• The Korean Journal of Pain
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• 제13권1호
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• pp.60-66
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• 2000

Background: For terminal cancer pain management, controlled-release oral morphine (morphine sulfate tablet, MST) is a simple and convenient regimen. Recently, fentanyl transdermal therapeutic system (F-TTS, transdermal fentanyl) has been developed and became one of the alternative ways of providing adequate pain relief. This open prospective study was designed to compare the analgesic efficacy and safety of MST and transdermal fentanyl in the management of terminal cancer pain. Methods: In this open comparative and randomized study, 64 terminal cancer patients received one treatment for 15 days, controlled-release oral morphine (MST group) or fentanyl transdermal therapeutic system (F-TTS group). Daily diaries about the vital sign, visual analogue scale (VAS) for pain, opioids requirement, co-anagesics, adjuvant drugs and adverse effects were completed with 24 patients in MST group, 18 patients in F-TTS group. Results: The majority of patients in both treatment groups were late-stage cancer and their distribution was not different in both groups. Daily opioids requirement was 126.4 mg in MST uced in F-TTS group (P<0.05). The incidence of nausea, vomiting and constipation was lower in F-TTS group (P<0.05). Patients satisfaction was similar, but F-TTS patient group favored continous use of same treatment compared with MST group after the study was finished. Conclusions: Transdermal fentanyl seems to be safe and similar analgesic effect to controlled-release oral morphine for the control of the terminal cancer patients. However, transdermal fentanyl provides a simpler and more convenient especially in respect to constipation, nausea & vomiting. To determine the exact analgesic effect, cost-effectiveness and complications, controlled trials should be followed.

• 한국임상약학회지
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• 제28권2호
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• pp.81-87
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• 2018

Objective: There have been many cases of spontaneous adverse drug reactions to fentanyl at a regional pharmacovigilance center in the hospital. To assess the factors causing the adverse drug reactions reported in patients receiving fentanyl patient-controlled analgesia (PCA) monotherapy or in combination with fentanyl transdermal therapeutic system (TTS) for acute post-operative pain management. Methods: We conducted a retrospective cohort study with all patients prescribed fentanyl PCA for pain management after orthopedic surgery at a single university hospital from June 2012 to May 2013. We analysed the factors causing adverse drug reactions reported by a spontaneous reporting system in patients receiving fentanyl PCA monotherapy and those receiving fentanyl TTS in combination with fentanyl PCA. Results: Based on the spontaneous adverse drug reaction reporting, the risk ratio for the incidence rate of adverse drug reaction in the fentanyl TTS combination therapy group was 3.04 (95 % CI: 2.4-4.00, P < 0.0001), which was approximately 3-fold higher than that reported for fentanyl PCA monotherapy. Only 60 % of the adverse drug reactions were reported. Conclusion: It is inappropriate to add fentanyl TTS to fentanyl PCA to manage post-operative acute pain. There is a need to improve adverse drug reaction reporting. We expect that regular analysis of adverse drug reactions reported at regional pharmacovigilance centre would aid in appropriate drug utilization by patients.

• 한국음향학회:학술대회논문집
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• 한국음향학회 1994년도 FIFTH WESTERN PACIFIC REGIONAL ACOUSTICS CONFERENCE SEOUL KOREA
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• pp.937-942
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• 1994

Text-to-Speech(TTS) conversion system can convert any words or sentences into speech. To synthesize the speech like human beings do, careful prosody control including intonation, duration, accent, and pause is required. It helps listeners to understand the speech clearly and makes the speech sound more natural. In this paper, a prosody control scheme which makes use of the information of the function word is proposed. Among many factors of prosody, intonation, duration, and pause are closely related to syntactic structure, and their relations have been formalized and embodied in TTS. To evaluate the synthesized speech with the proposed prosody control, one of the subjective evaluation methods-MOS(Mean Opinion Score) method has been used. Synthesized speech has been tested on 10 listeners and each listener scored the speech between 1 and 5. Through the evaluation experiments, it is observed that the proposed prosody control helps TTS system synthesize the more natural speech.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2005년도 춘계 학술대회 발표논문집
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• pp.37-40
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• 2005

Recently due to the rapid development of speech synthesis based on the corpora, the performance of TTS systems, which convert text into speech through synthesis, has enhanced, and they are applied in various fields. However, the procedure for objective assessment of the performance of systems is not well established in Korea. The establishment of the procedure for objective assessment of the performance of systems is essential for the assessment of development systems for the developers and as the standard for choosing the suitable systems for the users. In this paper we will report on the results of the basic research for the establishment of the systematic standard for the procedure of objective assessment of the performance of Korean TTS systems with reference to the various attempts for this project in Korea and other countries.

