• Biomolecules & Therapeutics
• /
• 제3권3호
• /
• pp.192-198
• /
• 1995

The affinity of mequitazine, a non-sedating antihistamine, for muscarinic receptors was evaluated in the guinea-pig ventricle and ileum by in vitro binding techniques and functional studies. In binding studies, [$^3$H]quinuclidinyl benzilate (QNB) identified a single class of muscarinic receptors with similar apparent $K_{D}$ value of about 100 pM in two tissues. Mequitazine inhibited [$^3$H]QNB binding to muscarinic receptors competitively. Analysis of the mequitazine inhibition curve of [$^3$H]QNB binding to ventricular microsome and ileal homogenate indicated the presence of a single homogeneous binding site with Ki value of 25 nM and 18 nM, respectively. In functional studies, mequitazine caused parallel rightward shifts of concentration-response curves for carbachol and histamine in the isolated guinea-pig ileum. The slope values obtained from Schild plot analysis for the antagonistic action of mequitazine on muscarinic and histamine $H_1$-receptors were not significantly different from unity. The p $A_2$values of mequitazine for muscarinic and histamine $H_1$-receptors were about 7.6 ( $K_{M}$= 25.1 nM) and 8.88 ( $K_{H}$= 1.32 nM), respectively. These results indicate that the muscarinic receptor blocking action of mequitazine is 15 times less potent than the $H_1$receptor blocking action, but high concentration of this drug may cause the peripheral muscarinic receptor blocking effect.t.t.t.

• 한국초전도학회:학술대회논문집
• /
• 한국초전도학회 1999년도 High Temperature Superconductivity Vol.IX
• /
• pp.229-232
• /
• 1999

We have measured the temperature dependence of thermoelectric power (TEP) and resistivity for the Sr$_{1-x}K_xBiO_3$ superconductor (x=0.45-0.6). At T=10.2K, the resisitivity starts to increase from zero and a rather broad superconducting phase transition (${\Delta}$T ${\sim}$ 2.3K) is observed. TEP at room temperature has a small negative value ( S =-1.96${\mu}$V/K), characteristic of metallic-like TEP. The temperature dependence of TEP shows two distinct features. With decreasing temperature from room temperature, the absolute value of TEP decreases and the sign of TEP changes from negative to positive around 200k. Also, the negative slope of TEP(dS/dT) decreases substantially and becomes rather flat at around 160k, which is a feature already noted in Ba$_{1-x}K_xBiO_3$[1].

• 한국안광학회지
• /
• 제13권3호
• /
• pp.79-87
• /
• 2008

목적: 본 연구에서는 첫째, 원, 근거리의 주시시차와 사위를 측정하여 방향과 분포 등을 연구한다. 둘째, 주시시차 곡선의 3가지 변수(일부융합제거사위를 의미하는 X-intercept, 주시시차를 의미하는 Y-intercept, 주시시차 곡선의 기울기)들의 값을 구하여 임상에서 사용되는 주시시차와 사위에 어떠한 영향을 미치는지 연구한다. 셋째, 측정된 항목을 원, 근거리에 따라 비교하여 검사거리에 따라 측정된 검사 값이 유의한지를 연구하였다. 방법: 안질환이 없고 건강한 20대 대학생 51명을 대상으로 원, 근거리에서 사위 및 주시시차를 측정하였다. 원거리의 완전융합제거사위는 원거리용 MIM을 사용하여 측정하였고, 주시시차는 Mallett Far Unit을 사용하여 측정하였다. 근거리의 완전융합제 거사위는 원거리와 마찬가지로 근거리용 MIM을 사용하여 측정하였고, 주시시차는 Wesson fixation disparity card를 이용하여 측정하였다. 결과: 1. 원, 근거리 주시시차 곡선의 유형을 조사한 결과 원거리에서는 제 I유형>제 IV유형 >제 II유형=제 III유형의 순으로 나타났고, 근거리에서는 제 I유형 >제 III유형>제 IV유형>제 II유형의 순으로 나타났다. 2. 원, 근거리 모두 완전융합제거사위, 주시시차(Y-intercept), 일부융합제거사위(X-intercept)는 서로 밀접한 상관관계를 가졌다. 3. 원거리에서 주시시차에 가장 큰 영향을 주는 것은 일부융합제거사위(X-intercept)로 나타났고(p=0.000), 완전융합제거사위에 가장 큰 영향을 주는 것은 주시시차(Y-intercept)이었지만 그 영향력의 유의성은 미미하였다(p=0.342). 4. 근거리에서 주시시차(Y-intercept)에 가장 큰 영향을 주는 것은 일부융합제거사위(Xintercept)로 나타났고(p=0.000), 또한 완전융합제거사위에 가장 큰 영향을 주는 것도 일부융합제거사위(X-intercept)로 나타났다(p=0.009). 5. 원, 근거리에서 측정한 각각의 변수들을 비교해 본 결과 완전융합제거사위(t=7.529 p=0.000), 일부융합제거사위(t=5.860 p=0.000), 주시시차(t=4.640 p=0.000)은 유의한 차이가 있었으나 주시시차 곡선의 기울기는 그 차이가 미미하였다(t=1.336 p=0.188). 결론: 원, 근거리에서 주시시차와 사위의 관계는 상관관계가 있었다.

