• Journal of Ginseng Research
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• v.40 no.1
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• pp.76-85
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• 2016

Background: Binding of adhesive proteins (i.e., fibrinogen, fibronectin, vitronectin) to platelet integrin glycoprotein IIb/IIIa (${\alpha}IIb/{\beta}3$) by various agonists (thrombin, collagen, adenosine diphosphate) involve in strength of thrombus. This study was carried out to evaluate the antiplatelet effect of total saponin from Korean Red Ginseng (KRG-TS) by investigating whether KRG-TS inhibits thrombin-induced binding of fibrinogen and fibronectin to ${\alpha}IIb/{\beta}3$. Methods: We investigated the effect of KRG-TS on phosphorylation of vasodilator-stimulated phosphoprotein (VASP) and dephosphorylation of phosphatidylinositol 3-kinase (PI3K) and Akt, affecting binding of fibrinogen and fibronectin to ${\alpha}IIb/{\beta}3$, and clot retraction. Results: KRG-TS had an antiplatelet effect by inhibiting the binding of fibrinogen and fibronectin to ${\alpha}IIb/{\beta}3$ via phosphorylation of VASP ($Ser^{157}$), and dephosphorylation of PI3K and Akt on thrombin-induced platelet aggregation. Moreover, A-kinase inhibitor Rp-8-Br-cyclic adenosine monophosphates (cAMPs) reduced KRG-TS-increased VASP ($Ser^{157}$) phosphorylation, and increased KRG-TS-inhibited fibrinogen-, and fibronectin-binding to ${\alpha}IIb/{\beta}3$. These findings indicate that KRG-TS interferes with the binding of fibrinogen and fibronectin to ${\alpha}IIb/{\beta}3$ via cAMP-dependent phosphorylation of VASP ($Ser^{157}$). In addition, KRG-TS decreased the rate of clot retraction, reflecting inhibition of ${\alpha}IIb/{\beta}3$ activation. In this study, we clarified ginsenoside Ro (G-Ro) in KRG-TS inhibited thrombin-induced platelet aggregation via both inhibition of $[Ca^{2+}]_i$ mobilization and increase of cAMP production. Conclusion: These results strongly indicate that KRG-TS is a beneficial herbal substance inhibiting fibrinogen-, and fibronectin-binding to ${\alpha}IIb/{\beta}3$, and clot retraction, and may prevent platelet ${\alpha}IIb/{\beta}3$-mediated thrombotic disease. In addition, we demonstrate that G-Ro is a novel compound with antiplatelet characteristics of KRG-TS.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2015.11a
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• pp.87-90
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• 2015

MPEG-2 TS(Transport Stream)는 DTV(Digital Television), IPTV(Internet Protocol Television), DMB(Digital Multimedia Broadcasting) 등 디지털 방송 분야에서 압축된 오디오 및 비디오 데이터를 다중화하는 데에 전 세계적으로 널리 사용되고 있다. MPEG-2 TS 표준이 제정된 것은 1990년대 초반으로서 20여 년이 지난 오늘날의 방송과 통신 환경에 적합하지 않은 부분이 많이 포함되어 있다. 이러한 상황을 고려하여, MPEG(Moving Picture Experts Group)에서는 2014년에 MPEG-2 TS를 대체하고자 차세대 멀티미디어 전송 표준으로서 MMT(MPEG Media Transport)를 표준화하였다. 특히 네트워크 환경의 발전에 따라, MMT 표준은 IP 친화적이고 여러 가지 다른 종류의 네트워크를 병용한 멀티미디어 전달이 쉽도록 설계되었다. 본 논문에서는 실시간 방송에 의해 수신되는 MPEG-2 TS로부터 실시간으로 MMTP(MMT Protocol) 스트림을 생성하여 UDP/IP로 유무선 인터넷을 통해 멀티미디어 스트리밍 서비스를 제공하는 시스템을 구현하였다. 이를 위해 MPEG-2 TS 실시간 변환 기능을 갖춘 MMT 스트리밍 서버와 이로부터 서비스를 받을 수 있는 MMT 클라이언트를 구현하고 그 동작을 실험을 통해 검증하였다.

