• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.199-203
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• 2012

Purpose: To evaluate the prognostic value of serum CYFRA21-1, CEA and hemoglobin levels regarding long-term survival of patients with esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CRT). Methods: Age, gender, Karnofsky Performance Status (KPS), tumor location, tumor length, T stage, N stage and serum hemoglobin, and CYFRA21-1 and CEA levels before concurrent CRT were retrospectively investigated and related to outcome in 113 patients receiving 5-fluorouracil and cisplatin combined with radiotherapy for ESCC. The Kaplan-Meier method was used to analyze prognosis, the log-rank to compare groups, the Cox proportional hazards model for multivariate analysis, and ROC curve analysis for assessment of predictive performance of biologic markers. Results: The median survival time was 20.1 months and the 1-, 2-, 3-, 5- year overall survival rates were 66.4%, 43.4%, 31.9% and 15.0%, respectively. Univariate analysis showed that factors associated with prognosis were KPS, tumor length, T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level. Multivariate analysis showed T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis. By ROC curve, CYFRA21-1 and hemoglobin showed better predictive performance for OS than CEA (AUC= 0.791, 0.704, 0.545; P=0.000, 0.000, 0.409). Conclusions: Of all clinicopathological and molecular factors, T stage, N stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis for patients with ESCC treated with concurrent CRT. Among biomarkers, CYFRA21-1 and hemoglobin may have a better predictive potential than CEA for long-term outcomes.

• Journal of Korean Society on Water Environment
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• v.28 no.3
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• pp.409-417
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• 2012

SWAT model was applied for the Nakdong River Basin to characterize water quality variability and assess the feasibility of using the load duration curve to water quality management. The basin was divided into 67 sub-basins considering various watershed environment, and rainfall runoff and pollutant loading were simulated based on 6 year measurements of meteo-hydrological data, discharge data of treatment plants, and water quality data (SS, T-N and T-P). The results demonstrate that non-point source loads during wet season increase by 80 ~ 95% of total loads. Although the rate of water flow governs the amount of SS that is transported to the main streams, nutrient concentrations are highly elevated during dry season by being concentrated. This phenomenon is more pronounced in the lower basin, receiving large amounts of urban point source discharges such as treated sewages. Also, the load duration curves (LDC) demonstrate dominant source problems based on the load exceedances, showing that SS concentrations are associated with the rainy season and nutrients, such as T-P, may be more concentrated at low flow and more diluted at higher flow. Overall, the LDC method could be used conveniently to assess watershed characteristics and pollutant loads in watershed scale.

• Annals of Hepato-Biliary-Pancreatic Surgery
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• v.27 no.3
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• pp.251-257
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• 2023

Backgrounds/Aims: This is a retrospective analysis of whether the 8th edition American Joint Committee on Cancer (AJCC) was a significant improvement over the 7th AJCC distal extrahepatic cholangiocarcinoma classification. Methods: In total, 111 patients who underwent curative resection of mid-distal bile duct cancer from 2002 to 2019 were included. Cases were re-classified into 7th and 8th AJCC as well as clinicopathological univariate and multivariate, and Kaplan-Meier survival curve and log rank were calculated using R software. Results: In patient characteristics, pancreaticoduodenectomy/pylorus preserving pancreaticoduodenectomy had better survival than segmental resection. Only lymphovascular invasion was found to be significant (hazard ratio 2.01, p = 0.039) among all clinicopathological variables. The 8th edition AJCC Kaplan Meier survival curve showed an inability to properly segregate stage I and IIA, while there was a large difference in survival probability between IIA and IIB. Conclusions: The 8th distal AJCC classification did resolve the anatomical issue with the T stage, as T1 and T3 showed improvement over the 7th AJCC, and the N stage division of the N1 and N2 category was found to be justified, with poorer survival in N2 than N1. Meanwhile, in TMN staging, the 8th AJCC was able differentiate between early stage (I and IIA) and late stage (IIB and III) to better explain the patient prognosis.

