• 대한방사선기술학회지:방사선기술과학
• /
• 제46권4호
• /
• pp.303-313
• /
• 2023

This study aimed to investigate the relevance of cardiovascular disease risk factors AI and AIP, divided into three groups, among 300 individuals who underwent health checkups at the hospital. Various variables such as Age, Sex, BMI, WC, TC, TG, HDL-C, LDL-C, FBS, HbA1C, SBP, DBP, HR, AI (TC/HDL-C), and AIP (log(TG/HDL-C)) were analyzed using statistical methods including frequency analysis, cross-tabulation, one-way ANOVA, Pearson's correlation analysis, and multiple linear regression analysis. The cross-analysis based on cardiovascular disease risk criteria revealed that men and individuals in their 50s had higher cardiovascular disease risk based on AI and AIP. Significant differences were observed in TG, TC, HDL-C, LDL-C, SBP, DBP, AI (TC/HDL-C), and AIP (log(TG/HDL-C)) according to AI criteria. For the AIP criteria, TG, TC, HDL-C, FBS, HbA1C, HR, AI (TC/HDL-C), and AIP (log(TG/HDL-C)) were identified as cardiovascular disease risk factors. FBS and HbA1c showed the highest positive correlation In the correlation analysis, followed by TC and LDL-C. The lowest positive correlation was observed between LDL-C and DBP. In terms of negative correlation, HDL-C and AI had the highest negative correlation, while LDL-C and TG showed the lowest negative correlation. Multiple regression analysis indicated that the AI and AIP risk criteria had explanatory powers of 73.6% and 72.5%, respectively. HDL-C had the greatest negative effect on the AI risk criterion, while TG had the most significant influence on the AIP risk criterion. In conclusion, while other serological variables are important, managing HDL-C and TG levels may help reduce the risk of cardiovascular disease.

• 한국산학기술학회논문지
• /
• 제14권9호
• /
• pp.4342-4348
• /
• 2013

본 연구는 혈청지질과 비만 및 혈압과의 관련성을 검토하기 위하여 2011년 1월부터 12월까지 1년 동안에 대전광역시의 한 대학병원에서 종합건강검진을 받았던 30세에서 69세의 여성 1,381명을 대상으로 TC, TG, HDL-C, LDL-C, SBP, DBP, 비만도, 체지방률을 측정하여 혈청지질과 비만 및 혈압과의 관련성을 분석하였다. 연구결과, TC, TG, LDL-C, 비만도, 체지방률은 30대에서부터 60대에 걸쳐 단계적으로 상승하는 경향을 보였다. TC, TG 및 LDL-C는 혈압이 높아짐에 따라 상승하였으며, 정상혈압군에 비해 고혈압군에서 유의하게 높은 값을 보였다. TC, TG, SBP 는 비만도가 높아짐에 따라 단계적으로 상승하였고, 정상군에 비해 비만군에서 유의하게 높았으며, HDL-C는 비만도가 높아짐에 따라 감소하는 경향을 보였고, 정상군에 비해 비만군에서 유의하게 낮았다. TC, TG, LDL-C, 체지방률 및 비만도는 상호간에 유의한 정상관을 보인 반면, HDL-C와는 음의 상관을 보였다. 주성분분석 결과 제1주성분은 고혈압 인자, 제2주성분은 비만관련 인자, 제3주성분은 연령과 고지혈증 인자, 제4주성분은 고단백지콜레스테롤 인자가 선정되었다. HDL-C와 관련된 요인을 다중회귀분석을 사용하여 검토한 결과 HDL-C에 영향을 미치는 변수로는 연령, TC, TG 및 체지방률이 선정되었다. 위와 같은 결과는 비만도가 높고 혈압이 높은 군일수록 혈청지질치가 높아짐을 시사하고 있다.