• 대한전자공학회:학술대회논문집
• /
• 대한전자공학회 2000년도 추계종합학술대회 논문집(4)
• /
• pp.203-206
• /
• 2000

Since the amplitude of voiced fall off at about -20dB/decade, dynamic range is often compressed prior to spectral analysis so that details at weak, high frequencies may be visible. Preemphasizing the speech, either by differentiating the analog speech s$\sub$a(t) prior to A/D conversion or by differencing the discrete-time s(n)=s$\sub$a(nT), compensating for falloff at high frequencies. The most common form of preemphasis is y(n)=s(n)-As(n-1), where A typically lies between 0.9 and 1.0 and reflects the degree of pre-emphasis. In This paper, we proposed that A is adjusted at each time by measuring the slope of envelope in frequency domain.

• 한국산학기술학회:학술대회논문집
• /
• 한국산학기술학회 2010년도 춘계학술발표논문집 1부
• /
• pp.253-256
• /
• 2010

Since the amplitude of voiced fall off at about -20dB/decade, dynamic range is often compressed prior to spectral analysis so that details at weak, high frequencies may be visible. Preemphasizing the speech, either by differentiating the analog speech $s_a$(t) prior to A/D conversion or by differencing the discrete-time s(n)=$s_a$(nT), compensating for falloff at high frequencies. The most common form of preemphasis is y(n)=s(n)-As(n-1), where A typically lies between 0.9 and 1.0 and reflects the degree of pre-emphasis. In this paper, we proposed that A is adjusted at each time by measuring the slope of envelope in frequency domain.

• 대한기계학회논문집A
• /
• 제24권9호
• /
• pp.2326-2333
• /
• 2000

Creep tests for type 316L(N) stainless steel were carried out using constant-load creep machines at 55$0^{\circ}C$, 575$^{\circ}C$ and $600^{\circ}C$. Material constants necessary to predict creep rupture time were obtained from the experimental creep data. And the applicability of Monkman-Grant(M-G) and modified M-G relationships was discussed. The log-log plot of M-G relationship between the rupture time($t_r$,) and the minimum creep rate ($ $\varepsilon$ _m$) was dependent on test temperatures. The slope of m was 1,05 at 55$0^{\circ}C$ and m was 1.30 at $600^{\circ}C$. On the other hand, the log-log plot of modified M-G relationship between $t_r/$\varepsilon$_r$, and $ $\varepsilon$ _m$ was independent on stresses and temperatures. That is, the slope of m＇ was approximately 1.35 in all the data. Thus, modified M-G relationship for creep life prediction could be utilized more reasonably than that of M-G relationship for type 316L(N) stainless steel. It was analyzed that the constant slopes regardless of temperatures or applied stresses in the modified relationship were due to an intergranular fracture grown by wedge-type cavities.

• 대한화학회지
• /
• 제35권1호
• /
• pp.51-58
• /
• 1991

새로운 管形 PVC膜 질산이온 選擇性 電極을 제작하여 그 性能을 조사하였다. 電極膜의 組成을 5${\%}$ aliquat-NO$_3$ 용액+ 32${\%}$ poly(vinyl chloride) + 63${\%}$ dibutyl sebecate로 하였을 때 전극의 感應特性이 최적이었으며, 이 때의 감응기울기는 58.5 ${\pm}$ 0.1 mV/decade, 檢出限界는 0.02mM, 感應時間 (t$_{99}$)은 25초이었다. 이 전극을 써서 아질산이온을 連續${\cdot}$自動化法으로 정량하였다. Recipient 용액은 pH 7.6의 10$^{-2}$ M 燐酸鹽 緩衝溶液을 쓰고, 여기에 酸化劑로서 過酸化水素를 0.3${\%}$가 되도록 포함시켰다. 전극계의 最適條件에서 아질산이온 標集溶液 8.0 ${\times}$ 10$^{-5}$ M ∼ 5.0 ${\times}$ 10$^{-2}$ M의 범위에서 직선적인 감응을 나타내었으며, 이 때의 감응기울기는 56.8 ${\pm}$ 0.2 mV/decade이었다.