• Smart Media Journal
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• v.9 no.4
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• pp.126-133
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• 2020

The treatment policy and prognosis are determined based on the final stage of lung cancer patients. The final stage of lung cancer patients is determined based on the T, N, and M stage classification table provided by the American Cancer Society (AJCC). However, the final stage of AJCC has limitations in its use for various fields such as patient treatment, prognosis and survival days prediction. In this paper, clustering algorithm which is one of non-supervised learning algorithms was assessed in order to check whether using only T, N, M stages with a data science method is effective for classifying the group of patients in the aspect of survival days. The final stage groups and T, N, M stage clustering groups of lung cancer patients were compared by using the cox proportional hazard model. It is confirmed that the accuracy of prediction of survival days with only T, N, M stages becomes higher than the accuracy with the final stages of patients. Especially, the accuracy of prediction of survival days with clustering of T, N, M stages improves when more or less clusters are analyzed than the seven clusters which is same to the number of final stage of AJCC.

• Journal of Biomedical Engineering Research
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• v.25 no.4
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• pp.243-251
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• 2004

This study was to quantitative analysis compare to dynamic characteristic change of the regional cerebral blood volume (rCBV) after development of cerebral fat embolism in cats using perfusion MR Imaging. Forty-four adult rats were used. Triolein (n = 15), oleic acid (n = 9) and linoleic acid (n = 11) were injected into the internal carotid artery using microcatheter through the transfemoral approach. Polyvinyl alcohol (Ivalon) (n = 9) was injected as a control group. Perfusion MR images were obtained at 30 minutes and 2 hours after embolization, based on T2 and diffusion-weighted images. The data was time-to-signal intensity curve and ΔR$_2$＊ curve were obtained continuously with the aid of home-maid image proc in.leased significantly at 2 hours compared with those of 30 minutes (P＜0.005). In conclusion, cerebral blood flow decreased in cerebral fat embolism immediately after embolization and recovered remarkably in time course. It is thought that clinically informations to dynamic characteristic change of the cerebral hemodynamics to the early finding in cerebral infarction by DWI and PWI

• Journal of the Korea Computer Graphics Society
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• v.8 no.2
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• pp.1-7
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• 2002

The fast extraction of the silhouettes of a model is very useful for many applications in computer graphics and animation. In this paper, we present an efficient algorithm to compute a sequence of perspective silhouettes for a polyhedral model from a moving viewpoint. The viewpoint is assumed to move along a trajectory q(t), which is a space curve of a time parameter t. Then, we can compute the time-intervals for each edge of the model to be contained in the silhouette by two major computations: (i) intersecting q(t) with two planes and (ii) a number of dot products. If q(t) is a curve of degree n, then there are at most of n + 1 time-intervals for an edge to be in a silhouette. For each time point $t_i$ we can extract silhouette edges by searching the intervals containing $t_i$ among the computed intervals. For the efficient search, we propose two kinds of data structures for storing the intervals: an interval tree and an array. Our algorithm can be easily extended to compute the parallel silhouettes with minor modifications.

• Journal of Environmental Science International
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• v.21 no.10
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• pp.1203-1212
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• 2012

Yongsan ward is located at central place connecting south and north ecology axis of seoul. Various environment-friendly Yongsan development could pose positive effects on NPS(non pollutant source) pollutant reductions and water quality improvement at Han-rive because BOD, T-N, and T-P NPS discharges took 90% of total pollutant from this area. In this study, direct runoff and NPS pollutant loads were evaluated before and after development using spatio-tamporal change in CN(curve number) and EMC(event mean concentration) data. It was found that direct runoff value is $23,584,724m^3$, and BOD, T-N and T-P loads are 104,456 kg/year, 111,483 kg/year and 7,500 kg/year under pre-development condition, respectively. Annual runoff, BOD, T-N and T-P reducing rate were 12.9%, 33.3%, 35.6% and 40.7% under integrated post-development condition, respectively. Based on the results obtained in this study, environment-friendly urban development could be achieved at Yongsan area.

