• 제목/요약/키워드: TASK-1 channel

검색결과 59건 처리시간 0.029초

한우의 자궁내막세포에서 발현되는 Two-pore Domain 포타슘 통로 (Expression of Two-pore Domain $K^+$ Channels in Endometrial Cells of Korean Cattle)

  • 강다원;김은숙;양혜영;최창용;한재희
    • 한국수정란이식학회지
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    • 제22권3호
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    • pp.149-154
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    • 2007
  • 임신의 성립 및 유지에 중요한 역할을 하는 자궁내막세포에 $K_{2P}$ 통로의 존재를 확인하기 위하여 본 연구를 수행하였다. $K_{2P}$ 통로는 일반적으로 중추신경계에 풍부하게 존재하면서 세포의 안정막 전압을 유지시킨다. 역전사 중합 효소 중합 반응과 면역 세포 화학 염색 방법을 이용하여 자궁내막세포에 존재하는 $K_{2P}$ 통로를 조사한 결과, TASK-1, TASK-3, TREK-1, TREK-2 및 TRAAK의 발현이 확인되었다. TASK-3와 TREK-1은 핵을 포함한 세포 전역에 발현하였고, TREK-2와 TRAAK은 핵을 제외한 세포 전역에 발현하였다. 그러나 자궁내막염이 있는 자궁내막세포와 정상 자궁내막세포에서 $K_{2P}$ 통로의 발현 변화를 비교한 결과, 두 군간의 mRNA 발현 수준이 변화하지 않았다. 본 연구는 한우의 자궁내막세포에서 $K_{2P}$ 통로의 존재를 처음으로 보고하는데, 이를 통하여 한우의 자궁내막세포에서 확인된 $K_{2P}$ 통로들은 자궁의 생리 작용과 자궁암 등과 같은 여러 자궁 관련 질병에 관여할 가능성이 높을 것으로 생각된다.

Implementation of CEI frequency operation function in IMDC for FA-50 aircraft

  • You, Eun-Kyung;Kim, Hyeock-Jin
    • 한국컴퓨터정보학회논문지
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    • 제23권1호
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    • pp.1-7
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    • 2018
  • The Korean Air Force FA-50 aircraft currently operating in the Air Force is using Ultra High Frequency (UHF) frequency communications for navigation communications with ground control stations or other aircraft. The pilot communicates by changing frequency at any time during flight, and performs communication by directly inputting from the Integrated Up-Front Controller installed in the cockpit. The frequency is designated as secret, and the pilot receives the task with the frequency channel number (001~xxx) and finds the frequency of the channel in the list of 4,000 frequency channels and inputs it manually. This reduces the safety and convenience of pilots' operations and exposes them to hazards that may occur especially during night flight missions. In this paper, we propose a function to embed the frequency corresponding to the frequency channel list in IMDC, the aircraft mission computer, and to automatically change the frequency when the pilot only inputs the channel number.

지역보건의료계획 수립과정에서의 주민참여실태와 이에 미치는 영향 (The Impacts of Community Participation on Regional Health Planning Process)

  • 김성옥;송건용
    • 보건행정학회지
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    • 제8권1호
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    • pp.112-134
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    • 1998
  • The purpose of this study is to analyze the community participation in regional health planning by using the operational definition of participation channels, and to find out the significant variables of community participation channel which are highly related to the scores of regional health plan. The channels we adopted for the study are recommended in the guidebook for regional health planning. They are performing residents' helath survey, submitting written agreement of publics, holding public hearings, putting publicnotice, conducting community health committee meeting, submitting opinion of chambers and Mayors, and operating task-force for planning. We analyzed the selected data of 8 community participation channels, which were submitted by 141 rural health centers for the pursuit of governmental subsidy in 1997. The major findings of this study are as follows; 1. In the process of regional health planning, 88.7% of rural community health centers have performed the residents' health survey, 14.9% submitted written agreement of publics, 11.3% held public hearings, 39.0% put public notice, 46.8% conducting community health committee meeting, 48.9% submitted opinion of chambers, 61.7% submitted opinion of Mayors and 25.5% operated task-force for planning. The result shows that most of community participation channels have been utilized at very low rates, except the residents' health survey. 2. We have analyzed the impact of these community participation channels on the regional health plan scores. In the multiple regression model, we set the regional health plan score as the dependent variable., and the use of participation channels as the idependent variables(1 if the channels are used, 0 otherwise). Finally, the regression analyses show that two channel variables, opinion of chambers and public notice, were the significant positive channel variables on the score of community health plan.

