancement of cholinergic related excitatory neural system.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.6
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• pp.337-342
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• 2008

Human bone marrow mesenchymal stem cells (hBM-MSCs) represent a potentially valuable cell type for clinical therapeutic applications. The present study was designed to evaluate the effect of long-term culturing (up to $10^{th}$ passages) of hBM-MSCs from eight individual amyotrophic lateral sclerosis (ALS) patients, focusing on functional ion channels. All hBM-MSCs contain several MSCs markers with no significant differences, whereas the distribution of functional ion channels was shown to be different between cells. Four types of $K^+$ currents, including noise-like $Ca^{+2}$-activated $K^+$ current ($IK_{Ca}$), a transient outward $K^+$ current ($I_{to}$), a delayed rectifier $K^+$ current ($IK_{DR}$), and an inward-rectifier $K^+$ current ($K_{ir}$) were heterogeneously present in these cells, and a TTX-sensitive $Na^+$ current ($I_{Na,TTX}$) was also recorded. In the RT-PCR analysis, Kv1.1,, heag1, Kv4.2, Kir2.1, MaxiK, and hNE-Na were detected. In particular, ($I_{Na,TTX}$) showed a significant passage-dependent increase. This is the first report showing that functional ion channel profiling depend on the cellular passage of hBM-MSCs.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.20 no.12
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• pp.1093-1098
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• 2007

Tilting trains are currently in operation in 13 countries around the world. With the advances in tilting technology, verification of economic efficiency, and changes in economic situations, the introduction of tilting trains will rapidly spread across the globe. The measurement system is composed of the industrial computers installed in the console and the measurement racks mounted on each car. It is utilized to accumulate the data by the communication card and the optical cable. The optical cable and power cable are coupled at the connector located in joint of train to make easy to disconnect car each other. The signal conditioner is designed to choose and to extend the channel for each sensor readily. The sensor measurement rack has adopted as decentralization method. It is installed in each car to minimize the cable length. In also, it is manufactured based on 19"rack and covered to protect the cable. In this study, the programs for measurement and analysis were also developed to understand the traction system characteristics of TTX. Using this measurement system, we studied that acceleration test, re-powering test, and gradually powering test. The acceleration performance of TTX is 1.735 km/h/s, and it is inner standard value. The notch test result from 1 to 7 steps, DC link voltage is under standard value, and the output electric current of inverter is controlled normally. From the test results, we saw the performances of the traction systems are normal.

• Journal of Food Hygiene and Safety
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• v.27 no.1
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• pp.37-41
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• 2012

The current standard for testing tetrodotoxin (TTX) in foodstuffs is the mouse bioassay (MBA) in Korea as in many other countries. However, this test suffers from potential ethical concerns over the use of live animals. In addition, the mouse bioassay does not test for a specific toxin thus a sample resulting in mouse incapacitation would need further confirmatory testing to determine the exact source toxin (e.g., TTX, STX, brevotoxin, etc.). Furthermore, though the time of death is proportional to toxicity in this assay, the dynamic range for this proportional relationship is small thus many samples must be diluted and new mice be injected to yield a result that falls within the quantitative dynamic range. Therefore, in recent years, there have been many efforts in this field to develop alternative assays. High performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) has been emerged as one of the most promising options. A LC-MS-MS method involves solid-phase extraction (SPE) and followed by analysis using an electrospray in the positive ionization mode and multiple reactions monitoring (MRM). To adopt LC-MS-MS method as alternative standard for testing TTX, we performed a validation study for the quantification of TTX in puffer fish. This LC-MS-MS method showed good sensitivity as limits of detection (LOD) of $0.03{\sim}0.08{\mu}g/g$ and limits of quantification (LOQ) of $0.10{\sim}0.25{\mu}g/g$. The linearity ($r^2$) of tetrodotoxin were 0.9986~0.9997, the recovery were 80.9~103.0% and the relative standard deviations (RSD) were 4.3~13.0%. The correlation coefficient between the mouse bioassay and LC/MS/MS method was higher than 0.95.

• Proceedings of the Korean Aquaculture Society Conference
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• 2004.05a
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• pp.270-271
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• 2004

• Proceedings of the KSR Conference
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• 2006.05b
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• pp.276-276
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• 2006

• Proceedings of the KIEE Conference
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• 2008.04c
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• pp.178-180
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• 2008

With the increase in population, the area of human activities has expanded, resulting in the dramatic increase in the need for transportation system. Tilting trains are currently in operation in 13 countries around the world. TTX(Tilting Train express) has been developed by KRRI(Korea Railroad Research Institute) for last 6 years to satisfy the need. This train developed in this Project is designed for a design speed of 200km/h and a maximum operating speed of 180km/h. We developed a measurement system for on-line test. the measurement console desk is mounted on T car, which is designed as the DAQ system train. It is comprehensive of the industrial computers, LCD monitors, communication cards and the communication channel measurement system. Using this system, SIV performance evaluation was conducted.