• 대한의용생체공학회:의공학회지
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• 제16권4호
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• pp.447-456
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• 1995

완전 이식형 인공심장 개발의 일환으로 무선에너지 전송장치를 개발하였다. 본 연구에서는 피하에 이식된 2차 코일과 피부표면에 놓인 1차 코일 간의 자기 유도의 원리에 의한 전기에너지 전송시스템을 개발하였으며, 이식될 소자의 소형화 및 전송효율의 향상을 목표로 하였다. 클래스 E 공진 증폭기를 이용하여 인공심자의 구동에 요구되는 40 Watt 전송시 75% 이상의 전송 효율을 얻었다. 또한 동물 실험을 실시하여, 체내 성능을 검증하였고 체내 이식부의 생체 적합성도 확인하였다.

• Journal of Chest Surgery
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• 제28권6호
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• pp.533-541
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• 1995

We recently developed a new model of moving actuator type totally implantable artificial heart[TIAH , based on the reverse position of the aortic and pulmonary conduits. This concept was proposed by one of surgeons in our team[Joon-Ryang Rho, M.D. to facilitate anatomical fitting of TIAHs. The moving actuator type electromechanical TIAH consisted of the left and right blood sacs, and the moving actuator including a motor. The inverted umbrella type polyurethane valves were used in the blood pumps. The aortic conduit was positioned anterior to the pulmonary conduit, which was the opposite relation to the conventional configuration of other total artificial hearts. We also adapted slip-in connectors for the aortic and pulmonary conduits. Two sheep , weighing 60-69 kg, were used for implantation. After small cervical incision and trans-sternal bilateral thoracotomy, cardiopulmonary bypass [CPB was administered using an American Optical 5-head pump and a membrane oxygenator[Univox-IC, Bentley . The anterior and posterior vena cavae were drained separately for venous return. An arterial return cannula was inserted into the right common carotid artery. During CPB, almost all of the ventricular myocardium was excised down to the atrioventricular groove and the artificial heart was implanted. We achieved 3-day survival in the first sheep and 2-day survival in the second. The day after operation the first sheep was successfully extubated and the second sheep was weaned from a respirator with good condition. After extubation, the first sheep walked around in the cage and fed herself. Serial laboratory and hemodynamic examinations were done during the experiments. In both sheep, pulmonary dysfunction was gradually developed, which was accompanied by acute renal failure. The animals were sacrificed and autopsy was done. Unexpected pregnnacy was incidentally found in both sheep. To our knowledge this is the first report of significant survival cases in the orthotopic implantation of electric TIAH using sheep.