• Bulletin of the Korean Chemical Society
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• v.23 no.1
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• pp.19-20
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• 2002

• Bulletin of the Korean Chemical Society
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• v.13 no.5
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• pp.565-570
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• 1992

The 1,5-sigmatropic rearrangements involving group (X) migration in ${\omega}$(X)-substituted 1,3-pentadiene, $C^1H_2=C^2H-C^3H=C^4H-C^5H_2-X$, where X = H, $CH_3$, $BH_2$, $NH_2$, OH or F, are investigated MO theoretically using the AM1 method. For the migrating groups without lone pair electrons, X = H, $CH_3$, or $BH_2$, the suprafacial pathway is favored, whereas for the migrating groups with lone pair electrons participating in the TS, $X=NH_2$, OH, or F, the antarafacial pathway is favored electronically. However excessive steric inhibition in the antarafacial TS for $X=NH_2$ leads to subjacent orbital controlled suprafacial process. The antarafacial shift of F is relatively disfavored compared to that of OH due to smaller orbital overlap and larger interfrontier energy gap in the TS.

• Korean Journal of Breeding Science
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• v.41 no.4
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• pp.403-411
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• 2009

We inspected seed sizes of 353 genetic accessions of watermelon to diversify functional utility related to seed size and classified them into six representative groups based on their seed sizes. Each group was named as giant seed (GS), big seed (BS), medium size (NS), small size (SS), micro seed (MS) and tomato seed (TS) from the biggest. As the seed size was getting smaller, decreased seed length and seed width, increased seed number per fruit, and decreased seed weight per fruit were observed, but seed shape did not change significantly. In order to study the effect of seed size on fruit weight and seed germination, we developed three near isogenic lines (NILs) with three different seed sizes, SS, MS and TS, from crossing between two accessions 'NT' and 'TDR', and one NIL with seed size of TS from crossing between two accessions 'S55' and 'TDR'. In the study on the fruit weight of NILs with various seed sizes, NS, SS, MS, and TS NILs produced an average of 6.4, 6.3, 5.9, and 4.2 kg fruits, respectively. The bigger seed types showed the better germination rate. NS type showed the highest germination percentage, while TS showed very low germination percentage. Fermentation treatment for 48 hrs increased the germination percentage on TS type seed, but still remained at a low level. In NS, SS, and MS material, the ratio of embryo/whole seed weight was over 50%, meanwhile that of TS was only 44.4% of which low embryo percentage would be one of the reason of low germination percentage. From this study, we concluded that watermelon has very wide genetic diversity on seed size which is somehow related to fruit sizes and germination rate.

• Bulletin of the Korean Chemical Society
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• v.18 no.2
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• pp.161-164
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• 1997

Kinetic studies are carried out on the reactions of 1- and 2-naphthylmethyl arenesulfonates with anilines in acetonitrile at 25.0 ℃. The rates are faster for the 2-naphthylmethyl series than for the corresponding 1-naphthylmethyl series suggesting that there is a greater stabilization of positive charge development in the TS at the arylmethyl reaction center carbon for the former. The sign and magnitude of ρxz (=-0.12) are similar to those of the benzylic series. Thus, benzyl, 1- and 2-naphthylmethyl derivatives belong to a class of compounds which react with aniline nucleophiles through a relatively loose SN2 TS. Kinetic secondary deuterium isotope effects indicated that a stronger nucleophile and nucleofuge lead to a later TS as the definition of ρxz requires.