• 식품보건융합연구
• /
• 제4권4호
• /
• pp.1-9
• /
• 2018

To determine the effect of Vitex doniana (leaves stem and root bark) ethanolic extracts on lipid profiles of Poloxamer 407 (P407) induced hyperlipidemic and normal rats. Fifty four mixed sex rats weighing 100-200g were divided into nine groups comprising six animals per group. At the end of the 21 day, the animals were sacrificed and blood sample were collected for determination of serum levels of: Total cholesterol (TC), Triacylglycerides (TAG), High-density lipoprotein cholesterol (HDL-c) and Low-density lipoprotein cholesterol (LDL-c). The studies showed that all induced treated groups significantly (P<0.05) lower serum levels of TC, TAG, LDL-c and significantly (P<0.05) increased HDL-c when compared to the P407 induced hyperlipidemic control. The normal treated groups showed no significant (P>0.05) difference in the serum levels of TC, TAG, LDL and HDL when compared to the normal control group. Calculation of atherogenic risk predictor indices of the induced treated groups showed that all the extracts significantly (P<0.05) lowered the LDL-c/HDL-c, log (TAG/HDL-c) and significantly (P<0.05) increased HDL-c/TC ratio when compared to the P407 induced hyperlipidemic control group. The atherogenic risk predictor indices of normal treated groups showed no significant difference (P>0.05) in LDL-c/HDL-c, Log (TAG/HDL-c) and HDL-c/TC ratio when compared to the normal control group. The study demonstrates the phytotherapeutic effect of Vitex doniana (leaves, stem and root bark) ethanolic extract in poloxamer 407 induced hyperlipidemia.

• Preventive Nutrition and Food Science
• /
• 제1권2호
• /
• pp.234-238
• /
• 1996

The purpose of this study was to determine whether vitamin {TEX}$B_{6}${/TEX} deficiency and age affect the blood cho-lesterol profile in exercising rats. Fifty four rats were fed either a viramin {TEX}$B_{6}${/TEX} deficient dief(-{TEX}$B_{6}${/TEX}) of a control diet(+{TEX}$B_{6}${/TEX}) for 6 weeks, then subdivided into 3 groups:non-exercise group(NE), exercise and sacrifice group(ES), exercise and recuperation group(ER). ES group was exercised in treadmill({TEX}$10^{o}${/TEX}, 0.5~0.8km/h) for 2 hours and sacrifice. ER group was recuperated three days with respective diet after exercise. At week 3 and 6, and level of plasma total cholesterol(TC), high density lipoprotein cholesterol(HDL_C) and low density lipoprotein cholesterol(LDL_C) were compared. In NE group, there was no difference in the levels of TC, HDL_C and LDL_C between +{TEX}$B_{6}${/TEX} rats and -{TEX}$B_{6}${/TEX} rats. The plasma levels of TC and LDL_C of 6 weeks were higher than those of 3 weeks and on difference in HDL_V between 3 weeks rats and 6 weeks rats. In ES group, there was also no difference in the levels of TC, HDL_C and LDL_C between +{TEX}$B_{6}${/TEX} rats and -{TEX}$B_{6}${/TEX} rats and there was no difference in TC, LDL-cholesterol between 3 weeks rats and 6 weeks rats. The level of HDL_C pf 6 weeks was lower than that of 3 weeks rats. In ER group, there was no difference in the levels of TC and LDL_C not only between +{TEX}$B_{6}${/TEX} rats and-{TEX}$B_{6}${/TEX} rats but also between 3 weeks rats and 6 weeks rats. The level of HDL_C was lower in -{TEX}$B_{6}${/TEX} rats than in +{TEX}$B_{6}${/TEX} rats and higher in 6 weeks rats than in 3 weeks rats. These results suggest that vitamin {TEX}$B_{6}${/TEX} deficiency may affect the HDL_C during exercise and after recuperation. The desirable effect of exercise on plasma Cholesterol profile is strengthened in adult age than young age.

• Journal of Korean Biological Nursing Science
• /
• 제19권2호
• /
• pp.107-112
• /
• 2017

Purpose: The purpose of this study was to identify the lipid profile ratios as factors affecting disease progress in patients with high-grade primary brain cancers undergoing concurrent chemoradiotherapy (CCRT) and adjuvant chemotherapy. Methods: The levels of lipid profile ratios were evaluated by looking at the total cholesterol (TC) to high-density lipoprotein (HDL)-cholesterol (TC/HDL-c), low-density lipoprotein (LDL)-cholesterol to HDL-cholesterol (LDL-c/HDL-c), and triglycerides to HDL-cholesterol (TG/HDL-c). This descriptive research was conducted 7 months after the initiation of CCRT and adjuvant chemotherapy. Results: A total of 36 patients with newly diagnosed primary malignant brain cancer were included in the study. The levels of lipid profile ratios such as TC/HDL-c, LDL-c/HDL-c, TG/HDL-c were significantly different between the patients with and without disease progress at 7 months after initiation of CCRT and adjuvant chemotherapy. Conclusion: The lipid profile ratios were indicators affecting disease prognosis with tumor-related factors at 7 months after initiation of CCRT and adjuvant chemotherapy. Therefore, lipid profile ratios indicating hyperlipidemia in patients with high-grade brain cancers should be carefully monitored during and after cancer-related therapy.

