• Korean Journal of Biological Psychiatry
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• v.10 no.2
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• pp.133-140
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• 2003

Objective:Some candidate gene polymorphisms were reported to be associated with tardive dyskinesia (TD). The aim of this study was to investigate the association of the 5-$HT_{2A}$ receptor gene polymorphisms with TD in Korean schizophrenic subjects. Method:Subjects were of 59 schizophrenic patients with TD and 60 schizophrenic patients without TD for studying of 5-$HT_{2A}$ receptor gene polymorphisms. TD was evaluated using the Abnormal Involuntary Movement Scale(AIMS). Genomic DNA was amplified by PCR and digestion with MspI and BsmI. Result:There were no statistically significant differences in the demographic variables, such as age, male to female percentage, duration of illnesses and duration of antipsychotic drug exposure between the TD group and control group. 1) T102C polymorphisms and TD Comparing the TD group and control group, the 102T/C allele was associated with a significantly increased risk for TD (${\chi}^2$=5.560, df=1, p=0.018). 2) Three AIMS categories of TD and T102C genotype. There were statistically significant differences in the three AIMS categories(${\chi}^2$=6.835, df=2, p=0.033). Conclusion:These result suggest 102T/C genotypes of the 5-$HT_{2A}$ receptor gene are related to the development of TD. The 102T/C genotypes were associated with significantly higher AIMS orofacial dyskinesia scores. These findings suggest that the 5-$HT_{2A}$ receptor gene is significantly associated with susceptibility to TD in patients with chronic schizophrenia.

• Journal of Digital Convergence
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• v.16 no.12
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• pp.309-315
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• 2018

In this paper, propose an efficient arc detection and control method to achieve fast machining speed, improved precision and surface roughness in discharge machining, especially for carbide and hard material processing and metal processing using discharge phenomenon as energy. A single discharge waveform is divided into three sections of Td (Time-Delay), Ton (Time-on) and Toff (Time-off) and the gate control timing is simulated using the HDL language. In this paper, we analyze the effect of the gap between the electrode and the workpiece on the machining results by determining the operation of the servo mechanism by sampling the Td section through the comparator circuit. As a result of the analysis, the Td section of the formed waveform was more precisely sampled at a high speed and the results were improved when applied to the gap control between the electrode and the workpiece.

• Clinical Endoscopy
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• v.55 no.5
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• pp.655-664
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• 2022

Background/Aims: Endoscopic submucosal dissection (ESD) for residual or recurrent colorectal lesions after incomplete resection is challenging because of severe fibrosis. This study aimed to compare the efficacy of the pocket-creation method (PCM) with a traction device (TD) with that of conventional ESD for residual or recurrent colorectal lesions. Methods: We retrospectively studied 72 patients with residual or recurrent colorectal lesions resected using ESD. Overall, 31 and 41 lesions were resected using PCM with TD and conventional ESD methods, respectively. We compared patient background and treatment outcomes between the PCM with TD and conventional ESD groups, respectively. The primary endpoints were en bloc resection and R0 resection rates. The secondary endpoints were the dissection speed and incidence of adverse events. Results: En bloc resection was feasible in all cases with PCM with TD, but failed in 22% of cases of conventional ESD. The R0 resection rates for PCM with TD and conventional ESD were 97% and 66%, respectively. Dissection was significantly faster in the PCM with TD group (13.0 vs. 7.9 mm²/min). Perforation and postoperative bleeding were observed in one patient in each group. Conclusions: PCM with TD is an effective method for treating residual or recurrent colorectal lesions after incomplete resection.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.8 no.1
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• pp.38-42
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• 1983

The characteristic of a Tunnel Diode(TD) is approximated by the summation of two exponential terms, obtained from the haracteristic curves displayed on the curve tracer. Using this result, static characteristic of a TD pair was plotted by a computer programming. From these static characteristic curves, the triggering behavior of TC pair multi-vibrators was described graphically. Two stable characteristics were analyzed by piecewise linear Method. Theoritical switching Theoritical switching times of a TD pair flip-flop(F-F) circuits were compared with experimental results.

• Bulletin of the Korean Chemical Society
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• v.34 no.8
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• pp.2276-2280
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• 2013

The accurate prediction of vertical excitation energies is very important for the development of new materials in the dye and pigment industry. A time-dependent density functional theory (TD-DFT) approach coupled with 22 different exchange-correlation functionals was used for the prediction of vertical excitation energies in the halogenated copper phthalocyanine molecules in order to find the most appropriate functional and to determine the accuracy of the prediction of the absorption wavelength and observed spectral shifts. Among the tested functional, B3LYP functional provides much more accurate vertical excitation energies and UV-vis spectra. Our results clearly provide a benchmark calibration of the TD-DFT method for phthalocyanine based dyes and pigments used in industry.

