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Atypical triggers in trigeminal neuralgia: the role of A-delta sensory afferents in food and weather triggers

  • Koh, Wenjun;Lim, Huili;Chen, Xuanxuan
    • The Korean Journal of Pain
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    • v.34 no.1
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    • pp.66-71
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    • 2021
  • Background: Trigeminal neuralgia is a debilitating craniofacial pain syndrome that is characterized by paroxysms of intense, short-lived electric shock-like pains in the trigeminal nerve distribution. Recently, the presence of triggers has become one of the key diagnostic criteria in the 3rd edition of the International Classification of Headache Disorders. Light touch is the most common trigger, however other non-mechanical triggers, such as cold weather and certain foods, have been thought to provoke trigeminal neuralgia anecdotally. We aimed to characterize the prevalence and characteristics of these atypical triggers. Methods: We conducted a retrospective, cross-sectional study of atypical triggers in trigeminal neuralgia patients seen in a tertiary pain clinic in Singapore. Patients were recruited via clinic records, and study data were identified from physician documentation. Results: A total of 60 patients met the inclusion criteria. Weather triggers were observed in 12 patients (20%), of which five patients (8%) reported strong winds, 4 patients (7%) reported cold temperatures, and 3 patients (5%) reported cold winds as triggers. Fifteen patients (25%) had a specific food trigger, of which 10 patients (17%) reported hard or tough food, 5 patients (8%) reported hot/cold food, 4 patients (7%) reported spicy food, and 2 patients (3%) reported sweet food as triggers. Conclusions: Although trigeminal neuralgia is most commonly triggered by mechanical stimuli, atypical triggers such as cold temperatures and certain foods are seen in a significant proportion of patients. These atypical triggers may share a common pathway of sensory afferent Aδ fiber activation.

Gas Migration in Low- and Intermediate-Level Waste (LILW) Disposal Facility in Korea (중·저준위 방사성폐기물 처분시설 폐쇄후 기체이동)

  • Ha, Jaechul;Lee, Jeong-Hwan;Jung, Haeryong;Kim, Juyub;Kim, Juyoul
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.12 no.4
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    • pp.267-274
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    • 2014
  • The first Low- and Intermediate-Level Waste (LILW) disposal facility with 6 silos has been constructed in granite host rock saturated with groundwater in Korea. A two-dimensional numerical modeling on gas migration was carried out using TOUGH2 with EOS5 module in the disposal facility. Laboratory-scale experiments were also performed to measure the important properties of silo concrete related with gas migration. The gas entry pressure and relative gas permeability of the concrete was determined to be $0.97{\pm}0.15bar$ and $2.44{\times}10^{-17}m^2$, respectively. The results of the numerical modeling showed that hydrogen gas generated from radioactive wastes was dissolved in groundwater and migrated to biosphere as an aqueous phase. Only a small portion of hydrogen appeared as a gas phase after 1,000 years of gas generation. The results strongly suggested that hydrogen gas does not accumulate inside the disposal facility as a gas phase. Therefore, it is expected that there would be no harmful effects on the integrity of the silo concrete due to gas generation.

Optimization of Manufacturing Condition for Fried Garlic Flake and the Physicochemical Properties (튀긴 마늘 flake 제조조건의 최적화 및 이화학적 특성)