• Journal of the Korean Society of Physical Medicine
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• v.4 no.4
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• pp.275-280
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• 2009

Purpose：We have investigated to analysis biomechanics for pinch strength due to elbow flexion degree. Methods：Pinch strength was measured by Electro Dynamometer(G-100) using four elbow flexion degree ($0^{\circ}$, $45^{\circ}$, $90^{\circ}$, $135^{\circ}$). Results：In experimental results, we found that pinch strengths were 5.4kg($0^{\circ}$), 4.8kg($45^{\circ}$), 5.6kg($90^{\circ}$) and 5.2kg($135^{\circ}$), respectively. The Pinch strengths got maximum at $90^{\circ}$ degree, minimum at $45^{\circ}$ degree. We have calculated F1 values using $\sum$T=0. As a result F1 values were 540N($0^{\circ}$), 480N($45^{\circ}$), 560N($90^{\circ}$) and 520N($135^{\circ}$), respectively. F1 values got maximum at $90^{\circ}$ degree, minimum at $45^{\circ}$ degree. Data curve line of $F_1$ values was increased in 45~90 section and decreased in 0~45, 90~135 sections, respectively. Conclusion：$F_1$ (Flexor digitorum superficialis and profundus) values were 10 times bigger than pinch strengths. Data curve line of $F_1$ values was similar to active length-tension curve in 45~90, 90~135 sections.

• Journal of Oral Medicine and Pain
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• v.25 no.4
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• pp.345-353
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• 2000

This study was to investigate normal salivary flow rates and normal indices of Quantitative analysis of salivary scintigraphy. 96 adult volunteers were studied by Questionnaire evaluating salivary conditions and clinical examinations. 35(male 23, female 12, age range 23-31years) that absented subjective and objective symptoms related saliva were classified as normal group. The normal group underwent measurement unstimulated and stimulated salivary flow rates and salivary scintigraphy. The obtained results were as follows: 1. There were not significant in sex differences of unstimulated and stimulated salivary flow rates. The unstimulated salivary flow rate was $0.66{\pm}0.41g/min$, stimulated salivary flow rates was $1.61{\pm}0.69g/min$. 2. As comparing of parameters of salivary scintigraphy, the Uptake ratio(UR), $T_{max}$, $T_{min}$, Maximum accumulation (MA), Maximum secretion(MS) of parotid and submandibular glands were not significant in sex and side-ralated differences. 3. The UR, $T_{max}$, MA, MS of parotid gland were significantly higher than those of submandibular gland; in the parotid gland, UR, $3.67{\pm}0.88$, $T_{max}$, $18.77{\pm}0.43min$, MA, $41.35{\pm}9.22%$, MS, $43.13{\pm}9.13%$; in the submandibular gland, UR, $3.04{\pm}0.10$, $T_{max}$, $18.48{\pm}0.52min$, MA, $36.47{\pm}14.18%$, MS, $36.88{\pm}12.20%$. 4. As classifying of time-activity curve, the most of parotid gland was N-type(97.1%), submandibular gland was observed in order of M-type(67.1%), N-type(21.4%), F-type(11.4%), however, was not observed S-type. 5. As the type of time-activity curve of submandibular gland was more flattened, the UR, $T_{max}$, MA, MS were significantly decresed.

• Structural Engineering and Mechanics
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• v.9 no.4
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• pp.375-382
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• 2000

Experimental investigation into the cyclic behaviour of sand plast brick masonry was performed on forty two square panels. The panels were subjected to cyclic uniaxial compression for two cases of loading: normal to bed joint and parallel to bed joint. Experimental data were used to plot the unloading-reloading curves for the entire range of the stress-strain curve. Mathematical expressions to predict the reloading and unloading stress-strain curves at various values of residual strain are proposed. A simple parabola and an exponential type formula are found adequate to model the unloading and reloading curves respectively. The models account for the potential effects of residual strain on these curves. Comparison of test results with the proposed mathematical expression shows good correspondence.