• Archives of Pharmacal Research
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• 제21권4호
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• pp.465-469
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• 1998

The search for platinum (II)-based compounds with improved therapeutic properties was prompted to design and synthesize a new family of water-soluble, third generation cis-diaminedichloroplatinum (II) complexes linked to uracil and uridine. Six heretofore unreported uracil and uridine-platinum (II) complexes are; [N-(uracil-5-yl-methyl)ethane-1,2-di-amine]dichloroplatinum (II) (3a), [N-(uracil-6-yl-methyl)ethane-1,2-diaminel dichloroplatinum (II) (3b), t[N-($2^1$, $3^1$,$5^1$-tri-O-acetyl)uridine-5-yl-methyl] ethane-1,2-diamineldichloroplatinum (II) (6a), {[N-($2^1$,$3^1$, $5^1$-tri-O-acetyl) uridine-6-yl-methyl]ethane-1,2-diamine)dichloroplatinum (II) (6b),[N-(uridine- 5-yl-methyl)ethane-1,2-diamine]dichloroplatinum (II) (7a), [N-(uridine-6-yl- methyl)ethane-1,2-diamine]dichloroplatinum (II) (7b). These analogues were prepared from the key starting materials, 5-chloromethyluracil (1a) and 6-chloromethyluracil (1b) which were reacted with ethylenediamine to afford the respective 5-[(2-aminoethyl)aminol methyluracil (2a) and 6-[(2-aminoethyl)amino]methyluracil (2b). The cis-platin complexes 3a and 3b were obtained through the reaction of the respective 2a and 2b with potassium tetrachloroplatinate (II). The heterocyclic nucleic acid bases 1a and 1b were efficiently introduced on the .betha.-D-ribose ring via a Vorbruggen-type nucleoside coupling procedure with hexamethyldisilazane, trimethylchlorosilane and stannic chloride under anhydrous acetonitrile to yield the stereospecific .betha.-anomeric 5-chloromethyl- $2^1$,$3^1$,$5^1$-tri-O-acetyluridine (4a) and 6-chloromethyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (4b), respectively. The nucleosides 4a and 4b were coupled with ethylenediamine to provide the respective 5-[(amino-ethyl)aminolmethyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (5a) and 6-[(aminoethyl)amino] methyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (5b). The diamino-uridines 5a and 5b were reacted with potassium tetrachloroplatinate (II) to give the novel nucleoside complexes, 6a and 6b, respectively which were deacetylated into the free nucleosides, 7a and 7b by the treatment with CH$_{3}$ONa. The cytotoxic activities were evaluated against three cell lines (FM-3A, P-388 and J-82) and none of the synthesized compounds showed any significant activity.

• 대한임상검사과학회지
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• 제38권3호
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• pp.166-172
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• 2006

Metallo-${\beta}$-lactamase (MBL) can hydrolyze all ${\beta}$-lactams except monobactams and frequently coexists with various antibiotic resistance genes such as aminoglycoside resistance, sulfonamide resistance gene, etc. Therefore, the effective antibiotics against infections by these bacteria are markedly limited or can't even be found. We tried to search in-vitro antimicrobial combinations with synergistic effects for a VIM-2 type MBL producing Pseudomonas aeruginosa, isolated from clinical specimen. On the selection of antibiotic combinations with synergistic effects, we performed a one disk synergy test, modified Pestel's method, in agar without aztreonam (AZT). The bacteriostatic synergistic effects of this tests were scored as $S_1$ (by susceptibility pattern in agar without antibiotics), $S_2$ (by the change of susceptibility in agar with or without antibiotics) and $S_3$ ($S_1$ + $S_2$) and was classified into weak (1 point), moderate (2 points) and strong (3 points) by $S_3$ score. Subsequently, we carried out the time-killing curve for the antibiotic combinations with the strong synergistic bacteriostatic effect. One VIM-2 type MBL producing P. aeruginosa confirmed by the PCR showed all resistance against all ${\beta}$-lactams except AZT, aminoglycoside and ciprofloxacin. In the one disk synergy test, this isolate showed a strong bacteriostatic synergistic effect for the antibiotic combination of AZT and piperacillin-tazobactam (PIP-TZP) or AZT and amikacin (AN). On the time-killing curve after six hours of incubation, the colony forming units (CFUs/mL) of this bacteria in the medium broth with both combination antibiotics were decreased to 1/18.7, 1/17.1 of the least CFUs of each single antibiotics. The triple antibiotic combination therapy including AZT, PIP-TZP and AN was shown to be significantly synergistic after 8 hrs of exposure. In a VIM-2 MBL producing P. aeruginosa with susceptibility for AZT, the triple antibiotic combination therapy including AZT, PIP-TZP and AN may be considered as an alternative antibiotics modality against the infection by some MBL type. But the antimicrobial combination therapy for many more MBL producing isolates is essential to know as soon as possible for the selection of effective treatment against the infection by this bacteria.