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A Robotic Vision System for Turbine Blade Cooling Hole Detection

  • Wang, Jianjun;Tang, Qing;Gan, Zhongxue
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2003년도 ICCAS
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    • pp.237-240
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    • 2003
  • Gas turbines are extensively used in flight propulsion, electrical power generation, and other industrial applications. During its life span, a turbine blade is taken out periodically for repair and maintenance. This includes re-coating the blade surface and re-drilling the cooling holes/channels. A successful laser re-drilling requires the measurement of a hole within the accuracy of ${\pm}0.15mm$ in position and ${\pm}3^{\circ}$ in orientation. Detection of gas turbine blade/vane cooling hole position and orientation thus becomes a very important step for the vane/blade repair process. The industry is in urgent need of an automated system to fulfill the above task. This paper proposes approaches and algorithms to detect the cooling hole position and orientation by using a vision system mounted on a robot arm. The channel orientation is determined based on the alignment of the vision system with the channel axis. The opening position of the channel is the intersection between the channel axis and the surface around the channel opening. Experimental results have indicated that the concept of cooling hole identification is feasible. It has been shown that the reproducible detection of cooling channel position is with +/- 0.15mm accuracy and cooling channel orientation is with +/$-\;3^{\circ}$ with the current test conditions. Average processing time to search and identify channel position and orientation is less than 1 minute.

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On-Line Blind Channel Normalization for Noise-Robust Speech Recognition

  • Jung, Ho-Young
    • IEIE Transactions on Smart Processing and Computing
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    • 제1권3호
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    • pp.143-151
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    • 2012
  • A new data-driven method for the design of a blind modulation frequency filter that suppresses the slow-varying noise components is proposed. The proposed method is based on the temporal local decorrelation of the feature vector sequence, and is done on an utterance-by-utterance basis. Although the conventional modulation frequency filtering approaches the same form regardless of the task and environment conditions, the proposed method can provide an adaptive modulation frequency filter that outperforms conventional methods for each utterance. In addition, the method ultimately performs channel normalization in a feature domain with applications to log-spectral parameters. The performance was evaluated by speaker-independent isolated-word recognition experiments under additive noise environments. The proposed method achieved outstanding improvement for speech recognition in environments with significant noise and was also effective in a range of feature representations.

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인간-컴퓨터 인터페이스를 위한 청각 동기방식 뇌파신호의 패턴 분류 (Pattern classification of the synchronized EEG records by an auditory stimulus for human-computer interface)

  • 이용희;최천호
    • 한국정보통신학회논문지
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    • 제12권12호
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    • pp.2349-2356
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    • 2008
  • 본 논문에서는 정상인의 정신적인 뇌 활동에 의한 순수한 뇌파를 측정하고 효과적으로 분류하기 위한 방법을 제시한다. 과정은 대상자가 특정한 작업에 대해 생각하게 하고 이때의 뇌파를 청각이벤트에 동기시켜 측정하고, 측정된 뇌파의 기준선의 이동과, 생리적인 아티펙트의 영향을 줄인다. 마지막으로, 평균가산법에 의해 정신적인 작업에 대한 신호만을 추출하고 AR 계수를 가지고 인식작업을 수행한다. 실험에서, 청각자극을 이벤트로 사용하였으며, 뇌파의 도출은 $C_3-A_1$, $C_4-A_2$, $P_Z-A_1$의 3채널에서 기록하였다. 각 채널당 16회의 평균가산후에, 12차 AR계수로 특정한 정신적인 작업에 대한 특징을 추출하였다. 전체 36개의 특징계수를 신경망의 입력으로 사용하고, 각 작업 당 50회를 훈련데이터로 사용하였다. 제안한 방법의 인식률은 2종류 작업에 대해 34-92%, 4종류 작업에 대해 38-54%를 얻었다.

시각추적과제의 뇌자도 : 예비실험 (A Pilot MEG Study During A Visual Search Task)

  • 김성훈;이상건;김광기
    • Annals of Clinical Neurophysiology
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    • 제8권1호
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    • pp.44-47
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    • 2006
  • Background: The present study used magnetoencephalography (MEG) to investigate the neural substrates for modified version of Treisman's visual search task. Methods: Two volunteers who gave informed consent participated MEG experiment. One was 27- year old male and another was 24-year-old female. All were right handed. Experiment were performed using a 306-channel biomagnetometer (Neuromag LTD). There were three task conditions in this experiment. The first was searching an open circle among seven closed circles (open condition). The second was searching a closed circle among seven uni-directionally open circles (closed condition). And the third was searching a closed circle among seven eight-directionally open circles (random (closed) condition). In one run, participants performed one task condition so there were three runs in one session of experiment. During one session, 128 trials were performed during every three runs. One participant underwent one session of experiment. The participant pressed button when they found targets. Magnetic source localization images were generated using software programs that allowed for interactive identification of a common set of fiduciary points in the MRI and MEG coordinate frames. Results: In each participant we can found activations of anterior cingulate, primary visual and association cortices, posterior parietal cortex and brain areas in the vicinity of thalamus. Conclusions: we could find activations corresponding to anterior and posterior visual attention systems.

