• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.199-203
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• 2012

Purpose: To evaluate the prognostic value of serum CYFRA21-1, CEA and hemoglobin levels regarding long-term survival of patients with esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CRT). Methods: Age, gender, Karnofsky Performance Status (KPS), tumor location, tumor length, T stage, N stage and serum hemoglobin, and CYFRA21-1 and CEA levels before concurrent CRT were retrospectively investigated and related to outcome in 113 patients receiving 5-fluorouracil and cisplatin combined with radiotherapy for ESCC. The Kaplan-Meier method was used to analyze prognosis, the log-rank to compare groups, the Cox proportional hazards model for multivariate analysis, and ROC curve analysis for assessment of predictive performance of biologic markers. Results: The median survival time was 20.1 months and the 1-, 2-, 3-, 5- year overall survival rates were 66.4%, 43.4%, 31.9% and 15.0%, respectively. Univariate analysis showed that factors associated with prognosis were KPS, tumor length, T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level. Multivariate analysis showed T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis. By ROC curve, CYFRA21-1 and hemoglobin showed better predictive performance for OS than CEA (AUC= 0.791, 0.704, 0.545; P=0.000, 0.000, 0.409). Conclusions: Of all clinicopathological and molecular factors, T stage, N stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis for patients with ESCC treated with concurrent CRT. Among biomarkers, CYFRA21-1 and hemoglobin may have a better predictive potential than CEA for long-term outcomes.

• Clinical and Experimental Otorhinolaryngology
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• v.11 no.4
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• pp.259-266
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• 2018

Objectives. Carcinomas of the external auditory canal (EAC) are rare, and management remains challenging. Previous studies seeking prognostic factors for EAC cancers included cancers other than carcinomas. In this study, we analyzed the treatment outcomes of, prognostic factors for, and survival rates associated with specifically squamous cell carcinoma (SCC) of the EAC. Methods. A retrospective review of 26 consecutive patients diagnosed with SCCs of the EAC in a 10-year period was performed in terms of clinical presentation, stage, choice of surgical procedure, and adjunct therapy. Overall survival (OS) and recurrence-free survival (RFS) were calculated and univariate analysis of prognostic factors was performed. Results. The median age of the 26 patients with SCCs of the EAC was 63 years (range, 40 to 72 years), and 16 males and 10 females were included. According to the modified University of Pittsburgh staging system, the T stages were T1 in 11, T2 in six, T3 in four, and T4 in five cases. The surgical procedures employed were wide excision in three cases, lateral temporal bone resection (LTBR) in 17, and extended LTBR in four, and subtotal temporal bone resection in two. Two patients underwent neoadjuvant chemotherapy, and two underwent adjuvant chemotherapy. One patient received preoperative radiation therapy, and eleven received postoperative radiation therapy. Of the possibly prognostic factors examined, advanced preoperative T stage and advanced overall stage were significant predictors of RFS, but not of OS. Conclusion. The advanced T stage and overall stage were associated with decreased survival after surgical treatment in patients with SCC of the EAC, highlighting the importance of clinical vigilance and early detection.

• Journal of Chest Surgery
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• v.20 no.2
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• pp.328-341
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• 1987