• Journal of Aquaculture
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• v.8 no.1
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• pp.59-67
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• 1995

Growth rate, first reproductive age, life span and total offspring numbers were measured to study the effects of water temperature and salinity on the propagation of rotifer, Brachionus plicatilis. Three types of rotifer, Large (L), Small (S) and Thailand Small (TS)-types, were cultured in the $4\times4$ factorial culture conditions with four different salinities (5, 15, 25 and $35\%o$) at each of four different water temperatures (15, 20, 25 and $29^{\circ}C$). The results are as follows; Under the 4 different salinity gradients %$(5\%o,\;15\%o,\;25\%o,\;and\;35\%o)\;at\;29^{\circ}C$, the mean growth rates of L, Sand TS-type were 0.60, 0.84 and 0.96, respectively. The first reproductive age of three types rotifer appeared to be early at high water temperature. The total offspring numbers of the three types were higher at $25^{\circ}C\;and\;29^{\circ}C$, with the maximum value of 28.3 on the average at $29^{\circ}C$ for TS-type, and the minimum value at $15^{\circ}C$ for S-type. Life span decreased with high water temperature and increased with low water temperature. L-type and TS-type rotifer showed the longest life span of 13.5 days on the average at $15^{\circ}C$, and S-type showed shortest 6.2 days on the average at $29^{\circ}C$.

• Journal of Ginseng Research
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• v.10 no.1
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• pp.101-107
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• 1986

Relationships among ginsenosides, panaxadiol(PD), panaxatriol(PT), and total saponin(TS) in Panax ginseng root (2nd Year) grown with culture solotion different in nitrogen, phosphorus and potassium level were analyzed by simple correlation, multiple regression and standard partial regression coefficient. The closeness between ginsenosides by simple correlation was closely related with the similarity of molecular structure. The content of PT was much attributed to Re and Rg1. The contribution order of ginsenosides for PD was Rb1>Rb2$\geq$Rd>Rc. There was significant positive correlation between PT and PD but PD increased more rapidly than PT. Thus total saponin depended much on PD and PT/PD decreased with the increase of total saponin content. All ginsenosides, especially Re showed decreasing tendency with the increase of root weight.

• Journal of the Korean Institute of Navigation
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• v.16 no.4
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• pp.47-54
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• 1992

The purpose of this study is to provide against to the meteorological disasters in Korea caused by the typhoons by means of the statistical analyses for the relation between the intensities of the typhoons and the meteorological disasters. The data are extracted from the "TYPHOON REPORT OF KOREA" and the "TYPHOON WHITE BOOK" issued by the Central Meteorological Office. The results are summarized as follows : (1) The annual mean frequency and the total number of the typhoon causing the disasters during 30 years (1956∼1985) are 2.2, 65 respectively, and the highest number appears in August followed by September and the third is July. And the degrees of themeteorolgocal disasters are alsio the same order. (2) The more serious disasters occurred by the TS degree typhoons, and the TS degree typhoons occupy the highest frequency. (3) The more serious disasters occurred by the TS degree typhoons, and the TS degree typhoons occupy the highest frequency. (3) The meteorological disaster per typhoon is most severe in August, and the July and September are alike in the degree of the disasters per typhoon. (4) The meteorological disasters are approximately a proportional relation to the intensities of the typhoons. (5) The frequency of the Rain typhoon , Wind typhoon and Rain·Wind typhoon are about 2 : 1: 3 in July, August and September respectively. And the severe disasters occur more frequently by the Rain typhoon than by the Wind typhoon.

• The KIPS Transactions:PartB
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• v.16B no.2
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• pp.101-108
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• 2009

As content serviced for IP set-top boxes is streamed over IP network, the existing hacking tools for IP network can be used to capture the streamed content. Until recently, most of the content serviced on IP set-top boxes has been MPEG-2 TS. However, this content will be gradually moved to WMV, MPEG-4 or H.264 because of the relatively low compression efficiency and overhead of the TS packet. In this paper, we propose a DRM scheme other than WMRM for streamed WMV content. Our approach is to design a DRM scheme independent to the existing WMV streaming system. We also design this scheme in order to provide the feature for controlling the DRM processing time considering device performance. We verified it through the experiment.