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Calibration of frequency propagation channel sounder based on five-port reflectometer

  • Yem Van;Braga Judson;Huyart B;Begaud X;de Sousa F.R;Huyen Nguyen Bich
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 2004년도 ICEIC The International Conference on Electronics Informations and Communications
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    • pp.23-26
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    • 2004
  • Five-port reflectometer which consists of a ring with 5 arms (two inputs, three outputs) and three RF power detectors has been used as a vector network analyser, a demodulator in the homodyne receiver as well as in Phase Looked Loop (PLL) and so on. Calibration of five-port reflectometer is an important task. In this paper, we present a calibration method of five-port for a propagation channel sounder. The method is based on measurement of the phase differences between the three voltages at the five-port's outputs in order to determine the ratio of two input incident waves. The frequency channel sounder based on five-port is calibrated for each frequency from 2.2 GHz to 2.6 GHz with 1 MHz step. This method can also determine the absolute delays of each propagation path in the propagation channel. The calibration method is validated using measurement data.

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임신 자궁 내막에서 Two-pore Domain 칼륨 통로의 발현 변화 (Alteration in Two-pore Domain K$^+$ Channel Expression in Endometrium of Pregnant Korean Cattle)

  • 최창용;탁현민;김창운;한재희;강다원
    • 한국수정란이식학회지
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    • 제26권3호
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    • pp.209-214
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    • 2011
  • 임신의 성립 및 유지에 중요한 자궁 내막과 호르몬의 변화는 생식기관에서 발현되는 K$_{2P}$ 통로의 발현을 변화시킬 수 있다. 본 연구는 한우의 임신 자궁 내막에서 K$_{2P}$ 통로의 발현 변화가 나타나는지 그리고 프로게스테론에 의해 그 발현량이 변화되는지를 확인하고자 수행하였다. 역전사중합효소 중합반응과 웨스턴블닷 분석을 통하여 임신한 한우의 자궁 내막에서 mRNA와 단백질의 발현 변화를 조사하였다. TREK-1을 제외한 K$_{2P}$ 통로의 mRNA 발현량이 임신 자궁 내막에서 변화되었다. mRNA가 크게 변화되는 TASK-3, TREK-2, TRAAK 및 TRESK의 단백발현 변화량을 임신 자궁 내막에서 확인하였는데, TREK-2와 TRESK만 mRNA 발현 변화 양상과 동일하게 임신 자궁 내막에서 각각 7.9배, 2배 증가하였다. 자궁 내막세포에 프로게스테론(10 ${\mu}g$/mL)을 처리하였을 때 TREK-2와 TRESK는 자궁 내막 조직에서 보여준 결과와 유사하게 단백 발현량이 각각 10배, 6배 증가하였다. 이상의 결과로부터 K$_{2P}$ 통로, 특히 TREK-2와 TRESK는 프로게스테론 변화에 의해 임신 자궁 내막에서 발현량이 증가할 것으로 생각된다. 그리고 증가된 TREK-2와 TRESK는 임신에 의해 유발되는 생리학적 변화를 조절하는데 기여할 것으로 생각된다.

Valproic Acid 복용에 의해 유발된 연축성 발성장애 1예 (Spasmodic Dysphonia Induced by Valproic Acid)

  • 오지영;조현지;박기덕;정성민
    • 대한후두음성언어의학회지
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    • 제14권1호
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    • pp.54-56
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    • 2003
  • Spasmodic dysphonia is a task-specific dystonia affecting the laryngeal muscles, resulting forced, strained voice. The pathophysiologic mechanism is not fully understood. We experienced a patient with epilepsy developed transient spasmodic dysphonia during valproic acid monotherapy. The spasmodic dysphonia resolved with dose reduction of valproic acid. Change of neurotransmitters, such as GABA in basal ganglia or blockade of sodium channel is possible mechanism in our case of drug-related spasmodic dysphonia.

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