• The Journal of Information Technology
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• v.3 no.3
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• pp.117-134
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• 2000

Client-server DBMS based on a data-skipping model can exploit client resources effectively by allowing inter-transaction caching. However, inter-transaction caching raises the need of transactional cache consistency maintenance(TCCM) protocol, since each client is able to cache a portion of the database dynamically. Detection-based TCCM schemes can reduce the message overhead required for cache consistency if they validate clients replica asynchronously, and thus they cm show high throughput rates. However, they tend to show high ratios of transaction abort since transactions can access invalid replica. For coping with this drawback, this paper develops a new notion of shadow transaction, which is a backup-purpose one that is kept ready to replace an aborted transaction. This paper proposes a new detection-based TCCM scheme named DL-ST on the basis of the notion of shadow transaction. Using a simulation model, this paper evaluates the effect of shadow transaction in terms of transaction through rate and abort ratio.

• BMB Reports
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• v.55 no.2
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• pp.81-86
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• 2022

Macrophages are a major cellular component of innate immunity and are mainly known to have phagocytic activity. In the tumor microenvironment (TME), they can be differentiated into tumor-associated macrophages (TAMs). As the most abundant immune cells in the TME, TAMs promote tumor progression by enhancing angiogenesis, suppressing T cells and increasing immunosuppressive cytokine production. N-myc downstream-regulated gene 2 (NDRG2) is a tumor suppressor gene, whose expression is down-regulated in various cancers. However, the effect of NDRG2 on the differentiation of macrophages into TAMs in breast cancer remains elusive. In this study, we investigated the effect of NDRG2 expression in breast cancer cells on the differentiation of macrophages into TAMs. Compared to tumor cell-conditioned medium (TCCM) from 4T1-mock cells, TCCM from NDRG2-over-expressing 4T1 mouse breast cancer cells did not significantly change the morphology of RAW 264.7 cells. However, TCCM from 4T1-NDRG2 cells reduced the mRNA levels of TAM-related genes, including MR1, IL-10, ARG1 and iNOS, in RAW 264.7 cells. In addition, TCCM from 4T1-NDRG2 cells reduced the expression of TAM-related surface markers, such as CD206, in peritoneal macrophages (PEM). The mRNA expression of TAM-related genes, including IL-10, YM1, FIZZ1, MR1, ARG1 and iNOS, was also downregulated by TCCM from 4T1-NDRG2 cells. Remarkably, TCCM from 4T1-NDRG2 cells reduced the expression of PD-L1 and Fra-1 as well as the production of GM-CSF, IL-10 and ROS, leading to the attenuation of T cell-inhibitory activity of PEM. These data showed that compared with TCCM from 4T1-mock cells, TCCM from 4T1-NDRG2 cells suppressed the TAM differentiation and activation. Collectively, these results suggest that NDRG2 expression in breast cancer may reduce the differentiation of macrophages into TAMs in the TME.

• The Transactions of the Korea Information Processing Society
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• v.7 no.8
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• pp.2310-2326
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• 2000

Client-server DBMS based on a data-shipping model can exploit e1ient resources effectively by allowing inter-transaction caching. However, inter-transaction caching raises the need of transactional cache consistency maintenancetTCCM protocol. since each client is able to cache a portion of the database dynamically. Deferred locking(DL) is a new detection-based TCCM scheme designed on the basis of a primary copy locking algorithm. In DL, a number of lock ,ujuests and a data shipping request are combined into a single message packet to minimize the communication overhead required for consistency checking. Lsing a simulation model. the performance of the prolxlsed scheme is compared with those of two representative detection based schemes, the adaptive optimistic concurrency control and the caching two-phase locking. The performance results indicate that DL improves the overall system throughput with a reasonable transaction abort ratio over other detection - based schemes.

• Asia pacific journal of information systems
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• v.32 no.2
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• pp.191-225
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• 2022

Based on its technological elements (distribution, encryption, immutability, tokenisation, decentralisation, and smart contracts), blockchain has drawn considerable attention in various industries and verticals. Still, the strategic adoption of blockchain is in its early stages because of the current barriers and challenges in the areas of 'customer experience', 'business models', and 'operational processes.' This work delivers a comprehensive synopsis of the fundamental challenges faced by blockchain adopters in their digital journey, based on a literature survey. The authors leveraged MAXQDA software and the theory, context, characteristics, and methodology (TCCM) framework to develop themes, findings, and evidence for adoption barriers. The research evaluates the literature on blockchain adoption challenges and offers research insights and managerial agendas for future inferences.