• Journal of the Korean Society of Physical Medicine
• /
• v.12 no.2
• /
• pp.91-101
• /
• 2017

PURPOSE: The aim of this study was to verify the effect of trunk strengthening exercise using oscillation by comparing trunk muscle thickness, as well as balance of healthy adults during exercises performed with an oscillatory device and non-oscillatory device. METHODS: Twenty-two participants were randomly assigned to one of two groups: the trunk strengthening exercise using oscillation (TSEO) group (n=11) or the trunk strengthening exercise using non-oscillation (TSEN) group (n=11). Subjects in all groups performed the exercises three days per week for 6 weeks. All subjects performed four types of exercises: pull over, seated twist, power push, and diagonal power plank. Trunk muscle thickness of the rectus abdominis (RA), internal oblique (IO), external oblique (EO), transverse abdominis (TrA), and multifidus (MT) were measured with an ultrasonography. The balance ability were evaluated using the Romberg test with eyes open, eyes closed, one-leg standing test (OLST), and limits of stability (LOS). All tests were performed before the intervention, as well as after 6 weeks and 8 weeks of exercises. RESULTS: There was a significant difference of RA, IO, TrA, and MT according to the main effect of the time (p<.05). There was a significant difference of IO and LOS according to interaction effect between the time and group (p<.05). CONCLUSION: As intended, the cyclic forces induced by the oscillating device did increase trunk muscle thickness. However, the effect was limited and significant only for the IO muscle. Combining trunk strengthening exercise with oscillation appears to be more effective in improving dynamic balance.

• Journal of The Korean Society of Integrative Medicine
• /
• v.4 no.2
• /
• pp.23-28
• /
• 2016

Purpose : The purpose of this study was to investigate the effects of transverse abdominal muscle contraction on pulmonary function in supine position. Methods : 10 female and 10 male college students were recruited this study. Pulmonary Function test was measured with QUARK SPIRO. To check the changes in lung function with transverse abdominal muscle contraction, we tested pulmonary function in the supine, with and without transverse abdominal muscle contraction. While the transverse abdominis was activating, we investigate in the change of forced expiration. All statistical analyses were performed using SPSS Statistics VER.12.0 for window version p-values less than 0.05 were used to identify significant differences. Statistical analysis was used Paired t-test to know difference between activated and non-activated TrA of forced expiration. Results : The subject with transverse abdominal muscle contraction showed significant increments in variable of FVC, FEV1, PEF compared to the pre-intervention results (p<0.01). Conclusion : These results indicate that spontaneous contraction of the TrA helps pulmonary function. And the selective contraction of the transverse abdominis at the end of forced inspiration makes increases in the lung capacity.

• Korean Journal of Clinical Pharmacy
• /
• v.19 no.1
• /
• pp.50-60
• /
• 2009

Highly variable drugs (within-subject variability greater than 30%) have been difficult to meet current regulatory acceptance criteria using a reasonable number of study subjects. In this study, we reviewed previous studies presenting alternative approaches for bioequivalence evaluation of highly variable drugs, and focused on an approach for widening the bioequivalence acceptance limits using within-subject variability. We discussed the suggested five solutions for highly variable drug including the deletion of $C_{max}$ of the bioequivalence criteria, direct expansion of bioequivalence limit, multiple dose studies in steady state, bioequivalence assessment on the metabolite, add-on study, and widening the bioequivalence acceptance limits based on reference variability. The methods for widening of bioequivalence limits based on reference variability are scaled average bioequivalence containing within-subject variability on reference drug (${\sigma}_{WR}$), population bioequivalence derived from total variability on reference drug (${\sigma}_{TR}$) and test drug (${\sigma}_{TT}$), and individual bioequivalence derived from subject by formulation interaction variability (${\sigma}_D$) and within subject variability on reference drug (${\sigma}_{WR}$) and test drug (${\sigma}_{TR}$). To apply these methods, the switching variability (${\sigma}_0$) will have to be set by the regulatory authorities. The proposals of bioequivalence evaluation approach for the highly variable in Korea are presented for both of new drug and reevaluation drug.

