• The Korean Journal of Physiology and Pharmacology
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• 제28권4호
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• pp.345-359
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• 2024

Deposition of extracellular matrix (ECM) in the trabecular meshwork (TM) increases aqueous humour outflow resistance leading to elevation of intraocular pressure (IOP) in primary open-angle glaucoma, which remains the only modifiable risk factor. Resveratrol has been shown to counteract the steroid-induced increase in IOP and increase the TM expression of ECM proteolytic enzymes; however, its effects on the deposition of ECM components by TM and its associated pathways, such as TGF-β-SMAD signalling remain uncertain. This study, therefore, explored the effects of trans-resveratrol on the expression of ECM components, SMAD signalling molecules, plasminogen activator inhibitor-1 and tissue plasminogen activator in dexamethasone-treated human TM cells (HTMCs). We also studied the nature of molecular interaction of trans-resveratrol with SMAD4 domains using ensemble docking. Treatment of HTMCs with 12.5 µM trans-resveratrol downregulated the dexamethasone-induced increase in collagen, fibronectin and α-smooth muscle actin at gene and protein levels through downregulation of TGF-β1, SMAD4, and upregulation of SMAD7. Downregulation of TGF-β1 signalling by trans-resveratrol could be attributed to its effect on the transcriptional activity due to high affinity for the MH2 domain of SMAD4. These effects may contribute to resveratrol's IOP-lowering properties by reducing ECM deposition and enhancing aqueous humour outflow in the TM.

• The KIPS Transactions:PartA
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• 제8A권4호
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• pp.359-366
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• 2001

This paper overviews the design of SANique$^{TM}$ -a shred file system for Linux cluster based on SAN environment. SANique$^{TM}$ has the capability of transferring user data from network-attached SAN disks to client applcations directly without the control of centralized file server system. The paper also presents the characteristics of each SANique$^{TM}$ subsystem: CFM(Cluster File Manager), CVM(Cluster Volume Manager), CLM(Cluster Lock Manager), CBM(Cluster Buffer Manager) and CRM(Cluster Recovery Manager). Under the SANique$^{TM}$ design layout, then, the syndrome of '||'&'||'quot;split-brain'||'&'||'quot; in shared file system environments is described and defined. The work first generalizes and illustrates possible situations in each of which a shared file system environment may split into two or more pieces of separate brain. Finally, the work describes the SANique$^{TM}$ approach to the given "split-brain"problem using SAN disk named "split-brain" and develops the overall recovery procedure of shared file systems.

• Journal of Physiology & Pathology in Korean Medicine
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• 제28권4호
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• pp.384-389
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• 2014

The purpose of this study is to investigate the modulatory effect of oroxylin A on hydrogen peroxide production in TM4 mouse testis sertoli cells induced by the synthetic analog of double-stranded RNA [polyinosinic-polycytidylic acid]. Hydrogen peroxide production was measured by dihydrorhodamine 123 (DHR) assay. Oroxylin A significantly inhibited the polyinosinic-polycytidylic acid (PIC)-induced production of hydrogen peroxide for 0.5, 2, 12, 18, and 24 hr incubation at the concentrations of 5, 10, 25, and $50{\mu}M$ in TM4 (P < 0.05) in dose dependent manner. These results suggest that oroxylin A has a protective effect against PIC-induced cellular toxicity with its inhibition of hydrogen peroxide production in PIC-induced sertoli cells.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제12권sup1호
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• pp.72-76
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• 2009

Rotavirus infection is the leading cause of severe diarrhea disease in infants and young children worldwide. Rotavirus infects every child at least once by her/his $5^{th}$ birthday. It has been known that single episode of rotavirus infection can protect or alleviate subsequent illness caused by both homotypic and heterotypic rotaviruses. There are two currently licensed rotavirus vaccines. One is human-bovine rotavirus reassortant pentavalent vaccine ($RotaTeq^{TM}$), which contains five reassortant rotavirus (expressing protein G1, G2, G3, G4 and P[8]) and was licensed in Korea for use among infants in 2007. Another is live-attenuated human rotavirus vaccine ($Rotarix^{TM}$) derived from 89-12 strain which represents the most common of the human rotavirus VP7(G1) and VP4(P[8]) antigens. $Rotarix^{TM}$ was licensed in Korea in 2008. Both live oral rotavirus vaccines are efficacious in preventing severe rotavirus gastroenteritis.