We reviewed 147 cases of primary carcinoma of the lung between January 1975 and December 1986 at the Thoracic and Cardiovascular Department, Yonsei university College of Medicine, Seoul, Korea. There were 116 males and 31 females with 93.72% ranging in age from 40 to 69 years. The mean age was 61.01 years. To 69 years of age with 61.01 years of mean age. There were 92 [62.59%] cases of squamous cell carcinoma, 29 [19.73%] cases of adenocarcinoma, 8 [5.44%] cases of undifferentiated large cell carcinoma, 8 [5.44%] cases of undifferentiated small cell carcinoma and 10 [6.8%] cases of bronchoalveolar cell carcinoma. 50 [34.01%] patients in stage I and 49 [33.26%] patients in stage II underwent pneumonectomies and lobectomies with a 67.27% rate of resection, where as only 49.12% of stage III patients were resected. Also 7 [30.43%] of the 23 stage IV cases were surgically resected and confirmed stage IV after surgical resection. The actuarial survival rate according to classification are as follows. The one and 3 year survival rate of the patients in stage I were 96% and 84% respectively. The one and `3 year survival rate of the patients in stage II were 100% and 66.6%, whereas the one and 3 year survival rate of the patients in stage III, T3 were 78.57% and 69.84%. The survival rates of patients in stage I, II, III T3 were better than those of the other stages. There were significant differences in observed survival for patients with stage II as compared with the patients with stage Ill, T3. [p=0.0005]. An aggressive surgical approach still offered the greatest chance for long-term survival even in stage Ill, T3. The survival rate in patients with resectable cases including stage III, T3 might be improved with an aggressive surgical approach. The one and 3 year survival rates of patients in stage III, N2 were 56.67% and 43.7 I%. The one and 3 year survival rates of patients in stage IV were 21.43% and 3.57%. Patients in stage III, N2 or IV had markedly decreased survival rates. When the carcinoma cell type was the basis for the determination of rate of survival, the result were as follows; The one, 3 and 5 year survival rates of squamous cell carcinoma were 78.33%, 60.19%, and 57.32%, and the one and 3 year survival rates of adenocarcinoma were 55.56% and 44.49%. The survival rates of large cell carcinoma were 66.67%, and 44.45%, at one, three and five years respectively. The one and 3 year survival rates of bronchoalveolar cell carcinoma were 71.43% and 47.62%, the one, 3 and 5 year survival rates of small cell carcinoma were 40%, 20% and 20%. The survival rate of squamous cell carcinoma was better than that of other cell carcinomas, the survival rate of small cell carcinoma was the worst. The operative mortality rate was 1.36%. There were 10 cases of post-operative complications including 2 cases of bleeding which required further surgery, 2 cases of wound infection, and 4 cases of empyema thoracis. The length of survival of three of the empyema thoracis cases was 16, 98 and 108 months respectively, Four male patients all older than 47 years survived more than 9 years, post surgery, although one developed empyema thoracis. These four cases were initially classified as 2 cases of stage I and one each of stage II and stage III, T3. We have concluded that the survival rates of patients in stages I, II and III, T3 were improved after complete surgical resection.

• Journal of Hospice and Palliative Care
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• v.7 no.1
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• pp.8-16
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• 2004

Purpose: The porpose of this descriptive study was grasp the QOL (Quality of Life) of cervix cancer patient and to analysis QOL (Quality of Life) by stage of disease, type of treatment and de me graphic characteristics Methods: Data were collected from 67 patients with cervical cancer from 3 General Hospitals from March 15 to June 4 using The "QOL (Quality of Life)-Cancer Version" inventory made by Ferrell et al (1995). The data were analysed by using SPSS $PC^+$ program including t-test, ANOVA, and Scheffe test. Results: Progressing stage of disease and QOL, the significant between the progressing stage of disease and QOL was significant (F=5.06, P=.003). The degree of difference between the progresstion of the stage of the disease and each item in the test was physical well-being (F=3.97 P=.012), the items of psychological well-being (F=3.91, P=.013), the items of social well-being (F=4.96, P=.004). It show a significant difference, but the item of spiritual well-being (F=1.36, P=.262) was not significant difference. The significance between the type of treatment and QOL was insignificant. The degree of difference between each area of life was the psychological well-being (t=-2.14, P=.037), the social well-being (t=-2.15, P=.036). But the physical well-being (t=-.93, P=.356), the spiritual well-being (t=.73, P=.469) was insignificant. Conclusion: As a result, The QOL of patients with cervical cancer is differentiated by the stage of disease, the type of treatment, and the demographic data. Therefore, there is a need to apply nursing intervention to patients with cervical cancer by considering the stage of disease, the type of treatment, and the demographic data.

• Korean Journal of Ichthyology
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• v.12 no.1
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• pp.71-84
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• 2000

Annual reproductive cycle of the file fish, Thamnaconus modestus (Gunther), was histologically investigated. Samples were collected monthly in the coastal waters of Chungmun, south of Cheju Island, Korea from July 1997 to June 1999. In males and females of T. modestus GSI values reached the maximum in June and May, respectively. Reproductive cycle could be divided into the following successive stages: in females, growing stage (March to April), mature stage (April to May), spawning stage (May to June), degenerative and resting stage (July to February), and in males, growing stage (January to March), mature stage (April to May), spent stage (May to June), degenerative and resting stage (July to December), respectively. To clarify the spawning cycle of female in T. modestus, some were examined, that is, the weekly changes of GSI, detail developmental stages in the ovary and the weekly changes of sex steroid hormones ($E_2$ and T) levels in plasma during the spawning period. Throughout histological observation of the ovary during the spawning period, T. modestus belonged to an asynchronous and multiple spawner. Changes of plasma $E_2$ and T levels were similar to the changes of GSI and ovary maturity.