• Toxicological Research
• /
• v.29 no.4
• /
• pp.249-255
• /
• 2013

Erythritol is a sugar alcohol that is widely used as a natural sugar substitute. Thus, the safety of its usage is very important. In the present study, short-term genotoxicity assays were conducted to evaluate the potential genotoxic effects of erythritol. According to the OECD test guidelines, the maximum test dose was 5,000 ${\mu}g$/plate in bacterial reverse mutation tests, 5,000 ${\mu}g/ml$ in cell-based assays, and 5,000 mg/kg for in vivo testing. An Ames test did not reveal any positive results. No clastogenicity was observed in a chromosomal aberration test with CHL cells or an in vitro micronucleus test with L5178Y $tk^{+/-}$ cells. Erythritol induced a marginal increase of DNA damage at two high doses by 24 hr of exposure in a comet assay using L5178Y $tk^{+/-}$ cells. Additionally, in vivo micronucleus tests clearly demonstrated that oral administration of erythritol did not induce micronuclei formation of the bone marrow cells of male ICR mice. Taken together, our results indicate that erythritol is not mutagenic to bacterial cells and does not cause chromosomal damage in mammalian cells either in vitro or in vivo.

• The Transactions of the Korean Institute of Electrical Engineers A
• /
• v.54 no.6
• /
• pp.284-292
• /
• 2005

Because all of the short-circuit testing laboratories have the limitation of test facilities, the synthetic making test methods have been used to estimate the short-circuit making performance of the ultra high-voltage circuit breaker as the alternative to direct test methods. So, KERI(Korea Eelctrotechnology Research institute) has completed the construction of the synthetic making test facilities using the low capacity step-up transformer method which fulfill the requirements specified in newly revised IEC 62271-100 Edition 1.1(2003) and have the testing capability up to 550kV, 63kA full-pole circuit breaker. The test facilities using the low capacity step-up transformer method presented in this paper are made up of the unit equipments such as HCS(High-speed Closing Switch), ITMC(Initial Transient Making Current) circuit and UP TR(low capacity step-up transformer) and have the operating range of 17.6$^{\circ}$ $\~$ 145.1$^{\circ}$ for testing the circuit breaker rated on up to 50kA and 43.1$^{\circ}$ $\~$ 119.6$^{\circ}$ for more than 50kA.

• Journal of the Korea Concrete Institute
• /
• v.28 no.1
• /
• pp.3-11
• /
• 2016

The concern about hollow core PC slab has been increased to improve the workability during a construction of building by reducing self weight of structural members. In this manner, recently, TRS (Tripple Ribs Slab) was developed as a new type of half PC slab system. TRS member consists of the triple webs and the bottom flange prestressed by strands. The slab system is completed by casting of topping concrete on the TRS after filling styrofoam between the webs. This paper, presents a flexural experiment to investigate the flexural capacity of the TRS. Five full scale TRS members were made and tested under simple support condition to be failed by flexure and their strength was evaluated by code equations; the variables in the test are the depth and the presence of topping or raised spot formed when slip-forming. In addition, a nonlinear sectional analysis was performed for the specimens and the result was compared with the test results. From the study, it was found that the TRS has enough flexural strength and ductility to resist the design loads and its strength can be suitably predicted by using code equations. The raised spot did not affect the strength so that the spot need not to be removed by doing additional work. For the more accurate prediction of TRS's flexural behavior by using nonlinear sectional analysis, it is recommended to consider the concrete's brittle property due to slip-forming process in the modeling.