  • Kim, Kyeong-Yee;Lee, Eun-Kyung
    • Korean journal of food and cookery science
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    • v.28 no.6
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    • pp.805-811
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    • 2012
  • This study was carried out in order to optimize the manufacturing condition of fried garlic flakes as well as to investigate the physicochemical properties of the flakes. Fried garlic flake samples were prepared as follows: garlic was sliced by a thickness of 1.5 mm, 2.0 mm, 2.5 mm, which were measured by a thickness gage. The samples were fried in vegetable oil under different temperatures of $140{\sim}150^{\circ}C$, $160{\sim}170^{\circ}C$ and $180{\sim}185^{\circ}C$. The compression strength depending on the height (h) was measured in order to find the thickness effect by the rheometer (force control: 50 N, h: 3.25 mm). Moreover, the sample with 1.5 mm thickness showed crisp phenomena of the split compared with the crush shape of the 2.0 mm and 2.5 mm thick samples. The result of strength for time dependence showed a sample with a thickness of 1.5 mm, which was measured 5~9 times more than the 2.0 mm and 2.5 mm thick samples. We thought the reason that the 1.5 mm sample had less response power equivalent to compression force than the other samples. Alliin has been found to affect the immune responses in the blood, it is a derivative of the amino acid cysteine and is also quite heat stable. The LC system with a UV detection at 210 nm consists of a separation on a Zorbax TMS column and isocratic elution with water and ACN as a mobile phase. The alliin contents of raw and fried garlic flake under $140{\sim}150^{\circ}C$, $160{\sim}170^{\circ}C$ and $180{\sim}185^{\circ}C$ were 18.10 mg/mL, 14.0 mg/mL, 11.6 mg/mL and 11.1 mg/mL, respectively. The decrement of alliin content under different temperature was a small quantity hence, we confirmed that the increasing manufacturing temperature was not affected by the alliin content. Examining for the particle structure of fried garlic flakes by a polarization microscope, the color of the sample treated at $160{\sim}170^{\circ}C$ was pure yellow. Furder, the fiber shaped particle, which has an effect on the tough texture, almost did not appear compared to the different temperature conditions. Finally, the sensory test for the preference of fried garlic flake under different conditions was carried out and the scores for various sensory characteristics were surveyed. According to the physicochemical measurements and sensory evaluation, we confirmed that the optimum manufacturing condition of fried garlic flake was 1.5 mm thick at a temperature of $160{\sim}170^{\circ}C$.

The Beauty Dimensions Related to Human Attractiveness (인물의 매력에 관련된 아름다움의 차원)

  • Park, Sang-June;Lee, Yeong-Ran;Kim, Eun-Jeong
    • Science of Emotion and Sensibility
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    • v.11 no.2
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    • pp.139-152
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    • 2008
  • Most marketing practitioners prospect that the beauty industry, which consists of various services and product related to the beauty, will be one of major industries in future. Thus they have been paying more attention to dramatic changes of the beauty industry. Furthermore they have been trying to differentiate their services and products from existing ones because of the tough competition in the market. For scientific marketing of the beauty services and beauty products, the beauty should be able to be measured. However marketing practitioners have no actual method to measure the beauty. In this study, we tried to find the beauty dimensions which are necessary to measure the beauty, based on Langmeyer and Shank(1994)'s study. We collected a total 258 samples as data through survey on university students, and explored the beauty dimension related to human attractiveness, and derived the implications for measuring the beauty. Based on the quantitative analysis, we derived the 4 beauty dimensions related to human attractiveness. The two of them were the inner beauty dimensions(energetic personality and thoughtful personality) whereas the others were the outer beauty dimensions(appearance and style). Additionally we analyzed if the variables, which are gender, perceived social value of beauty, and appearance satisfaction, affect on respondents' beauty perception. The empirical results showed that the beauty perception in the derived beauty dimensions is affected by the perceived social value of beauty and the appearance satisfaction: 1)The both of the inner beauty and the outer beauty are evaluated more positively when the appearance satisfaction is higher, 2)The outer beauty is evaluated more positively than the inner beauty when the perceived social value of beauty is higher.

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Comparison of Educational Effects of Difficult Endotracheal Intubation in the 119 Rescue Service (119구급대의 어려운 기관내삽관 교육 전·후 비교)

  • Yun, Hyeong-Wan;Yu, Eun-Yeong;Yun, Young-Hyun
    • The Journal of the Korea Contents Association
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    • v.11 no.1
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    • pp.254-265
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    • 2011
  • The purpose of this study was to examine the effect of difficult endotracheal intubation education in the 119 rescue services. The subjects in this study were 60 members of the 119 rescue services that was under the umbrella of the Fire Service Headquarters of J province. A SPSS 14.0 program was utilized to find out the effect of tough tracheal intubation education on their relevant knowledge, self-confidence, academic self-efficacy and technical Performance in consideration of general characteristics. The findings of the study were as follows: 1. They showed a significant improvement in all the knowledge, self-confidence, academic self-efficacy and technical Performance after they received that education. 2. As for connections between general characteristics and knowledge before and after that education, there were significant differences in their knowledge according to gender and career of working in the hospital, and their rank and career of working in the hospital made a significant differences to their self-confidence. Their academic self-efficacy significantly differed with rank, career of working in the hospital and academic credential. There were significant gaps among them technical Performance Case 1 according to career of working in the 119 rescue services, and technical Performance Case 2 significantly varied with age and academic credential. There were significant gaps in technical Performance Case 3 according to career of working in the 119 rescue services and career of working in the hospital after that education was provided, and technical Performance Case 4 significantly varied with age and rank before and after the education was conducted. In conclusion, the kind of education programs that aim at stirring up the interest of the 119 rescue services in advanced airway and helping the members learn about tracheal intubation accurately with confidence is urgently required.