• 대한지역사회영양학회지
• /
• 제2권3호
• /
• pp.319-326
• /
• 1997

This study was to investigate the level of serum lipids and obesity in housewives in Mooan, and relationships between them. The average age, height and weight were 51.1 years, 154.3cm and 58.3kg respectively. The level of obesity of subjects was higher than that of housewives in other areas investigated in other studies. BMI and RBW underestimated in the obese compared to BIA. The amounts of lean body mass and total body water of subjects above 60 years old were smaller than those of forties and their BMI and RBW were lower than those of forties. However, their body fat percentage was nearly same as that of forties. Serum HDL-cholesterol(HDL-C) of subjects was lower than 55mg/㎗, the lower limit of normal range. Triglyceride of subjects above 60years old was higher than the 95th percentile of those of the same age with reference to Mayo clinic. The serum total cholesterol(TC) showed positive correlation with LDL-cholesterol(LDL-C) and TC/HDL-C(p<0.001). LDL-C showed positive correlation with TC(p<0.001), but negative correlation with HDL-C(p<0.05). HDL-C showed negative correlation with triglyceride(p<0.05). TC/HDL-C showed a positive correlation with triglyceride(p<0.05). HDL-C was the serum lipid which showed the highest correlation with obesity and body composition. It showed a negative correlation with the percentage of body fat(p<0.001), total body fat(p<0.001), BMI(p< 0.05) and RBW(p<0.05). TC/HDL-C showed positive correlation with the percentage of body fat(p<0.01) and total body fat(p<0.05). As the result of above, it is needed to make more researches to find out the proper method to estimate the obesity of subjects and educate subjects in Mooan about nutritional information for obesity.

• 한국산학기술학회논문지
• /
• 제14권9호
• /
• pp.4394-4401
• /
• 2013

본 연구의 목적은 건강검진을 받은 일반 성인들의 혈압과 혈청지질치 및 비만지표와의 관련성을 검토하고자 하였다. 조사대상은 2012년 한 대학교병원에서 건강검진을 받았던 20세 이상 일반 성인 2,734명(남자 1,344명, 여자 1,390명)을 대상으로 하였다. 조사는 해당 대학병원 연구윤리위원회(IRB)의 승인을 받은 후 대상자들의 종합건강검진 결과표와 문진표로부터 자료를 수집하였으며, 조사항목으로는 피조사자들의 성별, 연령, 안정 시 혈압(SBP, DBP), 혈청지질치(TC, HDL-C, LDL-C, TG, AI) 및 비만관련지표(BMI, 체지방률, 허리둘레) 등이었다. 연구결과, TC, TG, AI는 남녀 모두 고혈압군이 비고혈압군보다 유의하게 높았으며, HDL-C는 여자에서 비고혈압군이 고혈압군보다 유의하게 높은 반면, LDL-C는 고혈압군이 비고혈압군보다 유의하게 높았다. BMI, 체지방률, 허리둘레는 남녀 모두 고혈압군이 비고혈압군보다 유의하게 높았다. SBP와 DBP는 남녀 모두 연령, TC, TG, AI, BMI, 체지방률 및 허리둘레와 유의한 양의 상관관계를 보였다. 그러나 HDL-C와 LDL-C는 여자에서만 각각 음의 상관관계와 양의 상관관계를 보였다. 연령을 조정한 고혈압발생위험비는 남녀 모두에서 TC, TG, BMI, 허리둘레가 정상인 군보다 비정상인 군에서 유의하게 증가하였으며, HDL-C는 여자에서만, 체지방률은 남자에서만 유의하게 증가하였다. 이상과 같은 결과는 혈압이 여러 혈청지질치 및 비만지표들과 유의한 관련성을 갖고 있음을 시사한다.

