• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3331-3333
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• 2014

Background: The results of previous researches that analyzed the association between genetic polymorphisms of transcription factor-7-like 2 (TCF7L2, rs7903146) and polycystic ovary syndrome (PCOS) were conflicting. Current systematic analysis was conducted to re-explore this association using updated materials. Materials and Methods: The PubMed database was used for data collection and the final search was conducted on January 3, 2014. For TCF7L2 rs7903146, a non-signficiant slight increase in risk of PCOS development was observed under three genetic models (dominant model: OR=1.06, 95%CI: 0.93-1.21, p>0.05; recessive model: OR=1.12, 95%CI: 0.87-1.43, p> 0.05; homozygous model: OR=1.14, 95%CI: 0.87-1.47, p>0.05). In the subgroup analyses in Asian group, allele susceptibility of PCOS was calculated (allele model: OR=1.00, 95%CI: 0.74-1.35, p>0.05; dominant model: OR=0.98, 95%CI: 0.71-1.35, p>0.05; recessive model: OR=1.79, 95%CI: 0.33-9.84, p>0.05; homozygous model: OR=1.78, 95%CI: 0.32-9.80, p>0.05), the differences were again not statistically significant. Conclusions: The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 may not be associated with the susceptibility to PCOS.

• 한국세라믹학회지
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• 제38권11호
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• pp.1042-1045
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• 2001

Ba(Zn$_{1}$3/Nb$_{2}$3/) $O_3$-Sr(Zn$_{1}$3/Nb$_{2}$3/) $O_3$계에 대하여 소결 온도 변화와 Zr $O_2$첨가량에 따른 마이크로파 유전특성을 조사하였다. 동일 조성에서 소결 온도가 증가함에 따라 밀도가 향상되고 공진 주파수의 온도계수($ au$$_{f}$)는 감소하는 경향을 보였으나, 유전상수(K)와 품질계수(Q$\times$f)는 커다란 변화가 없었다. 또한 Zr $O_2$첨가량이 증가함에 따라 소결 시편의 밀도가 향상되었고 더불어 유전상수, 품질계수가 증가하는 경향을 보였으며, 공진 주파수의 온도계수가 감소하는 우수한 특성이 나타났다. 특히, 소결온도 1575$^{\circ}C$, 0.6 wt% Zr $O_2$를 첨가했을 때 유전상수가 최대($\varepsilon$$_{r}$=41)로 나타났으며, 공진 주파수의 온도계수는 1.0wt% Zr $O_2$를 첨가했을 때 최소($\tau$$_{f}$=+0.8ppm/$^{\circ}C$)로서 양호한 값을 얻을 수 있었다.었다.

• Molecules and Cells
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• 제26권5호
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• pp.462-467
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• 2008

TPA is known to cooperate with an activated Ras oncogene in the transformation of rodent fibroblasts, but the biochemical mechanisms responsible for this effect have not been established. In the present study we used c-fos promoter-luciferase constructs as reporters, in transient transfection assays, in NIH3T3 cells to assess the mechanism of this cooperation. We found a marked synergistic interaction between TPA and a transfected v-Ha-ras oncogene in the activation of c-fos promoter and SRE. SRE has binding sites for TCF and SRF. A dominant-negative Ras (ras-N17) inhibited the TPA-Ras synergy by blocking the PKC-MAPK-TCF pathway. Dominant-negative RhoA and Rac1 (but not Cdc42Hs) inhibited the TPA-Ras synergy by blocking the Ras-Rho-SRF signaling pathway. Constitutively active $PKC{\alpha}$ and $PKC{\varepsilon}$ showed synergy with v-Ras. These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways.