• Journal of Magnetics
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• 제2권4호
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• pp.135-137
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• 1997

We report the salient features of the magnetic properties of amorphous TM70Cr5Si10B15(TM=Fe, Co, Ni) alloys. The temperature dependence of magnetization for amorphous ribbons were measured by a SQUID and a VSM from 5 K to 700 K under an external field of 10 kOe. Except TM70Cr5Si10B15 that shows a paramagnetic behaviour, both Fe and Co based amorphous alloys show a typical ferromagnetic thermo-magnetization curves. For these two ferromagnetic alloys, the saturation magnetization in the temperature range from 5 K to about 0.4 Tc can be descrived by the Bloch relation, Ms (T)=Ms(0) [1-BT3/2-CT5/2]. The spin wave stiffness constants and the range of exchange interaction were analyzed from the magnetization behaviour. The variation of the magnetic properties are discussed and compared with the composition of the alloys.

• Journal of Veterinary Clinics
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• 제15권1호
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• pp.30-35
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• 1998

Susceptibility or resistance of the Bordetella bronchiseptica was determined by using the broth microdilution method. Each Bordetella bronchiseptica was tested fur sutraceptluility with 7 different antimicrobial agents.4 high prevalence of resistance (greater than 80 %) was found when Bordetella bronchiseptica was tested with amikacin (AK), ciprofloxacin ILrJl gentamlcin IGAgf, kanamycin (Kbf) and tobramycin (TM). However, the Bordetella bronchiseptica were sensitive to chloramphenicol (CP) and tetracycline (TC). Three different combination of drug resistance were observed : AM-CF-GM-TM (1 strain), AM-CF-GM- KM-TM (45 strains), and AM-CF-GM-KM-TM-CP (3 strains). The MICs against Bordetella bronchiseptica were 0.13 to >2.00 for TC, 4 to >648 for CP, 8 to >128 for CF 16 to >256 for GM, 16 to >256 for TM, 32 to >256 for KM and 64 to 256 for AM.

• The korean journal of orthodontics
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• 제24권1호
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• pp.125-134
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• 1994

This study was designed for comparison of shear bond strengths and failure patterns of four experimental groups which combinated mesh-backed metal brackets and texture based ceramic brackets (Transcend series $2000^{(TM)}$) with chemically cured resin (Mono $Lok2^{(TM)}$) and visible light cured resin $(Transbond^{(TM)})$. Brackets were bonded on the extracted human bicuspids, after etching them by manufacturer's recommand, and the shear bond strengths were measured on the Instron machine after 24 hrs passed in the $37^{\circ}C$ water bath. The results were as follows. 1. Ceramic brackets, transcend series $2000^{(TM)}$, bonded with $MonoLok2^{(TM)}$ showed statistically higher shear bond strength than mesh-backed metal brackets bonded with $MonoLok2^{(TM)}$. 2. There was no significant difference in shear bond strengths between metal and ceramic brackets bonded with $(Transbond^{(TM)})$. 3. Ceramic brackets bonded with both $(Transbond^{(TM)})$) and $MonoLok2^{(TM)}$ showed primarily fractures between brackets adhesive interface. 4. Enamel crack was not found in anyone specimen.

• Journal of Korean Public Health Nursing
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• 제30권1호
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• pp.136-148
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• 2016

Purpose: Patterns of traditional medicine (TM) utilization vary depending on culture, historical significance, and regulations. We seek to understand how socio-demographic factors are related to TM use in Korea. Methods: The longitudinal cohort survey data of the Korea Health Panel (2008-2012) were used for the analysis. Information on TM included questions on 4 types of TM therapies used in South Korea (e.g., acupuncture, moxibustion and cupping, herbal therapies, and massage using hand). To adjust clustering across multiple observations per individual, individual random effects were used in the multivariate analysis. All analyses were performed using Stata 11.0. Results: A majority of Koreans (60%) used WM only during a year, and few people used TM only. Among TM users, most (93%) used it along with WM and 8% used TM only. Our regression analysis showed that female, age 34-64, low-educated, and sicker people were more likely to use TM. Conclusion: This study provides evidence on the relationship between TM utilization and socio-demographic factors.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 한국표면공학회 2012년도 추계총회 및 학술대회 논문집
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• pp.105-106
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• 2012

고상반응법을 사용하여 다양한 활성제 이온 (Eu, Sm, Tb, Tm, Dy)을 도핑한 $BaMoO_4$ 형광체 분말을 제조하였다. 합성한 형광체의 결정 구조는 활성제 종류에 관계없이 $2{\theta}=26.34^{\circ}$에서 주 피크를 갖는 정방정계이었다. 발광스펙트럼의 경우에 첨가한 활성제이온에 따라 다양한 색상을 발생하였다.

• Journal of Magnetics
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• 제15권1호
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• pp.29-31
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• 2010

We studied the magnetic properties of $TmFe_2O_4$. The magnetization measurements revealed the magnetic ordering of Fe spins at around 240 K. The difference between zero-field-cooled (ZFC) and field-cooled (FC) magnetization was close to the thermoremanent magnetization (TRM), indicating the glass behavior exhibited by this material.