• 한국산학기술학회논문지
• /
• 제18권4호
• /
• pp.285-292
• /
• 2017

본 연구는 제조업 근로자들의 공복 시 혈당과 혈청지질치(TC, TG, HDL-C, LDL-C) 및 비만지표(BMI, 체지방률, 허리둘레, 허리둘레와 엉덩이둘레의 비)와의 관련성을 검토할 목적으로 시도하였다. 연구는 2015년 1월부터 12월까지의 기간에 한 대학병원 건강검진센터에서 종합건강검진을 받았던 30~59세의 근로자 1,473명을 대상으로 하였다. 자료의 분석은 조사대상자의 공복 시 혈당을 정상군과 비정상군으로 구분하여 혈청지질치 및 비만지표의 평균치를 비교하였고, 성과 연령을 조정한 다중 회귀분석을 통해 공복시 혈당에 영향을 미치는 관련요인을 검토하였다. 연구결과, 조사대상자의 TC, TG, LDL-C, BMI 및 허리둘레는 공복 시 혈당이 정상인 군보다 비정상인 군에서 유의하게 높았고, HDL-C는 공복 시 혈당이 정상군보다 비정상군에서 유의하게 낮았다. 조사대상자의 공복시 혈당치는 TC, TG, LDL-C, BMI 및 허리둘레와 유의한 양의 상관관계를 보였다. 공복 시 혈당에 영향을 미치는 요인으로는 TC, TG, BMI 및 체지방률이 유의한 변수로 선정되었다. 이상과 같은 결과는 제조업 근로자들의 공복시 혈당은 TC, TG, LDL-C와 같은 혈청지질치 및 BMI, 체지방률과 같은 비만지표와 유의한 관련성이 있음을 시사한다.

• 대한임상검사과학회지
• /
• 제37권3호
• /
• pp.185-189
• /
• 2005

Lipids such as total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and high sensitivity C-reactive protein (hs-CRP) are known as good risk factors for coronary artery diseases caused by arthrosclerosis. We measured the serum concentrations of hs-CRP, TC, and HDL-C of 6,128 persons who underwent medical examinations in the Health Screening Center at Kangbuk Samsung Hospital. We classified the subjects into normotensive and hypertensive groups according to the blood pressure measured. We investigated whether there was a difference of hs-CRP and lipids between the normotensive and hypertensive groups. There was significant difference of TC, TC/HDL-C ratio, and hs-CRP concentration between the normotensive and hypertensive groups in both men and women, but there was no significant difference of HDL-C concentration between two groups. Our results indicated that the concentrations of hs-CRP and lipids were higher in patients with hypertension and confirmed the usefulness of lipids and hs-CRP in predicting the risk for coronary artery diseases.

• Journal of Preventive Medicine and Public Health
• /
• 제39권6호
• /
• pp.462-468
• /
• 2006

Objectives : The purpose of this study was to gain an understanding of the effects of three exercise types on anthropometric and serum lipids and physiological index factors, which are known to be the three risk factors of cardiovascular disease in male workers. Methods : The experimental study period was 12 weeks. In this study, 30-40's males (N=31) were assigned to 3 experimental groups: regular aerobic(treadmill walking) exercise group, regular anaerobic(muscular endurance) exercise group, irregular aerobic & anaerobic exercise group and a control group using a stratified random assignment method. Results : In relation to anthropometric factors, the regular aerobic & anaerobic exercise groups showed significant decreases in Weight, Broca's index, WC, BMI, WHtR, WHpR and HRrest. With regard to the serum lipid factors, the TC was decreased, but the HDL-c increased among the regular aerobic & anaerobic exercise groups. However, no significant difference was found between the other groups in respect to the LDL-c and TG. Considering the physiological factors, the TC/HD-c, TC-HDL/HDL-c, LDL-C/HDL-c and NON-HDL-c ratios were decreased, but the HDL-c/TC ratio increased among the regular aerobic & anaerobic exercise groups. The TG/HDL-c and HDL-c/LDL-c ratios showed no significant differences between the groups. These results indicated that the positive change for each factor is much larger in the regular exercise groups, especially in the anaerobic exercise group. Conclusions : The results indicate that not only regular aerobic exercise, but also regular anaerobic(muscular endurance) exercise could be utilized in lessening the deleterious effects of the risk index factors for cardiovascular disease.