• Journal of Acupuncture Research
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• v.22 no.2
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• pp.71-81
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• 2005

Objective : Dear antler (Cervus korean TEMMINCK var. mantchuricus Swinhoe) used for traditional immunosuppressive and immuno-activating action. The effect of deer antler herbal-acupuncture(DAH) solution, prepared by water extract method, on cathepsin activities in bone tissues (cartilage and synovial) cells from mouse rheumatoid arthritis (RA) model was studied. The cysteine endoprotease cathepsin mediates degradation of the MHC class II invariant chain (Ii) in human and mouse antigen-presenting cells. The studies described here examine the functional significance of cathepsin inhibition on autoantigen presentation and organ-specific autoimmune diseases in a murine model for RA. Methods : An animal model for RA in BALB/c mice thymectomized 3 days after birth (3d-Tx) was constructed All 3d-Tx BALB/c mice developed autoimmune lesions in the bone tissue cells, starting at 3 weeks of age, and the disease mediated by CD4+ T cells was chronic and progressive. Significant inhibitory effects of DAH solution on cathepsin S and L were observed in each organ in a dose-dependent manner. Moreover, we confirmed that cathepsin S and L activity in each organ were clearly inhibited by DAB solution. When we examined the inhibitory effects of DAH solution against autoantigen-specific T cell responses in vitro, in regional lymph node cells, but not in spleens, from model mice, a significant inhibitory effect of DAB solution was observed in a dose-dependent manner. DAH solution do not block T cell proliferation to Con A, indicated that the dose of DAB solution 10 to $20\;{\mu}g/m{\ell}$ was sufficient to inactivate the autoantigen-specific T cell responses in vitro. In vivo therapeutic effects of DAB solution were examined in a murine model for RA, autoantigen-specific (C-II-specific) T cell response were significantly inhibited in LNCs from DAH solution-treated mice. Results : Iinhibition of cathepsin S and L in vivo alters autoantigen presentation and development of organ-specific autoimmunity in RA model. Conclusion : These data identify selective inhibition of cysteine protease cathepsin S and L as a potential therapeutic strategy for autoimmune disease process such RA. Thus, DAH solution will served as a potent anti-inflammatory and anti-arthritic agents for treatment of human RA.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.42 no.2
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• pp.444-452
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• 2017

Recently, a demand of Internet-of-things (IoT) rises dramatically and an interest in Low Power Wide Area (LPWA) grows larger accordingly. In this paper, performance in LoRa which is included in LPWA standard is analyzed. Particularly, after measuring Received Signal Strength Indication (RSSI) of received signal on Line-of-sight (LoS) and Non-line-of-sight (NLoS) environment and it is compared with RSSI which theoretical path loss model is applied to. Among many path loss models, the simulation for theoretical RSSI use Log-distance, Two-ray model and Okumura-Hata model that is based on the test database. Consequently, the result of Okumura-Hata model is the most similar with the measured RSSI. When a network based on LoRa is built, this result can used to decide optimal node arrangement.

• The Pure and Applied Mathematics
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• v.2 no.2
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• pp.173-181
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• 1995

Our objective is to investigate approximate controllability of a class of partial integrodifferential systems. This work continuous the investigations of [8]. As a model for this class one may take the equation $\frac{\partialy(t,\;\xi)}{\partialt}\;=\;\frac{\partial}{\partial\xi}(a(t,\;\xi\frac{\partialy(t,\;\xi)}{\partial\xi})\;+\;F(t,\;y(t\;-\;r,\;\xi),\;{{\int_0}^t}\;k(t,\;s,\;y(s\;-\;r,\;\xi))ds)\;+\;b(\xi)u(t),\;0\;\leq\;\xi\;\leq\;1,\;\leq\;t\;\leq\;T$ with initial-boundary conditions y(t,\;0)\;=\;y(t,\;1)\;=\;0,\;0\;\leq\;t\;\leq\;T,\;y(t,\;\xi)\;=\;\phi(t,\;\xi),\;0\;\leq\;1,\;-r\;\leq\;t\;\leq\;0$.(omitted)

• Journal of Ocean Engineering and Technology
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• v.30 no.5
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• pp.405-414
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• 2016

This paper presents an internal oil leakage detection problem for a hydraulic single-rod cylinder. We derive the dynamics of the hydraulic cylinder as a state space model, and then design a T—S fuzzy model-based fault detection observer. We adopt an H_∞ observer design scheme so that the observer is robust against disturbance and relatively sensitive to the leakage fault. Sufficient design conditions are derived in the form of linear matrix inequalities. A numerical example is provided to verify the proposed techniques.