• Journal of Korean Society for Quality Management
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• v.8 no.2
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• pp.29-37
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• 1980

The purpose of this study is to define the role of a T. Q. C. engineer in the plant engineering activities. A "plant engineering" moves to complete a new project through a series of stages such as: 1. Research & Development stage. 2. Economic evaluation & engineering design stage. 3. Erection & start up stage. 4. Final production & control stage. This suggests that the plant engineering project should be carried out with a wide variety of tasks, as well as a central control. For a successful completion of the project, a T. Q. C. engineer is required, in practice, either as a central activity creator or as a key advisor in each task.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.28 no.3
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• pp.286-294
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• 1992

In this paper, the corrosion fatigue crack propagation behavior of structure rolled steel (SWS 41C) was investigated by changing the thickness, and this experiment was done by the three point bending corrosion fatigue tester. The main results obtained are as follows: 1) As the thickness of specimen becomes thicker, the corrosion sensitivity to initial stage crack becomes some sensitive, and that the fatigue life becomes more sensitive. 2) The crack growth rate to initial stage crack (da/dN) was retarded as the thickness of specimen becomes thicker. But after initial stage crack, as the thickness of specimen is more thicker, da/dN is more rapid. 3) As the corrosion fatigue crack length grows, the accelerative factor of thick specimen (t=12mm) is more higher than that of thin specimen (t=6mm). 4) As the corrosion fatigue crack length grows, the corroson potential of both thick specimen and thin specimen becomes more less noble potential, however thick specimen (t=12mm) tends to more less noble potential than that of thin specimen(t=6mm).

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2008.10a
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• pp.290-296
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• 2008

This paper considers a two-stage dynamic lot-sizing problem constrained by a supplier's production capacity. We derive an improved O($T^6$) algorithm over the O($T^7$) algorithm in van Hoesel et al. (2005).

• Radiation Oncology Journal
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• v.8 no.1
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• pp.29-34
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• 1990

Total of 154 patients of pathologically proven and previously untreated nasopharyngeal carcinoma who were treated in the Department of Therapeutic Radiology, Korea Cancer Center Hospital during the period from 1964 to 1984 were analyzed. Minimal follow-up period of survivors was 3 years. Thirteen percent of the patients had $T_4$ primary lesions and $65\%$ had stage IV disease. Total radiation dose to the primary site was $1550\~1750$ ret in 82 and above 1750 ret in 72 patients. Local control was obtained in $79\%$ of patients. Significant prognostic factors for the survival were tumor dose (above vs. below 1750 ret), age (below vs. above 30 years), stage (AJCC I-III vs. IV), T stage ($T_1\;vs.\;T_2-4$), and N stage (NO vs. $N^+$).

• KOREAN JOURNAL OF CROP SCIENCE
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• v.50 no.3
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• pp.161-169
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• 2005

With various Korean domestic soybeans, growth and yields analysis were conducted to select the suitable soybean cultivars for cultivation in paddy field. Distinctive aspects of the soybean growth were observed in paddy field such as retarded growth of top plants and roots, relatively higher T/R ratio followed by overgrowth of top plant. However, growth and yields were significantly different among the cultivars showing 134kg/10a in Paldokong and 385 kg/10a in Doremikong. At V5. and R2 stage, highly positive correlations $(r=0.76^{**}\~0.91^{**})$ were observed between leaf area and dry weight of top plant and/or root. T/R ratio was negatively correlated with dry weight of root $(r=-0.37^*)$ at V5 stage, while significantly correlated with leaf area $(r=-0.37^{**})$ and dry weight of top plant $(r=0.65^{**})$at R2 stage. Among the characters, only 100-seed weight was significantly correlated with yield. Considering the growth characters, 37 cultivars could be included in 3 different groups and genotypic properties such as maturity and growth habit were similar in each group. Nine cultivars in group 1 showed retarded growth from V5 to R2 stage, relatively lower T/R ratio, and good seed ripening. Average yields of the cultivers was 257kg/10a. In group 2, 12 cultivars showed higher T/R ratio due to overgrowth of top plant and lowest average yields (230 kg/l0a) due to poor seed ripening. Sixteen cultivars in group 3 grew fast from V5 to R2 stage representing late maturity traits, low T/R ratio, and good seed ripening. Average yields of the cultivars was highest among groups showing 270kg/l0a. In results, stable self-sufficiency of soybean yields could be expected by selective cultivation with high yielding cultivars ranging from 301 to 385kg/10a, such as Shinpaldalkong 2, Sohokong, Doremikong, Keumkangkong, Bukangkong, Dajangkong, and Geomjeongkong 2, or with cultivars included in group 3.