• Title/Summary/Keyword: TIM

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Practical Approach for Angina and Non-Obstructive Coronary Arteries: A State-of-the-Art Review

  • Coen K.M. Boerhout;Marcel A.M. Beijk;Peter Damman;Jan J. Piek;Tim P. van de Hoef
    • Korean Circulation Journal
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    • v.53 no.8
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    • pp.519-534
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    • 2023
  • Anginal symptoms are frequently encountered in patients without the presence of significant obstructive coronary artery disease (CAD). It is increasingly recognized that vasomotor disorders, such as an abnormal vasodilatory capacity of the coronary microcirculation or coronary vasospasm, are the dominant pathophysiological substrate in these patients. Although the evidence with respect to angina in patients with non-obstructive coronary arteries is accumulating, the diagnosis and treatment of these patients remains challenging. In this review, we aimed to provide a comprehensive overview regarding the pathophysiological origins of angina with non-obstructive coronary arteries disorders and its diagnostic and therapeutic considerations. Hereby, we provide a practical approach for the management of patents with angina and non-obstructive CAD.

A Study on the Thermal Conductivity and Mechanical Properties of Electrical Insulation Polymer Composite Materials (실리콘 고분자 복합소재의 열전도도와 기계적 물성에 관한 연구)

  • Won-il Choil;Kye-Kwang Choi
    • Design & Manufacturing
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    • v.18 no.3
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    • pp.37-43
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    • 2024
  • With the development of technology in the electrical and electronic field, research on heat dissipation materials that can efficiently emit and control heat to solve the heat generation problem is being actively conducted. Since heat dissipation materials require electrical insulation and thermal conductivity, the polymer composite material was manufactured by mixing chemically stable silicone resins and ceramic fillers, and thermal conductivity and mechanical properties were observed. At the same filling amount, the larger the particle size and the higher the high thermal conductivity filler was added, the higher the thermal conductivity was, mechanical properties were confirmed to have higher tensile strength and elongation as the particles were smaller and the tissue was denser. After selecting materials in consideration of thermal conductivity and mechanical properties, an appropriate mixing ratio is considered important.

Estimation of Forest Growing Stock by Combining Annual Forest Inventory Data (연년 산림자원조사 자료를 이용한 임목축적 추정)

  • Yim, Jong Su;Jung, Il Bin;Kim, Jong Chan;Kim, Sung Ho;Ryu, Joo Hyung;Shin, Man Yong
    • Journal of Korean Society of Forest Science
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    • v.101 no.2
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    • pp.213-219
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    • 2012
  • The $5^{th}$ national forest inventory (NFI5) has been reorganized to annual inventory system for providing multi-resources forest statistics at a point in time. The objective of this study is to evaluate statistical estimators for estimating forest growing stock in Chungcheongbuk-Do from annual inventory data. When comparing two estimators; simple random sampling (SRS) and double sampling for post-stratification (DSS), for estimating mean forest growing stock ($m^3/ha$) at each surveyed year, the estimate for DSS in which a population of interest is stratified into three sub-population (forest cover types) was more precise than that for SRS. To combine annual inventory field data, three estimators (Temporally Indifferent Method; TIM, Moving Average; MA, and Weighted Moving Average; WMA) were compared. Even though the estimated mean for TIM and WMA is identical, WMA-DSS is preferred to provide more smaller variance of estimated mean and to adjust for catastrophic events at a surveyed year (so-called "lag bias") by annual inventory data.

Cortical Thickness Estimation Using DIR Imaging with GRAPPA Factor 2 (DIR 영상을 이용한 피질두께 측정: GRAPPA 인자 2를 이용한 비교)