• 음성과학
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• 제8권4호
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• pp.35-43
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• 2001

New speech synthesis algorithms capable of flexible prosody (especially F0) modification are desired for a high quality TTS system. TD-PSOLA is the most popular synthesis algorithm. The algorithm shows very high quality when F0 modification is limited. However, the quality degradation due to pitch epoch detection error becomes severe as the F0 modification factor becomes large. On the other hand, the vocoder framework is very flexible in F0 manipulation. The synthesized speech quality from the vocoder is far from natural human speech and suffers from buzziness. To remedy the buzzy quality from the vocoder and make more natural synthetic speech, we propose a mixed phase vocoder.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2016년도 춘계학술발표대회
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• pp.815-817
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• 2016

웹 기술의 발전은 인간 사회의 변화에 많은 영향을 주고 있다. 웹 발전 분야에서도 전자책 기술 발전은 확연하게 달라지고 있으며, 단순 텍스트 정보만을 제공하는 기술을 넘어 음성서비스를 위한 기술 분야에도 많은 연구가 활발하게 진행되고 있다. 따라서 본 논문에서는 웹 표준 기술인 HTML5기반 지능형 전자책 다국어 TTS 서비스를 위한 관련 연구 조사와 전자책 사용자의 편리성 및 접근성을 강화하기 위한 전자책 제작 및 서비스 방법에 대하여 연구하였다. 본 연구의 목적은 전자책 사용자들에게 텍스트를 포함한 전자책에서 텍스트 및 여러 객체들에 주제 혹은 설명을 TTS 서비스가 가능하도록 하고, 사용자의 선택적 영역과 언어에 따라 다국어 TTS가 자동 변환되어 서비스 할 수 있도록 연구 개발 하는 것이다.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2013년도 추계학술발표대회
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• pp.1238-1240
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• 2013

본 논문에서는 AAC기술과 TTS기술을 조사 및 분석하여 스마트폰의 가장기본적인 기능인 전화와 문자전달 기능을 일반적으로 의사소통이 어려운 언어장애인들에게 보완 대체 의사소통의 수단을 제공하는 MLS시스템을 제안하고, Text to Speech기능과 의사소통기능, TTS전화기능, 설정기능을 설계하였다.

• 대한임베디드공학회논문지
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• 제1권2호
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• pp.31-36
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• 2006

As two dimensional bar code can collect data and information quickly, it is used and recognized as a useful tool for the many industrial application field. But the information capacity of two dimensional bar code is still limited. Recently, the two dimensional AD bar code (analog-digital code) that can increase its application range and overcome capacity limitation is developed. In this paper, we implement an effective system which can transform text information into voice using two dimensional AD bar code and TTS(Text To Speech). It can be transmitted to blind people by capturing the AD bar code on the papers or the books.

• 한국응용과학기술학회지
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• 제25권2호
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• pp.123-129
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• 2008

Transdermal therapeutic system(TTS) is often used as the method of drug dosage into the epidermic skin. Natural polymer were selected as ointment material of TTS. We investigated the permeation of natural polymer ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as Nicotinic acid N-oxide in vitro. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. This result suggests a possible use of natural polymer ointment base as TTS of antihyperlipoproteinemic agent.

• 디지털콘텐츠학회 논문지
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• 제4권2호
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• pp.233-242
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• 2003

TTS(Text-To-Speech) 시스템은 텍스트 문장을 자연스러운 음성으로 출력하는 시스템이다. 자연스러운 음성을 출력하기 위해서 언어에 대한 전문적 지식을 비롯하여 많은 시간과 노력이 요구된다. 또한 영어의 음운 변환은 음소에 따라 형태소에 따라 의미에 따라 다양한 변환을 가진다. 이를 일괄적으로 처리하기란 매우 힘든 일이다. 이러한 문제들을 해결하기 위하여 모음과 자음의 변화의 규칙을 적용한 시스템을 구현한다. 이 시스템은 문장의 분석을 통해 분류하고 음소 규칙 데이터를 통해 자연스러운 음성을 출력하게 되는 이전 과정을 통해 특수문자나 숫자 등을 정규화하여 처리한다. 이렇게 처리된 문자 데이터를 운율규칙을 통해 최종 출력한다. 그 결과, 40개의 음소 규칙 데이터를 통해 보다. 정확한 음성을 출력할 수 있었으며, 시스템의 효율성도 높였다. 본 논문에서 제시한 시스템은 각종 통신장비와 자동화기기에 적용하여 다양한 분야에 활용될 수 있을 것이다.