• 한국환경보건학회지
• /
• 제27권2호
• /
• pp.51-59
• /
• 2001

Song stream is located in the upstream of the Namhan River. Normal times, the stream flows down to the east sea through the drainage pipe but at rainy season, it flows to the Namhan River. There are large stock farm, leisure town and cultivated land in this basin. The pollutants from these contamination source cause eutrophication at lake Doam and deterioration of water quality in namdai stream. In this case, this study was carried out to evaluate water quality and environmental capacity as well as economical efficiency of each industry. The basin shape factor of subject stream was 0.315, slope is higher than usual basin. The BOD, T-N and T-P productive contamination loading from each contamination source was 2,690, 974 and 194 kg/day, respectively, and major contamination source was stock farm and cultivated land. Annual BOD, T-N, T-P distribution(median value) of Song stream showed 1.0~2.2 mg/L, 3.16~5.85 mg/L and 0.024~0.197 mg/L Doam lake showed 1.1~1.9, 2.51~3.89 and 0.042~0.114 mg/L, respectively. Being compared of water quality at main stream between past and present, it showed that the water quality has improved since last five years. BOD improvement rate was 8~50%. Run off loading of BOD, T-N, T-P was 366, 1129, 17.2 kg/day, and run off rate was 13.6%, 86.2%, 11.3% respectively. Finally, the result of productivity survey of each industry, leisure town, cultivated land and large stock farm was 118, 46, 50 billion won, per T-P 1kg productive, and productivity portion was 100, 39, 42% respectively, and the highest economical efficiency industry was leisure facilities.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제38권
• /
• pp.18.1-18.9
• /
• 2016

Background: The aim of this study was to examine the relationship between improvements in lip asymmetry at rest and while smiling after orthognathic surgery in patients with skeletal class III malocclusion. Methods: This study included 21 patients with skeletal class III malocclusion and facial asymmetry. We used preoperative and postoperative CT data and photographs to measure the vertical distance of the lips when smiling. The photographs were calibrated based on these distances and the CT image. We compared preoperative and postoperative results with the t test and correlations between measurements at rest and when smiling by regression analyses. Results: There were significant correlations between the postoperative changes in canting of the mouth corners at rest, canting of the canines, canting of the first molars, the slope of the line connecting the canines, and the slope of the line connecting first molars. The magnitude of the postoperative lip line improvement while smiling was not significantly correlated with changes in the canting and slopes of the canines, molars, and lip lines at rest. Conclusions: It remains difficult to predict lip line changes while smiling compared with at rest after orthognathic surgery in patients with mandibular prognathism, accompanied by facial asymmetry.

• 대한음성학회:학술대회논문집
• /
• 대한음성학회 1996년도 2월 학술대회지
• /
• pp.137-155
• /
• 1996

The purpose of this paper is to generate a pitch contour which is affected by tile phonetic environment and the number of syllables in each Korean isolated word using a neural network. To do this, we analyzed a set of 513 Korean isolated words, consisting of 1-4 syllables and extracted the pitch contour and the duration of each phoneme in all the words. The total number of phonemes we analyzed is about 3800. After that we approximated the pitch contour with a 1st order polynominal by a regression analysis. We could get the slope, the initial pitch and the duration of each phoneme. We used these 3 parameters as the target pattern of the neural network and let the neural network learn the rule of the variation of the pitch and duration, which was affected by the phonetic environment of each phoneme. We used 7 consecutive phoneme strings as an input pattern for a neural network to make the network learn the effect of phonetic environment around the center phoneme. In the learning phase, we used 3545 items(463 words) as target patterns which contained the phonetic environment of front and rear 3 phonemes and the neural network showed the correctness rate of 98.43%, 98.59%, 97.7% in the estimation of the duration, the slope, the initial pitch. In the recall phase, we tested the performance of tile neural network with 251 items(50 words) which weren't need as learning data and we could get the good correctness rate of 97.34%, 95.45%, 96.3% in the generation of the duration, the slope, and the initial pitch of each phoneme.