  • Choi, Na-Rae;Nam, Yoon-Ho;Kim, Dong-Hyun
    • Investigative Magnetic Resonance Imaging
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    • v.14 no.1
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    • pp.56-63
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    • 2010
  • Purpose : DIR image is relatively free from susceptibility artifacts therefore, DIR image can make it possible to reliably measure cortical thickness/volume. One drawback of the DIR acquisition is the long scan time to acquire the fully sampled 3D data set. To solve this problem, we applied a parallel imaging method (GRAPPA) and verify the reliability of using the volumetric study. Materials and methods : Six healthy volunteers (3 males and 3 females; age $25.33{\pm}2.25$ years) underwent MRI using the 3D DIR sequence at a 3.0T Siemens Tim Trio MRI scanner. GRAPPA simulation was performed from the fully sampled data set for reduction factor 2. Data reconstruction was performed using MATLAB R2009b. Freesurfer v.4.3.0 was used to evaluate the cortical thickness of the entire brain, and to extract white matter information from the DIR image, Analyze 9.0 was used. The global cortical thickness estimated from the reconstructed image was compared with reference image by using a T-test in SPSS. Results : Although reduced SNR and blurring are observed from the reconstructed image, in terms of segmentation the effect was not so significant. The volumetric result was validated that there were no significant differences in many cortical regions. Conclusion : This study was performed with DIR image for a volumetric MRI study. To solve the long scan time of 3D DIR imaging, we applied GRAPPA algorithm. According to the results, fast imaging can be done with reduction factor 2 with little loss of image quality at 3.0T.

Suppression of a Residue 173 Mutant Form on Aggregation of Tryptophan Synthase α-Subunits from Escherichia coli (대장균 트립토판 중합효소 α 소단위체의 응집 형성에 미치는 잔기 173 치환체의 억제 효과)

  • Jeong, Jae Kap;Park, Hoo Hwi;Lim, Woon Ki
    • Journal of Life Science
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    • v.32 no.9
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    • pp.729-733
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    • 2022
  • Aggregation of normally soluble proteins can cause disease-related problems. Tryptophan synthase α-subunit (αTS) in E. coli adopts one of most popular structural scaffolds, the TIM barrel fold. Previous mutagenesis of the αTS gene resulted in many aggregation-prone mutant proteins. Here, Y173F (Tyr at residue 173 to Phe) substitution, which imparts increased stability, was tested for its ability to suppress aggregation of aggregation-prone mutant proteins (Y4C, S33L, P28L, P28S, G44S, D46N, P96L, and P96S). Aggregation was suppressed in all eight severe aggregate-forming mutants (all differing in their mutation positions), by the Y173F replacement. P28L αTS, which was available in pure form, was further analyzed and showed reduced secondary structure content, lower stability, and a looser structure with more exposed hydrophobic surface compared to the wild type protein. A double mutant P28L/Y173F protein showed almost no indication of these changes compared to the wild type protein. We hypothesized that Tyr at position 173 in αTS is positioned at the hydrophobic core and may serve to suppress the aggregation of this protein caused by other residues. Important residue (s) could be working widely in the prevention/suppression of protein aggregation.

A Study on the Data Compression Algorithm for Just-in-Time Rendering of Concentric Mosaic (동심원 모자이크의 실시간 표현을 위한 데이터 압축 알고리즘에 관한 연구)

  • Jee, Inn-Ho;Ahn, Hong-Yeoung
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.10 no.1
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    • pp.91-96
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    • 2010
  • Concentric mosaics are made with arranging and summing of video frames by using common spacial standards. Compared with previous works on 3-D wavelet transform coding, we have made important design considerations to enable flexible partial decoding and bit-stream random access. A just-in-time(JIT) rendering engine of the compressed concentric mosaic is developed. However, computationally, it is still demanding to accomplish the real-time rendering. Only the contents for specific scene representation are need to be decoded by maintaining compressed data. Thus our proposed algorithm is able to render real concentric mosaic by using lifting scheme instead of wavelet transform.

Thermal Characteristics of the Optimal Design on 20W COB LED Down Light Heat Sink

  • Kwon, Jae-Hyun;Lee, Jun-Myung;Huang, Wei;Park, Keon-Jun;Kim, Yong-Kab
    • International journal of advanced smart convergence
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    • v.2 no.2
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    • pp.19-22
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    • 2013
  • As the demand of the LED for lighting that emits light by p-n junction is increasing, studies on heatproof plate technology is being conducted to minimize the temperature of the LED lighting. As for the temperature of the LED devices, their light emitting efficiency decreases and the maximum lifespan drops down to 1/5. Therefore there are heat dissipation studies going on to minimize the heat. For LED heat dissipation, aluminum heat sink plates are mostly used. For this paper, we designed heat sink that fits residential 20W COB LED Down Light; packaged the heat sink and 20W COB and analyzed and evaluated the thermal properties through a Solidworks flow simulation. We are planning to design the optimal heat sink plate to solve the thermal agglomeration considering TIM(Thermal Interface material).

