• Title/Summary/Keyword: TAE-RA.

Search Result 734, Processing Time 0.035 seconds

A Numerical Study on the Natural Convection in the L-shaped enclosure having a Protrusion (돌출부를 가진 L형 공간 내에서의 자연대류 열전달)

  • Bae, Suk-Tae
    • Solar Energy
    • /
    • v.17 no.1
    • /
    • pp.93-102
    • /
    • 1997
  • The numerical study on the natural convection inside the L-shaped enclosure having a protrusion of which left wall is maintained at $T_c$. Right wall and part of the bottom and 2nd floor are at $T_h$ has been performed numerically for aspect ratio A=1, geometrically different cases and for $Ra=5{\times}10^5{\sim}2{\times}10^6$. As the L-shaped of the enclosure goes thicker horizontally and the smaller 2nd floor's length, the mean Nusselt number at the left cold wall becomes smaller for same Ra, and there is little influence of the increase of Ra on mean Nusselt number.

  • PDF

Flood Inundation Analysis Based on HEC-GeoRAS & HEC-RAS (HEC-GeoRAS & HEC-RAS를 이용한 홍수범람 연구)

  • Hwang, Tae-Ha;Jang, Dae Woon;Kim, Hung Soo;Seo, Byung Ha
    • Proceedings of the Korea Water Resources Association Conference
    • /
    • 2004.05b
    • /
    • pp.737-741
    • /
    • 2004
  • 본 연구에서는 지리정보시스템을 이용한 홍수범람에 대한 변화, 홍수범람면적, 홍수범람 위험지역을 산정하기 위해 HEC-GeoRAS 와 HEC-RAS 및 GIS Tool인 ArcView를 이용하여 경안천 유역에 이를 적용하였다. 1:5000 DEM과 경안천 수계 하천정비 기본계획상의 부도를 바탕으로 HEC-GeoRAS를 이용하여 HEC-RAS로 입력하기 위한 기하학적인 자료를 추출하였으며, 추출된 단면을 보정하기 위해 경안천 수계 하천정비기본계획상의 하천단면자료을 이용하였다. 그리고 20년, 30년, 50년, 80년, 100년 빈도별 홍수량자료를 사용하여 경안천 유역의 홍수범람을 모의하였다. 그 결과 빈도별 홍수량에 따른 홍수범람면적과 범람위험지역을 파악할 수 있었다.

  • PDF

Natural TACE (TNF-$\alpha$ Convertase) Inhibitor, Gelastatin Hydroxamate: Biological Evaluation and Target Validation

  • Chun, Tae-Gyu;Lee, Jin-Ha;An, Mi-Hyun;Park, Song-Kyu;Lee, Hee-Yeon;Han, Gyoon-Hee
    • Proceedings of the PSK Conference
    • /
    • 2003.10b
    • /
    • pp.173.1-173.1
    • /
    • 2003
  • One of attractive target for Rheumatoid Arthritis (RA) therapy is the cytokine, tumor necrosis factor-alpha (TNF-$\alpha$), which has been shown to be overproduced in the joint of RA patients. The clinical success of anti- TNFR biologics has validated TNF-$\alpha$ as a drug discovery target. Thus, inhibiting of formation of TNF-$\alpha$ has been emerged to an intriguing approach for RA therapy. TNF-$\alpha$ is processed from its membrane bound precursor by the metalloprotease TNF-$\alpha$ converting enzyme (TACE), Here, biological evaluation, mode of action of natural TACE inhibitor, Gelastatin hydroxamate, are addressed. (omitted)

  • PDF