• Advances in Energy Research
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• 제1권2호
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• pp.147-163
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• 2013

The world faces several issues of energy crisis and environmental deterioration due to over-dependence on single source of which is fossil fuel. Though, fuel is needed as ingredients for industrial development and growth of any country, however the fossil fuel which is a major source of energy for this purpose has always been terrifying thus the need for alternative and renewable energy sources. The search for alternative energy sources resulted into the acceptance of a biofuel as a reliable alternative energy source. This work presents the study of optimization of process of transesterification of vegetable oil to biodiesel using NaOH as catalyst. A $2^4$ factorial design method was employed to investigate the influence of ratio of oil to methanol, temperature, NaOH concentration, and transesterification time on the yield of biodiesel from vegetable oil. Low and high levels of the key factors considered were 4:1 and 6:1 mole ratio, 30 and $60^{\circ}C$ temperatures, 0.5 and 1.0 wt% catalyst concentration, and 30 and 60 min reaction time. Results obtained revealed that oil to methanol molar ratio of 6:1, tranesetrification temperature of $60^{\circ}C$, catalyst concentration of 1.0wt % and reaction time of 30 min are the best operating conditions for the optimum yield of biofuel from vegetable oil, with optimum yield of 95.8%. Results obtained on the characterizzation of the produced biodiesel indicate that the specific gravity, cloud point, flash point, sulphur content, viscosity, diesel index, centane number, acid value, free glycerine, total glycerine and total recovery are 0.8899, 4, 13, 0.0087%, 4.83, 25, 54.6. 0.228mgKOH/g, 0.018, 0.23% and 96% respectively. Results also indicate that the qualities of the biodiesel tested for are in conformity with the set standard. A model equation was developed based on the results obtained using a statistical tool. Analysis of variance (ANOVA) of data shows that mole ratio of ground nut oil to methanol and transesterification time have the most pronounced effect on the biodiesel yield with contributions of 55.06% and 9.22% respectively. It can be inferred from the results various conducted that vegetable oil locally produced from groundnut oil can be utilized as a feedstock for biodiesel production.

• 대한방사선기술학회지:방사선기술과학
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• 제25권2호
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• pp.57-64
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• 2002

의료영상의 접근 용이성에 관한 대한 평가는 과거 영상의 조회 시 장기 저장장소에 있는 영상은 요청에 의해 기다렸으나, 쉽게 접근하여 자유롭게 조회 할 수 있다는 평가를 받았다. 임상적 유용성의 가치는 진료나 판독의 경우 더 많은 정보를 짧은 시간 내에 쉽게 제공받을 수 있고, 타과의 검사결과나, 진행상태, 검사주기를 파악하기에 편리하다는 평가였다. 외래 진료 시 편리성은 짧은 시간 내에 많은 환자를 대하는 진료환경에서 환자에게 제공해야 할 데이터의 긴 대기시간으로 충분히 설명하지 못하는 문제점을 해결하여, 환자와 같이 환자 본인의 의료영상을 조회하는 우수성을 인정했다. 영상관리의 용이성은 환자 개인 디지털 의료영상을 하나로 시간을 기준으로 통합 관리 할 수 있는 평가를 받았으며, 이는 과거 환자 개인의 Film 봉투와 같은 역할을 할 것이라는 결론을 얻었다. 또한 협진과 컨설팅에 있어서도 타 과의 도움을 받는데 큰 도움이 되리라는 평가이다. 마지막으로 전반적인 MIH의 선호도에 있어서도 타 프로그램과의 호환성과 조회시간 단축에 있어서 선호도를 나타내었다. 환자 개인의 의료영상을 시간별, 기간별로 나누어 조회가 가능하며, 환자의 검사 주기를 쉽게 볼 수 있어 진료에 도움이 될 것으로 사료된다.