• The Korean Journal of Mycology
• /
• v.20 no.4
• /
• pp.337-346
• /
• 1992

Trichoderma spp. are an effective control agent for damping-off or other plant diseases. The interaction between. T. hamatum and Rhizoctonia solani on the rhizosphere or surface soil were examined to assess the possible roles of antibiosis or competition in the mechanisms of biological control agents as a basic research. In a proportional comparison, total bacteria, fungi, actinomycetes and Trichoderma spp were 65%, 8.8%, 25.9% and 0.28% respectively in their distribution in the soil. Among Trichoderma spp isolated, the 5 species of Trichoderma spp were indentified as T. koninggii, T. pseudokoninggii, T. aureoviridi, T. hamatum and T. viride respectively. In a mycoparasitic test, one isolate of T. hamatum strain Tr-5 showed an enzymatic ability to break fungal hyphae into piecies and infected on the R. solani hyphae showing a parasitism. Spore germination of the all isolates of Trichoderma spp showed a 1.7-7.3% of germination in natural soil conditions, but the percentage was high in sterile soil indicating all the natural soil were fungistatic on conidia of Trichoderma spp. In rhizosphere competent assay in pea plant, the antagonistic T. hamatum, T. viride, T. koninggii, T. pseudokoninggii showed a colonizing upper soil depth in rhizosphere around 1-3 cm in root zone, but the colonizing ability was much reduced along the deeper the soil depth. Propagule density was decreased in deeper the soil layer. Disease development rate treated alone with plant pathogens, Fusarium solani, Rhizoctonia solani, Cylindrocarpon destructans increased, but disease incidence rate reduced in treatment with combinations with antagonistic T. hamatum strain Tr-5.

• Toxicological Research
• /
• v.29 no.2
• /
• pp.87-90
• /
• 2013

The potential role of topical valproate (VPA) in hair regrowth has been recently suggested. However, safety reports of VPA as a topical formulation are lacking. Therefore, in the present study, we investigated whether VPA causes skin irritation in humans. We first performed a cell viability test and showed that VPA did not exhibit toxicity toward HaCaT keratinocytes, fibroblasts, and RBL-3H mast cells. We then performed clinical patch test and skin irritation test through transdermal drug delivery with the help of microneedle rollers. No significant findings were obtained in the clinical patch test. In the skin irritation test, only 1 patient showed erythema at 1 hr, but the irritation reaction faded away within a few hours. Erythema and edema were not observed at 24 hr. We concluded that VPA has minimal potential to elicit skin irritation. Therefore, we consider that VPA can safely be applied to human skin.

• Toxicological Research
• /
• v.33 no.3
• /
• pp.191-203
• /
• 2017

Human eyes and skin are frequently exposed to chemicals accidentally or on purpose due to their external location. Therefore, chemicals are required to undergo the evaluation of the ocular and dermal irritancy for their safe handling and use before release into the market. Draize rabbit eye and skin irritation test developed in 1944, has been a gold standard test which was enlisted as OECD TG 404 and OECD TG 405 but it has been criticized with respect to animal welfare due to invasive and cruel procedure. To replace it, diverse alternatives have been developed: (i) For Draize eye irritation test, organotypic assay, in vitro cytotoxicity-based method, in chemico tests, in silico prediction model, and 3D reconstructed human cornealike epithelium (RhCE); (ii) For Draize skin irritation test, in vitro cytotoxicity-based cell model, and 3D reconstructed human epidermis models (RhE). Of these, RhCE and RhE models are getting spotlight as a promising alternative with a wide applicability domain covering cosmetics and personal care products. In this review, we overviewed the current alternatives to Draize test with a focus on 3D human epithelium models to provide an insight into advancing and widening their utility.

• The Korean Journal of Community Living Science
• /
• v.22 no.3
• /
• pp.445-454
• /
• 2011

This study was performed on 5 prehypertensive male participants to investigate the effects of the clothing program for improving the vascular compliance on heat tolerance. The clothing program means the alternate stimulation of the temperature using clothes. The participants wore two different garments with $1.5^{\circ}C$ difference in the temperature inside clothing in a climatic chamber ($18.8{\pm}0.2^{\circ}C$, $38{\pm}3%RH$) alternately for 4 weeks. Heat tolerance tests were conducted in the climatic chamber of $35.2{\pm}0.5^{\circ}C$, $54{\pm}3%RH$ before and after the clothing program. The results were as follows. The $\overline{T}$sk, Tr and heart rate were lower in the post test than in the pre test (p<.01). The whole body and local sweat rates as well as systolic and diastolic blood pressures had reduced the tendencies in the post test. Participants felt less wet and more comfortable in the post test than in the pre test(p<.01). These results showed that the clothing program through the alternate stimulation of the temperature positively affected the improvement of heat tolerance.