Gemological Characterization of B. C. Jade (비씨 제이드의 보석학적 연구)

  • Kim, Won-Sa;Wight, Willow
    • Journal of the Mineralogical Society of Korea
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    • v.21 no.2
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    • pp.177-182
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    • 2008
  • The Gemological characteristics of B.C. jade from Cassiar Mine, British Colombia, Canada, have been investigated, using polarizing microscopy, Mohs' hardness, refractive index and density measurements, X-ray powder diffraction, X-ray fluorescence spectrometry, ICP-MS, Infrared absorption spectrometry, and DTA/TGA. The B.C. jade is deeply green (spinach peen or olive green) in color and is translucent. It shows a resinous or waxy luster. The principal mineral of the material is tremolite-actinolite solid solution and minor amount of Cr-garnet and unidentified opaque minerals are accompanied. Mohs' hardness value ($5.5{\sim}6$). refractive index (1.62), and specific gravity (3.01) are measured. It is very highly tough and shows hackly fracture. The high Fe content ($Fe_2O_3\;4.14{\sim}4.66\;wt%$) in B.C. jade is attributable to a deepening of green color of the material. The B.C. jade starts to dehydrate at v and dehydration is completed at $1000.8^{\circ}C$, transforming tremolite-actinolite solid solution to enstatite, diopside, quartz, and water in its place. This possible reaction is supported by the weight loss of B.C. jade (1.93 wt%) at $1000.8^{\circ}C$ indicated by TGA curve.

Genetic Variation of the Major Histocompatibility Complex DRB3.2 Locus in the Native Bos indicus Cattle Breeds

  • Behl, Jyotsna Dhingra;Verma, Naresh Kumar;Behl, Rahul;Sodhi, Monika
    • Asian-Australasian Journal of Animal Sciences
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    • v.22 no.11
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    • pp.1487-1494
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    • 2009
  • The major histocompatibility complex (MHC) plays well-defined roles in eliciting immune responses and combating infectious diseases. The major histocompatibility complex of cattle is referred to as BoLA (Bovine Lymphocyte Antigen). This genetic system is among the most polymorphic. In the present study, polymorphism of the BoLA- DRB3.2 locus in three Bos indicus breeds viz., Sahiwal, Rathi and Hariana was studied by polymerase chain reaction restriction fragment length polymorphism technique using the enzymes RsaI, Bst Y1 and Hae III. Both Sahiwal and Rathi are good Indian dairy breeds and survive under tough tropical conditions, while Hariana is a prominent dual-purpose breed reared both as a dairy animal and for bullock production. A total of 30 different BoLADRB3.2 alleles were observed to be present in the 3 Bos indicus breeds. Certain alleles were common amongst the three breeds while there were others that were unique to each breed. Allelic distribution amongst the three breeds showed that each breed had a unique allelic distribution pattern that was different from each other and also different from the earlier breeds studied so far for the existence of allelic variation at this locus. A dendogram was constructed based on the frequencies of the BoLA-DRB3 alleles using the UPGMA method. The Rathi and Hariana animals were genetically the most apart. The Hariana animals clustered on a different branch from the other two breeds viz. the Rathi and the Sahiwal. The smallest genetic distances for the DRB3 alleles were those between Sahiwal and Rathi (0.5461) while genetic distance between Hariana and Sahiwal was 0.6123. A comparison of the allelic frequencies of the BoLADRB3.2 locus in these 3 breeds viz. Sahiwal, Hariana and Rathi with the allelic frequencies present in the previously characterized Bos indicus Kankrej breed, which is a dual purpose breed reared both as a draught and a dairy animal, showed that the Bos indicus Sahiwal and Rathi breeds clustered into one group while the Hariana and Kankrej breeds formed another group. The Rathi and Sahiwal showed the least genetic distance of 0.5461 amongst the breeds whereas the Rathi and Kankrej, with a Nei''s genetic distance of 1.1622, were genetically the most distant apart.