• Radiation Oncology Journal
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• v.34 no.1
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• pp.64-75
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• 2016

Purpose: In order to evaluate the relationship between the dose to the liver parenchyma and focal liver reaction (FLR) after stereotactic ablative body radiotherapy (SABR), we suggest a novel method using a three-dimensional dose distribution and change in signal intensity of gadoxetate disodium-gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) hepatobiliary phase images. Materials and Methods: In our method, change of the signal intensity between the pretreatment and follow-up hepatobiliary phase images of Gd-EOB-DTPA-enhanced MRI was calculated and then threshold dose (TD) for developing FLR was obtained from correlation of dose with the change of the signal intensity. For validation of the method, TDs for six patients, who had been treated for liver cancer with SABR with 45-60 Gy in 3 fractions, were calculated using the method, and we evaluated concordance between volume enclosed by isodose of TD by the method and volume identified as FLR by a physician. Results: The dose to normal liver was correlated with change in signal intensity between pretreatment and follow-up MRI with a median $R^2$ of 0.935 (range, 0.748 to 0.985). The median TD by the method was 23.5 Gy (range, 18.3 to 39.4 Gy). The median value of concordance was 84.5% (range, 44.7% to 95.9%). Conclusion: Our method is capable of providing a quantitative evaluation of the relationship between dose and intensity changes on follow-up MRI, as well as determining individual TD for developing FLR. We expect our method to provide better information about the individual relationship between dose and FLR in radiotherapy for liver cancer.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.5 s.96
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• pp.447-454
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• 2005

JEC method for Debye medium is required more memory resources and long calculation time than already well-known method such as RC method. It has been observed that JEC method would be converted to a memory effcient method by a change of discrete convolution integral range. The modified JEC method proposed here requires memory and calculation time similar to RC method, while it has a same or a smaller dispersion error than conventional methods, RC and JEC.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.8
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• pp.1595-1611
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• 1994

In this paper, the numerical wave propagation properties of the finite difference-time domain(FD-TD) method is investigated as a discrete model describing electromagnetic(EM) wave propagation phenomena. The leap-frog approximation of Maxwell's curl equations in time-space simulates EM wave propagation in terms of the numerical characteristic and the domain of dependence. A geometrical interpretation of the FD-TD numerical procedure is presented. The numerical dispersion error due to the leap-frog approximation and its dependence on the stability factor are illustrated. The FD-TD method using the leap-frog approximation is inherently a descriptive model. Thus, not only any physical picture about EM wave propagation phenomena can be drawn through this model, but also physical or engineering parameters in the frequency domain can be extracted from descriptive results. E-plane filter characteristics in the WR-28 rectangular waveguide and reflection property of an inductive iris in the WR-90 rectangluar waveguide extracted from simulation of the FD-TD model is included.

• Current Optics and Photonics
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• v.8 no.3
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• pp.282-299
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• 2024

Target detection (TD) is a research hotspot in the field of hyperspectral imaging (HSI). Traditional TD methods often mine targets from HSIs under a single imaging condition, without considering the influence of imaging conditions. In fact, the spectra of ground objects in HSIs are uncertain and affected by the imaging conditions (weather, atmospheric, light, time, and other angle conditions including zenith angle). Hyperspectral data changes under different imaging conditions. Therefore, the detection result for a single imaging condition cannot accurately reflect the effectiveness of the detection method used. It is necessary to analyze the performance of various detection methods under different imaging conditions, to find a more applicable detection method. In this paper, we study the performance of TD methods under various land-based imaging conditions. We first summarize classical TD methods and evaluation methods. Then, the detection effects under various imaging conditions are analyzed. Finally, the concepts of the stability coefficient (SC) and effective area under the curve (EAUC) are proposed to comprehensively evaluate the applicability of detection methods under land-based imaging conditions, in terms of both detection accuracy and stability. This is conducive to our selection of detection methods with better applicability in land-based contexts, to improve detection accuracy and stability.

• Korean Journal of Materials Research
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• v.25 no.1
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• pp.1-8
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• 2015

This study suggested comprehensive structural characterization methods for the commercial blue light emitting diodes(LEDs). By using the Z-contrast intensity profile of Cs-corrected high-angle annular dark field scanning transmission electron microscope(HAADF-STEM) images from a commercial lateral GaN-based blue light emitting diode, we obtained important structural information on the epilayer structure of the LED, which would have been difficult to obtain by conventional analysis. This method was simple but very powerful to obtain structural and chemical information on epi-structures in a nanometer-scale resolution. One of the examples was that we could determine whether the barrier in the multi-quantum well(MQW) was GaN or InGaN. Plan-view TEM observations were performed from the commercial blue LED to characterize the threading dislocations(TDs) and the related V-pit defects. Each TD observed in the region with the total LED epilayer structure including the MQW showed V-pit defects for almost of TDs independent of the TD types: edge-, screw-, mixed TDs. The total TD density from the region with the total LED epilayer structure including the MQW was about $3.6{\times}10^8cm^{-2}$ with a relative ratio of Edge- : Screw- :Mixed-TD portion as 80%: 7%: 13%. However, in the mesa-etched region without the MQW total TD density was about $2.5{\times}10^8cm^{-2}$ with a relative ratio of Edge- : Screw- :Mixed-TD portion of 86%: 5%: 9 %. The higher TD density in the total LED epilayer structure implied new generation of TDs mostly from the MQW region.