• International Journal of Advanced Culture Technology
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• v.7 no.3
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• pp.25-34
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• 2019

Purpose: The purpose of this study was to examine the effects of health promotion program, which was based on the Health Belief Model, on the health belief, health promoting behavior and quality of life for middle-aged women. Methods: The study focused nonequivalent control group pretest-posttest design. Data were collected among 40 middle-aged women (20 were experimental group and 20 were control group) on 1st November 2014 and 25th April 2015. The experimental group received 12 sessions of health promotion program for aging preparation once a week for 12 weeks. Data were analyzed by ${\chi}^2$ and t-test and paired t-test using the PASW 21.0 program. Results: The study results shown that, health belief (t=-2.94, p=.006), health promoting behavior (t=-4.76, p<.001) and higher quality of life (t=-7.65, p<.001) scores of experimental group were higher than the control group. Conclusion: The health promotion program based on the Health Belief Model was effective and increased the health belief and health promoting behavior and quality of life among middle-aged women. It seems health promotion program is necessary to improve middle age women's health and quality of later life.

• Journal of Power Electronics
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• v.17 no.4
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• pp.884-891
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• 2017

The improved transfer functions of the modified Sheppard-Taylor (MS-T) converter, which is capable of regulating output voltage under a wide range of input voltage and load variations, negligible current ripple, and fewer components in comparison to the Sheppard-Taylor (S-T) converter, operating in continuous conduction mode (CCM) are investigated in this study. Its DC equilibrium point, small signal model, and transfer functions are derived and analyzed. Then, the voltage controller is applied for this MS-T converter. The comparisons between the derived model and the existing model are presented. The hardware circuit is designed and the circuit experiments are provided for validation. The results show that the improved transfer functions of the MS-T converter are more effective and general than the previous ones for describing its real characteristics.

• Communications for Statistical Applications and Methods
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• v.5 no.3
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• pp.887-894
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• 1998

Let T=( $T_1$,…, $T_{k}$;k$\geq$2) be a minimal sufficient and complete statistic for a k-parameter exponential model. Consider a partition of T into ( $T_1$, $T_2$), where $T_1$=( $T_1$,…, $T_{r}$ and $T_2$=( $T_{r+1}$,…, $T_{k}$1$\leq$r$\leq$k-1/). This article represents a way to obtain higher moments such as skewness and kurtosis for the distribution T and the conditional distribution of $T_1$, given $T_2$= $t_2$. These results are illustrated by some examples.s.les.s.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2001.11a
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• pp.67-67
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• 2001

The structure zone model has been used to provide an overview of the relationship between the microstructure of the films deposited by PVD and the most prominent deposition condition.s. B.AMovchan and AV.Demchishin have proposed it firstls such model. They concluded that the general features of the resulting structures could be correlated into three zones depending on $T/T_m$. Here T m is the melting point of the coating material and T is the substrate temperature in kelvines. Zone 1 ($T/Tm_) is dominated by tapered macrograins with domed tops, zone 2 ($O.3) by columnar grains with denser boundaries and zone 3 ($T/T_m>O.5$) by equiaxed grains formed by recrystallization. J.AThomton has extended this model to include the effect of the sputtering gas pressure and found a fourth zone termed zone T(transition zone) consisting of a dense array of poorly defined fibrous grains. R.Messier found that the zone I-T boundary (fourth zone of Thorton) varies in a fashion similar to the film bias potential as a function of gas pressure. However, there has not nearly enough model for explaining the change in morphology with crystal orientation of the films. The structure zone model only provide an information about the morphology of the deposited film. In general, the nucleation and growth mechanism for granular and fine structure of the deposited films are very complex in an PVD technique because the morphology and orientation depend not only on the substrate temperature but also on the energy of deposition of the atoms or ions, the kinetic mechanism between metal atoms and argon or nitrogen gas, and even on the presence of impurities. In order to clarify these relationship, AI and Mg thin films were prepared on SPCC steel substrates by PVD techniques. The influence of gas pressures and bias voltages on their crystal orientation and morphology of the prepared films were investigated by SEM and XRD, respectively. And the effect of crystal orientation and morphology of the prepared films on corrosion resistance was estimated by measuring polarization curves in 3% NaCI solution.

• Journal of the Korea Convergence Society
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• v.12 no.3
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• pp.17-25
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• 2021

When a person wears clothing, it is important to configure an outfit appropriate to the intended occasion. Therefore, T.P.O(Time, Place, Occasion) of the outfit is considered in various fashion recommendation systems based on artificial intelligence. However, there are few studies that directly infer the T.P.O from outfit images, as the nature of the problem causes multi-label and class imbalance problems, which makes model training challenging. Therefore, in this study, we propose a model that can infer the T.P.O of outfit images by employing a label-distribution-aware margin(LDAM) loss function. Datasets for the model training and evaluation were collected from fashion shopping malls. As a result of measuring performance, it was confirmed that the proposed model showed balanced performance in all T.P.O classes compared to baselines.

• Bulletin of the Korean Mathematical Society
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• v.34 no.1
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• pp.19-28
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• 1997

Let $H$ and $K$ be separable, complex Hilbert spaces and $L(H, K)$ denote the space of all linear, bounded operators from $H$ to $K$. If $H = K$, we write $L(H)$ in place of $L(H, K)$. An operator $T$ in $L(H)$ is called hyponormal if $TT^* \leq T^*T$, or equivalently, if $\left\$\mid$ T^*h \right\$\mid$ \leq \left\$\mid$ Th \right\$\mid$$ for each h in $H$. In [Pu], M. Putinar constructed a universal functional model for hyponormal operators.