Experimental Study of Capture Effect for Medium Access Control with ALOHA

  • Kosunalp, Selahattin;Mitchell, Paul D.;Grace, David;Clarke, Tim
    • ETRI Journal
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    • v.37 no.2
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    • pp.359-368
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    • 2015
  • In this paper, we investigate the capture effect through experiments conducted with Iris nodes equipped with AT86RF230 radio transceivers. It is shown that the first arriving packet in a collision can capture the radio channel for equal power transmissions and may be decoded depending on the amount of overlap. A new 3-packet-capture scenario is introduced and implemented. To be able to understand the impact of capture on the throughput performance of wireless sensor networks, we present an analysis of the capture coefficient using our practical results. For real-world implementations, the throughput of pure ALOHA considering a finite number of users is presented in analytical form. The capture coefficient is then applied to pure ALOHA as a case study. Using analytical and practical implementations of the capture effect on ALOHA, a very good match in channel throughput performance enhancement is demonstrated over the non-capture effect case. TinyOS-2.x is used to program the nodes and to observe data exchange on a computer through a base station.

Deep Packet Inspection Time-Aware Load Balancer on Many-Core Processors for Fast Intrusion Detection

  • Choi, Yoon-Ho;Park, Woojin;Choi, Seok-Hwan;Seo, Seung-Woo
    • IEIE Transactions on Smart Processing and Computing
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    • v.5 no.3
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    • pp.169-177
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    • 2016
  • To realize high-speed intrusion detection by accommodating many regular expression (regex)-based signatures and growing network link capacities, we propose the Service TimE-Aware Load-balancing (STEAL) algorithm. This work is motivated from the observation that utilization of a many-core network intrusion detection system (NIDS) is influenced by unfair computational distribution among many-core NIDS nodes. To avoid such unfair computational distribution, STEAL is designed to dynamically distribute a large volume of traffic among many-core NIDS nodes based on packet service time, which is represented by the deep packet time in many-core NIDS nodes. From experiments, we show that compared to the commonly used load-balancing algorithm based on arrival rate, STEAL increases the number of received packets (i.e., decreases the number of dropped packets) in many-core NIDS. Specifically, by integrating an open source NIDS (i.e. Bro) with STEAL, we show that even under attack-dominant traffic and with many signatures, STEAL can rapidly improve the performance of many-core NIDS to realize high-speed intrusion detection.

Analysis and Measurement of Effective Refractive Indices with Ion-exchanged Slab Waveguide (이온교환 평판도파로의 실효굴절율 측정 및 해석)

  • 천석표;박정일;박태성;정홍배
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1995.05a
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    • pp.73-76
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    • 1995
  • In this study, the slab waveguide was fabricated using potassium-nitride(KNO$_3$) or silver-nitride (AgNO$_3$) molten sources by ion-exchange process. The effective refractive indices of waveguide were measured by Prism-Coupling method. and The characteristics of waveguide(mode dispersion, effective diffusion depth. surface refractive index, diffusion coefficient, and refractive index profile etc,) were investigated by WKB method, In the case of potassium ion-exchange, the computer calculation showed that the refractive index profile of waveguide followed Gaussian function, the surface refractive index increased with ion-exchange time and the effective diffusion depth increased a little as ion-exchange time increased, while the surface refractive index of silver ion-exchanged waveguide decreased with ion-exchange time because of the ion depletion on the surface of waveguide, and the effective diffusion depth seriously with ion-exchange tim. Double ion-exchanged waveguide was fabricated by performing silver ion-exchange after potassium ion-exchange. Double ion-exchanged waveguide had a tight mode binding force since the surface refractive index was larger than single step ion-exchanged waveguide.

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