• 한국세라믹학회지
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• 제49권3호
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• pp.272-278
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• 2012

Effects of ceramics on the microwave dielectric properties of polytetrafluoroethylene (PTFE) composites filled with $MgTiO_3$ (MTi) and/or $MgTa_2O_6$ (MTa) were investigated. The dielectric constant ($K$), quality factor ($Qf$), and temperature coefficient of resonant frequency ($TCF$) of the composites were dependent on the type and volume fraction ($V_f$) of the ceramics. For the composites mixed with MTa and MTi, the $K$ and $TCF$ values decreased with increasing MTi content. The $Qf$ values of the composites were affected by relative density. The measured $K$ values of the composites were compared with those predicted by several theoretical models. Good microwave dielectric properties with values of $K$=3.6, $Qf$ = 7,788 GHz, and $TCF$ = -0.19 ppm/$^{\circ}C$ were obtained for the composites with 0.1 $V_f$ ceramics (mixed 0.025MTa and 0.075MTi).

• Biomolecules & Therapeutics
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• 제24권4호
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• pp.380-386
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• 2016

Silymarin from milk thistle (Silybum marianum) has been reported to show an anti-cancer activity. In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-${\kappa}B$-mediated threonine-286 phosphorylation. However, mechanism for the inhibition of Wnt signaling by silymarin still remains unanswered. Thus, we investigated whether silymarin affects Wnt signaling in human colorectal cancer cells to elucidate the additional anti-cancer mechanism of silymarin. Transient transfection with a TOP and FOP FLASH luciferase construct indicated that silymarin suppressed the transcriptional activity of ${\beta}$-catenin/TCF. Silymarin treatment resulted in a decrease of intracellular ${\beta}$-catenin protein but not mRNA. The inhibition of proteasome by MG132 and $GSK3{\beta}$ inhibition by SB216763 blocked silymarin-mediated downregulation of ${\beta}$-catenin. In addition, silymarin increased phosphorylation of ${\beta}$-catenin and a point mutation of S33Y attenuated silymarin-mediated ${\beta}$-catenin downregulation. In addition, silymarin decreased TCF4 and increased Axin expression in both protein and mRNA level. From these results, we suggest that silymarin-mediated downregulation of ${\beta}$-catenin and TCF4 may result in the inhibition of Wnt signaling in human colorectal cancer cells.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2020년도 춘계학술대회
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• pp.89-89
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• 2020

In this study, we evaluated the effect of the extracts from Lonicera caerulea leaves (LCLE), branches (LCBE) and fruits (LCFE) on the cell growth and migration in human colorectal cancer cells, HCT116 and SW480 cells. LCLE and LCBE dose- and time-dependently inhibited the proliferation of HCT116 and SW480 cells. However, LCFE did not affect the proliferation of HCT116 and SW480 cells. In addition, LCLE and LCBE dramatically cell migration and wound healing in HCT116 cells. LCLE and LCBE decreased β-catenin protein level but not mRNA level in HCT116 and SW480 cells. Furthermore, LCLE decreased TCF4 level in both protein and mRNA level in HCT116 and SW480 cells. However, LCBE decreased TCF4 protein level but not mRNA level in HCT116 and SW480 cells. Based on these findings, LCLE and LCBE may inhibit the cell proliferation and migration through blocking Wnt signaling activation in human colorectal cancer cells. Therefore, LCLE and LCBE may be a potential candidate for the development of chemopreventive or therapeutic agents for human colorectal cancer.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제43회 하계 정기 학술대회 초록집
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• pp.434-434
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• 2012