The optimal parameter estimation of storage function model based on the dynamic effect (동적효과를 고려한 저류함수모형의 최적 매개변수 결정)

  • Kim Jong-Rae;Kim Joo-Cheal;Jeong Dong-Kook;Kim Jae-Han
    • Journal of Korea Water Resources Association
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    • v.39 no.7 s.168
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    • pp.593-603
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    • 2006
  • The basin response to storm is regarded as nonlinearity inherently. In addition, the consistent nonlinearity of hydrologic system response to rainfall has been very tough and cumbersome to be treated analytically. The thing is that such nonlinear models have been avoided because of computational difficulties in identifying the model parameters from recorded data. The parameters of nonlinear system considered as dynamic effects in the conceptual model are optimized as the sum of errors between the observed and computed runoff is minimized. For obtaining the optimal parameters of functions, the historical data for the Bocheong watershed in the Geum river basin were tested by applying the numerical methods, such as quasi-linearization technique, Runge-Kutta procedure, and pattern-search method. The estimated runoff carried through from the storage function with dynamic effects was compared with the one of 1st-order differential equation model expressing just nonlinearity, and also done with Nash model. It was found that the 2nd-order model yields a better prediction of the hydrograph from each storm than the 1st-order model. However, the 2nd-order model was shown to be equivalent to Nash model when it comes to results. As a result, the parameters of nonlinear 2nd-order differential equation model performed from the present study provided not only a considerable physical meaning but also a applicability to Korean watersheds.

A study on increasing the water holding capacity of retorted beef for texture softening by pre-treatment (레토르트 쇠고기의 텍스처 연화를 위한 보수력 향상에 관한 전처리 방법 연구)

  • Choi, Jun-Bong;Chung, Myong-Soo;Cho, Won-Il
    • Korean Journal of Food Science and Technology
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    • v.48 no.6
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    • pp.565-568
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    • 2016
  • This study was conducted to soften the tough texture of retorted beef in storage by increasing the water holding capacity (WHC) after pretreatment involving soaking and blanching in a phosphate solution. The yield of pretreated beef, based on weight as an indirect indicator of WHC, soaked in 0.35% (w/w) complex phosphates for 1 h, increased by 5-10%, in contrast to the untreated control in which the rib and shank was heated at $100^{\circ}C$ for 5-40 min. Additionally, strength of mechanical toughness in the fore rump and rib after phosphate curing at $115^{\circ}C$ for 30 min and blanching at $100^{\circ}C$ for 2 min were significantly decreased to 1.3 and $1.4kg_f$ (p<0.05) as compared to 2.0 and $1.8kg_f$ in the control, respectively. During storage of retorted beef for 30 days at $10^{\circ}C$, rib and shank pretreated with 0.35% complex phosphates exhibited a highly soft texture as compared to that of untreated beef. The softening of pretreated beef was based on the increased WHC due to complex phosphates.

Colorless Copolyimide Films: Thermo-mechanical Properties, Morphology, and Optical Transparency (무색 투명한 폴리이미드 공중합체 필름 : 열적-기계적 성질, 모폴로지, 및 광학 투명성)

  • Jin, Hyo-Seong;Chang, Jin-Hae
    • Polymer(Korea)
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    • v.32 no.3
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    • pp.256-262
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    • 2008
  • Copolyimides containing pendant trifluoromethyl ($CF_3$) groups were synthesized from 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and bis[4-(3-aminophenoxy)phenyl]sulfone (BAPS) with various concentrations of 2,2-bis[4-(4-aminophenoxy)phenyl]hexafluoropropane(BAPP) to poly(amic acid)(PAA), followed by thermal imidization. These copolyimides were readily soluble in N,N'-dimethylacetamide (DMAc) and could be solution-cast into a flexible and tough film. The thermomechanical properties, morphology and an optical transparency of the copolyimide films were determined using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), wide angle X-ray diffraction (XRD), scanning electron microscopy (SEM), universal tensile machine (UTM), and a UV-Vis spectrometer. The cast copolyimide films exhibited high optical transparency with a cut-off wavelength (${\lambda}_0$) of $275{\sim}319\;nm$ in UV-vis absorption and a low yellow index(YI) value of $3.65{\sim}10.37$. The thermo-mechanical properties of copolyimide films were enhanced linearly with increasing a BAPP content. In contrast, the optical transparency of the copolyimide films was found to get worse with increasing a BAPP content.