• 대한예방한의학회지
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• 제5권1호
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• pp.116-133
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• 2001

Antifibrotic drugs could be delayed or inhibited massive collagen deposition in liver tissue or inhibited collagen synthesis. we investigated antifibrotic effects by several herbs(Schisnadra chinensis, Ganoderma japonicum, Sedum sarmentosum, Alisma canaliculatum, Plantago asiatica) extract with observations of collagen accumulation in liver tissue and collagen synthesis in sera. Rats were used for experimental animal that were devided 3 groups(sham control, BDL/S, BDL/S-ER). Rats were operated for inducing liver fibrosis(cirrhosis) by bile duct obstruction. Several herbs were prepared by water extraction and were applicated p. o. $3ml/day$ during 4 weeks. After observation period, rats were sacrificed and liver tissue and sera were collected. In result, the mortality of rats was 35% in BDL/S group and 20% in BDL/S-ER The color of bile juice in BDL/S-ER was bright yellow and murky yellow in BDL/S group. The significantly lower weight of liver($16.21g{\pm}5.3,\;20.58{\pm}2.4$) and spleen($1.96g{\pm}0.96,\;3.93{\pm}0.21$) were shown in BDL/S-ER than that of BDL/S(p<0.05) group. The value of collagen in liver tissue(25.7%) in BDL/S-ER was observed significantly lower than that of BDL/S group (Tab. 2). AST. ALT, ALP, t-bilirubin, BUN levels were low in BDL/S-ER as compared with those of BDL/S group, but the significance was not proven. The trichrome stained liver tissue in BDL/S-ER group was observed mild bile duct proliferation and fibrosis compared with BDL/S group. In conclusion, natural products inhibited new collagen synthesis and delayed massive collagen deposition in liver tissue, so that they have noticeable antifibrotic effects in experimental liver fibrosis(cirrhosis).

• 미술이론과 현장
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• 제5호
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• pp.7-24
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• 2007

The subject is connected with a structure named "The Symbolic" to Lacan, but he denied that the subject is explained simply as a fruit of language and "Other". From his point of view, passing through Subject, De-formation and Crack over it is designated as foundation of generation and creation rather than our destined defect. It should not be understood that subject of "The Real" is a concept of the subject free itself from restraint of "The Symbolic". However, this does not mean he asserts "Subject" is something incapable of being controlled by the unknown power. The problem is that this autonomous existence meets inside of it with something "more than one's own self" by "circulating around itself" like a permanent star. This is the indication of a "stranger in the middle of my privacy", or "extimit$\'{e}$", a coined-word by Lacan. Perhaps "Subject" is nothing more than the name of distance of object which is "too hot" to come close, and of this circulating movement. It's because of this object that the real subject stands against generalization and the subject can't be restored to any place in symbolic order-even though it is empty. The part which is told from Lacan's structural theory, that is to say, an importance to Lacan is that his Subject theory is not suggested or denied as a manual structure. On the contrary, it is a study of the relationship between the settled symbol that included in "real subject which is a unconscious one" and the symbolic subject hold- that is a metaphysical subject in general meaning. In Lacan's enlarged concept of subject beyond symbolic reality, it is noticeable that it gives justifiability to the union of a medium of different nature in artistic expression. We can recognize that the unconscious world is a living space which enables it to be a "condition of human being", not something dark under the surface of water through Magritte's(Rene Magritte, 1898~1967) surrealistic works. In other words, Magritte's art secures a core dimension of human nature through a mysterious gap of conscious and settled space. Magritte's drawings often evokes strange and unsettling feelings in people who view his paintings. This is because routine objects are found in "unsuitable" places from which we usually find them in our everyday lives. "Reality" in Magritte's paintings makes it aware that it is a strained field of concealment and disclosure basically between truths, and we can learn that his behavior to overturn to paint in-visible things is finally an effort to restore the "real subject" to the viewer's reality. In other words, such reversion arouses a nostalgic desire for the objects existing in their original appearance as they are - natural condition that our gaze had not been distorted yet by anamorphic stains. - and the state when we are conscious of them normally. Such desire offers an opportunity for us to get out of mental depression rather than operates to us as an abnormal crack. It's a successive process of effort to search for lost subject and Paradise Lost facing up to reality of subject human that is to be a subject of world and life are ousted from their place by structure and authority of culture.