Despite recent efforts for fabricating flexible transparent conducting films (TCFs) with low resistance and high transmittance, several obstacles to meet the requirement of flexible displays still remain. Indium tin oxide (ITO) thin films, which have been traditionally used as the TCFs, have a serious obstacle in TCFs applications. SWNTs are the most appropriate materials for conductive films for displays due to their excellent high mechanical strength and electrical conductivity. Recently, it has been demonstrated that acid treatment is an efficient method for surfactant removal. However, the treatment has been reported to destroy most SWNT. In this work, the fabrication by the spraying process of transparent SWNT films and reduction of its sheet resistance by Au-ionic doping treatment on PET substrates is researched. Arc-discharge SWNTs were dispersed in deionized water by adding sodium dodecyl sulfate (SDS) as surfactant and sonicated, followed by the centrifugation. The dispersed SWNT was spray-coated on PET substrate and dried on a hotplate. When the spray process was terminated, the TCF was immersed into deionized water to remove the surfactant and then it was dried on hotplate. The TCF film was then was doped with Au-ionic doping treatment, rinsed with deionized water and dried. The surface morphology of TCF was characterized by field emission scanning electron microscopy. The sheet resistance and optical transmission properties of the TCF were measured with a four-point probe method and a UV-visible spectrometry, respectively. This was confirmed and discussed on the XPS and UPS studies. We show that 87 ${\Omega}/{\Box}$ sheet resistances with 81% transmittance at the wavelength of 550 nm. The changes in electrical and optical conductivity of SWNT film before and after Au-ionic doping treatments were discussed. The effects of hole transport interface layer using Au-ionic doping SWNT on the performance of organic solar cells were investigated.

• 한국재료학회지
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• 제7권9호
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• pp.723-727
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• 1997

Nd치환이 Ag의 용융점 이하인 94$0^{\circ}C$에서 소결한 $Bi_{1-x}$$Nd_{x}$N$bO_{4}$세라믹스의 소결거동과 마이크로파 유전특성에 미치는 영향을 연구하였다. Nd치환량(x)이 증가함에 따라 사방점에서 삼사정으로 변하는 양이 증가하였고 결정립의 크기, 겉보기밀도, 유전상수는 감소하였다. Q$xf_{0}$값은 Nd 치환량이 0.025mole 이하의 경우 큰 변화가 없으나, 그 이상에서는 증가하여 0.1mol일 때 최고값을 보이고 다시 급격히 감소하였다. TCF값은 Nd치환량이 증가할수록(+)방향으로 증가하였다. 가장 우수한 마이크로파 유전특성은 Nd 치환량이 0.025mole일 때 얻어졌으며, 이때 유전상수는 43.7, Qxf/ sub 0/값은 11,046GHz, TCF값은 -1.82ppm/$^{\circ}C$이었다.

• 한국안전학회지
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• 제16권3호
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• pp.117-124
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• 2001

This paper introduces m analysis framework and procedure for the support of the cognitive error analysis of emergency tasks in nuclear poler plants. The framework provides a new perspective in the utilization of influencing factors into error prediction. The framework can be characterized by two features. First, influencing factors that affect the occurrence of human error me classified into three groups, i.e., task characteristic factors(TCF), situation factors(SF), and performance assisting factors(PAF). This classification aims to support error prediction from the viewpoint of assessing the adequacy of PAF under given TCF and SF. Second, the assessment of influencing factors is made by each cognitive function. Through this, influencing factors assessment and error prediction can be made in an integrative way according to each cognitive function. In addition, it helps analysts identify vulnerable cognitive functions and error factors, and obtain specific nor reduction strategies. The proposed framework was applied to the error analysis of the bleed and feed operation of nuclear emergency tasks.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2000년도 추계학술대회 논문집
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• pp.229-233
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• 2000

In this study, the temperature coefficient of resonant frequency($TCF_r$), dielectric and piezoelectric properties of $Pb_{1-x}Sr_x[(Sb_{1/2}Nb_{1/2})_{0.035}(Mn_{1/3}Nb_{2/3})_{0.065}(Zr_{0.49},Ti_{0.51})_{0.90}]O_3$ ceramics were investigated with the Sr substitution to Pb site. The dielectric constant was increased according to the increase of Sr substitution and electromechanical coupling factor($k_t$) also showed the highest values of 0.485 when the Sr substitution was 5 mol%. Moreover, the mechanical quality factor($Q_{mt}$) showed the highest value of 233 when the Sr substitution was 2 mol%.