• 비교문화연구
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• 제34권
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• pp.7-41
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• 2014

This article examines magical realism in contemporary european film, which is considered to be one of the most popular styles in the present culture, with regards to Antonio Negri's theory of art. Magical realism is "alternative approach to reality" (Maggie Ann Bowers, Magic(al) Realism) and defined as "a fictional technique that combines fantasy with raw physical reality or social reality in a search for truth beyond that available from the surface of everyday life" (Joan Mellen, Magic Realism). The term of Magic Realism was coined in 1923 by Franz Roh, German art historian, as the concept for the post-expressionist painting in Germany. It has flourished in the Latin-American literature during the 1950s to 1980s and spread worldwide. Since 1980s magical realism is considered to be a universal artistic mode. Since 1990s magical realism is to find in the various novels, and since 2000 one encounters magical realism in the cinema very often. Antonio Negri writes about the relationship between life, imagination, art and the political in his book Art et Multitude. According to Negri, the hard life of people in the present society liberates the imagination and this creates the art as "the excess of the existence". In this process the aesthetic becomes to the political. Negri calls this space of art as "magical time and space". Claire Denis' film Vendredi Soir is analyzed as a contemporary magic realist text, which realizes Negri's concept of art: vendredi soir (friday night) in Vendredi Soir is the magical time, when the impossible becomes the possible, and paris in the public transportation strike is the magical space, where the individuals meet the other in a new situation. The film analysis associates itself with Negri's theory of art: in Vendredi Soir, it is to see, that the excess of the existence liberates imagination and creates the magic reality both in the movements of things and the human relationship. The phenomenon of magical realism in contemporary culture can be understood as the symptom of the emotional and existential pains of contemporary people in the current world. The contemporaneity of the magical realism can be read in the film as "the metaphor for contemporary thought" (Alain Badiou, Cinema). As Antonio Negri writes, art can become "the aesthetic redemption" (Negri, Art et Multitude) for us. At the same time "(t)his is where aesthetics can be transformed into the political." (Lee, "Communism and the Void")

• 비교교육연구
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• 제27권1호
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• pp.29-49
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• 2017

이 연구는 그동안 일본의 교원정책에 관한 기존의 선행연구들이 교육개혁의 일부분으로 언급되거나 단편적으로 소개되어 왔다는 한계에 착안하여 교원생애에 걸친 질관리 정책을 종합적으로 그 특징을 규명하고 시사점을 도출한 것이다. 분석대상은 교원 선발 및 채용, 능력주의 인사관리, 지도력 부족 교원에 대한 관리, 초임 및 10년 경력자의 교원연수 관리, 그리고 교원자격 10년 면허제 등이다. 연구방법은 선행연구 및 정부보고서 등 문헌분석을 기본으로 하였고, 교원 양성기관의 교수 및 학교 현장의 교원과의 면담을 통해 현장의 의견을 반영했다. 교원의 선발을 위한 정원 책정은 기본적으로 국가관리(정원 산출 법정주의)를 기본으로 하면서, 실제적 선발 임용은 지방이 주관한다. 인건비는 현(縣)이 부담하면서, 인사관리는 시정촌(市町村)교육위원회가 주도(학교장의 내신 기초)한다. 교원 채용단계에서 전형방법이 다양화(교직경험자, 영어자격소지자 가산점제 등)되고 있고, '교사양성 숙(塾:연수기관)을 운영하기도 한다. 인사단계에서는 주간교사, 지도교사, 부교장제를 도입하고, 민간인 교장제 등 능력주의 관리를 강화하고 있다. 연수단계에 있어서는 지도력 부족 교사 대응과, 초임자 1년 연수제를 운영한다, 자격관리 면에서는 교원자격 10년 갱신제를 도입했다. 결론에서는 한국의 교원정책에 주는 10여 가지 정책적 시사점을 제언하였다.

• 한국컴퓨터정보학회논문지
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• 제24권10호
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• pp.183-188
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• 2019

본 연구는 응급구조학과와 간호학과에서 실시되는 재난관련 교육과정의 현황을 비교 분석하기 위한 서술적 조사 연구이다. 연구 분석대상은 인터넷 홈페이지를 이용하여 전국의 응급구조학과가 개설되어 있는 41개 대학을 대상으로 조사하였으며, 교육과정이 등재되어있지 않은 학교와 간호학과가 없는 학교를 제외하고 나머지 30개 대학을 연구대상으로 하였다. 연구 자료는 인터넷 홈페이지를 이용하여 교육과정을 수집하여 분석하였다. 키워드 '재난', '재해','응급'을 이용하여 만든 교과목을 조사하였으며, 교육과정은 재난관련 교과목의 개설현황, 전공 교양 분류, 학년, 학점, 이론 및 실습 시간 시수, 총 과목 개설수를 빈도와 백분율로 산출하였다. 연구결과는 재난관련 교과목 개설 현황은 응급구조학과는 29개교(96.7%) 간호학과 19개교(63.3%)였다. 개설 현황은 응급구조학과 2학년, 간호학과는 4학년이 가장 많았으며, 전공선택으로 2학점 개설이 가장 많았다. 본 연구결과를 토대로 재난에 대처할 수 있는 능력을 기르기 위해서는 재난현장에 맞는 지식과 술기가 필요하며 보건의료자원의 역할에 맞는 교육과정이 완성되어야 할 것이다.

• 한국치위생학회지
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• 제19권2호
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• pp.183-194
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• 2019

Objectives: This study aimed to identify the factors related to the completion status of continuing education and to help develop professional ability by presenting improvement directions. Methods: A questionnaire survey involving 500 dental hygienists working at 155 dental clinics in Gwang-ju was conducted between June 19 and July 29, 2017. Descriptive analysis, chi-square tests, and t-tests were conducted using Statistical Package for Social Sciences Version 21.0 for Windows. Finally, to investigate the factors related to the completion of continuing education, logistic regression analysis was performed. Results: The odds ratio (OR) was higher in the group with more than 16 years of total work carrier (OR=3.40, 95% confidence interval (CI)=1.22-9.45) than that in the group with 1-5 years of work carrier. Groups receiving information from associations (OR=5.35, 95% CI=1.74-16.40), groups that directly search for information (OR=6.53, 95% CI=1.84-23.12), and groups receiving information from colleagues (OR=3.55, 95% CI=1.17-10.77) had higher ORs than groups receiving no information. The OR was higher in the group receiving cost support for participation (OR=2.20, 95% CI=1.06-4.55) than the group receiving no support. Regarding total education completion status in 2012-2014, groups that completed grades 1-7 (OR=2.51, 95% CI=1.35-4.64) and those that completed grade 8 or higher (OR=14.37, 95% CI=7.68-26.89) had higher ORs than groups who received no education. Conclusions: The rate of completion of continuing education can be increased by reviewing the course contents, publicity activities, and cost of continuing education.